崔胜

崔胜，1961年8月生，男，汉族，甘肃省会宁县人，博士（1989，甘肃农业大学），教授，博士生导师。1990年被国务院学位委员会授予“有突出贡献的博士学位获得者”，2003年获国家杰出青年基金。现任中国农业大学生物学院教授，博士生导师，兼任动物学与动物生理学系主任。主要学术兼职包括中国生殖生物学会理事兼副秘书长，动物生理生化学会副理事长，英国生殖生物学会会员，中国畜牧兽医学会动物生理生化分会副理事长。^[1]

1978-1989年，甘肃农业大学，先后获学士、动物解剖学硕士、组织学与胚胎学专业博士学位。

1989-1992年，甘肃农业大学兽医学系，讲师、副教授，从事动物生理学以及生殖与发育生物学教学科研。1993-1995年，英国爱丁堡MRC (Medical Research Council)生殖生物学中心，博士后研究，研究动物胚胎期垂体促性腺激素分泌调控机制的研究、GnRH受体的DNA序列分析及核酸探针的合成等。1996年至今，中国农业大学生物学院，副教授、教授，先后受国家自然科学基金项目、国家863青年基金资助，主要研究动物胚胎期下丘脑－垂体－性腺轴调节机制的建立和相关机理。1999-2000年，以色列Bar-Ilan大学发育神经生物学实验室，高级访问学者，研究LIM同源盒基因对神经元增殖和分化过程的调控作用。2005年6月-12月，英国爱丁堡MRC人类生殖与发育研究中心，高级研究学者，研究垂体促性腺激素分泌调控机制。^[2]

崔胜教授的研究方向包括：1. 生殖与发育的细胞和分子机理，2. 胚胎早期发育与妊娠维持的调控，3. 发育神经生物学。具体研究内容涉及动物胚胎期下丘脑-垂体-性腺轴的发生与建立；类固醇激素和同源异型基因族蛋白对神经元增殖、分化的调节；动物生殖与发育的神经内分泌调节机制。^[1]

《动物生理学》（本科）

《发育生物学专题》（研究生）^[1]

中国生殖生物学会理事兼副秘书长，动物生理生化学会副理事长，英国生殖生物学会会员，中国畜牧兽医学会动物生理生化分会副理事长^[1]

崔胜教授在国际学术杂志《Endocrinology》《Journal of Pineal Research》《Journal of Neuroendocrinology》《Cell and Tissue Research》《Histochemistry and Cell Biology》《Brain Research》《Developmental Brain Research》等，发表研究论文50余篇。代表性论文包括：

He J, Zhang J, Wang Y, Liu W, Gou K, Liu Z*, Cui S*. MiR-7 Mediates the Zearalenone Signaling Pathway Regulating FSH Synthesis and Secretion by Targeting FOS in Female Pigs. Endocrinology. 2018, 159(8):2993-3006. doi: 10.1210en.2018-00097.

Wei C, Lin H, Cui S*. The Forkhead Transcription Factor FOXC2 Is Required for Maintaining Murine Spermatogonial Stem Cells. Stem Cells Dev. 2018, 27(9):624-636. doi: 10.1089scd.2017.0233.

Zhang J, Qiu J, Zhou Y, Wang Y, Li H, Zhang T, Jiang Y, Gou K*, Cui S*, LIM homeobox transcription factor Isl1 is required for melatonin synthesis in the pig pineal gland. J Pineal Res, 2018, 65(1):e12481. doi: 10.1111

Li X, Wang S, Zhang L, Zhang L, Liu J, Luo H, Gou K, Cui S*. Amitriptyline plays important roles in modifying the ovarian morphology and improving its functions in rats with estradiol valerate-induced polycystic ovary. Arch Pharm Res. 2017 Sep 8. doi: 10.1007/s12272-015-0573-z. [Epub ahead of print]

He J, Wei C, Li Y, Liu Y, Wang Y, Pan J, Liu J, Wu Y*, Cui S*. Zearalenone and alpha-zearalenol inhibit the synthesis and secretion of pig follicle stimulating hormone via the non-classical estrogen membrane receptor GPR30. Mol Cell Endocrinol. 2017 Aug 19. pii: S0303-7207(17)30432-X. doi: 10.1016j.mce.2017.08.010. [Epub ahead of print]

Zhang L, Zhang X, Zhang X, Lu Y, Li L, Cui S*. MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production. J Endocrinol. 2017 Jul;234(1):1-14. doi: 10.1530JOE-16-0488.

Zhang L, Gao J, Cui S*. miR-21 is involved in norepinephrine-mediated rat granulosa cell apoptosis by targeting SMAD7. J Mol Endocrinol. 2017 May;58(4):199-210. doi: 10.1530/JME-16-0248.

Gai Y, Zhang J, Wei C, Cao W, Cui Y, Cui S*. miR-375 negatively regulates the synthesis and secretion of catecholamines by targeting Sp1 in rat adrenal medulla. Am J Physiol Cell Physiol. 2017 May 1;312(5):C663-C672. doi:10.1152ajpcell.00345.2016. Epub 2017 Mar 29.

Yu C, Li M, Wang Y, Liu Y, Yan C, Pan J, Liu J, Cui S*. MiR-375 Mediates CRH Signaling Pathway in Inhibiting E2 Synthesis in Porcine Ovary. Reproduction. 2016 Oct 18. pii: REP-16-0323

Wang S, Liu J, Li X, Ji X, Zhang J, Wang Y, Cui S*. MiR-125b Regulates Primordial Follicle Assembly by Targeting Activin Receptor Type 2a in Neonatal Mouse Ovary. Biol Reprod. 2016 Apr;94(4):83. doi: 10.1095/biolreprod.115.131128. Epub 2016 Mar 9.

Yan C, Yu C, Zhang D, Cui Y, Zhou J, Cui S*. Protein Inhibitor of Activated STAT Y (PIASy) Regulates Insulin Secretion by Interacting with LIM Homeodomain Transcription Factor Isl1. Sci Rep. 2016 Dec 21;6:39308. doi: 10.1038srep39308.

Liu Y, Li Y, Zhang D, Liu J, Gou K, Cui S*. Mitogen-Activated Protein Kinase 8 (MAP3K8) Mediates the Signaling Pathway of Estradiol Stimulating Progesterone Production Through G Protein-Coupled Receptor 30 (GPR30) in Mouse Corpus Luteum. Mol Endocrinol. 2015, 29(5):703-15.

Ma Q, Zhao J, Cao W, Liu J, Cui S*. Estradiol decreases taurine level by reducing cysteine sulfinic acid decarboxylase via the estrogen receptor-α in female mice liver. Am J Physiol Gastrointest Liver Physiol. 2015, 308(4):G277-86.

Chen J, Fu R, Cui Y, Pan J, Li Y, Zhang X, Evans SM, Cui S, Liu J. LIM-homeodomain transcription factor Isl-1 mediates kisspeptin's effect on insulin secretion in mice. Mol Endocrinol. 2014 Aug;28(8):1276-90. doi: 10.1210me.2013-1410.

Li Y, Pan J, Wei C, Chen J, Liu Y, Liu J, Zhang X, Evans SM, Cui Y, Cui S*. LIM homeodomain transcription factor Isl1 directs normal pyloric development via targeting Gata3. BMC Biology. 2014, 12:25.

Cao W, Chen W, Liang X, Zhou J, Wei C, Cui S, Liu J. All-trans-retinoic Acid ameliorates the inflammation by inducing transforming growth factor Beta 1 and interleukin 10 in mouse epididymitis. Am J Reprod Immunol. 2014, 71(4):312-21.

Zhang X, Li J, Liu J, Luo H, Gou K, Cui S*. Prostaglandin F2α upregulates Slit/Robo expression in mouse corpus luteum during luteolysis. J Endocrinol. 2013, 218(3):299-310.

Chen J, Fu R, Cui Y, Li Y, Pan J, Liu J, Luo H, Yin J, Li D, Cui S*. LIM-homeodomain transcription factor Isl-1 mediates the effect of leptin on insulin secretion in mice. J Biol Chem. 2013, 288(17):12395-12405.

Zhang N, Lin J, Chen J, Liu X, Liu J, Luo H, Li Y, and Cui S*. MicroRNA 375 mediates the signaling pathway of corticotropin-releasing factor (CRF) regulating pro-opiomelanocortin (POMC) expression by targeting mitogen-activated protein. J Biol Chem. 2013, 288(15):10361-10373.

Zhang J, Ji X, Zhou D, Li Y, Lin J, Luo H, Liu J and Cui S*. miR-143 is critical for the formation of primordial follicles in mice. Front Biosci (Landmark) 2013; 18(1): 588-597.

Liang X, Zhou D, Wei C, Luo H, Liu J, Fu R , Cui S*. MicroRNA-34c enhances murine male germ cell apoptosis through targeting ATF1. PLoS ONE. 2012, 7(3):e33861.

Sun D, Cui T, Luo H, Li R, Cui S, Liu J. Cell-specific distributions of estrogen receptor alpha (ERα) and androgen receptor (AR) in anterior pituitary glands from adult cockerels as revealed by immunohistochemistry. Cell Tissue Res. 2012;348(3):551-558.

Fu R, Liu J, Fan J, Li R, Yin J, Cui S*. Novel evidence that testosterone promotes cell proliferation and differentiation via G protein-coupled receptors in the rat L6 skeletal muscle myoblast cell line. J Cell Physiol 2012; 227(1):98-107.

Wu Y, Luo H, Liu J, Kang D, McNeilly AS, Cui S*. LIM homeodomain transcription factor Isl-1 enhances follicle stimulating hormone-beta and luteinizing hormone-beta gene expression and mediates the activation of leptin on gonadotropin synthesis. Endocrinology. 2010; 151(10): 4787-4800.

Zhang X, Zhang L, Huo S, Wang J, Cui S*. Neonatal superior ovarian nerve transection inhibits follicle development by enhancing follicular atresia and suppressing granulosa cell proliferation in rats. Reprod Fertil Dev. 2010; 22(7): 1148-1158.

Huo S, Xu Z, Zhang X, Zhang J, Cui S*. Testicular denervation in prepuberty rat inhibits seminiferous tubule development and spermatogenesis. J Reprod Dev. 2010; 56(4): 370-378.

Hu G, Xue J, Duan H, Yang Z, Gao L, Luo H, Mu X, Cui S*. IFN-γ induces IFN-α and IFN-β expressions in cultured rat intestinal mucosa microvascular endothelial cells. Immunopharmacol Immunotoxicol. 2010; 32(4): 656-662.

Chen D, Wang G, Luo H, Liu J, Cui S*. Isl-1 down-regulates DRG cell proliferation during chicken embryo development. Neuro Endocrinol Lett. 2010; 31(1): 67-72.

Wang G, Chen D, Luo H, Liu J, Ji X, Fan J, Cui S*. Low-dose ethanol suppresses 17beta-estradiol activity in GH4C1 pituitary tumor cells. Cell Biol Toxicol. 2010; 26(3): 265-277.

Fan JJ, Zhou JL, Li JH, Cui S*. Accessory sex glands of male mice have the ability to synthesize taurine via the cysteine sulfinate decarboxylase pathway. Cell Biol Int. 2009; 33(6): 684-689.

Wu YJ, Chen da W, Liu JL, Zhang JH, Luo HS, Cui S*. Estradiol promotes pituitary cell proliferation and gonadotroph differentiation at different doses and with different mechanisms in chick embryo. Steroids. 2009; 74(4-5): 441-448.

Zhang L and Cui S*. Effects of daidzein on testosterone synthesis and secretion in cultured mouse Leydig cells. Asian-Austral J Anim Sci. 2009; 22(5): 618-625.

Luo H, Liu J, Kang D, Cui S*. Ontogeny of estrogen receptor alpha, estrogen receptor beta and androgen receptor, and their co-localization with Islet-1 in the dorsal root ganglia of sheep fetuses during gestation. Histochem Cell Biol. 2008; 129(4): 525-533.

Liu S, Luo H, Liu J, McNeilly AS, Cui S*. Specificity protein 1 (Sp1) plays role in regulating LIM homeodomain transcription factor Lhx4 gene expression. Biochem Biophys Res Commun. 2008; 366(1): 36-41.

Yang JY, Wang GX, Liu JL, Fan JJ, Cui S*. Toxic effects of zearalenone and its derivatives alpha-zearalenol on male reproductive system in mice. Reprod Toxicol. 2007; 24(3-4): 381-387.

Yuan X, He Y, Liu J, Luo H, Zhang J, Cui S*. Expression of androgen receptor and its co-localization with estrogen receptor-alpha in the developing pituitary gland of sheep fetus. Histochem Cell Biol. 2007; 127(4): 423-432.

Yang J, Zhang Y, Wang Y, Cui S*. Toxic effects of zearalenone and alpha-zearalenol on the regulation of steroidogenesis and testosterone production in mouse Leydig cells. Toxicol In Vitro. 2007; 21(4): 558-565.

Zhang JH, Liu JL, Wu YJ, Cui S*. LIM homeodomain proteins Islet-1 and Lim-3 expressions in the developing pineal gland of chick embryo by immunohistochemistry. J Pineal Res. 2006; 41(3): 247-254.

Chen HP, Fan J, Cui S*. Detection and estrogen regulation of leptin receptor expression in rat dorsal root ganglion. Histochem Cell Biol. 2006; 126(3):363-369.

Li JH, Ling YQ, Fan JJ, Zhang XP, Cui S*. Expression of cysteine sulfinate decarboxylase (CSD) in male reproductive organs of mice. Histochem Cell Biol. 2006; 125(6): 607-613.

Liu J, Liu Z, Yi S, Cui S*. Islet-1 expression and its co-localization with luteinising hormone, thyroid stimulating hormone and oestrogen receptor alpha in the developing pituitary gland of sheep fetuses. J Neuroendocrinol, 2005; 17(12): 773-780.

Liu J, Chen D, Goldstein RS，Cui S*.Effects of male and female sex steroids on the development of normal and the transient Froriep's dorsal root ganglia of the chick embryo. Dev Brain Res. 2005; 155(1): 14-25.

Liu J, Cui S*. Ontogeny of estrogen receptor (ER) alpha and its co-localization with pituitary hormones in the pituitary gland of chick embryos. Cell Tissue Res. 2005; 320(2): 235-242.

Liu J, He Y, Wang X, Zheng X, Cui S*. Developmental changes of Isl1 and its co-localization with pituitary hormones in the pituitary gland of chick embryo by immunohistochemistry. Cell Tissue Res. 2005; 322(2): 279-287.

国家自然科学基金面上项目 MicroRNA-7对垂体促性腺激素合成和分泌的调节功能及分子机理（31772692） 2018-2021

国家自然科学基金重点项目 猪垂体促性腺激素合成和分泌的分子机理（3143000189） 2015-2019

国家重点基础研究项目 猪繁殖力的生理学及相关遗传调控机理（2014CB138500）首席科学家兼课题五组长 2014-2018

国家自然科学基金面上项目 Isl-1对睾丸发育和精子发生的调节功能和分子机理（31372393） 2014-2017

国家自然科学基金面上项目 Isl-1对促性腺激素细胞的增殖分化和激素分泌的调节功能及分子机理（31172287） 2012-2015

国家重大基础研究项目 遗传因素导致精子异常的调控机理（2009CB941702）子课题2009-2014

国家自然科学基金面上项目 睾丸神经支配和促黄体激素（LH）对睾酮tóng分泌的调控机制（30871846） 2009-2011

国家重大基础研究项目 国家重大基础研究项目卵泡成熟的调控网络 （2007CB947402） 2008-2013

国家自然科学基金重点项目 垂体发育和促性腺激素分泌的细胞和分子机理（30630011） 2006-2011

1990年被国务院学位委员会授予有“突出贡献的博士学位获得者”，2003年获国家杰出青年基金。

主要受国家杰出青年科学基金、自然基金和北京市自然科学基金的资助，从事动物生殖发育的细胞和分子机理、动物早期胚胎发育和发育神经生物学的研究工作。^[3]