倪晔,女,教授,美国弗吉尼亚联邦大学化学与生命科学专业工学博士学位。研究生物催化剂的筛选、关键医药手性中间体的合成、非水相生物催化等。
学术简介
〖学习经历〗:
1992.9-1996.7 华东理工大学 生物化工专业 工学学士学位
1999.9-2002.7华东理工大学 生物化工专业 工学硕士学位
2002.8-2006.6美国弗吉尼亚联邦大学 化学与生命科学专业 工学博士学位
〖工作经历〗:
1996.7-1999.7 江南大学 应用化学系 助教
2006.7-2010.9 江南大学 生物工程学院 副教授
2010.9-2112.5 江南大学 生物工程学院 教授
2012.5-至今 江南大学 生物工程学院 副院长
〖学术及社会兼职〗:
2004-至今 美国化学学会会员
2005-至今 美国微生物学会会员
研究领域
1. 生物催化:生物催化剂的筛选、关键医药手性中间体的合成、非水相生物催化
2. 酶工程和蛋白质工程:酶的挖掘、分子改造和修饰
主要论著
近五年以来,以第一作者和通讯作者在主流杂志上发表SCI收录论文十余篇。代表作列举如下
1. Ye Ni, Jieyu Zhou, Zhihao Sun. Production of a key chiral intermediate of Betahistine with a newly isolated Kluyveromyces sp. in an aqueous two-phase system. Process Biochemistry (2012) DOI: 10.1016/j.procbio.2012.03.022
2. Ye Ni, Yun Wang, Zhihao Sun. Butanol production from cane molasses by Clostridium saccharobutylicum DSM 13864: Batch and semi-continuous fermentation. Applied Biochemistry & Biotechnology (2012) DOI: 10.1007/y
3. Ye Ni, Beihua Zhang, Zhihao Sun. Efficient Synthesis of (R)-2-Chloro-1-(3-Chlorophenyl)ethanol by Permeabilized Whole-Cells of Candida ontarioensis. Chinese Journal of Catalysis (2012) DOI: 10.1016/S1872-2067(11)60363-X
4. Ye Ni, Yongmei Liu, Ulrich Schwaneberg, Leilei Zhu, Na Li, Lifeng Li, Zhihao Sun. Rapid evolution of arginine deiminase for improved anti-tumor activity.Applied Microbiology & Biotechnology(2011) 90: 193-201
5. Zhong-Yi Yang, Ye Ni*, Zhong-Yuan Lu, Xiang-Ru Liao, Yu-Guo Zheng, Zhi-Hao Sun. Industrial production of S-2,2-Dimethylcyclopropanecarboxamide with a novel recombinant R-amidase from Delftia tsuruhatensis. Process Biochemistry (2011) 46: 182-187
6. Ning Li, Ye Ni*, Zhihao Sun. Purification and characterization of carbonyl reductase from Candida krusei SW 2026 involved in enantioselective reduction of ethyl 2-oxo-4-phenylbutyrate. Journal of Molecular Catalysis. B: Enzymatic (2010) 66: 190-197
7. Ye Ni, Rachel R. Chen. Extracellular recombinant protein production from Escherichia COLI. Biotechnology Letters (2009) 31:1661-1670.
8. Ye Ni, Zhi-Hao. Sun Recent progress on industrial fermentative production of acetone-butanol-ethanol by Clostridium acetobutylicumin China. Applied Microbiology & Biotechnology (2009) 83:415-423
9. Ye Ni, Zhen-Wei Li, Zhi-Hao Sun, Pu Zheng, Yong-Mei Liu, Lei-Lei Zhu, Ulrich Schwaneberg. Expression of arginine deiminase from Pseudomonas plecoglossicida CGMCC2039 in Escherichia coli and its anti-tumor activity. Current Microbiology (2009) 58: 593-598
10. Wen Zhang, Ye Ni*, Zhihao Sun, Pu Zheng, Wenqing Lin, Po Zhu, Nianfeng Ju Biocatalytic synthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate with Candida krusei SW2026: A practical process for high enantiopurity and product titer. Process Biochemistry (2009) 44:1270-1275
11. Ye Ni, Ulrich Schwaneberg, Zhi-Hao Sun. “Arginine deiminase, a potential anti-tumor drug” Cancer Letters(2008) 261: 1-11
12. Ye Ni, John Reye, Rachel R. Chen “lpp deletion as a permeabilization method.” Biotechnology & bioengineering (2007) 97: 1347-1356