张传溪

张传溪，男，1960年1月出生，浙江大学教授、博士生导师。1982年毕业于浙江农业大学植保系，1985年获得昆虫学专业硕士学位并留校任教。1994-1997年在中国科学院生物化学研究所从事博士学位论文工作，获得理学博士学位。1998年晋升为浙江大学教授。2001-2003年担任日本学术振兴会和爱媛大学CMES特别研究员。张传溪教授的研究领域主要集中在昆虫分子生物学和动物病毒分子生物学与基因工程，其博士学位论文被评为全国优秀博士学位论文。

本分子生物学实验室研究的目标是阐明昆虫和病毒重要基因的特性和功能及其利用。正在进行的主要研究项目和方向包括：

1．家蚕重要经济性状功能基因研究。国家“863”计划。

2．昆虫乙酰xiān胆碱酯zhǐ酶基因及表达产物在药效活性评价中应用。 国家重点基础研究发展计划（973计划）子项目。

3．BmNPV ODV囊膜蛋白在家蚕中肠细胞上受体基因的研究。国家自然科学基金。

4．家蚕2种类型乙酰胆碱酯酶基因的特性与生物学功能比较。国家自然科学基金。

5．以杆状病毒为载体，以昆虫细胞和家蚕为生物反应器，表达生产人与经济动物药用多肽和科学研究用蛋白；氢菌基因工程（中意国际合作项目、国内合作项目、浙江省科技厅项目；“863”探索）。

先后在《Virology》《BMC Genomics》等国内外学术刊物上发表论文100余篇（其中SCI收录34篇），书著有《昆虫杆状病毒ph、pk基因分析和人EPO基因在杆状病毒-昆虫系统中的表达》（高等教育出版社）等2本，参编4本。已申请国家发明专利9项，已授权4项。

入选浙江省“151人才工程”。曾被授予浙江省优秀教师称号。美国国家自然科学基金会（NSF）评审专家、《微生物学报》和《中国病毒学》编委。

(*corresponding author)

Ya-Ming Shao, Ke dong, Chuan-Xi Zhang★, 2007. The nicotinic acetylcholine receptor gene family of the silkworm, Bombyx mori. BMC Genomics, 8:324.

Xiu-Cui Ma, Jin-Yan Shang, Zhang-Nv Yang,Yan-Yuan Bao, Qiang Xiao and Chuan-Xi Zhang★. 2007. Genome sequence and organization of a nucleopolyhedrovirus that infects the tea looper caterpillar, Ectropis oblique. Virology , 360: 235–246.

Jun-Qing Ge, Zhang-Nv Yang, Xu-Dong Tang, Hai-Jun Xu, Jian Hong, Jian-Guo Chen and Chuan-Xi Zhang★, 2007. Characterization of a nucleopolyhedrovirus with a deletion of the baculovirus core gene Bm67. Journal of GeneralVirology .(accepted)

Dun Wang and Chuan-Xi Zhang★. 2007. Helicoverpa armigera nucleopolyhedrovirus orf80 encodes a late, nonstructural protein. JBMB, 40 (1) 65-71 .(SCI)

Dun Wang, Shao-wei Zhai, Chuan-xi Zhang,Qiang Zhang, Hui Chen. 2007 Nutrition value of the Chinese grasshopper Acrida cinerea (Thunberg) for broilers. Animal feed science and technology, 135 (1-2): 66-74. (SCI)

Hai-Jun Xu , Jian-Guo Lin, Chuan-Xi Zhang★ , Suzuki Satoru . 2007. Expression and immunogenic comparison of VP2 and VP3 from Marine Birnavirus (MABV) . Journal of Fish Diseases . (accepted)

Jin-Yan Shang ,Ya-Ming Shao , Chuan-Xi Zhang★, GanYuan and Zhen-Hua Tang. 2007. Expression of two types of acetylcholinesterase gene from the silkworm, Bombyx mori, in insect cells. Insect Science, DOI 10.1111/j.1744-7917.2007.00177.x.

Wan-Fu Yue, Min-Li Yao, Jian-Mei Liu, Guang-Li Li, Xing-Hua Li, Xiao-Feng Wu, Wen Deng, Hong-Xiang Sun, Ji-Yong Zhou, Chuan-Xi Zhang, Yun-Gen Miao. Manganese superoxide dismutase expressed in silkworm larvae, Bombyx mori L enhances the NK activity and splenocyte proliferation against Sarcoma 180 tumor cells in vivo. Mol Biol Rep, DOI 10.1007/s11033-007.

Xiu-Cui Ma, Hai-Jun Xu, Mei-Jun Tang, Qiang Xiao, Jian Hong, and Chuan-Xi Zhang★. 2006. Morphological, phylogenetic and biological characteristics of Ectropis obliqua single-nucleocapsid nucleopolyhedrovirus. Journal of Microbiology, 44(1): 77-82.(SCI)

Hai-Jun Xu, Yan-He Liu, Zhang-Nv Yang, Chuan-Xi Zhang★. 2006.Characterization of ORF39 from Helicoverpa armigera single-nucleocapsid Nucleopolyhedrovirus, the gene containing RNA recognition motif. Journal of Biochemistry and Molecular Biology, 39(3): 39(3):263-269 .(SCI)

Dun Wang and Chuan-Xi Zhang★. 2006. HearSNPV orf83 encodes a late, nonstructural protein with an active chitin binding domain. Virus Research. 117 (2006) 237–243. (SCI)

．Hai-jun Xu, Zhang-Nv Yang, Fang Wang, Chuan-Xi Zhang★.2006. Bombyx mori nucleopolyhedrovirus ORF79 encodes a structural protein of ODV envelope with a molecular weight of 28kDa. Archives of Virology,151(4):681-695 . (SCI)

Shi-Heng An, Li-Ping Xing, Wan-Jun Shi and Chuan-Xi Zhang★. 2006. Characterization of a lepidopteran nucleopolyhedrovirus (NPV) core gene, ORF17 from Autographa californica MNPV (AcMNPV). Acta Virologica, 50 (1):17-23. (SCI).

Shi-Heng An, Jin-Yan Shang, Yan-He Liu,V Shyam Kumar, Zhong-Jian Guo, Dun Wang, Zhang-Nv Yang and Chuan-Xi Zhang★.2006. Characterization of a unique gene ORF135 from Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus. Virus Genes, 2006, 32:21-26. (SCI)

Wang F., Yang LR, Tang XD, Mo JC, W-J Yang, Chuan-Xi Zhang★.2006. Characterization of the translational and transcriptional start site of BmNPV lef-7 gene. Virus Genes, 33:351–357 (SCI).

Li-Rong YANG, Dun WANG, Li-Qing DUAN, Chuan-Xi ZHANG★.2006. Polyhedrin gene sequence and phylogenetic analysis of a nucleopolyhedrovirus isolated from Orgyia ericae Germar. DNA Sequence, 17 (3): 215-222 .(SCI)

Wan-jun SHI, Jia-An CHENG, Chuan-Xi ZHANG★ 2006.Expression of the melittin gene of Apis cerana cerana in insect cells. European Journal of Entomology,103: 867–870. (SCI)

Zhong-Jian Guo, Jun-Qing Ge, Dun Wang, Ya-Ming Shao, Qi-Yi Tang, Chuan-Xi Zhang★. 2006. Biological comparison of two strains of Helicoverpa armigera single-nucleocapsid nucleopolyhedrovirus. Biocontrol, 51:809–820. (SCI)

Li-ming Tao, Ming-an Shi, Yuang Jiangzhong，Peijun Zhuang, Chuan-Xi Zhang and Zhen-HuaTang. 2006.Resistance pattern and point mutations of insensitive acetylcholinesterase in a propoxur-resistant strain of housefly (Musca domestica). Pesticide Biochemistry and Physhiology 86: 1–6. (SCI)

Shi-Heng An, Dun Wang,Yang Zhang-Nv, Zhong-Jian Guo, Hai-Jun Xu, Jianxin Sun and Chuan-Xi Zhang★.2005.Characterization of a late expression gene, Open reading frame 128 of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus. Archives of Virology. 150(12): 2453–2466. (SCI)

Jiang-Hong Li, Chuan-Xi Zhang★ and Zhen-hua Tang. (2005) Expression of melittin gene in the venom gland of the Chinese honeybee, Apis cerana cerana. Apidologie 36(4): 533–541. (SCI)

Jiang-Hong Li, Chuan-Xi Zhang★, Zhen-Hua Tang and Jia-an Cheng 2005 Expression and regulation of phospholipase A2 in the Chinese honeybee, Apis cerana cerana. Archives of Insect Biochemistry and Physiology, 60:1-12. (SCI)

Wang Dun, An Shi-Heng, Guo Zhong-Jian, Xu Hai-Jun and Zhang Chuan-Xi★. 2005.Characterization of Helicoverpa armigera nucleopolyhedrovirus orf33 that encodes a novel budded virion derived protein, BV-e31. Archives of Virology. 150（8）:1505- 1515. (SCI)

Zhong-Jian Guo, Shi-Heng An, Dun Wang, Yan-He Liu, Shyam Kumar and Chuan-Xi Zhang★ 2005. Characterization of Ha29, a specific gene for Helicoverpa armigera single-nucleocapsid nucleopolyhedrovirus. Journal of Biochemistry and Molecular Biology 38(3): 354-359. (SCI)

Jian-Guo Lin，Chuan-Xi Zhang★ and Satoru Suzuki.2005 An Anti-apoptosis Gene of the Bcl-2 Family from Marine Birnavirus Inhibiting Apoptosis of Insect Cells Infected with Baculovirus. Virus Genes, 31(2):185-193. (SCI)

Wang Fang, Zhang Chuan-Xi★, V Shyam Kumar and Wu Xiang-Fu 2005 Chitinase gene deletion from BmNPV influences cell lysis and host liquefaction. Archives of Virology，150（5）：981-990.(SCI)

Shi W.-J., Zhang C.-X., Cheng J.-A. 2005 Expression and activity identification of the melittin gene of Polistes hebraeus in insect expression system[abstract number: L3-032P]. FEBS Journal 272(s1): 516-516. (SCI)

Dun Wang, Shao Wei Zhai, Chuan Xi Zhang, Yao Yu Bai, Shi Heng An, Ying Nan Xu (2005) Evaluation on nutritional value of field cricket as poultry feedstuff. Asian-Australasian Journal of Animal Sciences. 18(5):667-670. (SCI)

Chuan-Xi Zhang★, Xiu-Cui Ma and Zhong-jian Guo.(2005) Comparison of the complete genome sequences between C1 and G4 isolates of the Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus. Virology: 333: 190-199. (SCI)

张传溪 2001 昆虫杆状病毒ph、pk基因分析和人EPO基因在杆状病毒-昆虫系统中的表达。高等教育出版社。287页。ISBN 7-04-010282-X。Zhang Chuan-Xi. 2001. Analysis of Baculovirus polyhedrin gene and protein kinase gene, and expression of human erythropoietin gene in baculovirus-insect system. Higher Education Press. Pp.287.

2. 张传溪、许文华（1990）资源昆虫 上海科学技术出版社。168页。Zhang Chuanxi and Xu WH. 1990. Insect Resources. Shanghai Science and Technology Press. pp168.

3. 张传溪 2011 昆虫与植物病毒传播. 10000个科学难题（农业科学卷）科学出版社，145-148。 Insect and plant virus transmition. 10000 Selected Problems in Sciences (Agriculture Science), Science Press, 145-148.

4. 张传溪、田泽君 1998 五倍子蚜。中国昆虫资源利用和产业化（杨冠煌主编），中国农业出版社，156-171。Zhang Chuanxi and Tian ZJ. 1998 Chinese gall aphids. In Chinese Insect Resources and Their Industrilization (Yang GH ed). Agricultural Press of China, 156-171.

4. 张传溪（1996）第三章 其它工业原料资源昆虫。资源昆虫及其利用（胡萃主编），中国农业出版社，104-159页。Zhang C.X.1996 Other industrial insects. In Insect Resource and Their Utilization (Hu ed). Agricultural Press of China, 104-159.

5. 杨冠煌、张传溪，2001，第五章.昆虫又是我们的朋友。在《21世纪学科发展丛书-昆虫学》。山东科技出版社。ISBN 7- 80603-534-6，第五章(是杨冠煌合写)185-240页，约38168字。Yang Guan-Huang, Zhang Chuan-Xi. 2001. Chapter 5 Many insects are our friends. In science book series for the 21th Century—Entomology. Shandong Science and Technology Press. Page 185-240.

6. 张传溪 2002。杆状病毒的分子生物学和基因工程。昆虫分子科学（程家安唐振华主编）。科学出版社。ISBN 7-03-009758-0。249-292页。Zhang Chuanxi. 2002..Baculovirus molecular biology and engineering. In Insect Molecular Science (Chen & Tang eds). Shanghai Literature Press of Science and Technology. 249-292.

7. 张传溪 鲁兴萌 2002。转基因昆虫。昆虫分子科学（程家安唐振华主编）。科学出版社ISBN 7-03-009758-0。347-362页。Zhang Chuanxi and Lu XM. 2002.Transgenetic insects. In Insect Molecular Science (Chen & Tang eds). Shanghai Literature Press of Science and Technology.

8. Zhang Chuanxi Xu Junliang (1994) Artificial diets for the silkworm. in Silkworm Physiology, Editorial Department, Bulletin of Sericulture, 211-232.9.

1.张传溪 郎国竣， 野蚕1型乙酰胆碱酯酶活性蛋白的制备方法及其用途 申请日：2009.1.8. 授权公告日2011-4-6。

2.张传溪、徐海君、 杨章女、林建国 海洋双RNA病毒MABV重组蛋白的制备方法与应用 申请日：2007.1.25授权公告日:⒛ 10年07月28日. 专利号：证书号第651848号。

3.张传溪、杨章女、孙建新 G-eGFP蛋白及其制备方法与应用。专利号：申请日： 2006.12.19. 授权公告日：2009-5-20。证书号：第499281号。

4.张素方，张传溪，施婉君，程家安，沈立荣. 已授权发明专利名称:大胡蜂镇静肽前体基因及其编码的多肽和制备方法. 授权发明专利。授权日：2005-3-23国际专利主分类号C12N 15/11. 证书号：第200613号。

5.施婉君，张传溪，张素方，程家安，沈立荣.已授权发明专利名称: 中华蜜蜂大胡蜂溶血肽前。

体基因及其编码的多肽和制备方法. 授权发明专利授权日：2005-12-28国际专利主分类号C12N 15/11. 证书号：第241698号。

6.施婉君，张传溪，张素方，程家安，沈立荣.亚非马蜂蜂毒溶血肽前体基因及其编码的多肽和制备方法. 授权发明专利授权日：06-1-18证书号：第245642号。

7.张素方，张传溪，施婉君，程家安，沈立荣.亚非马蜂镇静肽前体基因及其编码的多肽和制备方法. 授权发明专利授权日：06-1-18 证书号：第245641号。