徐志卿

徐志卿

徐志卿

徐志卿,博士,北京市特聘教授,博导,现任首都医科大学神经生物学系副主任及病理学系主任。兼任中国神经科学会常务理事、应激神经生物学分会主委。1. 1991年12月-1997年09月: 瑞典卡罗琳斯卡医学院神经科学系 博士生, 博士学位

徐志卿,博士,北京市特聘教授,博导,现任首都医科大学神经生物学系副主任及病理学系主任。兼任中国神经科学会常务理事、应激神经生物学分会主委。

个人简历

1. 1991年12月-1997年09月: 瑞典卡罗琳斯卡医学院神经科学系 博士生, 博士学位

2. 1997年09月-1999年09月: 瑞典卡罗琳斯卡医学院神经科学系 博士后

3. 1999年09月-2001年09月: 瑞典卡罗琳斯卡医学院医学生化和生物物理系 博士后

4. 2001年09月- : 瑞典卡罗琳斯卡医学院神经科学系 Forskare(研究员)

5. 2007年02月- : 首都医科大学神经生物学系 特聘教授

研究方向

1997年获瑞典瑞典卡罗林斯卡医学院博士学位,并在瑞典卡罗林斯卡医学院先后任研究员、高级研究员。

主要从事脑重大疾病(抑郁症、癫痫等)中神经肽及受体的作用及其分子机制研究。主持973子课题、国家自然科学基金等课题项目。已在PNAS等重要国际学术杂志上发表了100余篇学术论文(总引用超过5600次, H因子大于40)。

研究方向名称:神经递质受体和重大脑病。

社会任职

中国神经科学学会第八届理事会副理事长

2. 中国神经科学学会常务理事

3. 中国神经科学学会应激神经生物学分会主委

学术论文

1. Yang Y, Li Y , Liu B,Li C, Liu Z, Deng J, Luo H, Li X, Wu J,Li H, Wang C, Zhao M, Wu H, Lallemend F, Svenningsson P, Hökfelt T*, Xu ZQD* (2021) Involvement of Scratch2 in GalR1-mediateddepression-like behaviors in the rat ventral periaqueductal gray. Proc NatlAcad Sci U S A. 2021 Jun 15;118(24):e1922586118. SCI2. Luo H, Liu Z, Liu B, Li H, Yang Y*, Xu ZQD* (2019)Virus-Mediated Overexpression of ETS-1 in the Ventral Hippocampus CounteractsDepression-Like Behaviors in Rats. NeurosciBull. 2019 Dec;35(6):1035-1044.SCI3. Wang W, Xu T, Chen X, Dong K, Du C, Sun J, Shi C, Li X, Yang Y, Li H*, XuZQD* (2019) NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFCof LPS Rat by Suppressing NLRP3 Signaling Pathway. Mediators Inflamm. 2019 May 15;2019:7898095. SCI4.Li H*, Wang T,Shi C, Yang Y, Li X, Wu Y, Xu ZQD* (2018) Inhibition of GALR1 in PFC Alleviates Depressive-LikeBehaviors in Postpartum Depression Rat Model by Upregulating CREB-BNDF and 5-HTLevels. Front Psychiatry. 2018 Nov14;9:588.SCI5. Jing B, Liu B,Li H, Lei J, Wang Z, Yang Y, Sun PZ, Xue B, Liu H*, Xu ZQD* (2018) Within-subjecttest-retest reliability of the atlas-based cortical volume measurement in therat brain: A voxel-based morphometry study. J Neurosci Methods. 2018 Jun28;307:46-52.SCI6. Wang T, Shi C, Li X, Zhang P, Liu B, Wang H, Wang Y, Yang Y, WuY, Li H*, Xu ZQD* (2018) Injection of oxytocin into paraventricularnucleus reverses depressive-like behaviors in the postpartum depression rat model. Behav Brain Res. 2018 Jan15;336:236-243.SCI7. Mei Z, Yang Y*, Li Y, Yang F, Li J, Xing N, Xu ZQD* (2017)Galanin suppresses proliferation of human U251 and T98G glioma cells via itssubtype 1 receptor. Biol Chem. 2017 Sep 26; 398(10):1127-1139.SCI8. Yang Y, Liu L, LuoH, Li Y, Li H, Xu ZQD* (2017) Characterization of theRat GAL2R Promoter: Positive Role of ETS-1 in Regulation of the Rat GAL2R Genein PC12 Cells. Mol Neurobiol. 2017 Aug;54(6):4421-4431.SCI9. Yang Y*, Li Y,Di F, Cui J, Wang Y, Xu ZQD* (2017) Pokemon decreases thetranscriptional activity of RARα in the absence of ligand. Biol Chem. 2017 Mar1; 398(3): 331–340.SCI10. Li Y, Mei Z, Liu S, Wang T, Li H, Li X-X, Han S, Yang Y, Li J, XuZQD* (2017) Galanin Protects from Caspase-8/12-initiated Neuronal Apoptosisin the Ischemic Mouse Brain via GalR1. AgingDis. 2017 Feb 1;8(1):85-100.SCI11. Wang P, Li H, Barde S, Zhang MD, Sun J, Wang T, Zhang P,Luo H, Wang Y, Yang Y, Wang C, Svenningsson P, Theodorsson E, Hökfelt TG*,Xu ZQD* (2016) Depression-like behavior in rat: Involvement of galaninreceptor subtype 1 in the ventral periaqueductal gray. Proc Natl Acad Sci U SA. 2016 Aug 9;113(32):E4726-35.SCI12. Yang YT*, Cui J, XueF, Overstreet A-M, Zhang Y, Shan D, Li H, Li H, Wang Y, Zhang M, Yu CJ, XuZQD* (2016) Resveratrol represses Pokemon expression in human glioma cells.Mol Neurobiol. 2016 Mar;53(2):1266-78.SCI13. YangYT, Cui JJ, Xue F, Zhang CF, Mei Z, Wang Y, Bi MJ, Shan DP, Meredith A, XuZQD* (2015) Pokemon (FBI-1) interactswith Smad4 to repress TGF-β-induced transcriptional responses. BiochimBiophys Acta (BBA - Gene Regulatory Mechanisms) 2015; 1849(3):270-281.SCI14. Liu LN, Zhu FP, Song MY,Zhang B, Kuo ST, Liu W, Li ML, Zhou L, Jiao RY, Liu B, Zhang XY, Wang CH, WangSR, Yang H, Zhou Z and Xu ZQD* (2014) Effect of cocaine on ion channelsand glutamatergic EPSCs in noradrenergic locus coeruleus neurons. J Mol Neurosci 53(3):345-51.SCI15. WangYJ, Yang YT, Li H,Wang CY, Xu ZQD* (2014) Plasma galanin is a biomarker for symptomseverity of major depressive disorder. IntJ Psychiat Med 48(2):109-119.SCI16. Li H, Wang YJ, Yang YT, Zhang M, Zhang D, Wang C, Xu ZQD* (2013)Lack of association between dendritic cell nuclear protein-1 gene and majordepressive disorder in the Han Chinese population. Prog Neuro-Psychoph 45:7–10.SCI17. Fu W, Le Maıtre E, Fabre V, Bernard JF, Xu ZQD*, Hökfelt T* (2010)Chemical neuroanatomy of the dorsal raphe nucleus and adjacent structures ofthe mouse brain. J Comp Neurol518:3464–94.SCI18. Xia S,Dun X-P,Hu P-S, Kjaer S, Zheng K, Qian Y, Solén C, Xu T,Fredholm B, Hökfelt T*, and Xu ZQD* (2008)Postendocytotic traffic of the galanin R1 receptor: a lysosomal signalmotif on the cytoplasmic terminus. Proc Natl Acad Sci U S A. 105:5609-13.SCI19. Zheng K, Kuteeva E, Xia S,Bartfai T, Hökfelt T, Xu ZQD*(2005): Age-related impairments of synaptic plasticity in thelateral perforant path input to the dentate gyrus of galanin overexpressingmice. Neuropeptides. 39:259-67.SCI20. Xia S, Kjaer S, Kang Z, HuP-S, Bai L, Jia J, Rigler R, Pramanik A, Xu T, Hökfelt T, Xu ZQD* (2004)Visualization of afunctionally enhanced GFP-tagged galanin R2 receptor in PC12 cells:Constitutive and ligand-induced internalization.Proc Natl Acad Sci US A 101:15207-12.SCI21. MaX, Tong Y-G,Schmidt R, Brown W, Payza K, Hodzic L, Pou C, Godbout C, Hökfelt T, Xu ZQD*(2001) Effects of galanin receptor agonists on locus coeruleus neurons. Brain Res 919:169-174.SCI22. Xu ZQD*, Tong Y-G, Hökfelt T (2001) Galanin enhancesnoradrenaline-induced outward current on locus coeruleus noradrenergic neurons.Neuroreport 12:1779-82.SCI23. Xu ZQD*, Ma X, Soomets U, Langel U, Hökfelt T (1999)Electrophysiological evidence for a hyperpolarizing, galanin (1-15)-selectivereceptor on hippocampal CA3 pyramidal neurons. Proc Natl Acad Sci U S A,96:14583-7.SCI24. Xu ZQD*,de Vente J, Steinbusch H, Grillner S, Hökfelt T (1998) The NO-cGMP pathway inthe rat locus coeruleus: electrophysiological, immunohistochemical and in situhybridization studies. Eur J Neurosci 10:3508-3516.SCI25. Xu ZQD, Zhang X, Pieribone VA, Grillner S, Hökfelt T* (1998)Galanin-5-hydroxytryptamine interactions: electrophysiological,immunohistochemical and in situ hybridization studies on rat dorsal rapheneurons with a note on galanin R1 and R2 receptors. Neuroscience87:79-94.SCI26. Xu ZQD, Shi TJ, Hökfelt T* (1998) Galanin/GMAP- and NPY-likeimmunoreactivities in locus coeruleus and noradrenergic nerve terminals in thehippocampal formation and cortex with notes on the galanin-R1 and -R2receptors. J Comp Neurol 392:227-251.SCI27. Xu ZQD*, Zhang X, Grillner S, Hokfelt T*.Electrophysiological studies on rat dorsal root ganglion neurons after peripheral axotomy: changes in responses to neuropeptides. Proc Natl Acad Sci U S A. 1997,94:13262-13266.SCI28. Xu ZQD* and Hökfelt T (1997) Expression of galanin and nitricoxide synthase in subpopulations of serotonin neurons of the rat dorsal raphenucleus. J Chem Neuroanat 13:169-87.SCI29. Xu ZQD, Shi TJ, Hokfelt T*.Expression of galanin and a galanin receptor in several sensory systems and bone anlage of rat embryos.. Proc Natl Acad Sci U S A. 1996,93:14901-14905.SCI30. Xu Z-Q(徐志卿), Shi TJ, Landry M, Hokfelt T.Evidence for galanin receptors in primary sensory neurones and effect of axotomy and inflammation. Neuroreport . 1996,8:237-242 .SCI

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