李速明早年毕业于四川大学的高分子科学专业,随后去法国深造。
人物介绍
1980.9 — 1984.7成都科技大学高分子材料系,大学本科
1985.9 — 1986.7 法国鲁昂大学理学院,材料科学硕士
1986.9 — 1989.6 法国鲁昂大学理学院,高分子化学博士
1990.1 — 1992.6 法国国家科研中心,博士后
1992.10 — 1996.9 法国国家科研中心,二级研究员
1995.10 — 1996.9 美国麻省州立大学,访问学者
1996.10 — 2004.6 法国国家科研中心,一级研究员
2004.7 — 2011.4 复旦大学特聘教授
2011.4至今 青岛科技大学特聘教授
研究领域
期刊文章
1) S. Li, H. Garreau, M. Vert, "Structure-property relationships in the case of the degradation of massive poly(a-hydroxy acids) in aqueous media. part 1: poly(DL-lactic acid)",Journal of Materials Science: Materials in Medicne, 1990, 1,123-130.
4) M. Vert, S. Li, H. Garreau, "More about the degradation of LA/GA-derived matrices in aqueous media",Journal of Controlled Release, 1991, 16, 15-26.
5) M. Vert, S. Li, H. Garreau, "New insights on the degradation of bioresorbable polymeric devices based on lactic and glycolic acids",Clinical Materials, 1992, 10, 3-8.
6) M. Thérin, P. Christel, S. Li, H. Garreau, M. Vert, "In vivo degradation of massive poly(a-hydroxy acids): validation ofin vitro findings",Biomaterials, 1992, 13, 594-600.
7) M. Vert, S. Li, G. Spenleauer, Ph. Guérin, "Bioresorbility and biocompatibility of aliphatic polyesters",Journal of Materials Science: Materials in Medicne, 1992, 3, 432-446.
8) S. Li, M. Vert, "Crystalline oligomeric stereocomplex as intermediate compound in racemic poly(DL-lactic acid) degradation",Polymer International, 1994, 33, 37-41.
9) S. Li, M. Vert, "Morphological changes resulting from the hydrolytic degradation of stereocopolymers derived from L- and DL-lactides",Macromolecules, 1994, 27, 3107-3110.
10) M. Vert, J. Mauduit, S. Li, "Biodegradation of PLA/GA polymers: increasing complexity",Biomaterials, 1994, 15, 1209-1213.
11) M. Vert, S. Li, H. Garreau, "Attempts to map the structure and degradation characteristics of aliphatic polyesters derived from lactic and glycolic acids",Journal of Biomaterials Science: Polymer Edition, 1994, 6, 639-649.
12) I. Grizzi, H. Garreau, S. Li, M. Vert, "Biodegradation of devices based on poly(DL-lactic acid): size-dependence",Biomaterials, 1995, 16, 305-311.
13) I. Rashkov, N. Manolova, S. Li, J.L. Espartero, M. Vert, "Synthesis, charactarization and hydrolytic degradation of PLA/PEO/PLA triblock copolymers with short poly(L-lactic acid) chains",Macromolecules, 1996, 29, 50-56.
14) S. Li, I. Rashkov, J.L. Espartero, N. Manolova, M. Vert, "Synthesis, charactarization and hydrolytic degradation of PLA/PEO/PLA triblock copolymers with long poly(L-lactic acid) blocks",Macromolecules, 1996, 29, 57-62.
15) J.L. Espartero, I. Rashkov, S. Li, N. Manolova, M. Vert, "NMR analysis of low molecular weight poly(lactic acid)s",Macromolecules, 1996, 29, 3535-3539.
16) S. Li, M. Vert, "Hydrolytic degradation of coral/poly(DL-lactic acid) bioresorbable material",
17) S. Li, S. Girod-Holland, M. Vert, "Hydrolytic degradation of poly(DL-lactic acid) in the presence of caffeine base",Journal of Controlled Release, 1996, 40, 41-53.
18) S. Li, J.L. Espartero, P. Foch, M. Vert, "Structural characterization and hydrolytic degradation of a Zn metal initiated copolymer of L-lactide and e-caprolactone",Journal of Biomaterials Science: Polymer Edition, 1996, 8, 165-187.
19) A. Torres, S. Roussos, S. Li, M. Vert, "Screening of microorganisms for biodegradation of poly(lactic acid) and lactic acid-containing polymers",Applied and Environmental Microbiology, 1996, 62, 2393-2397.
20) A. Torres, S. Li, S. Roussos, M. Vert, "Degradation of L- and DL-lactic acid oligomers in the presence of Fusarium moniliforme and Pseudomonas putida",Journal of Environment & Polymer Degradation, 1996, 4, 213-223.
21) A. Torres, S. Li, S. Roussos, M. Vert, "Poly(lactic acid) degradation in soil or under controlled conditions",Journal of Applied Polymer Science, 1996, 62, 2295-2302.
22) M. Vert, S. Li, H. Garreau, J. Mauduit, M. Boustta, G. Schwach, R. Engel, J. Coudane, "Complexity of the hydrolytic degradation of aliphatic polyesters",AngewandteMakromolekulare Chemie, 1997, 247, 239-253.
23) T. Petrova, N. Manolova, I. Rashkov, S. Li, M. Vert, "Synthesis and characterization ofpoly(oxyethylene)/poly(e-caprolactone)multiblock copolymers",Polymer International, 1998, 45, 419-426.
24) S. Li, H. Garreau, M. Vert, T. Petrova, N. Manolova, I. Rashkov, "Hydrolytic degradation ofpoly(oxyethylene)/poly(e-caprolactone)multiblock copolymers",Journal of Applied Polymer Science, 1998, 68, 989-998.
25) S. Li, S. Anjard, I. Rashkov, M. Vert, "Hydrolytic degradation of PLA/PEO/PLA triblock copolymers prepared in the presence of Zn metal or CaH",Polymer, 1998, 39, 5421-5430.
26) S. Li, S.P. McCarthy, "Further investigations on the hydrolytic degradation of poly(DL-lactide)",Biomaterials, 1999, 20, 35-44.
27) S. Li, S.P. McCarthy, "Influence of crystallinity and stereochemistry on the enzymatic degradation of poly(lactide)s",Macromolecules, 1999, 32, 4454-4456.
28) S. Li, "Hydrolytic degradation characteristics of aliphatic polyesters derived from lactic and glycolic acids",Journal of Biomedical Materials Research, Part B: Applied Biomaterials, 1999, 48B, 342-353.
29) S. Li, M. Tenon, H. Garreau, C. Braud, M. Vert, "Enzymatic degradation of stereocopolymers derived from L-, DL- and meso-lactides",Polymer Degradation and Stability, 2000, 67, 85-90.
30) S. Li, X.H. Chen, R.A. Gross, S.P. McCarthy, "Hydrolytic degradation of PCL/PEO copolymers in alkaline media",Journal of Materials Science: Materials in Medicne, 2000, 11, 227-233.
31) L.J. Liu, S. Li, H. Garreau and M. Vert, "Selective enzymatic degradations of poly(L-lactide) and poly(e-caprolactone) blend films",Biomacromolecules, 2000, 1, 350-359.
32) S. Li, A. Girard, H. Garreau and M. Vert, "Enzymatic degradation of PLA stereocopolymers with predominant D-lactyl contents",Polymer Degradation & Stability, 2001, 71, 61-67.
33) I. Molina, S. Li, M. Bueno Martinez and M. Vert, "Protein release from physically crosslinked hydrogels of the PLA/PEO/PLA triblock copolymer-type",Biomaterials, 2001, 22, 363-369.
34) S. Li, I. Molina, M. Bueno Martinez and M. Vert, "Hydrolytic and enzymatic degradations of physically crosslinked hydrogels prepared from PLA/PEO/PLA triblock copolymers",Journal of Materials Science: Materials in Medicne, 2002, 13, 81-86.
35) W.J. Luo, S. Li, J.Z. Bei, S.G. Wang, "Dependence of morphology on composition of poly(L-lactide)/poly(ethylene glycol) multiblock copolymers",Polymers for Advanced Technologies, 2002, 13, 233-238.
36) W.J. Luo, S. Li, J.Z. Bei, S.G. Wang, "Synthesis and characterization of poly(L-lactide)-poly(ethylene glycol) multiblock copolymers ",Journal of Applied Polymer Science, 2002, 84, 1729-1736.
37) W.J. Luo, S. Li, J.Z. Bei, S.G. Wang, "Poly(L-lactide)/poly(ethylene glycol) multiblock copolymers : synthesis and properties",Chinese Chemical Letters, 2002, 13, 33-36.
38) S. Li, H. Garreau, B. Pauvert, J. McGrath, A. Toniolo, M. Vert, "Enzymatic degradation of block copolymers prepared from e-caprolactone and poly(ehtylene glycol)",Biomacromolecules, 2002, 3, 525-530.
39) S. Li, L.J. Liu, H. Garreau, M. Vert, “ Lipase-catalysed biodegradation of poly(e-caprolactone) blended with various polylactide-based polymers”,Biomacromolecules, 2003, 4, 372-377.
40) F. He, S. Li, M. Vert, R.X. Zhuo, "Enzyme-catalysed polymerization and degradation of block copolymers prepared from e-caprolactone and poly(ethylene glycol)",Polymer, 2003, 44, 5145-5151.
人物成就
生物高分子材料是李速明教授的研究领域。他通过对PLA、PGA、PCL及其共聚物等脂肪族聚酯的生物降解进行全面而系统的研究,发现了“内部自催化降解”这一新的降解机理,即聚酯材料在降解过程中,由于材料内部存在自催化现象,内部降解速度比表面更快。
他所发现的降解机理揭示了聚合物组成和构象结构、聚集态结构、分子量、尺寸、添加剂等一系列参数对聚合物材料降解行为的影响,以及这些参数在降解过程中的变化。这一发现对人类的健康极其有利。“内部自催化降解机理”及相关研究成果发表在一系列论文中,在国际学术界产生了广泛影响,被广泛引用。在1990年,这一发现被《人民日报》(海外版)称之为生物降解性高分子领域的“经典性论文”。
此外,他通过对PLA/PEG共聚物进一步深入研究,发明了新一代水凝胶,这种新型的产品可以有效的避免使用有机溶剂。这种水凝胶不仅具有优良的生物相容性、生物降解性、生物吸收性、可注射性,还具有热敏性,即水凝胶的性能随温度和时间变化,可以在体温下成胶。同时还具有合成简单,制备方便的优点。所以它们既是药物控释的理想载体,也可用作组织工程的骨架材料。
他通过参与科技部973计划“导向性纳米载药系统及其在脑部疾病治疗与诊断中的应用基础研究”,深入研究了PLA-PEG嵌段共聚物纳米胶束的制备、基本性质,以及胶束在药物控释领域的应用。提出了直接溶解法这一新型的纳米胶束制备方法,该方法避免了有毒的有机溶剂的使用,操作简单,在药物控释研究领域具有很好的发展前景;采用等摩尔的PLLA-PEG和PDLA-PEG制备得到了L/D混合型胶束溶液,利用PLLA和PDLA链段间较强的立体复合作用使得所得胶束结构更加致密;三是通过改变共聚物组成等方式控制胶束的包药能力及释药特性,实现了可控的药物缓释。PLA-PEG纳米胶束在药物控释领域,特别是疏水性抗癌药控释方面具有广阔的应用前景。
此外,他还对聚合物的酶降解进行了深入研究,初步揭示了酶降解机理,明确了聚合物结晶度、立体化学结构、共混等一系列参数对材料酶降解的影响。
获奖及学术兼职
1996年获得法国国家科研中心(CNRS)“科研成果铜牌奖”
1998年获得国家基金委首届“杰出青年科学基金(B类)”
2000-2003年担任上海交通大学“客座教授”
2000年起担任四川大学“客座教授”
法国高分子协会及欧洲生物材料协会会员