杨学东,男,1964年01月出生,现为天津大学药物科学与技术学院副教授、硕导。
主讲课程
本科生: 《天然药物化学》、《有机化合物的分离与结构鉴定》、《天然药物化学研究方法与技术》。
研究生: 《高等天然产物化学》、《新药和保健食品开发与评 价》、《药物分离原理与技术》、《药学研究进展(天然产物化学与新药研发)》。
教育研究背景
1996-2001 中国协和医科大学、中国医学科学院 博士(天然药物化学)
2002-2003 清华大学化学系、分析中心 博士后
2004 至今 天津大学药物科学与技术学院 副教授
2010-2011 美国麻省理工学院(MIT)生物工程系、化学系 访问学者
研究方向
针对中药、天然药物和保健食品,开展天然药物化学、分析化学和生物化学交叉及相关领域的应用基础研究,进行新药和天然保健食品的研发。中药与天然药物有效成分和保健食品功能因子的分离、结构鉴定和活性确证;药物构效关系研究,药物分子、功能因子与DNA和蛋白质相互作用研究。天然抗肿瘤药物和致癌剂DNA损伤和致突变机理研究与评价。中药与生物复杂体系分析与表征方法研究(包括中药指纹图谱技术、药物代谢和生物活性物质分析)制备色谱方法与技术研究。天然产物标准物质研制。抗癌和治疗缺血性心脑血管病中药物质基础、配伍规律与ADMET性质研究,肿瘤预防药物和食品研究。
研究课题
作为课题负责人或主要承担者,先后参加承担完成国家新药基金项目;国家重大科技攻关计划“重要技术标准研究”;国家973重点课题“方剂关键科学问题的基础研究”;科技部基础专项重点项目“食品、中药与天然药物质量检测平台及其支撑体系研究”(负责人);中国博士后科学基金(负责人);科技部科技基础专项“中药和保健食品标准物质研究”(负责人);国家重大新药创制专项(十一五):现代先进提取分离技术改造传统中药产业技术平台建设(负责人);国家重大新药创制专项(十二五):抗肿瘤中药艾迪注射剂的生产技术改造(主要承担者)。
学术兼职
部分代表性论文
Xuedong Yang, Deyu Li, and John Essigmann, Alkyl lesions in DNA repaired by E. coli AlkB protein in a sequence-dependant manner, 242nd ACS national meeting, Denver: 2011. 8Deyu Li, Xuedong Yang, John Essigmann, N2-Guanine related DNA alkyl lesions repaired by E. coli adaptive response protein AlkB, 242nd ACS national meeting, Denver: 2011. 8Xuedong Yang, Chengxiong Yang, Xiaodan Zang, Shiming Fang, Heran Li, Weiping Wang, Susumu Kitanaka, Flavonoids from caragana changduensis and their inhibitory effects on nitric oxide, 52nd Annual Meeting of the American Society of Pharmacognosy, San diego: 2011. 7Yang Xuedong, Wang Lian, Wang Wenjie, Guo Henan, Preparation and characterization of anthraquinones standard reference materials in Rhei, RM 2010-Beijing International Symposium on Reference Materials, Beijing: 2010. 10Xuedong Yang, Reference Materials for Chinese Herbal Medicine and Healthy Food, 2nd APMP TCQM-DEC International Workshop & Symposium and 2007 National Conference on Metrology in Chemistry, Xi’an: 2007. 6Xuedong Yang, Yingkui Hao, Weiping Wang, Haizhi Zhang, Heran Li, Susumu Kitanaka, The chemical constituents of Caragana jubata and inhibitory effects on nitric oxide, 67th World congress of pharmacy and pharmaceutical sciences, Beijing: 2007, 8. Liu JY, Yang XD, He JM, Xia M, Xu LZ, Yang SL, Structure analysis of triterpene saponins in Polygala tenuifolia by electrospray ionization ion trap multiple-stage mass spectrometry, JOURNAL OF MASS SPECTROMETRY, 2007, 42(7): 861-873.Xue-Dong Yang, Li-Zhen Xu, and Shi-Lin Yang; Xanthones from Securidaca inappendiculata, Phytochemistry, 2001, 58(8): 1245-1249. Xue-Dong Yang, Li-Zhen Xu, and Shi-Lin Yang; New Xanthone glycosides from Securidaca inappendiculata, J. Asian Nat. Prod. Res.,2002,4(2): 141-145. Xue-Dong Yang, Li-Zhen Xu, and Shi-Lin Yang; Two new xanthone glycosides from Securidaca inappendiculata, Chin. Chem. Lett., 2002, 13(6): 539-542. Xue-Dong Yang, Li-Zhen Xu, and Shi-Lin Yang,Two New Xanthones from the Stems of Securidaca inappendiculata, Acta Botanica Sinica,2003, 45 (3): 365-368.Xue-Dong Yang, Li-Zhen Xu, and Shi-Lin Yang; A new benzophenone from Securidaca inappendiculata, Chin. Chem. Lett., 2003, 14 (9): 930-931. Tao Bo, Xue-Dong Yang, Fei Gao, Hu-Wei Liu, Ke-An Li, and Li-Zhen Xu, Optimized separation of pharmacologically active xanthones by capillary electrophoresis, Chromatographia, 2002,55(3-4): 217-223. Tao Bo, Xuedong Yang, Ke An Li, Lizhen Xu, Huwei Liu,Comparison of micellar electrokinetic chromatography and microemulsion electrokinetic chromatography for separation of pharmacological- ly active xanthones from Securidaca inappendiculata, J. Sep. Sci. 2003, 26(1-2), 133?136. Tao Bo, Xuedong Yang, Feng Liu, Ke An Li, Lizhen Xu, Huwei Liu, Optimized separation of pharmacologically active xanthones from Securidaca inappendiculata by micellar electrokinetic chromatography and microemulsion electrokinetic chromatography, Anal. Chim. Acta, 2002,474(1-2): 37-48. Tao Bo, Xuedong Yang, Fei Gao, Huwei Liu, Kean li, Lizeng Xu, Optimized Separation of Pharmacologically Active Xanthones from Securidaca inappendiculata by Capillary Electrophoresis,Chin. Chem. Lett., 2002,13(3): 269-272. Tao Bo, Yongfa Huang, Xuedong Yang, Ke An Li, Huwei Liu, Lizhen Xiu, Capillary electrophoretic behaviors of pharmacologically active xanthones from Securidaca inappendiculata with ?-CD as a buffer additive, Journal of Chromatography Science, 2003, 41 (4): 182-186.Xue-Dong Yang, Li-Zhen Xu, and Shi-Lin Yang,Xanthones from the stems of Securidaca inappendiculata. UNESCO Regional Symposium on Chemistry of Medicinal Plants.Kunming,China,2000,4.Guoan Luo, Yiming Wang, Jin Cao, Xuedong Yang, Studies on Establish of Modern Quality Standards System of Traditional Chinese Medicne in China, 3rd International Conference on Science and Technology in Biodiversity Conservation and SustainableUtilization. Beijing, 2002/5. 杨学东、刘江云、许莉、徐丽珍、杨世林,蝉翼藤中的糖酯成分,高等学校化学学报,2003,24(1):61-63. 杨学东、徐丽珍、杨世林,蝉翼藤化学成分研究,药学学报,2002,37(5):348-351.杨学东、徐丽珍、杨世林,蝉翼藤茎中有机酸成分的研究,中国中药杂志,2001,26: 258-260.杨学东、徐丽珍、杨世林,蝉翼藤化学成分研究(II),中草药,2002, 33(10): 872-875.杨学东、张丽杰、梁波、徐丽珍、杨世林,远志科植物中的寡糖酯类成分,中草药,2002,33(10):954-958.