徐明良

徐明良，男，1964年2月出生，浙江宁波人。博士，教授、博士生导师。现任中国农业大学农学院教授，科技部‘十三五’重点专项首席科学家。^[1]

1980年9月－1984年7月，浙江农业大学宁波分校，获农学学士学位。

1984年9月－1987年7月，原江苏农学院，获农学硕士学位。

1987年7月－2003年9月，扬州大学，助教、讲师、副教授、教授、博士生导师

1993年9月－1996年7月，复旦大学，获理学博士学位

1997年2月－1999年2月，德国Hohenheim大学，博士后

1999年2月－2002年6月，美国Illinois大学，博士后

2003年－－中国农业大学，教授，博士生导师。

1、《玉米分子育种》分四讲：1）分子标记；2）原理与应用；3）茎腐病；2）丝黑穗病及其它。

2、《功能基因组学》

1. 挖掘和验证玉米主要病害的抗性QTL

2. 阐明QTL调节的宿主病原互作的抗性机制

3. 证实抗病QTL的进化途径

4. 改善玉米抗病性的分子育种

1、科技部‘十三五’重点专项首席科学家

2、完成和主持国家杰出青年基金、重大国际合作，科技部‘863’、‘973’计划，农业部转基因专项等多个国家级项目。在Nature Genetics、PNAS、Plant Cell等主流杂志发表论文50多篇。

3、受聘于SCI收录杂志《Theoretical and Applied Genetics》   、《Plant Molecular Biology Reporter》   、《Journal of Genetics and Genomics》编委，《作物学报》副主编。

4、2006年获国家杰出青年基金；2009年入选新世纪百千万国家级人才工程，享受国务院特殊津贴；2011年荣获全国百篇优秀博士论文指导教师。

5、长期来从事玉米等作物的功能基因组学与分子生物学研究。在玉米全基因组范围内筛选出了抗病和防御相关的候选基因300多个，并将他们定位到玉米基因组上，这一工作的完成为玉米各种抗病基因的克隆提供了材料、信息和技术平台；发展了一套全新的分离玉米Mu突变体旁邻序列方法，为玉米功能基因大规模克隆奠定了基础；克隆了玉米抗甘蔗花叶病毒病候选基因，已获得转基因植株，开展功能互补鉴定；完成抗青枯病、丝黑穗病基因的定位和基因区域高密度分子标记的发展，克隆候选基因，开展功能互补鉴定；构建了玉米抗病自交系FAP1360、1145等的BAC库。

Leng P, Ji Q, Tao Y, Ibrahim R, Pan G,Xu ML, Lübberstedt T.Characterization of sugarcane mosaic virus Scmv1 and Scmv2 resistance regions by regional association analysis in maize.PLoS One 2015, Doi: 10.1371/journal.pone.0140617. eCollection 201

Zuo WL, Chao Q, Zhang N, Ye JR, Tan GQ, Li BL, Xing YX, Zhang BQ, Liu HJ, Fengler KA, Zhao J, Zhao XR, Chen YS, Lai JS, Yan JB,Xu ML. A maize wall-associated kinase confers quantitative resistance to head smut. Nature Genetics, 2014, doi:10.1038/ng.3170

Konlasuk S, Xing YX, Zhang N, Zuo WL, Zhang BQ, Tan GQ,Xu ML.ZmWAK, a quantitative resistance gene to head smut in maize, improves yield performance by reducing the endophytic pathogen Sporisorium reiliana. Molecular Breeding 2015, 35:1-10.

Ye JR, Guo YL, Zhang DF, Zhang N, Wang C,Xu ML.Cytological and Molecular Characterization of QTL-qRfg1 Which Confers Resistance to Gibberella Stalk-Rot Disease in Maize. Mol. Plant-Microbe Interact. 2013, 26:1417-1428.

Qin Yang, Li Z, Li WQ, Ku LX, Wang C, Ye JR, Li K, Yang N, Li YP, Zhong T, Li JS, Chen YH, Yan JB, Yang XH,Xu ML. CACTA-like transposable element in ZmCCT attenuated photoperiod sensitivity and accelerated the post-domestication spread of maize. Proc Natl Acad Sci. 2013, 110: 16969–16974

Qin Yang, Zhang DF,Xu ML. A Sequential Quantitative Trait Locus Fine-Mapping Strategy Using Recombinant-Derived Progeny. Journal of Integrative Plant Biology, 2012, 54: 228–237

Qing Ji, Jufei Lu, Qing Chao, Yan Zhang, Meijing Zhang, Minghong Gu,Mingliang Xu*. 2010. Two sequence alterations, a 136-bp InDel and an A/C polymorphic site, in the S5 locus are associated with compatibility of indica/japonica hybrid in rice. J. Genet. Genomics 37

Qin Yang, Guangming Yin, Yanling Guo, Dongfeng Zhang, Shaojiang Chen, Mingliang Xu*. 2010. A major QTL for resistance to Gibberella stalk rot in maize. Theor Appl Genet 121:673

Lai JS, Li RQ, Xu X, Jin WW,Xu ML, Zhao HN, Xiang ZK, Song WB, Ying K, Zhang M, Jiao YP, Ni PX, Zhang JG, Li D, Guo XS, Ye KX, Jian M, Wang B, Zheng HS, Liang HQ, Zhang XQ, Wang SC, Cheng SJ, Li JS, Fu Y, Springer NM, Yang HM, Wang JA, Dai JR, Schnable PS, and Wang J. Genome-wide patterns of genetic variation among elite maize inbred lines. Nature Genetics, 2010, 42:1027-1030. (共 同第一作者)

Usarowska A, Dionisio G, Sarholz B, Piepho HP, Xu ML, Ingvardsen CR, Wenzel G, Lübberstedt T. 2009. Validation of candidate genes putatively associated with resistance to SCMV and MDMV in maize (Zea mays L.) by expression profiling. BMC Plant Biology 2009, 9:15 doi:10.1186/1471-2229-9-15

Chen SH, Yang Y, Shi WW, Ji Q, He F, Zhang ZD, Cheng ZK, Liu XN, andXu ML. Badh2, encoding betaine aldehyde dehydrogenase, inhibits the biosynthesis of 2-acetyl-1-pyrroline, a major component in rice fragrance. Plant Cell, 2008, 20: 1850-1861

Soria-Guerra R,Xu ML, Korban S. 2008. Transgenic apple lines carrying vfa genes in tandem for resistance to apple scab. Hortscience 43:1156-1156.

Chen YS, Chao Q, Tan GQ, Zhao J, Zhang MJ, Ji Q, and Xu ML*. 2008. Identification and fine-mapping of a major QTL conferring resistance against head smut in maize. Theor Appl Genet,117:1241.

Chen JJ, Ding JH, Ouyang YD, Du HY, Yang JY, Cheng K, Zhao J, Qiu SQ, Zhang XL, Yao JL, Liu KD, Wang L, CG Xu, Li XH, Xue YB, Xia M, Ji Q, Lu JF,Xu ML, and Zhang QF. 2008. A tri-allelic system of S5 is a major regulator of the reproductive barrier and compatibility of indica-japonica hybrids in rice. Proc Natl Acad Sci 105: 11436-11441

Jiang L, Ingvardsen CR, Lubberstedt T,Xu ML*. 2008. The Pic19 NBS-LRR gene family members are closely linked to Scmv1, but not involved in maize resistance to sugarcane mosaic virus. Genome, 51:673-684.

Wen WE, Li GQ, He ZH, Yang WY, Xu ML, Xia XC. 2008. Development of an STS marker closely linked to Yr26 against wheat stripe rust using the resistance gene-analog polymorphism (RGAP) technique. Mol Breed 22:507-515

Wang YJ, Yin GM, Yang Q, Tang JH, Lu XM, Korban SS, Xu ML*. 2008. Identification and isolation of Mu-flanking fragments from maize. J of Genetics and Genomics 35: 207-213

Malnoy M, Xu ML, Borejsza-Wysocka E, Korban SS, and Aldwinckle HS. 2008. Two receptor-like genes, Vfa1 and Vfa2, confer resistance to the fungal pathogen Venturia inaequalis inciting apple scab disease. Mol Plant-Microbe Interact 21:448-458. (共同第一作者)

Shi WW, Yang Y, Chen SH, Xu ML*. 2008. Discovery of a new fragrance allele and the development of functional markers for the breeding of fragrant rice varieties. Mol Breed 22:185-192.

Xiao WK, Zhao J, Fan SC, Li L, Dai JR, Xu ML*. 2007. Mapping of genome-wide resistance gene analogs (RGAs) in maize (Zea mays L.). Theor Appl Genet. 115:501-508.

Wang GX, Chen Y, Zhao JR, Li L, Korban SS, Wang FG, Dai JR, Xu ML*. 2007. Mapping of defense response gene homologues and their association with resistance loci in maize. Journal of Integrative Plant Biology 49:1580-1598.

Han YP, Gasic K, Sun FJ, Xu ML, Korban SS. 2006. A gene encoding starching branching enzyme I (SBEI) in apple (Malus × domestica, Rosaceae) and its phylogenetic relationship to Sbe genes from other angiosperms. Molecular Phylogenetics and Evolution 43:852-863.

Farrar K, Asp T, Lübberstedt T, Xu ML, Christiansen C, Thomas A, Humphreys M, Donnison I. 2006. Construction and utilization of two Lolium perenne BAC libraries. Mol Breed. 19:15-23.

Chen SH, Wu J, Yang Y, Shi WW, Xu ML*. 2006. The fgr gene responsible for rice fragrance was restricted within 69kb. Plant Science 171：505-514.

Xiao WK, Xu ML*, Zhao JR, Wang FG, Li JS, Dai JR. 2006. Genome-wide isolation of resistance gene analogs in maize (Zea mays L.) Theor Appl Genet. 113:63-72.

He Y, Han YP, Jiang L, Xu CW, Lu JF, Xu ML*. 2006. Functional analysis of starch-synthesis genes in determining rice eating and cooking qualities. Mol Breed 18:277-290.

Ji Q, Lu JF, Chao Q, Gu MH, Xu ML*. 2005. Delimiting a rice wide-compatibility gene S 5 n to a 50 kb region. Theor Appl Genet 111: 1495- 1503.

Xu ML, Li X and Korban SS, 2004. DNA methylation alterations and exchanges during in vitro cellular differentiation in rose (Rosa hybrida L.). Theor Appl Genet 109：899-910.

Xu ML and Korban SS, 2004. Somatic variation plays a key role in driving the evolution of the Vf gene family that confer resistance to apple scab disease. Molecular Phylogenetics and Evolution 32：57-65.

Huaracha, E.M., Xu ML, K. Gasic, E. Pauwels, A. van den Putte, J.W. Keulemans, and S.S. Korban. 2004. Phenotypic reaction and genetic analysis using AFLP-derived SCARs for resistance to apple scab. J. Phytopathology 152：260-266.

Han YP, Xu ML*, Liu XY, Yan CJ, Korban SS, Chen XL and Gu MH.2004. Genes coding for starch branching enzymes are major contributors to starch viscosity characteristics in waxy rice (Oryza sativa L.). Plant Science 166:357-364.

Liu XY, Gu MH, Han YP, Ji Q, Lu JF, Gu SL, Zhang R, Li X, Chen JM, Korban S S and Xu ML*. 2003. Developing gene-tagged molecular markers for functional analysis of starch-synthesizing genes in rice (Oryza Sativa L.). Euphytica 135:345-353.

Xu ML and Korban SS. 2003. Positional cloning of the apple scab resistance gene Vf. Proc. XXVII Intl. Hort. Cong. Acta Hort. 625:79-87.

Carr J, Xu ML and Korban SS. 2003. Estimating genetic diversity in New Guinea impatiens. Proc. XXVII Intl. Hort. Cong. 623:161-168.

Dußle C, Quin M, Melchinger AE, Xu ML and Luebberstedt T, 2003. Saturation of two chromosome regions conferring resistance to SCMV by targeted BSA. Theor Appl Genet 106:485-493.

Carr, J., Xu ML, J.W. Dudley, and S.S. Korban. 2003. AFLP analysis of genetic variability in New Guinea impatiens. Theor Appl Genet 106: 1509-1516.

Huaracha E, Xu ML, Pauwels E, Keulemans W and Korban SS, 2002. Comparison of marker-assisted selection and phenotypic selection for apple scab resistance in a set of apple progenies Theor Appl Genet 108:274-479.

Li XQ, Xu ML and Korban SS, 2002. DNA methylation profiles differ between field- and in vitro-grown leaves of apple. Journal of plant physiology 159:1229-1234.

Xu ML and Korban SS, 2002. A cluster of four active receptor-like genes reside in the Vf locus that confers resistance to apple scab disease. Genetics 162:1995-2006.

Dußle CM, Quint M, Xu ML, Melchinger AE and Luebberstedt T, 2002. Conversion of AFLP fragments tightly linked to SCMV resistance genes Scmv1 and Scmv2 into simple PCR-based markers. Theor Appl Genet 105: 1190-1195.

Quint M, Mihaljevic R, Dußle CM, Xu ML, Melchinger AE and Luebberstedt T, 2002. Genetic mapping of candidate genes for SCMV resistance in maize and conversion into RGA-CAPS markers. Theor Appl Genet 105:355-363.

Xu ML and Korban SS, 2002. AFLP-derived SCARs facilitate construction of a 1.1 Mb sequence-ready map of a region that spans the Vf locus in the apple genome. Plant Mol Biology 50: 803-818.

Korban SS and Xu ML, 2002. Going after the scab resistance gene. Trans. Ill. Hort. Soc. 134:15-20.

Xu ML, Korban SS, Song JQ, and Jiang JM 2002. Constructing a bacterial artificial chromosome library of the apple cultivar GoldRush. Acta Hort. 595:103-112.

Xu ML, Song JQ, Cheng ZK, Jiang JM and Korban SS, 2001. A bacterial artificial chromosome (BAC) library of Malus floribunda 821 and contig construction for positional cloning of the apple scab resistance gene Vf. Genome 44:1104-1113.

Xu ML, Huaracha E and Korban SS, 2001. Development of sequence-characterized amplified regions (SCARs) from amplified fragment length polymorphism (AFLP) markers tightly linked to the Vf gene in apple. Genome 44:63-70.

Xu ML, Li XQ and Korban SS, 2000. AFLP-based detection of DNA methylation. Plant Mol Biol Rep 18: 361-368.

Xu ML and Korban SS, 2000. Saturation mapping of the apple scab resistance gene Vf using AFLP markers. Theor Appl Genet 101: 844-851.

Xu ML, Melchinger AE and Luebberstedt T, 2000. Origin of Scm1 and Scm2 - two loci conferring resistance to sugarcane mosaic virus (SCMV)in maize. Theor Appl Genet 100: 934-941.

Luebberstedt T, Xia XC, Xu ML, Kuntze L, Melchinger AE, 1999. Inheritance of resistance to SCMV and MDMV in European maize. In: Proc. of the XVth EUCARPIA 1998 General Congress: Genetics and breeding for crop quality and resistance, G.T.S. Mugnozza (ed.), pp. 241-250 Kluwer

Academic Publishers, Dordrecht, The Netherlands

Xu ML, Melchinger AE, Xia XC and Luebberstedt T, 1999. High-resolution mapping of loci conferring resistance to sugarcane mosaic virus in maize using RFLP, SSR, and AFLP markers. Mol Gen Genet 261: 574-581.

Xu ML, Melchinger AE and Luebberstedt T, 1999. Species-specific detection of the maize pathogens Sporisorium reiliana and Ustilago maydis by dot blot hybridization and PCR-based assays. Plant Dis 83: 390-395.

教授：徐明良

副教授：叶建荣

科研助理：李茜

博士后：冷鹏飞

在读博士生：马传禹、刘庆彩、李懿璞、钟涛、张博琦、朱芒、刘建菊、张倩倩、龚央庆、邓穗宁、姚丽姗

在读硕士生：邓乐乐、童立秀、王利娜、杜腓利、于辉、汉和钰

丝黑穗病：

课题组发展出了利用重组个体后代测定的QTL连续精细定位和克隆策略。并利用这一策略在玉米第2染色体上检测到了一个抗丝黑穗病主效QTL，能显著提高25%的抗病率。

首次完整报道了玉米抗病QTL的克隆和抗病机理的研究，为揭示异化授粉玉米特有的抗病机制奠定了基础。在实践中，通过分子标记辅助导入该基因能够显著提高玉米对丝黑穗病的抗性，具有巨大的应用价值。合作单位吉林省农科院玉米所檀国庆研究员利用ZmWAK基因培育出生产潜力大，高抗的吉单系列品种，已在生产上推广应用。

在茎腐病、甘蔗花叶病毒病、粗缩病、灰斑病等病害研究也取得较大进展。