封文海

封文海，男，博士，中国农业大学微生物学与免疫学系教授、博士生导师。中国工程院院刊农业学部分刊 FASE 编委、中国兽医杂志编委、中国微生物学会病毒学专业委员会委员、Virologica Sinica 编辑。

1982年9月-1987年7月在北京农业大学动物医学院获学士学位。

1987年7月-1990年7月在北京农业大学动物医学院获硕士学位。

1990年7月-1993年7月在北京农业大学动物医学院担任助教。

1993年8月-1995年12月在美国Iowa State University获硕士学位。

1996年1月-1999年12月在美国North Carolina State University获博士学位。

2000年1月-2003年7月在美国University of North Carolina医学院获博士后学位。

2007年3月至今担任中国农业大学特聘教授。

主要从事病毒和免疫方面研究。目前的研究领域包括：1) 对PRRSV及EBV病毒的不同蛋白质进行分析和研究，从而进一步了解其在病毒感染、复制以及致病过程中所起的作用；2）对PRRSV及EBV病毒的逃避和免疫识别进行研究，以制定出更有效的措施来防制病毒性疾病。

Liu Y, Du Y, Wang H, Du L, andWen-hai Feng*. 2017. Porcine reproductive and respiratory syndrome virus (PRRSV) up-regulates IL-8 expression through TAK-1JNKAP-1 pathways. Virology. 506:64-72。

2.Liu F, Du Y, andWen-hai Feng*. 2017. New perspective of host microRNAs in the control of PRRSV infection. Vet Microbiology. S0378-1135(16)30612-5。

Yu Z, Huang C, Zhang Q, and Wen-hai Feng*. 2016. Porcine reproductive and respiratory syndrome virus (PRRSV) induces IL-12p40 production through JNK-AP-1 and NF-κB signaling pathways. Virus Res. 225:73-81。

Du L, Liu Y, Du Y, Wang H, Zhang M, Du Y, and Wen-hai Feng*.2016. Porcine reproductive and respiratory syndrome virus (PRRSV) up-regulates IL-15 through PKCβ1-TAK1-NF-κB signaling pathway. Virology 496:166-74。

Huang C, Du Y, Yu Z, Zhang Q, Liu Y, Tang J, Shi J, and Wen-hai Feng*. 2016. Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Nsp4 Cleaves VISA to Impair Antiviral Responses Mediated by RIG-I-like Receptors. Scientific Reports 6:28497。

Zhang Q, Huang C, Yang Q, Gao L, Liu HC, Tang J, and Wen-hai Feng*. 2016. MicroRNA-30c Modulates Type I IFN Responses To Facilitate Porcine Reproductive and Respiratory Syndrome Virus Infection by Targeting JAK1. Journal of Immunology 196(5):2272-82。

Gao L, Wang L, Huang C, Yang L, Guo XK, Yu Z, Liu Y, Yang P, and Wen-hai Feng*. 2015. HP-PRRSV is attenuated by de-optimization of codon pair bias in its RNA-dependent RNA polymerase nsp9 gene. Virology485:135-44。

Yang Q, Zhang Q, Tang J, and Wen-hai Feng*. 2015. Lipid rafts both in cellular membrane and viral envelope are critical for PRRSV efficient infection. Virology 484:170-180。

Huang C, Zhang Q, and Wen-hai Feng*. 2014. Regulation and evasion of antiviral immune responses by porcine reproductive and respiratorysyndrome virus.Virus Res. 202:101-11。

Wang L, Hou J, Gao L, Guo XK, Yu Z, Zhu Y, Liu Y, Tang J, Zhang H, and Wen-hai Feng*. 2014. Attenuation of highly pathogenic porcine reproductive and respiratory syndrome virus by inserting an additional transcription unit. Vaccine 32(43):5740-8。

Huang C, Zhang Q, Guo XK, Yu ZB, Xu AT, Tang J, and Wen-hai Feng*. 2014. Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 4 Antagonizes IFNbeta Expression by Targeting NEMO. Journal of virology88(18): 10934-10945。

Zhao H, Guo XK, Bi Y, Zhu Y, and Wen-hai Feng*. 2014. PKCσ is required for porcine reproductive and respiratory syndrome virus replication. Virology 468-470:96-103。

Chen XX, Quan R, Guo XK, Gao L, Shi J, and Wen-hai Feng*. 2014. Up-regulation of pro-inflammatory factors by HP-PRRSV infection in microglia: implications for HP-PRRSV neuropathogenesis. Vet Microbiol. 170(1-2):48-57。

Zhang Q, Guo XK, Gao L, Huang C, Li N, Jia X, Liu W, and Wen-hai Feng*. 2014. MicroRNA-23 inhibits PRRSV replication by directly targeting PRRSV RNA and possibly by upregulating type I interferons. Virology 450-451:182-95。

Zhao H, Wang Y, Ma Z, Wang Y, and Wen-hai Feng*. 2014. Recombinant Kluyveromyces lactis expressing highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) GP5 elicits mucosal and cell-mediated immune responses in mice. J Vet Sci. 15(2):199-208。

Bi Y, Guo XK, Zhao H, Gao L, Wang L, Tang J, and Wen-hai Feng*. 2014. Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Induces Prostaglandin E2 Production through Cyclooxygenase 1, Which Is Dependent on the ERK12-p-CEBP-β Pathway. Journal of Virology 88(5):2810-20。

Ma Z, Zhang W, Wang L, Zhu M, Wang H, and Wen-hai Feng*, Ng TB. 2013. A novel compound from the mushroom Cryptoporus volvatus inhibits porcine reproductive and respiratory syndrome virus (PRRSV) in vitro. PLoS One 8(11):e79333。

Ma Z, Wang Y, Zhao H, Xu AT, Wang Y, Tang J, and Wen-hai Feng*. 2013.Porcine reproductive and respiratory syndrome virus nonstructural protein 4 induces apoptosis dependent on its 3C-like serine protease activity. PLoS One8(7):e69387。

Wang Y, Zhao H, Ma Z, Wang Y, and Wen-hai Feng*. 2013.CTLA4 mediated targeting enhances immunogenicity against PRRSV in a DNA primekilled virus boost strategy. Vet Immunol Immunopathol. 154(3-4):121-8。

Gao L, Guo XK, Wang L, Zhang Q, Li N, Chen XX, Wang Y, and Wen-hai Feng*. 2013. MicroRNA 181 suppresses porcine reproductive and respiratory syndrome virus (PRRSV) infection by targeting PRRSV receptor CD163. Journal of Virology 87(15):8808-12。

Gao L, Zhang W, Sun Y, Yang Q, Ren J, Liu J, Wang H, and Wen-hai Feng*. 2013. Cryptoporus volvatus extract inhibits porcine reproductive and respiratory syndrome virus (PRRSV) in vitro and in vivo. PLoS One. 8(5):e63767。

Yang Q, Gao L, Si J, Sun Y, Liu J, Cao L, and Wen-hai Feng*. 2013. Inhibition of porcine reproductive and respiratory syndrome virus replication by flavaspidic acid AB. Antiviral Res. 97(1):66-73。

Guo XK, Zhang Q, Gao L, Li N, Chen XX, and Wen-hai Feng*. 2013. Increasing expression of microRNA 181 inhibits porcine reproductive and respiratory syndrome virus replication and has implications for controlling virus infection. Journal of Virology 87(2):1159-71。

Wang L, Hou J, Zhang H, and Wen-hai Feng*. 2012.Complete genome sequence of a novel highly pathogenic porcine reproductive and respiratory syndrome virus variant. Journal of Virology 86(23):13121。

Hou J, Wang L, Quan R, Fu Y, Zhang H, and Wen-hai Feng*. 2012. Induction of interleukin-10 is dependent on p38 mitogen-activated protein kinase pathway in macrophages infected with porcine reproductive and respiratory syndrome virus. Virol J. 2012 Aug 21;9:165。

Fu Y, Quan R, Zhang H, Hou J, Tang J, and Wen-hai Feng*. 2012. Porcine reproductive and respiratory syndrome virus induces interleukin-15 through the NF-κB signaling pathway. Journal of Virology 86(14):7625-36。

Hou J, Wang L, He W, Zhang H, and Wen-hai Feng*. 2012Highly pathogenic porcine reproductive and respiratory syndrome virus impairs LPS- and poly(I:C)-stimulated tumor necrosis factor-alpha release by inhibiting ERK signaling pathway. Virus Res. 167(1):106-11。

Wang L, Zhang H, Suo X, Zheng S, and Wen-hai Feng*. 2011. Increase of CD163 but not sialoadhesin on cultured peripheral blood monocytes is coordinated with enhanced susceptibility to porcine reproductive and respiratory syndrome virus infection. Vet Immunol Immunopathol. 141(3-4):209-20。

Quan, R., Y. Fu, W. He, and Wen-hai Feng*. 2012. Cloning and characterization of the porcine IL-10 promoter. Vet Immunol Immunopathol. 146:277-282。

Wen-hai Feng, Tompkins, M.B., Xu, J.S., Zhang, H.X., McCaw, M.B., 2003. Analysis of constitutive cytokine expression by pigs infected in-utero with porcine reproductive and respiratory syndrome virus. Vet. Immunol. Immunopathol. 94(1-2):35-45。

Wen-hai Feng, Tompkins, M, Xu, jin-shen, Brown, T, Laster, S, Zhang, He-xiao, and McCaw, M.B.2002. Thymocyte and peripheral blood T lymphocyte subpopulation changes in piglets following in-uteroinfection with porcine reproductive and respiratory syndrome virus. Virology 302 (2): 363-372。

Wen-hai Feng, S. M. Laster, M. Tompkins, T. Brown, J.-S. Xu, C. Altier, W. Gomez, D. Benfield, and M. B. McCaw. 2001. In Utero Infection by Porcine Reproductive and Respiratory Syndrome Virus Is Sufficient To Increase Susceptibility of Piglets to Challenge by Streptococcus suis Type II. Journal of Virology 75:4889-4895。

Yinping Du, Jieshi Yu, Li Du, JunTang, and Wen-Hai Feng*. 2016. Cordycepin enhances Epstein–Barr virus lytic infection and Epstein–Barr virus-positive tumor treatment efficacy by doxorubicin Epstein–Barr virus-positive tumor treatment efficacy by doxorubicin. Cancer letters, 376:240–248。

Wen-hai Feng,and Shannon C. Kenney. 2007. ZEB positively regulates the lytic-switch BZLF1 gene promoter of Epstein-Barr virus in AGS cells. Journal of Virology, 81: 10113-22。

Jones RJ, Seaman WT, Feng Wen-hai, Tsao SW, Man C, Delecluse HJ, and Kenney SC. 2007. Roles of lytic viral infection and IL-6 in early versus late passage lymphoblastoid cell lines and EBV-associated lymphoproliferative disease. International Journal of Cancer, 121(6):1274-81。

Bhende, PM, Dickerson, S., Feng, Wen-hai, and Kenney SC. 2007. The plasma cell differentiation factor, X-box-binding protein 1 (XBP-1), activates lytic Epstein-Barr virus gene expression in combination with Protein Kinase D (PKD). Journal of Virology, 81(14): 7363-70。

Wen-hai Feng,and Shannon C. Kenney. 2006. Valproic acid enhances chemoagents to treat EBV-positive tumors. Cancer Research, 66 (17) 8762-8768。

Bruce F. Israel, Margaret Gulley, Sandra Elmore, Silvano Ferrini, Wen-hai Feng, and Shannon C. Kenney. 2005. Anti-CD70 antibodies: a potential treatment for EBV-positive CD70-expressing lymphomas. Molecular Cancer Therapeutic, 4(12) 2037-2044。

Gregory K. Hong, Margaret L. Gulley, Wen-hai Feng, Henri-Jacques Delecluse, Elizabeth Holley-Guthrie, and Shannon C. Kenney. 2005. Epstein-Barr Virus Lytic Infection Contributes to Lymphoproliferative Disease in a SCID Mouse Model. Journal of Virology, 79: 13993-14003。

Gregory K. Hong, Henri-Jacques Delecluse, Henri Gruffat, Thomas E. Morrison, Wen-hai Feng, and Shannon C. Kenney. 2004. The BRRF1 early gene of Epstein-Barr virus encodes a transcription factor that enhances induction of lytic infection by BRLF1 Journal of Virology, 78:4983-4992。

Wen-hai Feng, Jeffrey I. Cohen, Henri-Jacques Delecluse, and Shannon C. Kenney. 2004. Methotrexate induces reactivation of latent Epstein-Barr virus (EBV): a potential contributor to methotrexate-associated lymphomas. Journal of the National Cancer Institute, 96(22):1691-1702。

Wen-hai Feng, Gregory Hong, Henri-Jacques Delecluse, and Shannon C. Kenney. Lytic induction therapy for Epstein-Barr virus-positive B-cell lymphomas. 2004. Journal of Virology, 78:1893-1902。

Wen-hai Feng, Bruce Israel, Nancy Raab-Traub, Pierre Busson, and Shannon C. Kenney. 2002. Chemotherapy induces lytic Epstein-Barr virus (EBV) replication and confers ganciclovir susceptibility to EBV-positive epithelial cell tumors. Cancer Research, 62: 1920-1926。

Wen-hai Feng, Eva Westphal, Amy Mauser, Nancy Raab-Traub, Margaret L. Gulley, Pierre Busson, and Shannon C. Kenney. 2002. Use of Adenovirus vectors expressing the Epstein-Barr virus (EBV) immediate-early proteins (BZLF1 or BRLF1) to treat Nasopharyngeal Carcinomas in vivo. Journal of Virology, 76:10951-10959。

Eva M. Westphal, William Blackstock, Wen-hai Feng, Bruce Israel, and Shannon C. Kenney. 2000. Activation of Lytic Epstein-Barr Virus (EBV) Infection by Radiation and Sodium Butyrate in Vitro and in Vivo: A Potential Method for Treating EBV-positive Malignancies. Cancer Research, 60: 5781-5788。

国家自然科学基金重点项目：“microRNAs调控猪繁殖与呼吸综合征病毒感染和细胞嗜性的分子机制研究”（2017-01-01至2021-12-31）334万，主持

国家自然科学基金面上项目：“高致病性猪繁殖与呼吸综合征病毒（HP-PRRSV）引起高热的分子机制研究”（2016-01-01至2019-12-31）76.2万，主持

北京市自然科学基金重点项目：“PRRSV干预抗病毒细胞因子表达和功能的分子机制”（2015-01-01至2018-12-31）65万，主持

转基因生物新品种培育专项：“动物重要基因克隆及功能验证”（2016-01-01至2018-12-31）2273.1万，参加

国家重点研发计划：“猪重要疫病免疫防控新技术研究”（2017年7月至2020年12月）58万，参加

重组猪繁殖与呼吸综合征病毒及其制备方法与应用（专利号201310018715.5）。

重组PRRS病毒HV-nsp29及其应用（专利号201310394862.2）。

重组PRRS病毒HV-nsp9及其应用（专利号201310394833.6）。

封文海教授为以上专利的第一发明人，专利授权单位为中华人民共和国国家知识产权局。