陈实

陈实，教授，博士生导师，美国微生物科学院Fellow、国家基金委杰出青年基金获得者。

2004年明治乳业生命科学优秀奖

2004年上海-联合利华研究与发展基金奖学金

2004年上海市科技进步一等奖

2004年上海市新长征突击手“标兵”

2004年新加坡陈嘉庚基金会第二届陈嘉庚青少年发明奖（上海）（银奖）

2006年上海市研究生学位论文优秀成果

2007年《环球科学》2007年度全球十大科学新闻

2007年上海市优秀发明奖选拔赛二等奖

2007年新加坡陈嘉庚基金会第五届陈嘉庚青少年发明奖（上海）（铜奖）

2008年国家自然科学奖二等奖

2008年新加坡陈嘉庚基金会第六届陈嘉庚青少年发明奖（上海）（铜奖）

2012年武汉大学医学部医学突出贡献奖

2014年中国微生物学会学术年会优秀学术论文奖

2015年高等学校科学研究优秀成果奖自然科学一等奖

2015年武汉大学医学部医学突出贡献奖

2016年中国微生物学会学术年会优秀学术论文奖

2017年湖北省医学领军人才

2017年武汉大学杰出青年（教职工）

2018年武汉大学朱裕璧医学奖

2019年国家基金委杰出青年基金

2020年美国微生物科学院Fellow (Fellow of American Academy of Microbiology)^[1]

1．基因组修饰及编辑

2．DNA骨架的磷硫酰xiān化生理修饰

3．创新药物的设计与改造^[1]

1.Chen C, Wang L, Chen S, Wu X, Gu M, Chen X, Jiang S, Wang Y, Deng Z, Dedon P, Chen S*. Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes. Proc Natl Acad Sci U S A, 2017, doi: 10.1073/pnas.1702450114.

2.Tong T#, Chen S#, Wang L#, Tang Y#, Ryu JY, Jiang S, Wu X, Chao Chen C, Luo J, Deng Z, Li Z, Lee SY*, Shi Chen*. Occurrence, evolution, and functions of DNA phosphorothioate epigenetics in bacteria, Proc Natl Acad Sci U S A, 2018, doi:10.1073/pnas.1721916115.

3.Lei Xiong#, Siyi Liu#, Si Chen#, Yao Xiao#, Bochen Zhu, Yali Gao, Yujing Zhang, Beibei Chen, Jie Luo, Zixin Deng, Xiangdong Chen, Lianrong Wang, Shi Chen*. A new type of DNA phosphorothioation-based antiviral system in archaea. Nature Communications, 2019, Apr 11;10(1):1688. doi: 10.1038/s41467-019-09390-9.

4.Cao B. #, Chen C. #, DeMott M.S. #, Cheng Q., Clark T.A., Xiong X., Zheng X., Butty V., Levine S.S., Yuan G., Boitano M., Luong K., Song Y., Zhou X., Deng Z., Turner S.W., Korlach J., You D.*, Wang L.*, Chen S.*, Dedon P.C. Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences. Nature Communications, 2014, 5, doi:10.1038/ncomms4951.

5.Wang L, Chen S*, Vergin KL, Giovannoni SJ, Chan SW, Demott MS, Taghizadeh K, Cordero OX, Cutler M, Timberlake S, Alm EJ, Polz MF, Pinhassi J, Deng Z, Dedon PC*. DNA phosphorothioation is widespread and quantized in bacterial genomes. Proc Natl Acad Sci U S A, 2011, 108 (7): 2963-2968.

6.Wang L, Jiang S, Chen C, He W, Wu X, Wang F, Tong T, Zou X, Li Z, Luo J, Deng Z, Chen S*. Synthetic genomes: from DNA synthesis to genome design. Angew Chemie Int Ed., 2018, 57: 2~11.

7.Wang L, Jiang S, Deng Z, Dedon P, Chen S*. DNA phosphorothioate modification – a new multi- functional epigenetic system in bacteria. FEMS Microbiology Reviews, 2019, 43(2), 109–122. https://doi.org/10.1093/femsre/fuy036

8. Deng Z, Lim J, Wang Q, Purtell K, Wu S, Palomo GM, Tan H, Manfredi G, Zhao Y, Peng J, Hu B, Chen S*, Yue Z*. ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway. Autophagy, 2019 Jul 30:1-15. doi: 10.1080/15548627.2019.1644076.

9. Chen Y., Deng Z, Jiang S., Hu Q., Liu H., Zhou S., Ma W., Chen S.*, Zhao Y*. Human cells lacking coilin and Cajal bodies areproficient in telomerase assembly, trafficking and telomere maintenance. Nucleic Acids Research, 2014, 1-11, doi: 10.1093/nar/gku1277.

10. Zou X#, Wang L#, Li Z, Luo J, Wang Y, Deng Z, Du S, Chen S*. Genome engineering and modification toward synthetic biology for the production of antibiotics. Medicinal Research Reviews, 2018, 38(1): 229~260.

11. Wang F#, Wang L#, Zou X., Duan S., Li Z., Deng Z., Luo J., Lee S. Y.*, Chen S*. Advances in CRISPR-Cas systems for RNA targeting, tracking and editing. Biotechnology Advances, 2019, https://doi.org/10.1016/j.biotechadv.2019.03.016.

12. Deng Z, Purtell K Lachance V, Wold M, Chen S*, Yue Z*. Autophagy Receptors and Neurodegenerative Diseases. Trends in Cell Biology, 2017, 27(7).491~504. doi.org/10.1016/j.tcb.2017.01.001.

13. Wu S#, Wang L# ; Gan R, Tong T, Bian H, Li Z, Du S, Deng Z, Chen S*. Signature arsenic detoxification pathways in Halomonas sp. GFAJ-1, mBio, 2018, May 1; 9 (3): e00515-18. doi: 10.1128/mBio.00515-18.

14. Xia S, Chen J, Liu L, Wei Y, Deng Z, Wang L, Chen S*. Tight control of genomic phosphorothioate modification by the ATP-modulated autoregulation and reusability of DndB. Molecular Microbiology, 2019 April, 11(4): 938-950. doi: 10.1111/mmi.14186.

15. Huang Q, Wang F, Yuan C, He Z, Rao L, Cai B, Chen B, Jiang S, Li Z, Chen J, Liu W, Guo F, Ao Z*, Chen S*, Zhao X*. Gelatin Nanoparticle-Coated Silicon Beads for Density-Selective Capture and Release of Heterogeneous Circulating Tumor Cells with High Purity. Theranostics, 2018, 8(6): 1624~1635

16. Liu L, Zhang Y, Jiang D, Du S, Deng Z, Wang L, and Chen S*. Recent Advances in the Genomic Profiling of Bacterial Epigenetic Modifications. Biotechnology Journal, 2019, 14, 1800001. DOI: 10.1002/biot.201800001.

17.Yan G, Chen X, Du S, Deng Z, Wang L, Chen S*. Genetic mechanisms of arsenic detoxification and

metabolism in bacteria. Current Genetics, 2019, 65: 329–338, doi.org/10.1007/s00294-018-0894-9.

18. Chen S.*, Wang L., Deng Z*. Twenty years hunting for sulfur in DNA. Protein & Cell, 2010, 1(1): 14-21.

19. Wang L.#, Chen S.#, Xu T., Taghizadeh K., Wishnok J., Zhou X., You D., Deng Z, Dedon P. Phosphorothioation of DNA in bacteria by dnd genes. Nature Chemical Biology, 2007, 3(11): 709-710.

20. Chen S.#, Galan M. C.#, Carla Coltharp, O’Connor S. E. Redesign of a central enzyme in alkaloid biosynthesis. Chemistry & Biology, 2006, 13(11): 1137-41.

21. Chen S, Huang X, Zhou X, Bai L, He J, Jeong KJ, Lee SY, Deng Z. Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex. Chemistry & Biology, 2003, 10(11): 1065-76.

22. Chen S.#, Mao X.#, Shen Y., Zhou Y., Li J., Wang L., Tao X., Yang L., Wang Y., Zhou X., Deng Z., Wei D. Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis. Applied and Environmental Microbiology, 2009, 75(6): 1778-81.^[1]