郁彭

郁彭，博士，天津科技大学生物工程学院副院长，教授，博士生导师。法国国家药学科学院外籍通讯院士。《欧洲药物化学杂志》(European Journal of Medicinal Chemistry)副主编（1区Top）。天津市特聘专家，天津市特聘教授。科技部“食品营养与安全和药物化学国家国际科技合作基地”主任。回国后先后发表SCI论文近百篇，共申请专利80余项，美国授权发明专利1项，中国授权发明专利16项。^[1]

郁彭1999年获得美国威斯康辛大学（密尔沃基）博士学位，随后加入美国Decode基因化学公司，专注于新药研发工作。在该公司期间，他主持了多项创新药物研发项目，并完成了两个Ⅱ期临床药物的核心结构的创新性设计和实验室合成。作为共同发明人，他获得了5项美国专利和20多项其他各国专利保护。2009年9月，郁彭回国受聘于天津科技大学生物工程院，组建小分子药物研究室。2010年4月，他入住天津国际生物医药联合研究院，组织团队开展创新药物研发。^[1]

郁彭教授为本科生讲授《药物合成反应实验》，为研究生讲授《新药研究与开发》《制药工程专题讲座》和《科技论文写作》等课程。^[1]

郁彭教授的研究方向涵盖药物化学（小分子抑制剂、激活剂等）、抗肿瘤药理学、糖化学生物学、药物作用机制研究、新型递药系统、天然产物全合成、药物新制剂新剂型研究、天然活性物质的功效评价及其在保健品和化妆品中的应用等。

(1) 一种能够对细胞培养板实现局部可控加热的水浴锅. ZL 201821308969.5；^[1]

(2) 一种8-氮杂色酮tóng的合成方法. ZL 201611202287.1；^[1]

(3) 天然双黄酮I3, II8-Biapgienin 和 Ridiculuflavone A 的制备. ZL 201610839344.0；^[1]

(4) 谷胱甘肽敏感的两亲性聚乙二醇-羟基喜树碱偶联物. ZL 201610845743.8；^[1]

(5) 天然黄酮Anastatin B的衍生物及制备和应用. ZL 201610325752.4；^[1]

(6) 一类香豆素取代黄酮类衍生物及其制备方法和应用. ZL 201510216650.4；^[1]

(7) 胡枝子酚E1类化合物及制备方法和应用. ZL 201510052946.7；^[1]

(8) 四环吲哚生物碱衍生物及其制备和应用. ZL 201510043073.3；^[1]

(9) 3，5-二异戊烯基，2，4，4'-三羟基查尔酮及其衍生物的用途和制备. ZL 201410483832.3；^[1]

(10) 一种合成2,5-二羰基哌嗪类化合物的方法. ZL 201410007958.3；^[1]

(11) 双吲哚duǒ类化合物及合成方法. ZL 201410246013.7；^[1]

(12) 2，5，6-三取代-3（2H）-苯并呋喃酮类衍生物及应用. ZL 201410217214.4；^[1]

(13) 一种1-（苯基）-2，3，4，9-四氢-1H-吡啶并[3，4-b]吲哚衍生物的制备及其在抗肿瘤药物中的应用. ZL 201210531525.9；^[1]

(14) 1,3- 取代-5- 乙酰氨基吲哚酮类化合物及其在抗肿瘤药物中的应用. ZL 201310540828.1；^[1]

(15) 一类新型4,5- 取代-7- 甲酸甲酯吲哚二酮衍生物及其在抗肿瘤药物中的应用. ZL 201310540643.0；^[1]

(1)Yunsong Chang, Yuan Yuan, Qian Zhang, Yao Rong, Yang Yang, Ming Chi, Zhen Liu, Yongmin Zhang, Peng Yu , Yuou Teng.Effects of an isatin derivative on tumor cell migration and angiogenesis. RSC Advances. 2020, 10, 1191-1197.^[1]

(2)Yongmin Zhang, Peng Yu and Yuou Teng.Antioxidant Activities of Anastatins A&B derivatives and compound 38c protective effect in a mouse model of CCl4-induced acute liver injury. RSC Advances. 2020, 10, 14337-1346.^[1]

(3)Yuou Teng, Kui Lu, Qian Zhang, Lianbo Zhao, Yuna Huang, Angela Maria Ingarra,Herv e Galons, Tingshen Li, Shanshan Cui, Peng Yu , Nassima Oumata . Recent advances in the development of cyclin-dependent kinase 7 inhibitors.European Journal of Medicinal Chemistry.2019,183：222641-222650.^[1]

(4)Dong Wang, Zhentao Wang, Zhenlin Liu, Mindong Huang, Jianyong Hu, and Peng Yu.Strategic C-C bond-forming dearomatization of pyridines and quinolones.Organic Letters，2019，21：4459-4463.^[1]

(5)Mingyuan Li, Chunyang Du, Na Guo, Yuou Teng, Xin Meng, Hua Sun, Shuangshuang Li, Peng Yu, Herve Galons.Composition design and medical application of liposomes.European Journal of Medicinal Chemistry.2019, 164：640-653.^[1]

(6)Yu Wang , Chunyan Dou, Guidong He, Litong Ban, Liang Huang, Zheng Li,,Jixian Gong, Jianfei Zhang and Peng Yu. Biomedical Potential of Ultrafine Ag Nanoparticles Coated on Poly (Gamma-Glutamic Acid) Hydrogel with Special Reference to Wound Healing.Nanomaterials.2018, 8, 324-335.^[1]

(7)Qian Zhang, Yuou Teng, Yuan Yuan, Tingting Ruan, Qi Wang, Xing Gao, Yao Zhou,Kailin Han, Peng Yu, Kui Lu，Synthesis and cytotoxic studies of novel 5-phenylisatin derivatives and their anti-migration and anti-angiogenic evaluation.European Journal of Medicinal Chemistry.2018，156， 800-814.^[1]

(8)Dong Wang, Zhenlin Liu， Zhentao Wang，Xinyue Maa and Peng Yu.Metal- and base-free regioselective thiolation of the methyl C(sp3)–H bond in 2-picoline N-oxides.Green Chemistry.2019，21：157-163.^[1]

(9)Hua Sun, Xiaotong Song, Yunchang Tao, Ming Li, Ke Yang, Hang Zheng, Zongxin Jin, Robert H Dodd， Guojun Pan, Kui Lu, & Peng Yu. Synthesis & α-glucosidase inhibitory & glucose consumption-promoting activities of flavonoid–coumarin hybrids.Future Medicinal Chemistry.2018, 10(9)：1055-1066.^[1]

(10)Dong Wang, Hairong Feng, Linna Li, Zhenlin Liu, Zhongli Yan, Peng Yu.Access to 8‑Azachromones via Activation of C−H in N‑Oxides.Journal Of Organic Chemis.2017, 82:11275−11287.^[1]

(11)Cen Xiang, Yuou Teng, Chaoran Yao,Xuehui Li, Menglin Cao, Xuzhe Li,Guojun Pan, Kui Lu, Herv´e Galons and Peng Yu.Antioxidant properties of flavonoid derivatives and their hepatoprotective effects on CCl4 induced acute liver injury in mice.RSC Advances.2018, 8：15366-15371.^[1]

(12)Yang Yang, Haojie He, Hao Chang, Yao Yu, Meibing Yang, Yun He, Zhenchuan Fan, Suri S. Iyer, Peng Yu.Multivalent oleanolic acid human serum albumin conjugate as nonglycosylated neomucin for influenza virus capture and entry inhibition.European Journal of Medicinal Chemistry.2018, 143: 1723-1731.^[1]

(13)Xin Meng, Chuanming Ji, Chao Su, Di Shen, Yaxin Li, Peijie Dong, Ding Yuan, Mengya Yang, Song Bai, Demei Meng, Zhenchuan Fan, Yang Yang, Peng Yu, Tao Zhu.Synthesis and immunogenicity of PG-tb1 monovalent glycoconjugate，European Journal of Medicinal Chemistry.2017, 134： 140-146.^[1]

(14)Yuou Teng, Lixin Wang, Huan Liu, Yuan Yuan, Qian Zhang, Meng Wu, Luyao Wang, Haomeng Wang, Zhen Liu, Peng Yu.3'-Geranyl-mono-substituted chalcone Xanthoangelovl induces apoptosis in human leukemia K562 cells via activation of mitochondrial pathway.Chemico-Biological Interactions. 2017 261：103-107.^[1]

(15)Xin Meng,, Meibing Yang, Yang Li, Xiaobin Li, Tianwei Jia, Haojie He, Qun Yu,Na Guo, Yun He, Peng Yu,Yang Yang.Multivalent neuraminidase hydrolysis resistant triazole-sialoside protein conjugates as influenza-adsorbents.Chinese Chemical Letters.2018，1：76-80.^[1]

(16)Hua Sun, Weina Ding, Xiaotong Song, Dong Wang, Mingzhu Chen, Kaili Wang, Yazhou Zhang, Peng Yuan, Ying Ma, Runling Wang, Robert H. Dodd, Yongmin Zhang, Kui Lu, and Peng Yu .Synthesis of 6-hydroxyaurone analogues and evaluation of their α-glucosidase inhibitory and glucose consumption-promoting activity: Development of highly active 5, 6-disubstituted derivatives.Bioorganic & Medicinal Chemistry Letters.2017, 27:3226-3230.^[1]

(17)Hua Sun,, Dong Wang, Xiaotong Song, Yazhou Zhang, Weina Ding, Xiaolin Peng, Xiaoting Zhang, Yashan Li, Ying Ma Runling Wang and Peng Yu，Natural Prenylchalconaringenins and Prenylnaringenins as Antidiabetic Agents: α‑Glucosidase and α‑Amylase Inhibition and in Vivo Antihyperglycemic and Antihyperlipidemic Effects，Journal of Agricutural Food Chemistry，2017, 65：1574-1581.^[1]

(18)Dong Wang, Yuxi Wang, Junjie Zhao, Meng Shen, Jianyong Hu, Zhenlin Liu, Linna Li, Furen Xue, and Peng Yu.Strategic Approach to 8‑Azacoumarins.Organic letters.2017, 19(5)：984-987.^[1]

(19)Kui Lu, Ke Yang, Xiaoliang Jia, Xing Gao, Xia Zhao, Guojun Pan, Yantao Ma, Qiyao Huang, and Peng Yu.Total Synthesis of I3,II8‐Biapigenin and Ridiculuflavone A.Organic Chemistry Frontiers.2017, 4, 578-586.^[1]

(20)Zhen Liu, Qi Zheng, Wenzhu Chen, Meng Wu, Guojun Pan, Ke Yang, Xuzhe Li, Shuli Man, Yuou Teng, Peng Yu, Wenyuan Gao.Chemosensitizing effect of Paris Saponin I on Camptothecin and 10-hydroxycamptothecin in lung cancer cells via p38 MAPK, ERK, and Akt signaling pathways.European Journal of Medicinal Chemistry.2017,125：760-769.^[1]

(21)Yuou Teng,Xuzhe Li,Ke Yang,Xuehui Li,Zijun Zhang,Luyao Wang,Zhijie Deng,Binbin Song, Zhihong Yan,Yongmin Zhang,Kui Lu,Peng Yu.Synthesis and antioxidant evaluation of desmethylxanthohumolanalogs and their dimers. European Journal of Medicinal Chemistry.2017, 125 :335-345.^[1]

(22)Kui Lu,, Yantao Ma, Meile Gao,Yan Liu, Ming Li,Chuanming Xu,Xia Zhao,,and Peng Yu. 1,4-Addition Ugi Reaction Using Cyclic α,β-Unsaturated Ketone as Substrate. Organic letters. 2016, 18, 5038-5041.^[1]