封洲燕

封洲燕

封洲燕

封洲燕,浙江大学教授,博士生导师,生物医学工程与仪器科学学院成员。封洲燕,教授,博士生导师。1986年、1989年和2001年在浙江大学生物医学工程专业获得学士、硕士和博士学位。1989年起留校并任教于生命科学学院,2005年起任教于生物医学工程与仪器科学学院。1996年晋升为副教授,2006年晋升为教授,2007年晋升为博士生导师。2002年至2004年在美国Case Western Reserve University的生物医学工程系神经工程中心工作两年。为IEEE Senior Member;为《生物医学工程学杂志》和《生物医学工程研究》期刊编委。[0]

封洲燕,浙江大学教授,博士生导师,生物医学工程与仪器科学学院成员。

人物简介

封洲燕,教授,博士生导师。1986年、1989年和2001年在浙江大学生物医学工程专业获得学士、硕士和博士学位。1989年起留校并任教于生命科学学院,2005年起任教于生物医学工程与仪器科学学院。1996年晋升为副教授,2006年晋升为教授,2007年晋升为博士生导师。2002年至2004年在美国Case Western Reserve University的生物医学工程系神经工程中心工作两年。为IEEE Senior Member;为《生物医学工程学杂志》和《生物医学工程研究》期刊编委。[1]

教学工作

封洲燕教授承担了多门本科生和博士生课程,包括生物医学统计学、定理生理学、生物医学工程方法学、生物医学仿真技术、专业英语、生物物理学、程序设计基础及实验、微处理机原理及应用、计算机在生物学中的应用等。

研究方向

封洲燕教授的研究领域包括生物医学信号处理、神经电生理和神经工程。其主要研究工作包括脑神经电信号记录和分析的新方法,设计和开发新型的电刺激模式,以及利用建模仿真的方法研究电刺激调控脑神经系统的机制。

工作研究项目

封洲燕教授负责国家自然科学基金项目2项,并承担过多项仪器开发课题。其研究项目包括基于高时空分辨率记录技术的在体神经网络研究、生理性自发放电信号诱导神经突触长时程可塑性变化的研究、癫痫在大脑不同区域的传播机制、嗅球僧帽细胞及其交互性突触的信息整合模型、小型全自动生化分析仪样机研发等。

出版著作

封洲燕教授翻译了多部生物医学工程领域的著作,包括《电生理学方法与仪器入门》《数值方法在生物医学工程中的应用》《生物医学工程学概论》(原书第2版和第3版)《医疗电子仪器的设计与开发——医疗仪器设计、制作和测试的实用技术》《信号统计分析方法——生物医学和电气工程应用指南》(原书第3版)等。此外,他还参与编写了《定量生理学》《从分子到行为》《一般集成论研究(第1辑)》等教材和专著。

代表论文

1.Feng Z*, Zheng L, Yuan Y, Yang G, Hu Y, Lu C, Wang Z. Cathodic- and anodic-pulses can alternately activate different sub-populations of neurons during sustained high-frequency stimulation of axons in rat hippocampus. Journal of Neural Engineering, 2022 Feb 18;19(1). (SCI摘录)

2.Zheng L, Feng Z*, Xu Y, Yuan Y, Hu Y. An anodic-phase can facilitate rather than weaken a cathodic-phase to activate neurons in biphasic-pulse axonal stimulations. Frontiers in Neuroscience, (In press) (SCI摘录)

3.杨刚生, 封洲燕*, 郑吕漂, 王兆祥. 时变参数神经电刺激系统的设计及其应用. 生物医学工程学杂志, 2021, 38(6): 1144-1153. (EI摘录)

4.Zheng L, Feng Z*, Hu Y, Wang Z, Yuan Y, Yang G, Lu C. Adjust Neuronal Reactions to Pulses of High-Frequency Stimulation with Designed Inter-Pulse-Intervals in Rat Hippocampus In Vivo. Brain Sciences. 2021 Apr 16;11(4):509.(SCI摘录)

5.Yuan Y, Zheng L, Feng Z*, Yang G. Different effects of monophasic pulses and biphasic pulses applied by a bipolar stimulation electrode in the rat hippocampal CA1 region. Biomed Eng Online. 2021 Mar 9;20(1):25.(SCI摘录)

6.Wang ZX, Feng ZY*, Yuan Y, Zheng LP. Suppressing synchronous firing of epileptiform activity by high-frequency stimulation of afferent fibers in rat hippocampus. CNS Neuroscience & Therapeutics. 2021 Mar;27(3):352-362.(SCI摘录)

7.胡一凡,封洲燕*,王兆祥,郑吕漂. 大鼠海马神经元对于高频脉冲刺激的暂态响应. 生物化学与生物物理进展. 2021, 48(7): 827-835.(SCI摘录)

8.王兆祥,封洲燕*,杨刚生,郑吕漂. 新型深部脑刺激模式的开发及研究进展. 生物化学与生物物理进展. 2021, 48(3): 263 - 274.(SCI摘录)

9.Wang ZX, Feng ZY*, Zheng LP, Yuan Y. Sinusoidal stimulation on afferent fibers modulates the firing pattern of downstream neurons in rat hippocampus. J Integr Neurosci. 2020 Sep 30;19(3):413-420. (SCI摘录)

10.Zheng L, Feng Z*, Hu H, Wang Z, Yuan Y, Wei X. The Appearance Order of Varying Intervals Introduces Extra Modulation Effects on Neuronal Firing Through Non-linear Dynamics of Sodium Channels During High-Frequency Stimulations. Front Neurosci. 2020 May 19;14:397. (SCI摘录)

11.Qiu C, Feng Z*, Zheng L, Ma W. Selective modulation of neuronal firing by pulse stimulations with different frequencies in rat hippocampus. Biomed Eng Online. 2019 Jul 23;18(1):79. (SCI摘录)

12.Feng Z*, Ma W, Wang Z, Qiu C, Hu H. Small Changes in Inter-Pulse-Intervals Can Cause Synchronized Neuronal Firing During High-Frequency Stimulations in Rat Hippocampus. Front Neurosci. 2019 Jan 31;13:36.(SCI摘录)

13.Ma W, Feng Z*, Wang Z, Zhou W. High-frequency stimulation of afferent axons alters firing rhythms of downstream neurons. J Integr Neurosci. 2019 Mar 30; 18(1): 33-41. (SCI摘录)

14.胡汉汉, 封洲燕*, 王兆祥, 郑吕漂, 黄璐. 变间隔的脉冲改变高频刺激对于脑神经元的作用. 生物化学与生物物理进展, 2019, (8). (SCI摘录,封面论文)

15.黄璐, 王兆祥, 封洲燕*. 深部脑刺激期间神经元动态活动的光栅图描述方法. 生物医学工程学杂志, 2019, 36(02): 177-182. (EI摘录)

16.Zhaoxiang Wang, Zhouyan Feng*, Hanhan Hu, Yue Yuan. Sinusoidal Stimulation on Afferent Fibers Can Selectively Activate Different Types of Neurons in Rat Hippocampus, 41th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2019 July (EI摘录)

17.Lvpiao Zheng, Zhouyan Feng*, Zheshan Guo, Lu Huang. Simulation Study of Intermittent Responses of Neuronal Populations to Axonal High-Frequency Stimulation, 41th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2019 July (EI摘录)

18.Hanhan Hu, Zhouyan Feng*, Lvpiao Zheng, Yue Yuan. Significant Differences in Neuronal Responses to High-Frequency Pulse Stimulation with Constant and Varying Inter-Pulse-Intervals, 41th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2019 July

19.Lu Huang, Zhouyan Feng*, Zhaoxiang Wang. Axonal Stimulations with High-Frequency Pulses Alter Firing Patterns of Neurons in the Downstream Region, 41th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2019 July

20.Guo Z, Feng Z*, Wang Y, Wei X. Simulation Study of Intermittent Axonal Block and Desynchronization Effect Induced by High-Frequency Stimulation of Electrical Pulses. Front Neurosci. 2018 Nov 22;12:858.(SCI摘录)

21.Wang Z, Feng Z*, Wei X. Axonal Stimulations With a Higher Frequency Generate More Randomness in Neuronal Firing Rather Than Increase Firing Rates in Rat Hippocampus. Front Neurosci. 2018 Oct 24;12:783. (SCI摘录)

22.封洲燕*,郭哲杉,王兆祥. 深部脑刺激作用机制的研究进展, 生物化学与生物物理进展, 2018, 45(12). 1197-1203(SCI摘录)

23.Cai Z, Feng Z*, Hu H, Hu N, Wei X, Design of a Novel Stimulation System with Time-varying Paradigms for Investigating New Modes of High Frequency Stimulation in Brain, BioMedical Engineering OnLine, 2018, 17(1), 90. (SCI摘录)

24.黄璐,封洲燕*,王兆祥. 神经元对于高频电刺激的动态响应. 生物化学与生物物理进展,2018, 45(4). 432-441. (SCI摘录)

25.马维健,封洲燕*,周文杰,王兆祥,蔡紫燕. 高频电刺激减弱神经元发放与场电位节律之间的锁相关系,生物医学工程学杂志,2018 (1) :1-7. (EI摘录)

26.Chen Qiu, Zhouyan Feng*, Lvpiao Zheng, Lu Huang. Frequency-Dependent Inhibition Induced by Stimulations in Rat Hippocampus, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2018 July (EI摘录)

27.Weijian Ma, Zhouyan Feng*, Hanhan Hu, Zhaoxiang Wang, Wenjie Zhou. Synchronous Responses of Population Neurons to the Changes of Inter-Pulse-Intervals during Stimulations of Afferent Fibers, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2018 July (EI摘录)

28.Cai Z, Feng Z*, Guo Z, Zhou W, Wang Z, Wei X. Novel Stimulation Paradigms with Temporally-Varying Parameters to Reduce Synchronous Activity at the Onset of High Frequency Stimulation in Rat Hippocampus. Front Neurosci. 2017 Oct 10;11:563. (SCI摘录)

29.周文杰,封洲燕*,邱晨,马维健;持续高频刺激改变短刺激产生的神经网络效应,生物化学与生物物理进展,2017, 44(9): 769~775(SCI摘录,封面论文)

30.陈小千,封洲燕*,郭哲杉,周文杰,王兆祥;癫痫模型中痫样棘波自动检测的新算法及其应用,生物医学工程学杂志,2017 (4) :485-492.(EI摘录)

31.Feng Z*, Wang Z, Guo Z, Zhou W, Cai Z, Durand DM. High frequency stimulation of afferent fibers generates asynchronous firing in the downstream neurons in hippocampus through partial block of axonal conduction. Brain Research. 2017; 1661:67-78.(SCI摘录)

32.朱玉芳, 封洲燕*, 王兆祥, 余颖, 郭哲杉. 高频电刺激改变神经元锋电位的波形. 生物化学与生物物理进展, 2016, 43(8), 787-795. (SCI摘录)

33.王兆祥, 封洲燕*, 余颖, 朱玉芳, 郭哲杉. 适用于宽频带记录信号的锋电位检测法. 仪器仪表学报, 2016, 37(3) : 481-489. (EI摘录)

34.曹嘉悦, 封洲燕*, 郭哲杉, 胡振华, 胡娜. 闭环式电刺激抑制痫样棘波发放的机制研究. 中国生物医学工程学报, 2016, 35(1): 79-87.

35.Zhaoxiang Wang, Zhouyan Feng*, Ying Yu, Yufang Zhu, Zheshan Guo. Detection of single unit spikes during orthodromic-high frequency stimulation in rat hippocampus. Conf Proc IEEE Eng Med Biol Soc. 2016 Aug; 2016:5813-5816. (EI摘录)

36.Zheshan Guo, Zhouyan Feng*, Ying Yu, Wenjie Zhou, Zhaoxiang Wang, Xuefeng Wei. Sinusoidal stimulation trains suppress epileptiform spikes induced by 4-AP in the rat hippocampal CA1 region in-vivo. Conf Proc IEEE Eng Med Biol Soc. 2016 Aug; 2016:5817-5820. (EI摘录)

37.胡娜, 封洲燕*, 郭哲杉, 王兆祥, 余颖. 深部脑刺激中单相脉冲与双相脉冲的作用比较, 中国生物医学工程学报, 2015, 34(5): 548-557.

38.Yu Y, Feng Z*, Cao J, Guo Z, Wang Z, Hu N and Wei X. Modulation of local field potentials by high-frequency stimulation of afferent axons in the hippocampal CA1 region. Journal of Integrative Neuroscience, 2015, 14(3): 1–17. (SCI摘录)

39.胡振华,封洲燕*,郑晓静,余颖. 实时癫痫电位检测与闭环式电刺激系统的设计,生物医学工程学杂志,2015, 32(1):168-174.

40.Feng Z*, Yu Y, Guo Z, Cao J, Durand DM. High frequency stimulation extends the refractory period and generates axonal block in the rat hippocampus. Brain Stimulation. 2014,7(5): 680-689.(SCI摘录)

41.Wang Y, Feng Z*, Wang J, Zheng X. Somatosensory stimulation suppresses the excitability of pyramidal cells in the hippocampal CA1 region in rats. Neural regeneration research, 2014, 9(11), 1138-1144.(SCI摘录)

42.曹嘉悦, 封洲燕*, 郑晓静, 陈白璐. 深度麻醉至脑死亡期间大鼠海马神经元活动的突变. 生物化学与生物物理进展, 2014, 41(4), 379-387.

43.吴蕴蕴, 封洲燕*, 郑晓静. 定量分析神经元锋电位与局部场电位锁相关系的新方法. 生物医学工程学杂志, 2014,31(1): 172-180.

44.封洲燕*, 余颖, 曹嘉悦, 郭哲杉. 大鼠海马神经元群体对于高频电刺激的响应. 中国生物医学工程学报, 2014, 33(2): 186-193.

45.Feng Z*, Zheng X, Yu Y, Durand DM. Functional disconnection of axonal fibers generated by high frequency stimulation in the hippocampal CA1 region in-vivo. Brain Research, 2013,1509: 32-42. (SCI摘录)

46.封洲燕*, 肖乾江, 胡振华. 电刺激期间神经细胞单元锋电位的检测. 中国生物医学工程学报, 2013, 32(4): 403-410.

47.封洲燕*,陈丹,肖乾江,一种闭环式神经电刺激系统的设计,仪器仪表学报,2012, 33(2): 279-285 (EI收录)

48.封洲燕*,王 静,汪洋,郑晓静. 神经元锋电位信号滤波频率的选择,浙江大学学报工学版,2012, 46 (2): 351-358. (EI收录)

49.杨彭举,封洲燕*. 海马锥体神经元细胞外动作电位的仿真,生物医学工程学杂志,2011, 28(5): 1007-1013

50.王静,封洲燕*,郑晓静. 低信噪比神经元锋电位检测的新方法,浙江大学学报(工学版),2011, 45(5): 941-947. (EI收录)

51.Feng ZY*,Zheng, XJ, Tian C, Wang Y, Xing HY, Changes of Paired-Pulse Evoked Responses During the Development of Epileptic Activity in the Hippocampus. Journal of Zhejiang University (Science B), 2011 12(9):704-711(SCI摘录)

52.封洲燕*,邢昊昱,田聪,等. 大鼠海马CA1区前馈抑制和反馈抑制的作用特性. 航天医学与医学工程,2011, 24 (3): 167-172

53.杨彭举,封洲燕*,孙静. 独立分量分析在神经元锋电位分类中的一种新应用,中国生物医学工程学报,2011,30(4):150-158.

54.吴丹,封洲燕*,王静. 微电极阵列神经元锋电位信号的去噪方法; 浙江大学学报工学版,2010, 44(1): 104-110. (EI收录)

55.Feng ZY*,Zheng, XJ,Wang, J. Effects of carnosine on the evoked potentials in hippocampal CA1 region. Journal of Zhejiang University (Science B), 2009,10(7): 505-511. (SCI收录)

56.封洲燕*,王静. 微电极阵列大脑电信号检测技术的进展,电子学报,2009,37(1), 153-159.(EI收录)

57.王静,封洲燕*. 多通道神经元锋电位检测和分类的新方法,生物化学与生物物理进展,2009, 5, 641-647.(SCI收录)

58.光磊,封洲燕*. 神经细胞群峰电位的自动定量分析,浙江大学学报(工学版),2008, 42(9): 1641-1647.(EI收录)

59.Park EH, Feng Z, Durand DM. Diffusive coupling and network periodicity: a computational study. Biophysical Journal , 2008, 95:1126-1137. (SCI收录)

60.封洲燕*, 光磊, 郑晓静等. 应用线性硅电极阵列检测海马场电位和单细胞动作电位. 生物化学与生物物理进展,2007, 34(4):401-407. (SCI收录)

61.Feng Zhou-yan, Chen Wei-dong, Ye Xue-song, et al. A remote control training system for rat navigation in complicated environment. Journal of Zhejiang University (Science A), 2007, 8(2): 323-30. (SCI收录)

62.Feng Z, Durand DM. Effects of potassium concentration on firing patterns of low-calcium epileptiform activity in anesthetized rat hippocampus: inducing of persistent spike activity. Epilepsia. 2006, 47(4):727-36. (SCI收录)

63.Feng Z, Durand DM. Propagation of low calcium non-synaptic induced epileptiform activity to the contralateral hippocampus in vivo. Brain Research. 2005, 1055(1-2):25-35. (SCI收录)

64.Feng Z, Durand DM. Decrease in Synaptic Transmission Can Reverse the Propagation Direction of Epileptiform Activity in Hippocampus in vivo. Journal of Neurophysiology, 2005, 93(3):1158-64. (SCI收录)

65.Feng Z, Durand DM. Suppression of Excitatory Synaptic Transmission Can Facilitate Low-Calcium Epileptiform Activity in the Hippocampus in-vivo. Brain Research, 2004, 1030(1): 57-65. (SCI收录)

66.封洲燕,郑筱祥. 不同麻醉深度下大鼠脑电复杂度和功率谱的变化过程, 中国生物医学工程学报, 2004, 23(1):87-91. (EI收录)

67.封洲燕,郑筱祥. 多分辨率小波信号分解用于大鼠睡眠纺锤波的分析,中国生物医学工程学报, 2004, 23(2):103-108. (EI收录)

68.封洲燕. 不同行为状态下大鼠脑电时频变化特性的直方图分析,生物医学工程学杂志, 2004, 21(3): 371-376.

69.Feng Z, Durand DM. Low-calcium epileptiform activity in the hippocampus in vivo. Journal of Neurophysiology. 2003, 90(4):2253-2260. (SCI收录)

70.FENG ZY. Analysis of rat electroencephalogram during slow wave sleep and transition sleep using wavelet transform. Acta Biochimica et Biophysica Sinica. 2003, 35(8):741-6.(SCI收录)

71.Caihua Shou, Zhouyan Feng, Jiang Wang, Xiaoxiang Zheng. The Inhibitory Effects of Jujuboside A on Rat Hippocampus in Vivo and in Vitro, Planta Medica, 2002, 68(9):799-803. (SCI收录)

72.FENG Zhou-yan, ZHENG Xiao-xiang. The Effect of Jujuboside A on the Evoked Field Potentials of Granule Cells in Dentate Gyrus, Journal of Zhejiang University (Science), 2002, 3(5):591-593. (EI收录)

73.封洲燕,郑筱祥. 大鼠皮层脑电和海马电位的复杂度和功率谱分析, 航天医学和医学工程, 2002, 15(4):276-280. (EI收录)

74.封洲燕. 应用小波熵shāng分析大鼠脑电信号的动态变化特性,生物物理学报, 2002, 18(3):325-330.

75.封洲燕,郑筱祥. 抖笼法药理实验数据采集和定量分析,浙江大学学报(工学版),2002, 36(2):183-185.

76.封洲燕,郭殿武,苏松,赵辉,郑筱祥. 酸枣仁皂甙dàiA镇静和抗惊厥作用试验, 浙江大学学报(医学版),2002,31(2):103-106.

77.封洲燕,郑筱祥. 采样参数变化对脑电信号复杂度分析的影响,生物医学工程学杂志, 2002, 19(4): 616-620.

78.Zhouyan Feng, Xiaoxiang Zheng, Changes in Complexities and Power Spectrum of Rat Electroencephalogram under Various Anesthesia Depth, Proceedings of the Second Joint EMBS/BMES Conference, Houston, TX, USA, Oct. 2002, p145-146 (EI收录)

79.Zhouyan Feng, Zheng Xu, Analysis of Rat Electroencephalogram under Slow Wave Sleep Using Wavelet Transform, Proceedings of the Second Joint EMBS/BMES Conference, Houston, TX, USA, Oct. 2002, p94-95 (EI收录)

80.封洲燕,郑筱祥. 齿状回突触后电位和群峰电位的负相关现象,生物物理学报. 2001,17(2):289-297.

81.封洲燕,沈公羽. 生化分析仪的软件设计, 中国医疗器械杂志, 1999, 23(2):89-92.

82.封洲燕,沈公羽. 实现对数和模数转换的一种电路, 电测与仪表, 1998, 35(7):30-32.

83.沈公羽,封洲燕,黄家骞等. SH-C1型全自动生化分析仪的设计原理和实现. 中国医疗器械杂志. 1998, 22(3):125-128.

84.封洲燕. CPU KTH-6 型电脑呼吸机的研制, 中国医疗器械杂志. 1996, 20(5):249-251.

85.封荣, 陈守川,封洲燕,王丽. MCS-51系列单片机在物理实验仪器中的应用-智能速度加速度仪,新疆大学学报:自然科学版. 1993,10(1): 61-63.

86.葛霁光 封洲燕. 兼具两种扫描的显示器,浙江大学学报(自然科学版). 1991,25(2): 182-187.

87.封荣 封洲燕, 付银生,陈永强. 激光大屏幕显示装置的微机控制系统,微型机与应用, 1991(8): 39-40.

88.葛霁光 封洲燕, 一种新型显示器的研制,中国医疗器械杂志,1989,13(1):1-4.

奖励荣誉

封洲燕教授曾获得国家教育委员会科学技术进步奖、浙江省科学技术奖、浙江大学教学成果奖、浙江大学金秀奖教金、浙江大学师德先进个人和事业家庭兼顾型先进个人等奖励。[1]

参考资料 1

  1. 封洲燕 — 浙江大学教师个人主页
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