吕镇梅

吕镇梅，女，浙江大学生命科学学院微生物学教授，博士生导师，浙江大学“求是青年学者”。她的研究领域涵盖污染物的微生物生态学、毒理学和分子生物学。吕镇梅教授曾获得国家自然科学优秀青年基金（2015年）和浙江省自然科学杰出青年基金（2014年）。她还担任中国环境科学学会水环境分会委员、中国微生物学会环境微生物学专业委员会委员、浙江省生态学会秘书长、浙江省微生物学会理事，并入选浙江大学学术带头人后备人才培养“新星计划”。

吕镇梅教授是国家和浙江省精品课程《微生物学》的主要申请人和主讲人之一。她主持了多项科研项目，包括国家自然科学基金、水体污染控制与治理科技重大专项子课题、浙江省科技支撑和引导计划面上项目、“十一五”国家科技支撑计划重大项目子课题等。她在《TheISMEJournal》《Appl Environ Microb》《Environmentalscience&technology》《Waterresearch》《Soilbiology&biochemistry》等环境科学领域的国际主流刊物上发表了30余篇学术论文，其中SCI收录论文28篇。

1.水体中四氢呋喃分布迁移规律及其污染水体生物修复初探

同济大学长江水环境教育部重点实验室开放课题(No. YRWEF06007) 项目主持

2.上海市水稻重大病虫预测预报可视化技术

上海市农委、上海交通大学合作课题(2007.01.01-2007.12.31) 项目主持

3.除草剂、杀虫剂等有机污染物对土壤放线菌活性和群落结构影响

浙江省教育厅项目(2005.01.01-2006.12.31) 项目主持

4.伯克氏菌WZ1对二氯喹啉酸复合污染物的降解及其应激蛋白质的研究

国家自然科学基金项目(2006.01.01-2008.12.31) 27万元 项目主持

5.假单胞菌菌株HF-1降解烟草废弃物中尼古丁的研究

浙江省科技支撑和引导计划面上项目(2008.01.01-2009.12.31) 30万元 项目主持

6.水稻转Bt基因对秸秆降解和土壤有机碳固定效应的影响

国家自然科学基金项目(2006.01.01-2008.12.31) 35万元 第二负责人

7.小城镇饮用水安全保障关键技术研究

“十一五”国家科技支撑计划重大项目——“小城镇受污染水源水修复关键技术研究”子课题(2006.01.01-2010.12.31) 50万元 子课题负责人

8.农业面源污染河流综合整治技术集成与示范工程

水体污染控制与治理科技重大专项(2010.01.01-2011.12.31) 100万元 子课题负责人

9.Pseudomonas sp. HF-1新尼古丁降解质粒pMH1的分子机制阐明与完善

国家自然科学基金项目(2012.01.01-2015.12.31) 58万元 项目主持

10.东部河网水源污染地区村镇饮用水安全保障技术

国家科技支撑计划，No. 2012BAJ25B07，2012.01.01-2015.12.31 子课题负责人

11.溢油沉积物中微生物功能种群演替及其与石油降解进程耦合机制

国家自然科学基金项目，No. 31370151，2014.01.01-2017.12.31，项目主持

12.环境微生物

国家自然科学基金优秀青年基金项目，No. 31422003，2015.01.01-2017.12.31，项目主持

浙江省自然科学杰出青年基金，LR14D030001，2014.01-2017.12，项目主持

吕镇梅教授在学术和教学方面获得了多项荣誉和奖励，包括2004年获得上海同济高廷耀环保科技发展基金会青年博士杰出人才奖学金、浙江大学优秀毕业研究生、浙江省优秀毕业研究生。2008年获得浙江大学优秀德育导师称号及浙江大学奖教金，2011年获浙江大学青年岗位能手，2012年获全国高校青年教师教学竞赛理科组一等奖，浙江省“三育人”先进个人，2013年获浙江省151人才工程第三层次培养人员，浙江大学2013年度优质教学奖。

2014

Zhixing He, Yanlai Yao, Zhenmei Lu*, Yangfang Ye. Dynamic metabolic and transcriptional profiling of Rhodococcus sp. strain YYL during the degradation of tetrahydrofuran. Appl Environ Microb. 2014, 80(9): 2656-2664.Zhixing He, Chengzhen Niu, Zhenmei Lu*. Individual or synchronous biodegradation of di-n-butyl phthalate and phenol by Rhodococcus ruber strain DP-2. Hazard Mater. 2014 273C: 104-109.

2013

Zhixing He, Hailong Xiao, Lu Tang, Hang Min, Zhenmei Lu* .Biodegradation of di-n-butyl phthalate by a stable bacterial consortium, HD-1,enriched from activated sludge.Bioresource Technology. 2013, 128:526-532.唐璐, 牛成镇, 吕镇梅*. 土霉素对活性污泥微生物群落结构的影响. 浙江大学学报(农业与生命科学版). 2013, 39(5): 545-555.Yao YL, Lu ZM*, Zhu FX, Min H, Bian CM. Successful bioaugmentation of an activated sludge reactor with Rhodococcus sp. YYL for efficient tetrahydrofuran degradation. J Hazard Mater. 2013, 261: 550-558.Lee YJ, Van Nostrand JD, Tu Q, Lu Z, Cheng L,Yuan T, Deng Y, Carter MQ, He Z, Wu L,Yang F, Xu J, Zhou J. The PathoChip, a functional gene array for assessing pathogenic properties of diverse microbial communities. ISME J. 2013, 7(10): 1974-1984.Wang X, Tang L, Yao YL, Wang HX, Min H,Lu ZM*. Bioremediation of the tobacco waste-contaminated soil by Pseudomonas sp. HF-1: nicotine degradation and microbial community analysis. Appl Microbiol Biot. 2013, 97(13): 6077-6088.

2012

Wang H, He ZL, Lu ZM, Zhou JZ, Van Nostrand JD, Xu XH, Zhang ZJ. Genetic linkage of sediment carbon pools and microbial functions in subtropical freshwater wetlands responding to experimental warming. Appl Environ Microb. 2012. 78(21)DOI:10.1128/AEM.01602-12.Frank Reith,Joel Brugger,Carla M Zammit,Adrienne L Gregg,Katherine C Goldfarb,Gary L Andersen,Todd Z DeSantis,Yvette M Piceno,Eoin L Brodie,Zhenmei Lu,Zhili He,Jizhong ZhouandSteven A Wakelin.Influence of geogenic factors on microbial communities in metallogenic Australian soils.ISME J, (7June2012) |doi:10.1038/ismej.2012.48Ye YF, Wang X, Zhang LM, Lu ZM*, Yan XJ. Unraveling the concentration-dependent metabolic response ofPseudomonas sp. HF-1 to nicotine stress by 1H NMR-based metabolomics. Ecotoxicology. 2012. DOI: 10.1007/s10646-012-0885-4.Lu ZM, He ZL, Parisi V, Kang SH, Deng Y, Van Nostrand JD, Masoner JR, Cozzarelli IM, Suflita JM, Zhou JZ. GeoChip-based analysis of microbial functional gene diversity in a landfill leachate-contaminated aquifer. Environ Sci Technol. 2012. DOI:10.1021/es300478j.

2011

Lu ZM, Deng Y,van Nostrand JD, HeZL,Voordeckers J, Zhou AF, Lee YJ, Mason OU, Dubinsky EA,Tom LM, Fortney JL,Lamendella R, Jansson JK, D'haeseller P, Hazen TC, Zhou JZ.Microbial gene functions enriched in the Deepwater Horizon deep-sea oil plume. ISME J. 2011.DOI: 10.1038/ismej.2011.91. The story has been selected for inclusion in Science for Environment Policy,http://ec.europa.eu/environment/integration/research/newsalert/pdf/280na6.pdf, the European Commission's environmental news service for policy makers, distributed toover 14,000 subscribers.Wang MZ, Yang GQ, Wang X, Yao YL, Min H*, Lu ZM*. Nicotine degradation by two novel bacterial isolates of Acinetobactersp. TW andSphingomonas sp. TY and their responses in the presence of neonicotinoid insecticides. World J Microb Biot. 2011. 27(7):1633-1640.Wang MZ, Yang GQ, Feng HJ, Lu ZM, Min H. Optimization of Fenton process for decoloration and COD removal in tobacco wastewater and toxicological evaluation of the effluent. Water Science and Technology. 2011. 63(11): 2471-2477.Yao YL,Lu ZM*,Min H, Gao HC, Zhu FX. The effect of tetrahydrofuran on the enzymatic activity and microbial community in activated sludge from a sequencing batch reactor.Ecotoxicoloy. 2011. DOI: 10.1007/s10646-011-0765-3He ZL, PicenoY, Deng Y, Xu MY, Lu ZM, DeSantis T, Andersen G, Hobbie SE, Reich PB, Zhou JZ. The phylogenetic composition and structure of soil microbial communities shifts in response to elevated carbon dioxide. ISME J. 2011. DOI:10.1038/ismej.2011.99

2010

Hazen TC, Dubinsky EA, DeSantis TZ, Andersen GL, Piceno YM, Singh N, Jansson JK, Probst A, Borglin SE, Fortney JL, Stringfellow WT, Bill M, Conrad MS, Tom LM, Chavarria KL, Alusi TR, Lamendella R, Joyner DC, Spier C, Baelum J, Auer M, Zemla ML, Chakraborty R, Sonnenthal EL, D’haeseleer P, Holman HN, Osman S, Lu ZM, Van Nostrand JD, Deng Y, Zhou JZ, Mason OU. Deep-sea oil plume enriches indigenous oil-degrading bacteria. Science 2010. 330: 204-208. IF= 31.364YLYao, J Guan,P Tang, HP Jiao,C Lin,JJ Wang, H Min,ZM Lu*, HC Gao. Assessment of toxicity of tetrahydrofuran on the microbial community in activated sludge. Bioresource Technol. 2010. 101(14): 5213-5221.ZQ Meng, Y Zhao, ZM Lu*, H Min*, JW Shen, XY Xu. Development of an advancedbiological treatmentsystemusingbioaugmentation technology for the treatment of eutrophic drinking water resources. Clean.2010, 37: 970-981.X Ding, WJ Yang*, H Min, XT Peng, HY Zhou, ZM Lu*. Isolation and characterization of a new strain of Methanothermobacter marburgensis DX01 fromhot springs in China. Anaerobe. 2010, 16: 54-59.吕镇梅, 孟智奇, 闵航. 用于水体修复的抗水力负荷微生物成膜装置及反应系统. 发明专利. 专利号：ZL201010039641.XTJ Shao, GQ Yang, MZ Wang, ZM Lu, L Zhao. Reduction of oxidative stress by bioaugmented strain Pseudomonas sp. HF-1 and selection of potential biomarkers in sequencing batch reactor treating tobacco wastewater. Ecotoxicology. 2010. 19(6):1117-23.

2009

MZ Wang, GQ Yang, H Min*, ZM Lu*, XY Jia. Bioaugmentation with the nicotine-degrading bacterium Pseudomonassp. HF-1 in a sequencing batch reactor treating tobacco wastewater: degradationstudy and analysis of its mechanisms. Water Research. 2009, 43(17): 4187-4196.ZM Lu, LY Sang, ZM Li, H Min. Catalase and superoxide dismutase activities in a Stenotrophomonas maltophiliaWZ2 resistant to herbicide pollution. Ecotoxicol Environ Saf 2009, 72(1): 136-143.ZM Li, TJ Shao, H Min, ZM Lu*, XY Xu. Stress response of Burkholderia cepaciaWZ1 exposed to quinclorac and biodegradation of quinclorac. Soil Biol Biochem 2009, 41(5): 984-990.HP Yuan, JH Zhang, ZM Lu*, H Min*. Studies on biosorption equilibrium and kinetics of Cd byStreptomycessp.K33andHL-12. J Hazard Mater. 2009, 164(2-3): 423-431.TJ Shao, HP Yuan, B Yan, ZM Lu*, H Min*. Antioxidant enzyme activity in bacterial resistance to nicotine toxicity by reactiveoxygenspecies. Arch Environ Contam Toxicol. 2009, 57:456-462.HP Yuan, H Min*, ZM Lu*, ZM Li. Antimicrobial activity of isolate HL-12 against Clavibacter michiganensissubsp. Michiganensisin the presence of cadmium. Ecotoxicology. 2009, 18: 447-454.YL Yao, ZM Lu, H Min, ZH Lu, HP Jiao. Isolation, identification and characterization of a novel Rhodococcussp. Strain in biodegradation of tetrahydrofuran and its medium optimization using sequential statistics-based experimental designs. Bioresoure Technol. 2009, 100(11): 2762-2769.MZ Wang, GQ Yang, H Min, ZM Lu. A novel nicotine catabolic plasmid pMH1 in Pseudomonas sp. Strain HF-1. Can J Microbiol. 2009. 55(3):228-233.JF Mei, H Min, ZM Lu. Enhanced biotransformation of L-phenylalanine to 2-phenylethanol using an in situproduct adsorption technique. Process Biochemistry. 2009, 44(8): 886-890.闵航主编. 吕镇梅副主编. 陈中云, 吴雪昌, 吴坤, 叶央芳编写. 微生物学－生命科学辅导丛书之名师点拨系列. 科学出版社. 2009.吕镇梅, 吴林, 高海春. 微生物修复技术研究进展. 2009年工业生物技术发展报告. 科学出版社. 176-191.

2008

ZM Lu, ZM Li,LY Sang, H Min. Characterization of a strain capable of synchronously degrading an herbicide mixture of quinclorac and bensulfuronmethyl. Pedosphere. 2008. 18(5): 554-563.X Ding, ZM Lu, Y Zhao, H Min, WJ Yang. MTH1745, a protein disulfide isomerase-like protein from thermophilic archaea, Methanothermobacter thermoautotrophicuminvolving in stress response. Cell Stress & Chaperones. 2008, 13: 239-246. IF=3.162YL Ying, ZM Lu (co-first author), H Min, J Chen. Dynamic changes of microbial community diversity in a photo-hydrogen-producing reactor monitored by PCR-DGGE. J Environ Sci. (China). 2008. 20: 1118-1125.ZH Lu, YL Yao, ZM Lu, H Min. Effect of tetrahydrofuran on enzyme activities in activated sludge. Ecotoxicol Environ Saf. 2008, 70: 259-265. IF=2.34ZH Lu, H Min, YL Yao, ZM Lu. Effects of tetrahydrofuran on dissolved oxygen, pH, culturable aerobic microbes and enzyme activity in wastewater. Toxicol Environ Chem. 2008, 90(6): 1177–1186.

2007年以前

ZM Lu, H Min, N Li, TJ Shao, YF Ye.Variations of bacterial community structure in flooded paddy soil contaminated with herbicide quinclorac. J Environ Sci Health B. 2006, 41(6): 821-832.ZM Lu, H Min, ZY Chen,FD Zhang. Effects of pesticide-contamination on population and activity of sulfate-reducing bacteria in paddy soils. The proceedings of the China association for science and technology. 2005, 2(3): 33-38.ZM Lu, H Min, YF Ye. Short-term influences of herbicide quinclorac on enzyme activities in flooded paddy soil. Pedosphere. 2004, 14(1): 71-76.ZM Lu, H Min, Y Xia. The response ofEscherichia coli, Bacillus subtilisand Burkholderia cepaciaWZ1 to oxidative stress of exposing to quinclorac. J Environ Sci Health B. 2004, 39 (3): 431-441.ZM Lu, H Min, SW Wu, AD Ruan. Phylogenetic and degradation characterization of Burkholderia cepaciaWZ1 degrading herbicide quinclorac. J Environ Sci Health B. 2003, 38 (6): 771-782.ZM Lu, H Min, YF Ye. Influences of quinclorac on culturable microorganisms and soil respiration in flooded paddy soil. Biomed Environ Sci. 2003, 16: 314-322.YF Ye, H Min, ZM Lu. Monitoring impact of mefenacet treatment on soil microbial communities by PCR-DGGE fingerprinting and conventional testing procedures, J. Environ. Sci. (China), 2006, 18(2):373-378Y Xia, H Min, G Rao, ZM Lu, J Liu, YF Ye, XJ Duan. Isolation and characterization of phenanthrene-degrading Sphingomonas paucimobilisStrain ZX4. Biodegradation. 2005, 16: 393-402.Y Xia, H Min, ZM Lu, YF Ye. Characterization and phylogenetic analysis of phenanthrene- degrading strain isolated from oil-contaminated soil. J. Environ. Sci. 2004, 16(4): 589-593.AD Ruan, H Min, ZQ Meng, ZM Lu. Protective effects of sea-buckthorn seed oil on mouse injury induced by sulfur dioxide Inhalation. Inhal Toxicol. 2003, 10(15): 1053-1058.吕镇梅,闵航,叶央芳. 除草剂二氯喹kuí啉酸对水稻田土壤中微生物种群的影响. 应用生态学报. 2004, 15(4): 605-609.吕镇梅，闵航，陈中云，吕琴. 水稻田土壤甲烷厌氧氧化在整个甲烷wán氧化中的贡献率. 环境科学. 2005, 26(4): 13-17.吴坤，徐淑霞，闵航，吕镇梅，汪伦记，陈红歌，喻子牛. 间甲酚对杂色云芝（Coriolus vericolor）生长及产漆酶能力的影响. 环境科学学报. 2004, 24(6): 1110-1115.叶央芳，闵航，吕镇梅. 除草剂苯噻草胺污染对多食鞘氨醇杆菌（Sphingobacterium multivolume）抗氧化酶和ATP酶的影响. 环境科学学报. 2006, 26(1): 151-156.郑平, 胡宝兰, 吕镇梅, 钱海丰等译. 生物技术概论. 科学出版社. 2006.