梅虎

梅虎，男，1972年10月生，安徽芜湖人，农工民主党成员，博士，重庆大学生物工程学院副教授、硕士生导师。美国ACS会员、重庆市化学学会和生物医学工程学会会员。主要研究领域包括计算机辅助药物设计、药物基因组学、生物信息学等。在国际知名期刊上发表SCI收录论文60余篇，单篇最高引用90余次，累计引用310余次。申请发明专利5项，获权2项。主持国家高技术发展研究计划（“863”计划）、国家自然科学基金等多项省部级以上科研项目。

药物设计与药物基因组学

梅虎教授的研究成果“肽定量构效关系研究与应用”获得教育部自然科学奖二等奖。他曾获得重庆大学“优秀青年教师”和“学生科技园丁”等荣誉称号。指导本科生参加美国数学建模竞赛，获得二等奖和三等奖各一项。

梅虎教授现为《Journal of Medicinal Chemistry》，《Bioorganic & Medicinal Chemistry Letters》，《SCIENCE IN CHINA》，《CHINESE JOURNAL OF STRUCTURAL CHEMISTRY》等杂志的审稿人。

梅虎教授在国际学术期刊上发表了多篇论文，其中包括：

1. Zhang ZH, Chen S, Mei H, Xuan JK, Guo XQ, Couch L, Dobrovolsky VN, Guo L, Mei N. 2015. Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells. Scientific Reports 5.

2. Sun JY, Mei H. 2015. QSAR and molecular mechanism analysis of N-substituted oseltamivir derivatives as potent avian influenza H5N1 neuraminidase inhibitors. Chemometrics and Intelligent Laboratory Systems 146: 485-93.

3. Pan XC, Chao L, Qu SJ, Huang SH, Yang L, Mei H. 2015. An improved large-scale prediction model of CYP1A2 inhibitors by using combined fragment descriptors. Rsc Advances 5: 84232-7.

4. Liu T, Pan X, Chao L, Tan W, Qu S, Yang L, Wang B, Mei H. 2014. Subangstrom accuracy in pHLA-I modeling by Rosetta FlexPepDock refinement protocol. J Chem Inf Model 54: 2233-42.

5. Xie JG, Xu ZL, Zhou SB, Pan XC, Cai SX, Yang L, Mei H. 2013. The VHSE-Based Prediction of Proteasomal Cleavage Sites. Plos One 8.

6. Tan W, Mei H, Chao L, Liu TF, Pan XC, Shu M, Yang L. 2013. Combined QSAR and molecule docking studies on predicting P-glycoprotein inhibitors. Journal of Computer-Aided Molecular Design 27: 1067-73.

7. Tan QY, Wu JY, Li Y, Mei H, Zhao CJ, Zhang JQ. 2013. A supermolecular curcumin for enhanced antiproliferative and proapoptotic activities: molecular characteristics, computer modeling and in vivo pharmacokinetics. Nanotechnology 24.

8. Tan QY, Li Y, Wu JY, Mei H, Zhao CJ, Zhang JQ. 2012. An optimized molecular inclusion complex of diferuloylmethane: enhanced physical properties and biological activity. International Journal of Nanomedicine 7: 5385-93.

9. Sun J, Mei H. 2012. Docking and 3D-QSAR investigations of pyrrolidine derivatives as potent neuraminidase inhibitors. Chemical Biology & Drug Design 79: 863-8.

10. Ostrov DA, Grant BJ, Pompeu YA, Sidney J, Harndahl M, Southwood S, Oseroff C, Lu S, Jakoncic J, de Oliveira CAF, Yang L, Mei H, Shi L, Shabanowitz J, English AM, Wriston A, Lucas A, Phillips E, Mallal S, Grey HM, Sette A, Hunt DF, Buus S, Peters B. 2012. Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire. Proceedings of the National Academy of Sciences of the United States of America 109: 9959-64.

11. Li Y, Mei H, Wu Q, Zhang S, Fang J-L, Shi L, Guo L. 2011. Methysticin and 7,8-Dihydromethysticin are Two Major Kavalactones in Kava Extract to Induce CYP1A1. Toxicological Sciences 124: 388-99.

12. Sun JY, Cai SX, Yan N, Mei H. 2010. Docking and 3D-QSAR studies of influenza neuraminidase inhibitors using three-dimensional holographic vector of atomic interaction field analysis. European Journal of Medicinal Chemistry 45: 1008-14.

13. Sun JY, Cai SX, Mei H, Li JA, Yan N, Wang Q, Lin ZH, Huo DQ. 2010. Molecular Docking and QSAR Studies on Substituted Acyl(thio)urea and Thiadiazolo [2,3-alpha] Pyrimidine Derivatives as Potent Inhibitors of Influenza Virus Neuraminidase. Chemical Biology & Drug Design 76: 245-54.