薛天

薛天，男，1977年出生，博士，中国科学技术大学人力资源部部长，生命科学与医学部执行部长，生命科学学院教授、博导，微尺度物质科学国家研究中心“神经环路与脑认知部”主任。^[1]中国科学技术大学党委委员、校长助理。^[2]1995年-2000年，薛天就读于中国科学技术大学少年班系（强化班），毕业获学士学位。^[3]2000年-2005年，薛天就读于美国约翰霍普金斯大学医学院，毕业获分子生理学博士学位。^[3]

2000年毕业于中国科学技术大学少年班系（强化班）获学士学位；

2005年获美国约翰霍普金斯大学医学院生理学博士；

2006-2011年在美国约翰霍普金斯大学医学院从事感受器官神经生物博士后研究工作；

2011-2012年任美国约翰霍普金斯大学医学院助理研究员；

2012-至今，中国科学技术大学生命科学学院和微尺度国家实验室，教授；

2014年3月20日薛天教授获得“人类前沿科学计划”青年科学家项目资助；^[4]

2018年起任生命科学与医学部执行部长；

2019年起任中国科学技术大学党委委员；

2020-2022年任党委教师工作部、人力资源部部长；^[2]

2022年1月任中国科学技术大学校长助理。^[5]

2023年6月14日，国家自然科学基金委员会公布2023年度医学科学部基础科学中心和创新研究群体项目专业评审组组成名单，薛天在列。^[6]

2020-至今，国务院学术委员会第八届学科评议组成员2019-至今，教育部生物技术与生物工程教学指导委员会，委员2019-至今，中国医师协会眼科医师分会基础与临床转化专委会，委员2019-至今，中国神经科学学会，理事2018-至今，海峡两岸医药卫生交流协会眼科专委会眼干细胞学组，副组长2018-至今，中国生理学会，常务理事2018-至今，中国生物物理学会“组织建设工作委员会”主任委员2015-至今，中国细胞生物学学会，理事2015-至今，安徽省细胞生物学会，副理事长^[7]

长期从事光感受神经生物学的光信号转导、神经环路以及视觉再生修复等方面研究。至今共发表SCI论文49篇，多篇通讯作者论文发表在Nature、Cell等学术期刊，被引用4000余次，h-index 27。优秀青年基金（2013），重大科学研究计划青年973项目首席科学家（2013），中科院脑科学卓越中心骨干（2014），国际研究资助组织Human Frontier Science Program (HFSP) Young Investigator Grants（2014），国家自然科学基金委杰出青年基金（2019），国家重点研发计划项目首席科学家（2020）。^[1]

1、视觉神经生物学

2、干细胞再生感光细胞

3、非成像视觉神经环路

部分论文著作：

Yi WY#, Lu YF#, Zhong SJ#, Zhang M#*, Sun L, Dong H, Wang MD, Wei M, Xie HH, Qu HQ, Peng RM, Hong J, Yao ZQ,Tong YY,Wang W, Ma Q, Liu ZY, Ma YQ, Li SZ, Yin CH, Liu JW, Ma C, Wang XQ*,Wu Q*, and Xue T*† (2020). A single-cell transcriptome atlas of the aging human and macaque retina, National Science Review. In press. (# equal contributions, *co-corresponding authors，†lead contact)Li SZ#, Hu YZ#, Li YQ#, Hu M, Wang WC, Ma YQ, Cai Y, Wei M, Yao YC, Wang Y, Dong K, Gu YH, Zhao H, Bao J, Qiu ZL, Zhang M*, Hu XT*, Xue T*† (2020). Generation of nonhuman primate retinitis pigmentosa model by in situ knockout of RHO in rhesus macaque retina. Science Bulletin. In press.Cheng P#, Tian X#, Tang W, Cheng J, Bao J, Wang H, Zheng S, Wang Y, Wei X, Chen T, Feng H, Xue T, Goda K, and He H. (2021). Direct control of store-operated calcium channels by ultrafast laser. Cell Res. In press.Huang X#, Huang P#, Huang L#, Hu Z, Liu X, Shen J, Xi Y, Yang Y, Fu Y, Tao Q, Lin S, Xu A, Xu F, Xue T, So KF*, Li H*, and Ren C*† (2021). A Visual Circuit Related to the Nucleus Reuniens for the Spatial-Memory-Promoting Effects of Light Treatment. Neuron 109, 347-362 e347.5. Li X#, Zhang J#*, Li D, He C, He K, Xue T, Wan L, Zhang C, and Liu Q*†. (2021). Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory. Neuron. In press.Liu Q#, Su LY#*, Sun C, Jiao L, Miao Y, Xu M, Luo R, Zuo X, Zhou R, Zheng P, Xiong W, Xue T, and Yao YG*† (2020). Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation. Redox Biol 34, 101560.An K#, Zhao H#*, Miao Y, Xu Q, Li YF, Ma YQ, Shi YM, Shen JW. Meng JJ, Yao YG, Zhang Z, Chen JT, Bao J, Zhang M and Xue T*† (2020). A Circadian Rhythm-gated Subcortical Visual Circuit for Nighttime Light Induced Depressive-like Behaviors, Nat. Neurosci.23, 869-880.Lu Y#, Shiau F#, Yi W#, Lu S, Wu Q, Pearson J, Kallman A, Zhong S, Hoang T, Zuo Z, Zhao F, Zhang M, Tsai N, Zhuo Y, He S, Zhang J, Stein-O’Brien G, Sherman T, Duan X, Fertig D, Goff L, Zack J, Handa J, Xue T*, Bremner R*, Blackshaw S*,Wang X* and Clark B*† (2020). Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development. Dev. Cell. 53, 473-491.^[7]Xie H#, Zhang W#, Zhang M#*, Akhtar T, Li Y, Yi W, Sun X, Zuo Z, Wei M, Fang X, Yao Z, Dong K, Zhong S, Liu Q, Shen Y, Wu Q, Wang X, Zhao H, Bao J, Qu K*, Xue T*. (2020). Chromatin accessibility analysis reveals regulatory dynamics of developing human retina and hiPSC-derived retinal organoids. Science Advances, 6(6): eaay5247. (*co-corresponding authors lead contact)Akhtar T, Xie H, Khan M I, Zhao H, Bao J, Zhang M*, Xue T*. (2019). Accelerated photoreceptor differentiation of hiPSC-derived retinal organoids by contact co-culture with retinal pigment epithelium. Stem Cell Research, 39, 101491.Ma Y#, Bao J#*, Zhang Y#, Li Z, Zhou Z, Zhou X, Wan C, Huang L, Zhao Y, Han G*, Xue T*. Injectable, Self-powered Retinal Nanoantennae for the Creation of Mammalian Near-infrared Image Vision. Cell, 177, 1-13, 2019 (*co-corresponding authors lead contact)Cai Y#, Cheng T#, Yao Y#, Li X, Ma Y, Li L, Zhao H, Bao J, Zhang M*, Qiu Z*, Xue T*. (2019). In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway. Science Advances, 5(4): eaav3335. (*co-corresponding authors lead contact)Yu N, Huang L, Zhou Y*, Xue T*, Chen Z*, and Han G* (2019). Near-Infrared-Light Activatable Nanoparticles for Deep-Tissue-Penetrating Wireless Optogenetics. Adv Healthc Mater, e1801132. (*co-corresponding authors)Zhu H#; Wang N#; Yao L; Chen Q; Zhang R; Qian J; Hou Y; Guo W; Fan S; Liu S; Zhao Q; Du F; Zuo X; Guo Y; Xu Y; Li J; Xue T; Zhong K; Song X; Huang G*;Xiong W*. Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain. Cell 173, 1716-1727 e1717. (2018)Ye F, Huang Y, Li J, Ma Y, Xie C, Liu Z, Deng X, Wan J, Xue T, Liu W, Zhang M(2018). An unexpected INAD PDZ tandem-mediated plcbeta binding in Drosophila photo receptors. Elife 7.Deng K, Shen J, Wang W, Li M, Li H, Chen C, Zhao H, Zhang M, Xue T, Liu Q, Lui VWY, Hong B, Lin W. Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer. Cancer Biol Ther. 2018 Sep 5:1-13.Deng WL, Gao ML, Lei XL, Lv JN, Zhao H, He KW, Xia XX, Li LY, Chen YC, Li YP, Pan D, Xue T, Jin, Z. B. Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients. Stem Cell Reports 2018, 10(4):1267-1281.Tang J, Qin N, Chong Y, Diao Y, Yiliguma, Wang Z, Xue T, Jiang M, Zhang J,Zheng G: Nanowire arrays restore vision in blind mice. Nat Commun 2018, 9(1):786.Cheng J, Huang X, Liang Y, Xue T, Wang L, Bao J: Plasticity of Light-induced concurrent Glutamatergic and GABAergic Quantal Events in the Suprachiasmatic Nucleus. J Biol Rhythms 2018, 33(1):65-75.Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Lin A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y, Yu X. (2017) A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. J Clin Invest. 127(7):2631-2646.Wang Q, Yue WWS, Jiang Z, Xue T, Kang SH, Bergles DE, Mikoshiba K, Offermanns S, Yau KW. (2017) Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle. Curr Biol. 27(12):1791-1800.Zhao H, Ma YQ, An K, Hu JX, Cai Y, Bao J, Xue T. (2017) Phototransduction and brain circuitry of non-image-forming vision. Sci Sin Vitae, 2017, 47: 69–77.(review)Liu CH, Gong Z, Liang ZL, Liu ZX, Yang F, Sun YJ, Ma ML, Wang YJ, Ji CR, Wang YH, Wang MJ, Cui FA, Lin A, Zheng WS, He DF, Qu C, Xiao P, Liu CY, Thomsen ARB, Joseph Cahill T, Kahsai AW, Yi F, Xiao KH, Xue T, Zhou Z, Yu X, Sun JP. (2017) Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. Nat Communications 8:14335.Wen M, Guo X, Sun P, Xiao L, Li J, Xiong Y, Bao J, Xue T, Zhang L, Tian C (2015) Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells. Chem Commun (Camb) 51(38):8153-6.Hu QX, Dong JH, Du HB, Zhang DL, Ren HZ, Ma ML, Cai Y, Zhao TC, Yin XL, Yu X, Xue T, Xu ZG, Sun JP. (2014) Constitutive Gαi Coupling Activity of VLGR1 and its Regulation by PDZD7. J Biol Chem 289(35):24215-2Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Park T, Zambidis E, Meyer J, Gamm MD, Yau KW, Canto-Soler MV (2014). Generation of three dimensional retinal tissue with functional photoreceptors from human iPSCs. Nature Communications 5:4047.Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L Jr, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai SI, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, Diantonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ. (2013). Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proc Natl Acad Sci U S A. 110(10):4045-50.Pearson RA, Barber AC, Rizzi M, Hippert C, Xue T, West EL, Duran Y, Smith AJ, Chuang JZ, Azam SA, Luhmann UFO, Benucci A, Sung CH, Carandini M, Yau KW, Sowden JC, Ali RR. (2012). Restoration of vision after transplantation of photoreceptors. Nature. 485(7396):99-103.Xue T¶, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW¶. (2011). Melanopsin Signaling in Mammalian Iris and Retina. Nature. 479(7371):67-73. (Research Article) (¶ co-corresponding authors); Faculty of 1000: f1000.com/13360986.Do MT, Kang SH, Xue T, Zhong H, Liao HW, Bergles DE, Yau KW. (2009) Photon capture and signalling by melanopsin retinal ganglion cells. Nature. 457(7227):281-7. (Research Article); Faculty of 1000: f1000.com/1144855.Luo DG, Xue T, Yau KW. (2008) How vision begins: An odyssey. Proc Natl Acad Sci U S A. 105(29): 9855-62 (review)Fu YB*, Kefalov V*, Luo DG*, Xue T*, Yau KW. (2008) Quantal noise from human red cone pigment. Nature Neuroscience. 11(5):565-71 (* equal contributions)Xue T, Siu CW, Lieu DK, Lau CP, Tse HF, Li RA. (2007) Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels. Circulation. 115(14):1839-1850.El-Kholy W, MacDonald PE, Fox JM, Bhattacharjee A, Xue T, Gao X, Zhang Y, Stieber J, Li RA, Tsushima RG, Wheeler MB. (2007) Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells. Mol Endocrinol. 21(3):753-764.Tse HF, Xue T, Lau CP, Siu CW, Wang K, Zhang QY, Tomaselli GF, Akar FG, Li RA (2006). A bio-artificial sinus node constructed via in vivo gene transfer of an engineered pacemaker (HCN) channel reduces the dependence on electronic pacemaker in a sick sinus syndrome model. Circulation 114: 1000-1011. Issue highlights, GROUND-BREAKING STUDY OF 2007 AHA.Ardehali H, Xue T, Dong P, Machamer C (2005). Targeting of the mitochondrial membrane proteins to the cell surface for functional studies. Biochem Bioph Res Comm. 338(2):1143-51.Abraham MR, Henrikson CA, Tung L, Chang MG, Aon M, Xue T, Li RA, O'Rourke B, Marban E (2005). Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circ Res. 97:159-67.Moore JC, van Laake LW, Braam SR, Xue T, Tsang SY, Ward D, Passier R, Tertoolen LL, Li RA, Mummery CL (2005). Human embryonic stem cells: Genetic manipulation on the way to cardiac cell therapies. Reprod Toxicol. 20:377-91.Azene EM, Xue T, Marban E, Tomaselli GF, Li RA (2005). Non-equilibrium behavior of HCN channels: Insights into the role of HCN channels in native and engineered pacemakers. Cardiovasc Res. 67:263-73.Wang G*, Xue T*, Tsang SY, Wong J, Cheng L, Zhang J, Li GR, Lau CP, Li RA, Tse HF (2005). Electrophysiological properties of pluripotent human and mouse embryonic stem cells. Stem Cells. 23(10):1526-34. (* equal contributions)Xue T*, Cho H*, Akar F*, Tsang SY, Jones S, Marbán E, Tomaselli GF, Li RA (2005). Functional Integration of Electrically Active Cardiac Derivatives from Genetically Engineered Human Embryonic Stem Cells with Quiescent Recipient Ventricular Cardiomyocytes. Insights into the Development of Cell-Based Pacemakers. Circulation. 111:11-20. issue highlights, (Best Paper Award, Circulation. 2005) (* equal contribution)Xue T, Sato K, Kodama K, Ennis I, French RJ, Li RA (2003). Novel interactions identified between µ-conotoxin and the Na+ channel Domain I P-loop: Implications for toxin-pore binding geometry. Biophys. J. 85(4):2299-310.Azene EM*, Xue T*, Li RA (2003). Molecular basis of the effects of potassium on heterologously-expressed pacemaker (HCN) channels. J. Physiol. (London) 547(2):349-356. (* equal contributions )Henrikson CA, Xue T, Dong P, Sang D, Marbán E, Li RA (2003). Identification of a surface charged residue in the S3-S4 linker of pacemaker (HCN) channel that influences activation gating. J. Biol. Chem. 278(16):13647-54.Li RA, Ennis I, Xue T, Nguyen HM, Tomaselli GF, Goldin AL, Marbán E (2003). Molecular basis of isoform-specific µ-conotoxin block of cardiac, skeletal muscle and brain Na channels. J. Biol. Chem. 278(10):8717-24.Xue T, Li RA (2002). An external determinant in the S5-P linker of the pacemaker (HCN) channel identified by sulfhydryl modification. J. Biol. Chem. 277(48):46233-42.Xue T, Marbán E, Li RA (2002). Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: Insights into structure-function relationships and multimerization. Circ. Res. 90:1267-1273.Li RA, Sato K, Kodama K, Kohno T, Xue T, Tomaselli GF, Marban E. (2002). Charge conversion enables quantification of the proximity between a normally-neutral mu-conotoxin (GIIIA) site and the Na+ channel pore. FEBS Lett. 511(1-3):159-164.^[8]

2003：American Heart Association (AHA) Scientific Sessions Selected Late-Breaking Science

2004：NIH Stem Cells Scholarship at the Keystone Stem Cells Symposium, NIH

2006：BEST BASIC SCIENCE PAPER by Circulation, AHA

2007：Final list of Life Science Research Foundation Fellowships

2013：国家自然科学基金委优秀青年基金

2014：Human Frontier Science Program (HFSP)，Young Investigator Grants

2019：2019年度“中国生命科学十大进展”

2019：Cell杂志2019年最佳论文

2019：国家自然科学基金委杰出青年基金

2020：2020年度“中国神经科学重大进展”^[7]

2021年3月，入选2020年度第十三届“谈家桢生命科学奖”候选名单。^[9]

2021年4月，第十三届谈家桢生命科学奖获奖名单公布，薛天荣获谈家桢生命科学创新奖。^[10]

2022年9月，第四届“科学探索奖”获奖名单公布，薛天荣获医学科学奖。^[11]

2023年8月31日，入选2023年中国科学院院士增选有效候选人名单。^[12]

中国科学技术大学生命科学与医学部薛天教授研究团队在《细胞》在线发表研究成果，揭示光感知调控血糖代谢的神经机制。^[13]

薛天长期期致力于视觉科学与眼科研究领域，从分子、细胞、环路和整体等多层次解析视觉神经系统的生物学机理，并在视觉修复与增强的多学科交叉技术方法领域作出了突出贡献。（腾讯医典评）^[14]