陈芝,女,博士,中国农业大学微生物学与免疫学系副教授,主要从事抗生素生物合成调控和裂殖壶菌高产DHA的代谢工程育种等研究。
人物经历
2007/1-现在:中国农业大学,生物学院微生物学系,副教授[1]
2004/04-2006/12:中国农业大学,生物学院微生物学系,讲师
2002/09-2003/10:德国Osnabruck University,博士后
1997/09-2002/07:中国农业大学,微生物学专业,博士
1993/09-1997/07:中国农业大学,微生物学专业,学士
研究方向
次级代谢产物生物合成调控[1]
代谢工程育种
主讲课程
《微生物学》(本科生课程)[1]
《微生物学实验》(本科生课程)
发表论文
Yaqing Cheng, Renjun Yang, Mengya Lyu, Shiwei Wang, Xingchao Liu, Ying Wen, Yuan Song, Jilun Li, &Zhi Chen*. IdeR, a DtxR-family iron-response regulator, controls iron homeostasis, morphological differentiation, secondary metabolism, and oxidative stress response inStreptomyces avermitilis. 2018. Applied and Environmental Microbiology. In press. (通讯作者)[1]Sun M, Lyu M, Wen Y, Song Y, Li J,Chen Z*. Organic Peroxide-Sensing Repressor OhrR Regulates Organic Hydroperoxide Stress Resistance and Avermectin Production inStreptomyces avermitilis. Front Microbiol. 2018 9:1398.(通讯作者)Anping Su, Shuang Chi, Ying Li, Siyuan Tan, Shan Qiang,Zhi Chen*, and Yonghong Meng*. Metabolic Redesign ofRhodobacter sphaeroidesfor Lycopene Production. Journal of Agricultural and Food Chemistry 2018 66 (23):5879-5885. (共同通讯作者)Xingchao Liu, Yaqing Cheng, Mengya Lyu, Ying Wen, Yuan Song,Zhi Chen*, & Jilun Li. Redox-sensing regulator Rex regulates aerobic metabolism, morphological differentiation, and avermectin production inStreptomyces avermitilis. Sci. Rep. 2017; 7, 44567; doi: 10.1038srep44567.(通讯作者)Xingchao Liu,Meng Sun, Yaqing Cheng, Renjun Yang, Ying Wen,ZhiChen*, Jilun Li. OxyR is a key regulator in response to oxidative stress inStreptomyces avermitilis. Microbiology-SGM. 2016. 162:707-716.(通讯作者)Yang Renjun, Xingchao Liu, Ying Wen, Yuan Song,Zhi Chen *, Jilun Li. The PhoP transcription factor negatively regulates avermectin biosynthesis inStreptomyces avermitilis. Appl Microbiol Biotechnol. 2015 Dec; 99(24):10547-57.(通讯作者)Yanping Liu, Tingting Yan, Libin Jiang, Ying Wen, Yuan Song,Zhi Chen*, Jilun Li. Characterization of SAV7471, a TetR-family transcriptional regulator involved in the regulation of coenzyme A metabolism inStreptomyces avermitilis. J Bacteriol. 2013 Oct; 195(19):4365-72.(通讯作者)Libin Jiang, Yanping Liu, Pan Wang, Ying Wen, Yuan Song,Zhi Chen*, Jilun Li. Inactivation of the extracytoplasmic function sigma factor Sig6 stimulates avermectin production inStreptomyces avermitilis. Biotechnol Lett. 2011. 33:1955–1961.(通讯作者)Zhi Chen, Wen Jia, Song Yuan*, Wen Ying and Li Jilun*. Enhancement and selective production of avermectin B by recombinants ofStreptomyces avermitilisvia intraspecific protoplast fusion. Chinese Science Bulletin. 2007. 52(5):616-622Zhi Chen, Lin Wen, Yu Ping and Song Yuan*. Enhancement of Monacolin K production via intergenric protoplast fusion betweenAspergillus terreusandMonascus anka. Progress in Natural Science. 2007. 17(6):703-707.陈芝,宋渊,文莹,李季伦*.阿维链霉菌次级代谢研究进展与展望.自然科学进展. 2007. 17(3):290-296.
课题研究
国家自然科学基金面上项目,31470190,阿维链霉菌氧化还原调控因子Rex的调控功能研究,2015/01-2018/12,84万元,在研,主持[1]国家自然科学基金面上项目,31170090,阿维链霉菌ECF sigma因子Sig6的调控机制研究,2012/01-2015/12,52万元,已结题,主持973项目,2009CB118905,农用抗生素的生物合成与调控,2009/01-2013/10,87万元,已结题,参与国家自然科学基金青年项目, 30700019,阿维菌素生物合成中决定B1:B2比例的分子机制的研究,2008/01-2010/12,16万元,已结题,主持
发明专利
陈芝,刘兴超,文莹,宋渊,李季伦,阿维链霉菌rex基因在提高阿维菌素产量中的应用. 2017. 09. 29.中国,ZL201510313874.7.[1]陈芝,姜利滨,文莹,宋渊,李季伦,一种提高阿维菌素产量的方法及其生产菌株,2013.5.8,中国,ZL201110050112.4李季伦,李萌,文莹,陈芝,宋渊.提高阿维菌素和/或伊维菌素产量的方法及生产菌株,2012.8.15,中国,ZL200910089970.2李季伦,林秀萍,文莹,陈芝.一种生产寡霉素A的方法及其专用菌株. 2012.3.7,中国,ZL200810223500.6文莹,李丽莉,陈芝,宋渊,李季伦.一种阿维链霉菌基因工程菌及其应用. 2010.10.20,中国,ZL200810224533.2文莹,张晓琳,陈芝,宋渊,李萌,李季伦.产伊维菌素的工程菌及其构建方法与应用. 2009.05.13,中国,ZL200510074936.X
获奖记录
参考资料 1
- 陈芝 — 中国农业大学