田勇

研究员，博士生导师。中科院生物物理所，蛋白质科学平台首席技术专家。非编码核酸北京市重点实验室，交叉科学所重点实验室，创新课题组组长（兼）。^[1]

研究组工作摘要

中科院生物物理所蛋白质科学平台首席技术专家，生物物理研究所动物实验中心主任；中国科学院核酸生物学重点实验室，交叉科学所重点实验室，创新课题组组长（兼），2009年入选中国科学院百人计划，2014年以来以通讯作者身份在Nature Immunology (IF=20), Journal of Experimental Medicine (IF=14)等国际顶级学术刊物上发表多篇研究论文。

1992-1997，北京医科大学临床医学学士

1997-2002，中国协和医科大学理学博士

2002-2008，美国ST JUDE儿童研究医院博士后

2009-今，中国科学院生物物理研究所研究员

1、第三代基因编辑技术（CRISPR/Cas9）在模式生物疾病动物模型研发中的应用

2、第三代基因组编辑技术（CRISPR/Cas9）在疾病诱导多能干细胞定向分化体系中的应用

3、疾病动物模型的致病机理研究

1. Xia P, Ye B, Wang S, Zhu X, Du Y, Xiong Z, Tian Y*, Fan Z*. Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Nat Immunol. 2016 Feb 1. doi: 10.1038/ni.3356.

2. Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia P, Zhang G, Tian Y, Chen R, Fan Z. The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. Cell Stem Cell. 2015 Apr 2;16(4):413-25. doi: 10.1016/j.stem.2015.03.003.

3. Chen J, Hao L, Li C, Ye B, Du Y, Zhang H, Long B, Zhu P, Liu B, Yang L, Li P, Tian Y*, Fan Z*. The endoplasmic reticulum adaptor protein ERAdP initiates NK cell activation via the Ubc13-mediated NF-κB pathway. J Immunol. 2015 Feb 1;194(3):1292-303. doi: 10.4049/jimmunol.1402593.

4. Ye B, Li C, Yang Z, Wang Y, Hao J, Wang L, Li Y, Du Y, Hao L, Liu B, Wang S, Xia P, Huang G, Sun L, Tian Y*, Fan Z*. Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation. J Exp Med. 2014 Nov 17;211(12):2439-54. doi: 10.1084/jem.20141123.

5. Zhu X, Xu Y, Yu S, Lu L, Ding M, Cheng J, Song G, Gao X, Yao L, Fan D, Meng S, Zhang X, Hu S, Tian Y. An efficient genotyping method for genome-modified animals and human cells generated with CRISPR/Cas9 system. Sci Rep. 2014 Sep 19;4:6420. doi: 10.1038/srep06420.

6. Li G, Ci W, Karmakar S, Chen K, Dhar R, Fan Z, Guo Z, Zhang J, Ke Y, Wang L, Zhuang M, Hu S, Li X, Zhou L, Li X, Calabrese MF, Watson ER, Prasad SM, Rinker-Schaeffer C, Eggener SE, Stricker T, Tian Y, Schulman BA, Liu J, White KP. SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer. Cancer Cell. 2014 Apr 14;25(4):455-68. doi: 10.1016/j.ccr.2014.02.007.

7. Han J, Li J, Jia W, Yao L, Li X, Jiang L*, Tian Y*. Photothermal therapy of cancer cells using novel hollow gold nanoflowers. Int J Nanomedicine. 2014 Jan 16;9:517-26. doi: 10.2147/IJN.S55800.

8. Zhang Q, Wu J, Wu R, Ma J, Du G, Jiao R, Tian Y, Zheng Z, Yuan Z. DJ-1 promotes the proteasomal degradation of Fis1: implications of DJ-1 in neuronal protection. Biochem J. 2012 Oct 15;447(2):261-9.

9. Winter H, Rüttiger L, Müller M, Kuhn S, Brandt N, Zimmermann U, Hirt B, Bress A, Sausbier M, Conscience A, Flamant F, Tian Y, Zuo J, Pfister M, Ruth P, L wenheim H, Samarut J, Engel J, Knipper M. Deafness in TRbeta mutants is caused by malformation of the tectorial membrane. J Neurosci. 2009 Feb 25;29(8):2581-7.

10. Tian Y, Pate C, Andreolotti A, Wang L, Tuomanen E, Boyd K, Claro E and Jackowski S. Cytokine Secretion Requires Phosphatidylcholine Synthesis. J Cell Biol. 2008 Jun;181(6):945-57.

11. Gunter C, Frank M, Tian Y, Murti KG, Rehg JE, Jackowski S. Probucol therapy overcomes the reproductive defect in CTP: phosphocholinecytidylyltransferase beta2 knockout mice. BiochimBiophysActa. 2007 Jul;1771(7):845-52.

12. Gao J, Maison SF, Wu X, Hirose K, Jones SM, Bayazitov I, Tian Y, Mittleman G, Matthews DB, Zakharenko SS, Liberman MC, Zuo J. Orphan glutamate receptor delta1 subunit required for high-frequency hearing. Mol Cell Biol. 2007 Jun;27(12):4500-12.

13. Tian Y, Zhou R, Rehg JE, Jackowski S. Role of phosphocholinecytidylyltransferase alpha in lung development. Mol Cell Biol. 2007 Feb;27(3):975-82.

14. Tian Y, Jackson P, Gunter C, Wang J, Rock CO, JackowskiS.Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2. J Biol Chem. 2006 Sep 22;281(38):28438-49.

15. Chow LM, Tian Y, Weber T, Corbett M, Zuo J, Baker SJ. Inducible Crerecombinase activity in mouse cerebellar granule cell precursors and inner ear hair cells. Dev Dyn. 2006 Nov;235(11):2991-8.

16. Tian Y, James S, Zuo J, Fritzsch B, Beisel KW. Conditional and inducible gene recombineering in the mouse inner ear. Brain Res. 2006 May 26;1091(1):243-54.

17. Tian Y, Li M, Fritzsch B, Zuo J. Creation of a transgenic mouse for hair-cell gene targeting by using a modified bacterial artificial chromosome containing Prestin. Dev Dyn. 2004 Sep; 231(1): 199-203.

18. Li M*, Tian Y*, Fritzsch B, Gao J, Wu X, Zuo J. Inner hair cell Cre-expressing transgenic mouse. Genesis. 2004 Jul; 39(3): 173-7. (Co-first author)

19. Tian Y, Breedveld GJ, Huang S, Oostra BA, Heutink P, Lo WH. Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome 19p13.1. BiochimBiophysActa. 2002 Aug 19; 1577(1): 121-5.

20. Zhao H*, Tian Y*, Breedveld G, Huang S, Zou Y, Y J, Chai J, Li H, Li M, Oostra BA, Lo WH, Heutink P. Postaxial polydactyly type A/B (PAP-A/B) is linked to chromosome 19p13.1-13.2 in a Chinese kindred. Eur J Hum Genet. 2002 Mar; 10(3): 162-6.

21. Tian Y, Zhao H, Chen J, Liu Y, Li M, Yang T, Luo H, Huang S. Cloning of a novel zinc finger gene ZNF333 and its expression analysis. Basic Medical Sciences and Clinics. 2002; 22(3): 232-235 (In Chinese)

22. Tian Y, Huang S. Current advances in genetic analysis of hereditary spastic paraplegia. Foreign Medical Sciences. 2000; 23 (4): 182-185 (In Chinese)