钟大放

钟大放，中国科学院上海药物研究所研究员，药代动力学家。1957年6月生于辽宁辽阳，现任药物代谢研究中心主任，同时也是博士生导师。

1982 年毕业于沈阳药学院化学制药专业，

1985 年获药物分析专业硕士学位，

1989 年在联邦德国波恩大学获药物化学专业博士学位，其后在德国药师中心实验室 从事 博士后研究。

1994 年 7 月回国，历任沈阳药科大学教授、博士生导师、药物代谢与药物动力学实验室主任。

1996 年获国家杰出青年科学基金。

2005 年 6 月起任中国科学院上海药物研究所研究员、药物代谢研究中心主任。

承担科研项目情况：曾主持国家自然科学基金重点项目和国家“863”项目等课题，为国内制药企业完成新药代谢和药动学临床前研究 20 余项，为国内外制药企业完成药物动力学和制剂生物等效性试验300余项。现承担科研课题有国家自然科学基金、国家 863 课题、上海市科委研发公共服务平台“上海药物代谢研究中心”建设项目，以及为国内外制药企业和研究院所提供药物代谢研究技术服务。

Liu J, Chen XY, Liu K, Li L, Zhong DF*. Derivatization of (5R)-hydroxytriptolide with benzylamine to enhance mass spectrometric detection: Application to a Phase I pharmacokinetic studie. Analytica Chimica Acta, 2011, 689: 69-76

Li L, Chen XY, Li D, Zhong DF*. Identification of 20(S)-protopanaxadiol metabolites in human liver microsomes and human hepatocytes. Drug Metabolism and Disposition, 2011, 39: 472-483

Deng P, You TG, Chen XY, Yuan T, Huang HH, Zhong DF*. Identification of amiodarone metabolites in human bile by ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry. Drug Metabolism and Disposition, 2011, 39: 1058-1069

Gao CY, Chen XY, Zhong DF*. Absorption and disposition of scutellarin in rats: a pharmacokinetic explanation for the high exposure of its isomeric metabolite. Drug Metabolism and Disposition, 2011, 39: 2034-2044

Zhong DF. Bioanalysis in China. Bioanalysis, 2010, 2: 153-156

Gong Aishen, Chen XY, Deng P, Zhong DF*. Metabolism of flumatinib, a novel antineoplastic tyrosine kinase inhibitor, in chronic myelogenous leukemia patients. Drug Metabolism and Disposition, 2010, 38: 1328-1340

Tan B, Zhang YF, Chen XY, Zhao XH, Li GX, Zhong DF*. The effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of glipizide in Chinese subjects. European Journal of Clinical Pharmacology, 2010, 66: 145-151

Liu J, Chen XY, Hu YH, Cheng G, Zhong DF*. Quantification of the major metabolites of bromhexine in human plasma using RRLC-MS/MS and its application to pharmacokinetics. Journal of Pharmaceutical and Biochemical Analysis, 2010, 51: 1134-1141

Deng P, Chen XY, Zhang GD, Zhong DF*. Bioanalysis of an oligonucleotide and its metabolites by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biochemical Analysis, 2010, 52: 571-579

Deng P, Chen XY, Zhong DF*. Quantification of polar drugs in human plasma with LC-MS/MS. Bioanalysis, 2009, 1: 187-203

Liu J, Duan XT, Chen XY, Zhong DF*. Determination of eptifibatide concentration in human plasma utilizing the liquid chromatography–tandem mass spectrometry method. Journal of Chromatography B, 2009, 877: 527-532

Zhan Y, Chen XY, Zhao XH, Zhong DF*. Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the determination of leuprolide in human serum. Journal of Chromatography B, 2009, 877: 3194-3200

Meng J, Zhao LZ, Hu YH, Chen XY, Zhong DF*. Synthesis of [3-3H]20(S)-protopanaxadiol. Journal of Labelled Compounds and Radiopharmaceuticals, 2009, 52: 482-484

Wang YY, Chen XY, Li Q, Zhong DF*. Metabolite identification of arbidol in human urine by the study of CID fragmentation pathways using HPLC coupled with ion trap mass spectrometry. Journal of Mass Spectrometry, 2008, 43: 1099-1109

Wang YY, Chen XY, Li Q, Zhong DF*. Characterization of metabolites of a novel histamine H2-receptor antagonist, lafutidine, in human liver microsomes by liquid chromatography coupled with ion trap mass spectrometry. Rapid Communications in Mass Spectrometry, 2008, 22: 1843-1852

Guan ZM, Chen XY, Wang YX, Zhong DF*. Metabolite identification of a new antitumor agent icotinib in rats using liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 2008, 22: 2176-2184

Zhang YF, Si DY, Chen XY, Lin N, Guo YJ, Zhou H, Zhong DF*. Influence of CYP2C9 and CYP2C19 genetic polymorphisms on pharmacokinetics of gliclazide MR in Chinese subjects. British Journal of Clinical Pharmacology, 2007, 64: 67-74

Li XY, Chen XY, Zhong DF*. Validated method for rapid inhibition screening of six cytochrome P450 enzymes by liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 2007, 852: 128-137

Duan XT, Chen XY, Yang YM, Zhong DF*. Precolumn derivatization of cysteine residues for quantitative analysis of five major cytochrome P450 isoenzymes by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 2007, 21: 3234-3244

Huang HH, Yang XW, Li Qiang, Sun L, Zhong DF*. Biotransformation of tolbutamide to 4’-tolbutamide by the fungus Cunninghamella blakesleeana. Applied Microbiology and Biotechnology, 2006, 72: 486-491