张彬

张彬，男，汉族，教授、主任医师、硕士生导师，硕士学历。现任山东省聊城市人民医院院长、泰山医学院口腔医学系主任、泰山医学院口腔颌面外科教研室主任、泰山医学院五官科教研室主任。^[1]

近年来共承担国家、省部级及市级科研课题20余项，其中承担山东省十大示范工程项目、山东省自然基金项目、山东省科技公关项目、山东省“十一五”卫生项目等多项省部级课题，获科技进步奖10余项。

近年来共出版著作6部，在国家核心期刊及中华系列杂志发表论著30多篇。

1. CDKL1在内质网应激介导的口腔磷状细胞癌HCPT耐药的分子机制 国家自然科学基金 2012.06-2015.06 第一位

2. OCDRA1负向调控PERK在口腔鳞状细胞癌HCPT耐药中的分子机制 国家自然科学基金 2014.06-2017.06第一位

3. 纺锤体和动粒关联蛋白-1基因在口腔鳞癌中的表达及其致癌机制研究 聊城市科技发展计划项目 2014.01-2016.12

4. 鲁西地区健康人群颜面部标志测量研究 山东省科技发展计划项目 2009.01-2011.12

5．血管化肋骨组织瓣游离移植修复下颌骨缺损 山东省科技发展计划项目 2006.01-2018.12

6．Super Lizer照射促进下颌骨骨折愈合的研究 山东省医药卫生科技发展计划项目2007.11-2009.12^[2]

承担泰山医学院2015年度教学质量与教学改革工程立项项目“口腔医学本科教学团队建设”^[2]

颌面部畸形整复、颌面部肿瘤的诊治。

荣获全国百姓放心示范医院优秀管理者、全国优秀医院院长、全国农村科普工作先进个人、2007年度中国五十佳医院管理与创新优秀院长、山东省人大代表、抗击“非典”记省二等功、“山东省富民兴鲁奖章”获得者、“聊城市富民兴聊奖章”获得者。^[3]

获奖时间奖项名称作品获奖结果2015年山东省科技进步奖带肋间神经的肋骨肌皮瓣移植修复下颌骨缺损的基础研究与临床应用一等奖2011年山东省软科学优秀奖三级医院医疗质量管理及其评价体系的研究成果奖2009年山东省科技进步奖先天性双侧唇裂切口改良设计及口轮匝肌解剖学修复研究二等奖2009年山东省医学科技奖口腔颌面-头颈部手术麻醉三等奖2008年山东省医学科技奖口腔科与耳鼻咽喉科急危重症三等奖2008年山东省医学科技奖医疗质量与安全管理三等奖

^[2]

中国头颈肿瘤专业委员会委员、山东省医学会口腔专业委员会委员。

中国医院协会医疗质量专业委员会委员、山东省医院协会常务理事。

聊城市医学会副会长、聊城市医学会口腔专业委员会主任委员。

山东省医师协会理事、山东省医师协会医疗质量管理委员会主任委员、中国青年科技工作者协会会员

1. Zhang B, Li KY, Jiang LC, Meng Z, Wang XM, Cui FZ, Zhu YN, Wu YP. Rib Composite Flap With Intercostal Nerve and Internal Thoracic Vessels for Mandibular Reconstruction. The Journal of craniofacial surgery 2016;27:1815-1818.

2. Zhang B, Li K-Y, Zhang W-F, Jiang L-C, Liu X-B, Xia C-P, Yuan D-Y, Liu S-W. Downregulation of KLF8 expression by shRNA induces inhibition of cell proliferation in CAL27 human oral cancer cells. Medicina Oral Patologia Oral Y Cirugia Bucal 2013;18:E591-E596.

3. Zhang B, Li KY, Chen HY, Pan SD, Jiang LC, Wu YP, Liu SW. Spindle and kinetochore associated complex subunit 1 regulates the proliferation of oral adenosquamous carcinoma CAL-27 cells in vitro. Cancer cell international 2013;13:83. 

4. Zhang B, Li KY, Chen HY, Pan SD, Chen SF, Zhang WF, Xia CP, Jiang LC, Bin Liu X, Zhao FJ, Yuan DY, Wang LX, Wu YP, Liu SW. Lentivirus-based RNA Silencing of Nemo-like Kinase (NLK) Inhibits the CAL 27 Human Adenosquamos Carcinoma Cells Proliferation and Blocks G0/G1 Phase to S Phase. International journal of medical sciences 2013;10:1301-1306.

5. Zhang B, Pan SD, Yuan Y, Li KY, Shen LL, Chen SF, Chen BX, Li DR, Zhang YH, Wang Z, Wang M, Li GY, Wu YP. Using fibrin composite interfaces in vitro experimental model to study of the ultra-structures of the fibrin composite generated by the plasma knife for surgery and electrocautery. Composite Interfaces 2012;19:189-195.

6. Liu JL, Zhang AQ, Jiang LC, Li KY, Liu FZ, Yuan DY, Xu K, Fan QC, Liu XB, Zou B, Meng Z, Feng Y, Zhang B. The efficacy of polidocanol sclerotherapy in mucocele of the minor salivary gland. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2018;47:895-899.

7. Zhao LJ, Yang HL, Li KY, Gao YH, Dong K, Liu ZH, Wang LX, Zhang B. Knockdown of SKA1 gene inhibits cell proliferation and metastasis in human adenoid cystic carcinoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017;90:8-14.

8. Yuan DY, Meng Z, Xu K, Li QF, Chen C, Li KY, Zhang B. Betulinic acid increases radiosensitization of oral squamous cell carcinoma through inducing Sp1 sumoylation and PTEN expression. Oncology reports 2017;38:2360-2368.

9. Yang H, Pan L, Xu C, Zhang Y, Li K, Chen S, Zhang B, Liu Z, Wang LX, Chen H. Overexpression of tumor suppressor gene ZNF750 inhibits oral squamous cell carcinoma metastasis. Oncology letters 2017;14:5591-5596.

10. Zhao L, Jiang L, Du P, Zhang D, Liu Z, Li K, Zhang B. Expression of SKA1 and MMP-9 in primary salivary adenoid cystic carcinoma: Correlation with tumor progression and patient prognosis. Acta oto-laryngologica 2016:1-5.

11. Zhang N, Chen B, Wang W, Chen C, Kang J, Deng SQ, Zhang B, Liu S, Han F. Isolation, characterization and multi-lineage differentiation of stem cells from human exfoliated deciduous teeth. Molecular medicine reports 2016;14:95-102.

12. Liu F, Chen K, Hou L, Li K, Wang D, Zhang B, Wang X. Determining the critical size of a rabbit rib segmental bone defect model. Regen Biomater 2016;3:323-328.

13. Li KY, Zhang J, Jiang LC, Zhang B, Xia CP, Xu K, Chen HY, Yang QZ, Liu SW, Zhu H. Knockdown of USP39 by lentivirus-mediated RNA interference suppresses the growth of oral squamous cell carcinoma. Cancer biomarkers : section A of Disease markers 2016;16:137-144.

14. Chen H, Yang H, Pan L, Wang W, Liu X, Ren X, Liu Y, Liu W, Zhang Y, Jiang L, Li K, Zhang B, Wang LX. The molecular mechanisms of XBP-1 gene silencing on IRE1alpha-TRAF2-ASK1-JNK pathways in oral squamous cell carcinoma under endoplasmic reticulum stress. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016;77:108-113.

15. Jiang L-C, Xin Z-Y, Deborah B, Zhang J-S, Yuan D-Y, Xu K, Liu X-B, Jiang H-Q, Fan Q-C, Zhang B, Li K-Y. Inhibition of autophagy augments apoptosis in human oral squamous cell carcinoma under nutrient depletion. Journal of Oral Pathology & Medicine 2015;44:361-366.

16. Jiang L, Huang S, Zhang D, Zhang B, Li K, Li W, Zhang S, Zhang W, Zheng P. Inhibition of autophagy augments chemotherapy in human salivary adenoid cystic carcinoma. Journal of Oral Pathology & Medicine 2014;43:265-272.  

17. Chen S-f, Chen H-y, Liu X-b, Zhang Y-x, Liu W, Wang W-h, Zhang B, Wang L-X. Apoptotic effect of MG-132 on human tongue squamous cell carcinoma. Biomedicine & Pharmacotherapy 2011;65:322-327.

18. Yu Z, Wang T, Xu J, Wang W, Wang G, Chen C, Zheng L, Pan L, Gong D, Li X, Qu H, Li F, Zhang B, Le W, Han F. Mutations in the glucocerebrosidase gene are responsible for Chinese patients with Parkinson's disease. Journal of Human Genetics 2015;60:85-90.

19. Yu X-L, Xu S-J, Shao J-D, Du C, Chen S-F, Zhang B, Wang Y-X, Wang X-M. Different fate of cancer cells on several chemical functional groups. Surface & Coatings Technology 2013;228:S48-S54.

20. Liu B, Xu F, Guo M-Y, Chen S-F, Wang J, Zhang B. Electrospun PLLA fibers coated with chitosan/heparin for scaffold of vascular tissue engineering. Surface & Coatings Technology 2013;228:S568-S573.

21. Li GY, Liu JZ, Zhang B, Yang M, Chen SG, Hou M, Wang LX. Tegillarca granosa extract Haishengsu (HSS) suppresses expression of mdr1, BCR/ABL and sorcin in drug-resistant K562/ADM tumors in mice. Advances in medical sciences 2013;58:112-117.

22. Chen SF, Xia ZL, Han JJ, Wang YT, Wang JY, Pan SD, Wu YP, Zhang B, Li GY, Du JW, Gao HQ, de Groot PG, de Laat B, Hollestelle MJ. Increased active von Willebrand factor during disease development in the aging diabetic patient population. Age 2013;35:171-177.

23. Chen H-y, Ren X-y, Wang W-h, Zhang Y-x, Chen S-f, Zhang B, Wang L-x. Upregulated ROS production induced by the proteasome inhibitor MG-132 on XBP1 gene expression and cell apoptosis in Tca-8113 cells. Biomedicine & Pharmacotherapy 2014;68:709-713.   

24. Wu YP, Stella PR, Chen SF, Wang YT, Wang JY, Moerland MA, Pan SD, Zhang B, Li GY, Doevendans PA, de Groot PG. Beta-radiation reduces the reactivity of extra cellular matrix proteins in intravascular brachytherapy (IVBT), resulting in decreased platelet adhesion. International journal of cardiology 2012;156:283-288.

25. Yu X-L, Zhang B, Wang X-M, Wang Y, Qiao L, He J, Wang J, Chen S-F, Lee I-S, Cui F-Z. Cancer cell proliferation controlled by surface chemistry in its microenvironment. Frontiers of Materials Science 2011;5:412-416.

26. Han J, Xu X, Zhang B, Chen B, Hang W. Expression of ATF4 and RUNX2 in periodontal tissue of pressure side during orthodontic tooth movement in rat. International journal of clinical and experimental medicine 2015;8:934-938.

27. Liang C, Zhang B, Wu L, Du Y, Wang X, Liu C, Yu F. The superiority of 3D-CISS sequence in displaying the cisternal segment of facial, vestibulocochlear nerves and their abnormal changes. European journal of radiology 2010;74:437-440.

28. Li G-Y, Liu J-Z, Chen S-G, Zhang B, Wang C-B, Wang L-X. Tegillarca granosa extract Haishengsu inhibits the expression of p-glycoprotein and induces apoptosis in drug-resistant K562/ADM cells. Pharmaceutical biology 2010;48:529-533.

29. Liu J-Z, Yang M, Li D-P, Zhang B, Chen S-G, Wang C-B, Li G-Y, Wang L-X. Effect of Haishengsu on transplanted K562 and drug-resistant K562/ADM tumors: An experimental study. Clinical and Investigative Medicine 2009;32:E117-E123.

30. Liu J-Z, Chen S-G, Zhang B, Wang C-B, Zhao X-W, Li G-Y, Wang L-X. Effect of Haishengsu as an Adjunct Therapy for Patients with Advanced Renal Cell Cancer: A Randomized and Placebo-Controlled Clinical Trial. Journal of Alternative and Complementary Medicine 2009;15:1127-1130.

31. Liu JZ, Chen SG, Bin Z, Wang CB, Li GY, Wang LX. Antitumor effect of the seashell protein Haishengsu on Ehrlich ascites tumor: an experimental study. J Nat Med 2009;63:459-462.

32. Li G-Y, Yu X-M, Zhang H-W, Zhang B, Wang C-B, Xin Y-C, Yang C-Z, Zhou R-X, Wang L-X. Haishengsu as an adjunct therapy to conventional chemotherapy in patients with non-small cell lung cancer: A pilot randomized and placebo-controlled clinical trial. Complementary therapies in medicine 2009;17:51-55.

33. Li G-Y, Liu J-Z, Zhang B, Wang L-X, Wang C-B, Chen S-G. Cyclosporine diminishes multidrug resistance in K562/ADM cells and improves complete remission in patients with acute myeloid leukemia. Biomedicine & Pharmacotherapy 2009;63:566-570.

34. Li GY, Liu JZ, Chen SG, Wang CB, Bin Z, Wang LX. Effect of a seashell protein Haishengsu on the immunological function of mice with Ehrlich ascites tumor. Immunopharmacol Immunotoxicol 2009;31:669-674.

35. Li G-Y, Liu J-Z, Yu X-M, Chen S-F, Zhang B, Zhang W-F, Xiao T-W, Wang C-B, Wang L-X. Effect of a seashell protein Haishengsu on cell growth and expression of apoptosis genes in leukemia K562 cells. Clinical and Investigative Medicine 2008;31:E218-E221.^[2]