刘静波,女,1962年12月17日出生,中共党员,工学博士,教授,博士生导师。现任吉林大学中国新农村发展研究院常务副院长,同时在吉林大学食品科学与工程学院担任教授。
个人简介
刘静波,教育部高等学校2018-2021食品科学与工程类专业教学指导委员会副主任、中国工程教育专业认证协会认证结论审议委员会委员、食品类专业认证委员会成员、亚洲蛋品协会副会长、国家蛋品工程技术研究中心专家组成员、吉林省高校“十二五”优势特色重点建设学科食品科学与工程专业学科带头人、吉林省功能食品工程研究中心主任、吉林省营养与功能食品重点实验室主任等。
主要研究方向为营养与功能性食品,近五年主持国家自然科学基金面上项目4项、博士导基金项目1项、“十三五”国家重点研发计划项目1项,“十二五”国家科技支撑计划课题1项、分题2项等。发表学术论文200余篇(其中以第一作者或通讯作者发表SCI/EI检索论文70余篇);申请国家发明专利90余项,获得授权32项,被认定吉林省科学技术成果6项,企业转化2项。国家精品课《食品营养学》课程负责人,吉林省《食品营养学》优秀教学团队负责人。获“全军优秀教师”、“吉林大学名师”、“吉林大学师德标兵”、“吉林省拔尖创新人才”等荣誉称号。
教育经历
1980.09-1984.07,吉林农业大学动物营养学专业本科生
1999.09-2004.06,吉林大学生物与农业工程学院博士研究生
工作经历
1984.08-1987.06,解放军兽医大学动物营养学专业助教
1987.07-1999.08,解放军农牧大学动物营养学专业副教授/讲师
1999.09-2003.08,解放军军需大学军需工程系副教授
2003.09-2004.08,解放军军需大学军需工程系教授
2004.08-2015.05,吉林大学军需科技学院教授
2015.05-至今,吉林大学食品科学与工程学院教授
学术任职
教育部高等学校2018-2021食品科学与工程类专业教学指导委员会副主任;
中国工程教育专业认证协会认证结论审议委员会委员;
食品类专业认证委员会成员、亚洲蛋品协会副会长;
国家蛋品工程技术研究中心专家组成员;
吉林省高校“十二五”优势特色重点建设学科食品科学与工程专业学科带头人;
吉林省功能食品工程研究中心主任;
吉林省营养与功能食品重点实验室主任;
《Food Chemistry》SCI收录期刊审稿专家;
《Food and Bioprocess Technologies》SCI收录期刊审稿专家;
《食品科学》杂志审稿专家;
《食品工业科技》杂志审稿专家等。
获奖情况
“吉林大学教学名师”;
“第二批吉林省拔尖创新人才”;
“吉林大学师德标兵”;
吉林省第六届高等教育教学成果三等奖1项(第一署名);
吉林省高等学校教育技术成果影视教材三等奖1项;
吉林省发明创造大赛优秀奖2项;
主讲课程《食品营养学》为国家级精品课程;
主编教材《功能食品学》为吉林省优秀教学成果三等奖;
主编教材《功能食品学》获吉林省高等学校优秀教材二等奖;
主编教材《功能食品学》获吉林大学教学成果一等奖;
主编教材《功能食品学》获吉林大学第四届优秀教材一等奖;
副主编教材《食品无菌加工技术与设备》获教育部教指委推荐特色教材优秀教材二等奖。
教学业绩
从1984年8月至今,先后在解放军兽医大学、农牧大学、军需大学和吉林大学承担教学工作,荣获个人三等功1次,集体二等功1次,被授予“全军优秀教师”、“吉林大学教学名师”、“第二批吉林省拔尖创新人才”荣誉称号;担任国家精品课《食品营养学》课程负责人,吉林省《食品营养学》优秀教学团队负责人;承担国家级、省级有关食品科学与工程专业教学研究课题6项;获得教学成果奖6项,其中省级以上教学成果奖3项;公开发表教学研究论文20余篇;出版教材专著30余部,其中第一主编公开出版教育部食品科学与工程专业教学指导分委员会推荐特色教材《功能食品学》,成功入选“十二五”普通高等教育本科国家级规划教材、被评为吉林省省级优秀教材二等奖、吉林大学优秀教材一等奖;并列主编公开出版教育部轻工与食品教学指导委员会推荐特色教材《食品无菌加工技术与设备》荣获中国石油和化学工业协会优秀教材二等奖。
科研业绩
研究方向:营养与功能食品,研究成果主要体现在以下几个方面:
(1)食源性生物活性肽的结构表征
经活性广谱筛选后确证食源性生物活性肽具有抗氧化活性、血管紧张素抑制活性、抗炎活性、抗菌活性、抗凝活性、抗细胞凋亡活性、降血糖活性;利用四极杆线性离子阱串联质谱,获得具有血管紧张素转化酶抑制活性的蛋清源生物活性肽的19个分子离子峰,并对母离子进行碰撞诱导解析形成二级质谱,并对分子离子进行二级质谱,解析阐明8个蛋清源血管紧张素转化酶抑制肽的结构RVPSLM, TPSPR, DLQGK, AGLAPY,RVPSL,DHPFLF, HAEIN和QIGLF;获得具有抗氧化活性的玉米源生物活性肽LPF, LLPF, FLPF, YFCLT,GLLLPH。
(2)高压脉冲电场技术对活性肽功能基团的影响
首次探索了高压脉冲电场(PEF)技术对不同分子量食源性源生物活性肽的功能基团影响,分析并获知变化规律及机制。首次报道了PEF技术提高蛋清源1 kDa、1-3 kDa、10-30 kDa不同分子量抗氧化活性的研究与其作用机制初探,探索了PEF技术对蛋清源抗氧化肽的巯基功能团的影响情况,能够为深入研究食源性抗氧化肽技术推广提供了技术支撑;增加了国际同行对PEF技术在功能食品领域技术研究提供思路;为后期探讨PEF技术提高蛋白酶活性的作用机制提供了基础研究理论依据。
(3)活性肽的一、二级结构与生物活性关系
在生物活性肽构效关系研究中,对ACEIP先导序列RVPSL进行了结构改造,采用神经网络、遗传算法结合多元线性回归方法建立ACEIP的构效关系模型,利用分子对接的生物信息学手段,首次阐明蛋清源ACEIP一级结构和二级结构与体外血管紧张素抑制活性的关系,确立氨基酸的组成与序列在ACEIP活性中的重要性,并验证了蛋白质源活性肽可用构效关系模型预测。
(4)活性肽的结构与小肠完整吸收关系
利用Caco-2细胞膜对蛋清源功能肽RVPSL、QIGLF、TNGIIR等进行了模拟小肠吸收实验,分析了功能肽的完整吸收特性和吸收机制,并以RVPSL为先导序列,采用Pro替换法和肽骨架拆分法进行肽结构改造,结果发现N端Pro残基对肽吸收的影响较为明显,肽吸收率顺序为PPP-X-X>RPP-X-X>PVP-X-X>RVP-X-X (X代表Pro、Leu或Ser),而C端氨基酸残基对肽吸收的影响则不显著,肽的分子量和疏水性等与吸收之间无明显的相关性;另外,RVPSL拆分后短肽的吸收率增大,且二肽的吸收率高于三肽和四肽。
出版著作
1.《功能食品学》化学工业出版社(第一主编)2008.03
2.《食品无菌加工技术与设备》化学工业出版社(第二主编)2006.01
3.《蛋与蛋制品加工学》中国农业出版社(副主编)2007.01
4.《畜产食品工艺学》中国农业出版社(副主编)2008.01
5.《食品安全与选购》化学工业出版社(第一主编)2006.09
6.《大豆食品工艺学》化学工业出版社(第二主编)2006.01
7.《蛋品科学技术》化学工业出版社(副主编)2006.03
8.《蛋制品生产技术》吉林科学技术出版社(副主编)2008.01
9.营养师系列丛书 —《青少年营养配餐》化学工业出版社(第一主编)2006.09
10.营养师系列丛书—《婴幼儿营养配餐》化学工业出版社(第一主编)2006.09
11.营养师系列丛书 —《中老年人营养配餐》化学工业出版社(第一主编)2006.09
12.营养师系列丛书—《上班族营养配餐》化学工业出版社(第一主编)2006.09
13.营养师系列丛书—《孕产妇营养配餐》化学工业出版社(第一主编)2006.09
SCI论文情况
公开发表学术论文200余篇(其中以第一作者或通讯作者发表SCI检索论文40余篇)。
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2. Liying Wang, Long Ding, Zhipeng Yu, Ting Zhang, Shuang Ma, Jingbo Liu.Intracellular ROS scavenging and antioxidant enzyme regulating capacities of corn gluten meal-derived antioxidant peptides in HepG2 cells. Food Research International.2016
3. Zhipeng Yu, Wenzhu Zhao, Long Ding, Yaqi Wang, Feng Chen, Jingbo Liu. Short- and Long-term Antihypertensive Effect of egg protein-derived Peptide QIGLF.Journal of The Science of Food and Agriculture.2016
4. Long Ding, Liying Wang, Zhipeng Yu, Ting Zhang, Jingbo Liu. Digestionand absorption of an egg white ACE-inhibitory peptide in human intestinalCaco-2 cell monolayers. International Journal of Food Sciences and Nutrition. 2016.
5. Yu Zhipeng, Zhao Wenzhu, Ding Long, Yu Yiding, Liu Jingbo. Anxioly tic eects of ACE inhibitory peptides on the behavior of rats in an elevated plus-maze. Food & Function. 2016.
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9. Zhang D, Wang Y, Xu M, et al. Antioxidant Synergetic Effect Between the Peptides Derived from the Egg White Pentapeptide Trp-Asn-Trp-Ala-Asp[J]. International Journal of Peptide Research & Therapeutics, 2017(8):1-10.
10. Ting Zhang, Shaoping Nie, Boqun Liu, Yiding Yu, Yan Zhang, Jingbo Liu*, Activity prediction and molecular mechanism of bovine blood derived angiotensin I-converting enzyme inhibitory peptides. PloS one, 10 (3): e0119598, 2015.
11. Liying Wang, Long Ding, Ying Wang, Yan Zhang, Jingbo Liu*, Isolation and Characterisation of in Vitro and Cellular Free Radical Scavenging Peptides from Corn Peptide Fractions. Molecules, 20(2): 3221-3237, 2015
12. Jingbo Liu, Zhifei Chen, Jing He, Yan Zhang, Ting Zhang and Yiqun Jiang*,Anti-oxidative and Anti-apoptosis Effects of Egg White Peptide, Trp-Asn-Trp-Ala-Asp, Against H2O2-Induced Oxidative Stress in Human Embryonic Kidney 293 Cells. Food & Function, 5,3179-3188, 2014.
13. Long Ding, Yan Zhang, Yiqun Jiang, Liying Wang, Boqun Liu, and Jingbo Liu*, Transport of Egg White ACE-Inhibitory Peptide, Gln-Ile-Gly-Leu-Phe, in Human Intestinal Caco‑2 Cell Monolayers with Cytoprotective Efffect, Journal of Agricultural and Food Chemsitry, 62, 3177-3182 , 2014.
14. Zhipeng Yu, Yongguang Yin, Wenzhu Zhao, Feng Chen, Jingbo Liu*, Antihypertensive Effect of Angiotensin-Converting Enzyme Inhibitory Peptide RVPSL on Spontaneously Hypertensive Rats by Regulating Gene Expression of the Renin-Angiotensin System, Journal of Agricultural and Food Chemistry, 62(4): 912-917, 2014.
15. Zhipeng Yu, Yongguang Yin, Wenzhu Zhao, Feng Chenb and Jingbo Liu*,Application and bioactive properties of proteins and peptides derived fromhen eggs: opportunities and challenges. J Sci Food Agric, 94: 2839-2845, 2014.
16. Zhipeng Yu, Yongguang Yin, Wenzhu Zhao, Jingbo Liu*, Feng Chen.“Anti-diabetic activity peptides from albumin against a-glucosidase and a-amylase”.Food Chemistry:135(2012)2078–2085.
17. Zhipeng Yu, Boqun Liu, Wenzhu Zhao, Yongguang Yin, Jingbo Liu*, Feng Chen .Primary and secondary structure of novel ACE-inhibitory peptides from egg white protein.Food emistry:133(2012): 315-322.
18.Zhao W, Yin Y, Yu Z, et al. Comparison of anti-diabetic effects of polysaccharides from corn silk on normal and hyperglycemia rats.[J]. International Journal of Biological Macromolecules, 2012, 50(4):1133-1137.
19. Li L, Liu J, Nie S, et al. Direct inhibition of Keap1–Nrf2 interaction by egg-derived peptides DKK and DDW revealed by molecular docking and fluorescence polarization[J]. Rsc Advances, 2017, 7(56):34963-34971.
20. Songyi Lina, LiyanWang, Gregory Jones, Hung Trang, Yongguang Yin, Jingbo Liu.Optimized extraction of calcium malate from eggshell treated by PEF and an absorption assessment in vitro, International Journal of Biological Macromolecules:50 (2012):1327–1333.
21. Songyi Lin,Yang Guo,Qi You, Yongguang Yin and Jingbo Liu. Preparation of antioxidant peptide from egg white protein and improvement of its activities assisted by high-intensity pulsed electricfield, Journal of the Science of Food and Agriculture:;92(2012): 1554–1561.
22. Liu M. Optimization of extraction parameters for protein from beer waste brewing yeast treated by pulsed electric fields (PEF) [J]. African Journal of Microbiology Research, 2012, 6(22):4739-4746.
23. Wang J, Wang K, Lin S, et al. Improvement of antioxidant activity of peptides with molecular weights ranging from 1 to 10 kDa by PEF technology.[J]. International Journal of Biological Macromolecules, 2012, 51(3):244-249.
24. Wang K, Wang J, Zhao P, et al. Optimized PEF treatment for antioxidant polypeptides with MW 10-30 kDa and preliminary analysis of structure change [J]. International Journal of Biological Macromolecules, 2012, 51(5):819-825.
25. Zhuang, Hong, Zhang, Tiehua, Liu, Jingbo, Yuan, Yuan.Detection of acrylamide content in traditional Chinese food by high-performance liquid chromatography tandem mass spectrometry method,CYTA-JOURNAL OF FOOD:2012,10(1): 36-41.
26. Zhang M, Ping H, Cao X, et al. Rapid determination of melamine in milk using water-soluble CdTe quantum dots as fluorescence probes [J]. Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 2012, 29(3):333-44.
27. Yu, Z. P., W. Z. Zhao, et al. (2011). QIGLF, a novel angiotensin I-converting enzyme-inhibitory peptide from egg white protein. Journal of the Science of Food and Agriculture 91(5): 921-926.
28. Zhao, W. Z., Z. P. Yu, et al. (2011). Optimized extraction of polysaccharides from corn silk by pulsed electric field and response surface quadratic design. Journal of the Science of Food and Agriculture 91(12): 2201-2209.
29. Yu, Z., Y. Yin, et al. (2011). Characterization of ACE-Inhibitory Peptide Associated with Antioxidant and Anticoagulation Properties. Journal of Food Science 76(8): C1149-C1155.
30. Liu, J., C. N. Wang, et al. (2011). The antioxidant and free-radical scavenging activities of extract and fractions from corn silk (Zea mays L.) and related flavone glycosides. Food Chemistry 126(1): 261-269.
31. Liu, J. B., Z. P. Yu, et al. (2010). Isolation and identification of angiotensin-converting enzyme inhibitory peptides from egg white protein hydrolysates. Food Chemistry 122(4): 1159-1163.
32. Liu, J. B., Z. P. Yu, et al. (2010). Liquid Chromatographic Assay of Peptides Activity with Inhibiting Angiotensin Converting Enzyme. Chemical Research in Chinese Universities 26(5): 712-716.
33. Lu, J., S. Guan, et al. (2011). In Vivo Genotoxicity Evaluation of Crude Extract from Ledum palustre and Protective Effects on Cyclophosphamide-Induced Genotoxicity in Mice. Latin American Journal of Pharmacy 30(1): 112-118.
34. Niu, X. D., H. S. Wang, et al. (2011). Efficient green-phosphorescent light-emitting diodes based on polymeric binary-host systems. Journal of Luminescence 131(12): 2589-2592.
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36. Jun Liu, Songyi Lin, Zuozhao Wang, Cuina Wang, Erlei Wang, Yan Zhang, Jingbo Liu (2011).Supercritical fluid extraction of flavonoids from Maydis stigma and its nitrite-scavenging ability.Food and Bioproducts Processing, 89(4):333-339.
37. Zhang, T. H., J. Zheng, et al. (2011). Purification Technology and Antimicrobial Activity Analysis of Antimicrobial Peptide from Ovotransferrin. Chemical Research in Chinese Universities 27(3): 361-365.
38. Yuan, Y., H. Zhuang, et al. (2010). Patulin content in apple products marketed in Northeast China. Food Control 21(11): 1488-1491.
39. Guan, S., J. Lu, et al. (2011). Florfenicol impairs the immune responses to vaccination against foot-and-mouth disease in mice. Immunopharmacology and Immunotoxicology 33(4): 609-613.
40. Guo, N., J. B. Liu, et al. (2009). Antifungal activity of thymol against clinical isolates of fluconazole-sensitive and -resistant Candida albicans. Journal of Medical Microbiology 58(8): 1074-1079.
41. Guo, N., X. P. Wu, et al. (2010). In vitro and in vivo interactions between fluconazole and allicin against clinical isolates of fluconazole-resistant Candida albicans determined by alternative methods. Fems Immunology and Medical Microbiology 58(2): 193-201.
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43. Niu X, Liu J, Xie Z. Efficient white polymer light-emitting diodes based on the control of a emissive polymer morphology through solvent processing[J]. Organic Electronics, 2010, 11(7):1273-1276.
44. Shi, X. L., Y. R. Jin, et al. (2011). Matrix solid phase dispersion extraction of ginsenosides in the leaves of Panax ginseng CM Mey. Food Chemistry 129(3): 1253-1257.
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授权专利
申请国家专利81件、获得授权37件、企业转化4件,其中,发明专利:玉米花丝饮品及其制备方法(申请号200810050578.2)等成果在吉林天景食品有限公司等企业得到推广应用,在国内首次开展了对玉米花丝原料进行产业示范化的研究,建立了一条可形成20000吨/年玉米花丝饮品(易拉罐)生产线1条,已投放生产。该专利技术的开发与应用,丰富了玉米类食品的品种,实现了食品企业在生产过程中废弃物的回收、利用、增收,不仅将废弃物玉米花丝变成有用的产业资源,同时可以有效解决玉米精深加工企业的废弃物所造成的环境污染问题,减少了废弃物排放,有利于环保。
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