郭晓奎

郭晓奎，男，生于1964年9月，现任上海交通大学全球健康学院副院长。

上海交通大学特聘教授，国家级教学名师，全国教育科研先进工作者，全国优秀教师。现任国家热带病研究中心副主任；上海交通大学-爱丁堡大学全健康研究中心常务副主任；上海交通大学国家热带病研究中心全球健康学院专职副院长；上海渥太华联合医学院副院长；生物医学科学专业管委会主任；致远学院医学方向主任。兼任中国微生物学会医学微生物学免疫学专业委员会主任委员；中国医药教育协会微生态与健康分会副主任委员；上海市微生物学会副理事长，秘书长；国家虚拟仿真实验教学创新联盟医学基础委员会主任；国家高等学校基础医学实验教学中心规范化建设与管理工作组组长。教育部基础医学类教指委专业建设工作组特聘专家、拔尖人才培养与实践教学工作组特聘专家。国家级研究生规划教材医学微生物学主编；国家级本科规划教材病原生物学中文、双语主编、医学微生物学英文版主编；国家级精品课程、国家精品共享课程、国家一流课程、上海市混合课程医学微生物学负责人。^[1]

倡导并实践全人教育，强化课程思政，建立的ASK体系得到全国医学教育界的认可，2017年校特等奖；积极推动能力导向梯度实验教学体系建设与实践，培养学生科创精神和研究素养，2019年校特等奖；作为我国生物医学科学专业的创立者之一，是专业设立可行报告和培养方案的主要起草人。交医2016年设立该专业，现已获批国家强基计划专业、国家拔尖人才培养基地和国家一流专业。2020年校特等奖；积极推动我国基础医学整合课程建设，包括针对医学相关专业的横向整合课程体系；具有我国特色的基予系统器官的整合课程体系；北美渥太华大学的整合课程体系和医学实验整合课程体系。到业界赞誉，2015年校特等奖；促进以学生为中心的积极的学习：秉承我国“教学有法，教无定法；教有定规，贵在得法”的教学思想，因材施教。与新体系实施相适应，推出以学生为中心的因材施教的多样性教学模式，减少大班课堂教学，增加小组教学、案例讨论、减少授课时数，采用多种学生参与式学习方法。在教学过程中，跳出以往LBL（Lecture based learning）灌输式教学方式，提倡TBL（Team based learning）、PBL（Problem based learning）、CBL（Case based learning）、RBL（Research based learning）、CAL（Computer assisted learning）相融合的多元模式；推进形成性评价：为全面公平地评价学生，并促进学生自主学习，强化形成性评价，建立了全新的评价体系。如PBL、CBL、实验、文献综述、小论文等考核，以配合整合课程对学生创新精神和能力培养的总体目标；课程建设方面，“医学微生物学”先后获国家精品课程、国家精品共享课程和国家级一流课程；作为全球健康学院的创立者之一，为全体医学生开设全球健康与全健康课程，得到了世界医学教育联合会（WFME）高级顾问和我国认证工作委员专家的赞赏；教材建设方面，是国家级本科规划教材《病原生物学》、《Medical Microbiology》和国家级研究生规划教材《医学微生物学》主编；教学学术研究，主持国家、上海市等教学课题20余项，发表教育教学论文31篇，出版《病原生物学教育教学》和《医学整合课程实践与研究》；曾先后获得全国教育科研优秀教学成果特等奖、国家教学成果一等奖（排名2）、4项省市级教学成果奖、7项校级教学成果特等奖、3次校长奖、2次校教书育人一等奖和1次2等奖。

科学研究主要聚焦微生态学和全健康（One Health）最重要的3个领域：1）钩端螺旋体病、布鲁菌病等人兽共患病，与团队一起在国际上率先完成钩端螺旋体基因组序列结构分析和重要功能基因研究，改写了教科书相关内容，研发了钩端螺旋体感染诊断试剂盒并成功转化；2）微生态制剂、益生菌等功能食品药品安全性，建立了基于基因组的益生菌安全性评价技术服务平台；3）细菌耐药性的防控，推动了我国首例经伦理审批的噬菌体治疗耐药性细菌感染的临床实践。主持包括4项863课题等20多个国家级科研项目，发表400余篇研究论文，其中151篇SCI论文；已主编出版20多本学术著作和教科书。

获全国教育科研成果特等奖、国家级教学成果一等奖等省部级以上科研教育奖励20余项。^[1]

1982年09月至1986年07月四川大学学习

1988年09月至1991年07月哈尔滨医科大学学习

1997年09月至2000年07月日本爱知学院大学学习  ^[1]

1986年08月2000年06月哈尔滨医科大学工作

2000年07月至2019年06月上海交通大学医学院基础医学院工作

2019年07月至今上海交通大学医学院-国家热带病研究中心全球健康学院工作^[1]

中国微生物学会理事兼医学微生物学免疫学专业委员会主任委员；中国微生物学会教学工作委员会副主任委员；

中国医药教育协会微生态与健康分会副主任委员；

上海市微生物学会副理事长、秘书长；

上海市微生物学会微生物组学专业委员会主任委员；

上海噬菌体与耐药研究所学术委员会主任委员；

全国公共卫生与预防医学名词审定委员会热带医学名词审定分委员会副主任委员^[1]

医学教育、全健康科学研究、细菌耐药控制、人兽共患病、食品安全^[1]

郭晓奎，王昊，钮晓音，胡翊群，洪梅，陈锋，叶曦，戴佳颖，邵莉，苏冰，程金科，张健，陈燕，唐华，孙雪青。生物医学科学人才培养生态体系的构建与实践，教学成果特等奖。上海交通大学，2020章俊良，王维克，郑杭，陈锋，俞勇，孙淮，郭晓奎，沈红斌，钱雪峰，叶曦，夏伟梁，吴晓玲，何峰，汪燕，姚乃嘉。建设荣誉课程体系，培养学术型创新人才教学成果二等奖，上海交通大学，2020王兆军，王昊，许文燮，李峰，王颖，吴健桦，贺明，张帆，吴琛耘，黄旭，王宏林，夏立，支建明，顾鸣敏，郭晓奎。能力为核心、融合为手段重构基础医学课程。教学成果一等奖，上海交通大学，2020程金科，王昊，郭晓奎，易静，徐天乐，董艳，王颖，苏懿，余健秀，童雪梅，苏冰，钟清，朱雯佳，钮晓音，张悦恬。突出学生主体、强化培养过程的研究生培养体系创新与实践，教学成果特等奖，上海交通大学，2020董为人，夏欧东，肖纯凌，郭晓奎，胡珍桥，关喆，黄巧冰，仇欣霞，王巧玲，陈英华。基于优质多元信息化平台，构筑“智能+”医学金课堂，第九届广东省教育教学成果奖二等奖，2020。广东省教育厅郭晓奎（负责人）国家级一流课程（国家级精品在线开放课程）：医学微生物学，教育部，2020.郭晓奎（负责人）在线开放课程《医学微生物学》，高教出版社，2019。郭晓奎（负责人）上海市高校优质混合式示范课程《医学微生物学》，上海市教委，2019。郭晓奎（成员）基础医学整合课程改革团队，教书育人奖一等奖，上海交通大学，2019董为人，夏欧东，肖纯凌，郭晓奎，胡珍桥，关喆，黄巧冰，仇欣霞，王巧玲，陈英华。基于多元化信息化优质平台，构筑“智能+”医学金课堂，教育教学成果奖一等奖，南方医科大学，2019。郭晓奎，顾鸣敏，许伟榕，钮晓音，赵蔚，胡优敏，孙岳平，陈荪sūn红，刘慧中，苏懿，能力导向梯度实验教学体系建设与实践，上海交通大学教学成果特等奖，2019郭晓奎（负责人）21教育讲坛，上海交通大学医学院，2019郭晓奎上海市“为人、为学、为师”先进宣传典型，中共上海市教育卫生工作委员会，2018陈国强，郭晓奎，胡翊群，钮晓音，邵莉，唐华，梅文翰，朱海燕，郁松，苏懿。夯实医教协同，综合性大学“有灵魂的卓越医学创新人才培养体系”构建与实践，高等教育国家级教学成果一等奖，教育部，2018。陈国强，郭晓奎，胡翊yì群，钮晓音，邵莉，唐华，梅文翰，朱海燕，郁松，苏懿。深化医教协同，校院联动构建有灵魂的卓越医学创新人才培养体系，上海市教学成果特等奖，上海市，2018。郭晓奎（负责人）上海市精品课程《基础医学器官系统整合课程》（含《病原生物学》），上海市教委，2018郭晓奎（负责人）21教育讲坛，上海交通大学医学院，2018郭晓奎（负责人）上海高校课程思政教育教学改革试点项目，上海市教委，2017郭晓奎（负责人）联盟规划课程《医学微生物学》，中国医学教育慕课联盟，2017。郭晓奎，胡翊群，钮晓音，梅文瀚，郁松，姜叙诚，富冀枫，丁文龙，张君慧，汤雪明，王一飞。基础医学ASK全人教育体系的实践与推广，上海交通大学教学成果特等奖，2017。郭晓奎（成员）深化医教协同推进卓越医学人才培养，第五届全国教育改革创新奖， 2017郭晓奎教书育人一等奖，上海交通大学，2017郭晓奎（成员）致远学院项目主任团队，教书育人二等奖，上海交通大学，2017郭晓奎（成员）校长奖（教师发展中心），上海交通大学，2017郭晓奎十佳班主任，上海交通大学，2017郭晓奎十佳班导师，上海交通大学医学院，2017郭晓奎（负责人）21教育讲坛，上海交通大学医学院，2017郭晓奎,唐华,钮晓音,缪青,郁松,顾锋,周栋,王甦sū平。医学生创新能力培养体系的建设与实践，上海交通大学教学成果一等奖，2016。邵莉,李卫平,陈芳源,陆勤,张勇,王婷,郦忆,梅文瀚,郭晓奎。基于国际化与信息化的北美医学课程和评估体系及师资队伍建设的探索与实践，上海交通大学教学成果一等奖， 2016。郭晓奎（负责人）上海市重点课程《医学导论（含医学微生物学）》，上海市教委，2016郭晓奎（负责人）21教育讲坛，上海交通大学医学院，2016郭晓奎（负责人）国家精品共享课程《医学微生物学》，教育部，2016郭晓奎，富冀枫，梅文瀚，郁松，胡翊群，钮晓音。基于器官系统的整合课程体系的改革与实践，上海交通大学教学成果特等奖，上海交通大学，2015。沈柏用、张勇、富冀枫、邵洁、张文慧、刘志宏、郭晓奎、郑民华、李宏为医学法语教学中的多主体、多模式国际合作的创新实践，上海交通大学教学成果二等奖，上海交通大学，2015。郭晓奎医学院首届班导师文化创建“十大精品项目”，2015。郭晓奎十佳班导师，上海交通大学医学院，2015丁文龙、郭晓奎等以学生创新能力培养为核心的基础医学实践教学模式的构建与应用，上海市教学成果二等奖，2014丁文龙、郭晓奎等以学生创新能力培养为核心的基础医学实践教学模式的构建与应用，上海交通大学教学成果一等奖，上海交通大学，2014。郭晓奎国家高等学校教学名师奖，2011郭晓奎（主编）《病原生物学纲要》，上海交通大学第十三届优秀教材一等奖，2011郭晓奎，徐大刚，赵蔚，吴健桦，张湘燕。病原生物学教育教学体系的建立与完善，全国“十一五”教育科研成果特等奖，2010。郭晓奎校长奖，上海交通大学，2010郭晓奎，张湘燕，赵蔚，吴健桦，陈洪。融合式教学模式在病原生物学的发展与实践，上海交通大学教学成果二等奖，上海交通大学，2010郭晓奎（负责人）病原生物学教育教学团队，全国“十一五”教育科研先进集体，2010郭晓奎（负责人）病原生物学教学团队，上海市优秀教学团队，2010。郭晓奎全国“十一五”教育科研先进工作者，2010郭晓奎全国优秀教师， 2009郭晓奎上海市教学名师,2009郭晓奎（负责人）病原生物学教学团队，上海市教育系统先进集体，2009。郭晓奎（负责人）病原生物学教学团队，上海市文明班组，2009。郭晓奎，徐大刚，赵蔚，吴健桦，张湘燕。病原生物学课程与教学模式的创新发展与实践，上海市教学成果三等奖，上海市政府，2009。郭晓奎，徐大刚，赵蔚，吴健桦，张湘燕。病原生物学教育教学体系的建立与完善，校教学成果特等奖，上海交通大学，2008。郭晓奎优秀教师，上海交通大学医学院，2008郭晓奎（负责人）病原生物学，双语示范课程，上海市教委，2008郭晓奎宝钢基金会优秀教师奖，2007郭晓奎（病原生物学教学团队负责人），优秀教学团队，上海交通大学，2007郭晓奎（负责人）双语示范课程《病原生物学》，上海交通大学医学院，2006郭晓奎（负责人）国家精品共享课程《医学微生物学》，2005郭晓奎（负责人）医学微生物数据库及其共享体系的建立，上海市教委，2005郭晓奎校长奖，上海第二医科大学，2004郭晓奎优秀青年教师，上海交通大学基础医学院，20042004年钩端螺旋体全基因组测序和部分功能的研究获上海市科技进步奖二等奖。1999年肺炎克雷伯杆菌的分子生物学研究及在院内感染监控中的应用获黑龙江省医药卫生科学技术进步一等奖和1999年获黑龙江省科学技术进步三等奖。1997年克隆识别技术研究及其应用获获黑龙江省教育委员会科学技术进步一等奖和1997年获黑龙江省科学技术进步三等奖。1997年住院患者肺炎杆菌感染的分子流行病学研究获黑龙江省教育委员会科学技术进步一等奖。郭晓奎霍英东教育基金会青年教师奖，19961995年淋病的病原学鉴别诊断的研究获哈尔滨市科学技术进步三等奖。1994年柯萨奇病毒性心肌炎诊断的研究获黑龙江省医药卫生科学技术进步一等奖。1994年淋球菌基因探针的制备及哈市淋球分子流行病学研究获黑龙江省科学技术进步二等奖。1993年绿脓杆菌质粒图谱血清型和耐药谱的研究获黑龙江省科学技术进步三等奖。程志，张凤民，郭晓奎，凌虹，牛美娟。改革实验教学、加强学生能力培养，黑龙江省优秀教学成果二等奖，1993^[1]

时间项目名称项目编号项目来源2001.01-2003.12钩端螺旋体致病及免疫机理的功能基因组学研究2001AA223030科技部863计划2004.01-2005.12钩端螺旋体致病及免疫机理的功能基因组学研究2003AA223030科技部863计划2004.01-2006.12钩端螺旋体溶血素基因结构、表达及功能的研究30670102国家自然科学基金面上项目2006.01-2008.12钩端螺旋体重要功能基因的发掘、鉴定和应用2006AA02Z176科技部863计划2007.01-2009.12钩体血清型相关基因的研究30670102国家自然科学基金面上项目2008.01-2010.12钩端螺旋体比较蛋白质组学研究30770111国家自然科学基金面上项目2011.01-2015.12自动化临床微生物分析检测仪器的研制2011AA02A100科技部863重大项目2012.01-2015.12超级细菌的预警监控和临床防治综合评价信息化平台的建立（子课题）2012EP001004科技部支撑计划2012.01-2015.12基于Pan-genome技术探究问号钩端螺旋体不同血清型致病性差异的遗传基础81171587国家自然科学基金面上项目2013.01-2015.12钩端螺旋体与宿主细胞相互作用及其分子致病机制的研究81261160321国家自然基金国际（地区）合作与交流项目2013.01-2016.12不同动物源性致病性钩端螺旋体遗传变异规律和致病差异的分子机制研究81271793国家自然科学基金面上项目2022.01-2025.12耐药肺炎克雷伯菌对靶向保守受体噬菌体鸡尾酒制剂的耐受突变机制及适应性代价研究3217010039国家自然科学基金面上项目^[1]

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Microbiology and immunology 2006, 50:929-36.Guo XK, Zhao WQ, Kondo C, Shimojo N, Yamashita K, Aoki T, Hayakawa T*: Tissue inhibitors of metalloproteinases-1 (TIMP-1) and -2(TIMP-2) are major serum factors that stimulate the TIMP-1 gene in human gingival fibroblasts. Biochimica et biophysica acta 2006, 1763:296-304.Zhang YX, Geng Y, Bi B, He JY, Wu CF, Guo XK, Zhao GP*: Identification and classification of all potential hemolysin encoding genes and their products from Leptospira interrogans serogroup Icterohae-morrhagiae serovar Lai. Acta pharmacologica Sinica 2005, 26:453-61.Zhang XY, Yu Y, He P, Zhang YX, Hu BY, Yang Y, Nie YX, Jiang XG, Zhao GP, Guo XK*: Expression and comparative analysis of genes encoding outer membrane proteins LipL21, LipL32 and OmpL1 in epidemic leptospires. Acta biochimica et biophysica Sinica 2005, 37:649-56.Wang HT, Li ZH, Yuan JP, Zhao W, Shi XD, Tong SQ, Guo XK*: Effect of Helicobacter pylori VacA on gene expression of gastric cancer cells. 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Journal of bacteriology 2004, 186:5400-9.Li ZH, Nie BM, Chen H, Chen SY, He P, Lu Y, Guo XK, Liu JX*: In vitro anti-coxsackievirus B(3) effect of ethyl acetate extract of Tian-hua-fen. World journal of gastroenterology 2004, 10:2263-6.He P, Zhang XY, Guo XK*, Hu BY, Huang XT, Yang Y, Zhao GP*: Identification and analysis of genes present in Leptospira interrogans serovar lai but absent in L. biflexa serovar monvalerio. Acta biochimica et biophysica Sinica 2004, 36:832-9.Yuan JP, Zhao W, Wang HT, Wu KY, Li T, Guo XK*, Tong SQ: Coxsackievirus B3-induced apoptosis and caspase-3. Cell research 2003, 13:203-9.Yuan JP, Li T, Shi XD, Hu BY, Yang GZ, Tong SQ, Guo XK*: Deletion of Helicobacter pylori vacuolating cytotoxin gene by introduction of directed mutagenesis. World journal of gastroenterology 2003, 9:2251-7.Ren SX, Fu G, Jiang XG, Zeng R, Miao YG, Xu H, Zhang YX, Xiong H, Lu G, Lu LF, Jiang HQ, Jia J, Tu YF, Jiang JX, Gu WY, Zhang YQ, Cai Z, Sheng HH, Yin HF, Zhang Y, Zhu GF, Wan M, Huang HL, Qian Z, Wang SY, Ma W, Yao ZJ, Shen Y, Qiang BQ, Xia QC, Guo XK, Danchin A, Saint Girons I, Somerville RL, Wen YM, Shi MH, Chen Z, Xu JG, Zhao GP*: Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature 2003, 422:888-93.Zhao WQ, Li H, Yamashita K, Guo XK, Hoshino T, Yoshida S, Shinya T, Hayakawa T*: Cell cycle-associated accumulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) in the nuclei of human gingival fibroblasts. Journal of cell science 1998, 111 ( Pt 9):1147-53.^[1]

主编《医学微生物学》，人民卫生出版社，2021主编《病原生物学，第3版》，科学出版社，2021主编《医学微生物学（英文改编版），第2版》，科学出版社，2021主编《基础医学实验示范教程》，人民卫生出版社，2020主编《Medical Microbiology》，人民卫生出版社，2019主编《医学微生物学》，人民卫生出版社，2019总主编《病原生物学实验教程》，人民卫生出版社，2019副主编《噬菌体学：从理论到应用》，科学出版社上海分社，2019总主编《细胞与分子物学实验教程》，人民卫生出版社，2018总主编《医学形态学实验教程》，人民卫生出版社，2018总主编《医学功能学实验教程》，人民卫生出版社，2018总主编《医用化学实验教程》，人民卫生出版社，2018副主编《医学微生物学 第九版》，人民卫生出版社，2018副主编《医学微生物学学习指导与习题集》，人民卫生出版社，2018主编《人体微生物组》，人民卫生出版社，2017主编《医学整合课程的实践与研究》，上海交通大学出版社，2017名誉主编《人体微生物组与健康》，上海科学普及出版社，2017副主编《医学微生物学》，全国高等教育医学数字化规划教材，2014主编《病原生物学 第2版》，科学出版社，2013主编《医学微生物学》，人民卫生出版社，2013主编《医学微生物学实验技术》，人民卫生出版社，2010主审《病原生物学实验》，上海交通大学医学院，2009主编《感染与优生优育》，第二军医大学出版社，2009主编《医学微生物学教育教学》，第二军医大学出版社，2008主编《病原生物学纲要》，科学出版社，2008主编《病原生物学 第1版》，科学出版社，2007主编《细胞微生物学》，第二军医大学出版社，2004主编《感染与优生优育》，黑龙江科技出版社，1996主编《克隆识别》，北京协和大学出版社，1994^[1]

钩端螺旋体两个疫苗候选的外膜蛋白 ZL 2007 1 0042222.X^[1]

2021-《公共卫生进展概述》2021-《公共卫生研究前沿》2020-本科生致远荣誉课程疾病学基础-医学微生物学2020-国家级一流课程《医学微生物学》2019-国家级精品在线开放课程在线开放课程《医学微生物学》2019-上海市高校优质混合式示范课程《医学微生物学》2018-研究生致远荣誉课程医学微生物学基础与进展2018-上海市精品课程《基础医学器官系统整合课程》（含《病原生物学》）2017-中国医学教育慕课联盟规划课程《医学微生物学》，2016-国家精品共享课程医学微生物学2005-国家精品课程医学微生物学2004-研究生细胞微生物学2004-研究生病原基因组学2004-选修课微生物与人类2003-上海市精品课程医学微生物学1996-医学微生物学^[1]