张智

张智，男，博士，中国科学技术大学生命科学学院教授、博士生导师。

2001年毕业于安徽大学并获生物化学学士学位，2008年获中国科学技术大学神经生物学博士学位，2008-2012年在美国德克萨斯大学MD Anderson cancer center从事博士后工作。2012年10月起任中国科学技术大学生命科学学院教授。

1.慢性疼痛相关的情绪疾病。

2.慢性疼痛产生的表观遗传学机制。

3.药物成瘾。

4.抑郁症

相关研究成果发表在Nature Medicine, Journal of Neuroscience, Cerebral Cortex和FASEB J等学术期刊上，其中两篇论文分别被Nature Reviews Neuroscience和Nature Reviews Drug Discovery杂志Highlight。

1) A basolateral amygdala input to the medial prefrontal cortex controls obsessive-compulsive disorder-like checking behavior - PNAS - 2019 -

2) Persistent inflammation-induced upregulation of BDNF promotes synaptic delivery of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor GluA1 subunits in descending pain modulatory circuits - J. Biol. Chem. - 2014 -

3) MeCP2 repression of G9a in regulation of pain and morphine reward - The Journal of Neuroscience - 2014 -

4) Persistent Pain Facilitates Response to Morphine Reward by Downregulation of Central Amygdala GABAergic Function - Neuropsychopharmacology - 2014 -

5) Epigenetic suppression of GAD65 expression mediates persistent pain - Nature Medicine - 2011 -

6) Brain-derived neurotrophic factor-mediated downregulation of brainstem K+-Cl- cotransporter and cell-type-specific GABA impairment for activation of descending pain facilitation - Molecular Pharmacology - 2013 -

7) Signaling cascades for δ-opioid receptor-mediated inhibition of GABA synaptic transmission and behavioral antinociception - Molecular Pharmacology - 2012 -

8) Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval - Cerebral Cortex - 2008 -

9) Synaptic mechanism for functional synergism between delta- and mu-opioid receptors - Journal of Neuroscience - 2010 -

10) Nerve growth factor-regulated emergence of functional delta-opioid receptors - Journal of Neuroscience - 2010 -

11) Central Amygdala GluA1 Facilitates Associative Learning of Opioid Reward - Journal of Neuroscience - 2013 -

2020年8月11日，入选国家自然科学基金委员会公布的2020年度国家杰出青年科学基金建议资助项目申请人名单。^[1]