工作经历
2003.6–2006.6南方医科大学南方医院-医师、助教。
2007.7–2009.3美国堪萨斯大学-博士后。
2009.4–2010.4美国马里兰大学-博士后。
2010.5–2011.3南方医科大学南方医院-讲师。
2011.3–2011.12广东省第二十七批援藏医疗队。
2014.6–2014.8美国纽约特种外科医院–访问教授。
2011.12–至今南方医科大学南方医院-副教授。
科研成就
阐明脐带间充质干细胞和磷酸钙骨水泥复合物组织工程骨在骨组织再生修复中的作用。
脐带间充质干细胞和可控梯度释放生物材料支架在组织工程骨软骨在软骨缺损修复中的作用。
科研领域
骨与软骨再生修复,干细胞与再生医学/外科学(骨外)。
著作
Nano-Apatitic Composite Scaffolds for Stem Cell Delivery and Bone Tissue Engineering.Book chapter in Nanotechnology forDental Applications(2012)。
人工髓核置换术。见:杨述华主编,实用脊柱外科学,北京:人民军医出版社,2004.844。
下腰痛的临床疗效评分,人工髓核假体置换术。见:金大地,瞿东滨,Charles D.Ray 主编。
脊柱椎间关节成形术,北京:科学技术文献出版社,2004。
人工髓核置换术。见:候树勋主编,脊椎外科学,北京:人民军医出版社,2005, 482。
论文
Gengtao Qiu, Ping Wang, Jinyu Sun, Yang Song, Guangjun Li, Hockin H. K. Xu*, Zhao Liang*(co-corresponding author). Bone regeneration in minipigs via calcium phosphate cement scaffold delivering autologous BMSCs and platelet-rich plasma. J Tissue Engineering and Regenerative Medicine. 2017.18. doi: 10.1002/term.2416. [Epub ahead of print]
Wenchuan Chen, Xian Liu, Qianmin Chen, Chongyun Bao, Zhao Liang*(co-corresponding author), Zhimin Zhu, Hockin H.K. Xu*. Angiogenic and osteogenic regeneration in rats via calcium phosphate scaffold and endothelial cell coculture with hBMSCs, hUCMSCs, hiPSC-MSCs and hESC-MSCs. J Tissue Engineering and Regenerative Medicine. 2017 Jan 18. doi: 10.1002/term.2395. [Epub ahead of print]
Xian Liu, Wenchuan Chen, Chi Zhang, Wahwah Thein-Han, Kevin Hu, Mark A. Reynolds, Chunyun Bao, Ping Wang, Zhao Liang*(co-corresponding author), Hockin H. K. Xu*. Co-seeding human endothelial cells with hiPSC-derived mesenchymal stem cells on calcium phosphate scaffold enhances osteogenesis and vascularization in rats. Tissue Engineering Part A. February 2017, ahead of print. doi:10.1089/ten.TEA.2016.0485.
Yang Song, Chi Zhang, Ping Wang, Lin Wang, Chunyun Bao,Michael D. Weir, Mark A. Reynolds, Ren Ke, Zhao Liang*(co-corresponding author), Hockin H. K. Xu*. Engineering bone regeneration with novel cell-laden hydrogel microfiber-injectable calcium phosphate scaffold. Materials Science & Engineering C-Materials for Biological Applications. (Accepted Feb. 2017)
Lin Wang, Xianju Xie, Michael D. Weir, Ashraf F. Fouad, Zhao Liang*(co-corresponding author), Hockin H. K. Xu*. Effect of bioactive dental adhesive on periodontal and endodontic pathogens. Journal of Materials Science: Materials in Medicine. 2016.27(11):168.
Gengtao Qiu, Ping Wang, Guangjun Li,Zhanjun Shi, Michael D. Weir,Jinyu Sun, Yang Song, Jixing Wang, Huakun H. Xu*, Zhao Liang*(co-corresponding author).Minipig-BMSCs combined with a self-setting calcium phosphate paste for bone tissue engineering. Mol Cell Biochem. 2016.58(11):748-756.
Wang Lin, Wang Ping, Weir Michael, Reynolds Mark, Zhao Liang*(co-corresponding author), Huakun H. Xu*. Hydrogel fibers encapsulating hiPSC-MSCs, hESC-MSCs and hUCMSCs in injectable calcium phosphate scaffold for bone tissue engineering. Biomedical Materials. 2016.11(6):065008.(journal's Highlights)
Lin Wang, Chi Zhang, Chunyan Li, Michael D. Weir, Ping Wang, Mark A. Reynolds, Zhao Liang*(co-corresponding author), Hockin H.K. Xu. Injectable calcium phosphate with hydrogel fibers encapsulating induced pluripotent, dental pulp and bone marrow stem cells for bone repair. Materials Science and Engineering:C. 69:1125-1136(2016).
Ping Wang, Yang Song, Michael D. Weir, Jinyu Sun, Zhao Liang*(co-corresponding author), Carl G. Simon, Hockin Xu. A self-setting iPSMSC-alginate-calcium phosphate paste for bone tissue engineering. Dental Materials. 32(2):252-63(2016).
Wang Ping, Liu Xian, Zhao Liang*(co-corresponding author), Michael Weir, Sun Jirun, Chen Wenchuan, Man Yi, Xu Huakun*. Bone tissue engineering via human induced pluripotent, umbilical cord and bone marrow mesenchymal stem cells in rat cranium. Acta Biomaterialia. 18:236-48(2015).
Shi Zhe, Zhao Liang*(co-corresponding author), Qiu Gengtao, He Ruixuan, Michael S. Detamore*. The effect of extended passaging on the phenotype and osteogenic potential of human umbilical cord mesenchymal stem cells. Mol Cell Biochem. 401:155–164,(2015).
P Wang, Zhao, L, W Chen, X. Liu, MD Weir, HHK Xu. Stem Cells and Calcium Phosphate Cement Scaffolds for Bone Regeneration. J Dent Res, 2014.(Epub ahead)
Wang Ping, Zhao Liang*(co-corresponding author), Liu Jason, Michael D Weir, Xuedong Zhou*, Xu Huakun*. Bone tissue engineering via nanostructured calcium phosphate biomaterials and stem cells. Bone Research.2:1-13(2014).
Dormer N, Singh M, Zhao L, Detamore MS. Osteochondral interface regeneration of the rabbit knee with macroscopic gradients of bioactive signals. Journal of Biomedical Materials Research: Part A.100(1):162-70,2012.
Wang, L, Liang Zhao, Michael S. Detamore. Human umbilical cord mesenchymal stromal cells in a sandwich approach for osteochondral. tissue engineering. J Tissue Eng Regen Med. 5(9): 712-721(2011).
Zhao, L, M Tang, MD Weir, MS Detamore, HHK Xu. Osteogenic media and rhBMP-2-induced differentiation of umbilical cord mesenchymal stem cells encapsulated in alginate microbeads and integrated in an injectable calcium phosphate-chitosan fibrous scaffold. Tissue Eng Part A. 17(7-8): 969-979(2011).
Zhao, L. and M. S. Detamore. Chondrogenic differentiation of stem cells in human umbilical cord stroma with PGA and PLLA scaffolds. J Biomed Sci Eng. 3(11): 1041-1049(2010).
Xu, H.H, M.S, Liang Zhao. Umbilical cord stem cell seeding on fast-resorbable calcium phosphate bone cement. Tissue Eng Part A. 16(9): 2743-2753 (2010).
[20 ]Xu, H. H, L. Zhao, M.D. Weir. Stem cell-calcium phosphate constructs for bone engineering. J Dent Res. 89(12): 1482-1488(2010).
Zhao, L, Burguera EF, Xu Huakun, Amin N, Ryou H, Arola DD. Fatigue and human umbilical cord stem cell seeding characteristics of calcium phosphate-chitosan-biodegradable fiber scaffolds. Biomaterials. 31(5): 840-847(2010).
Zhao, L, Weir MD(co-first author), Xu Huakun. An injectable calcium phosphate-alginate hydrogel-umbilical cord mesenchymal stem cell paste for bone tissue engineering. Biomaterials. 31(25): 6502-6510(2010).
Zhao, L, Weir MD, Xu Huakun. Human umbilical cord stem cell encapsulation in calcium phosphate scaffolds for bone engineering. Biomaterials. 31(14): 3848-3857(2010).
专利
赵亮。一种基于聚乳酸-羟基乙酸共聚物的生长因子梯度释放微球支架及其制备方法和应用:中国,ZL201110215643.4[P].2013.09.18[1]
赵亮。一种可注射强化型磷石灰/水凝胶微囊组织工程骨及其制备方法和应用:中国,ZL201010270416.7[P].2013.09.18[2]