姚镜

姚镜，男，是武汉大学生命科学学院细胞与发育生物学系的教授，专业领域为细胞生物学和神经生物学。他的研究方向主要集中在细胞膜离子通道的结构与功能。

学习经历：

2006/09－2009/07，美国纽约州立布法罗大学生理与生物物理系，联合培养博士生

2006/09－2009/07，华中科技大学生命科学与技术学院生物物理专业，博士

2002/09－2005/07，华中科技大学生命科学与技术学院生物物理专业，硕士

1996/09－2000/07，华中科技大学生命科学与技术学院生物技术专业，本科

主要工作经历与任职情况：

2012/12-至今，武汉大学，生命科学学院，细胞与发育生物学系，教授

2011/10，受聘为湖北省楚天学者特聘教授

2011/02-2012/12，华中科技大学，生命科学与技术学院，分子生物物理教育部重点实验室，教授

2005/10-2011/01，美国纽约州立布法罗大学，生理与生物物理系，先后担任研究助理与博士后。

主要社会兼职：

中国生物物理学会膜生物物理专业委员会委员

中国生物物理学会神经生物物理与神经信息学专业委员会委员

主要研究领域及兴趣：

目前，我们研究小组所感兴趣的是一类与痛觉和温度传导相关的TRP离子通道的门控机制、通道蛋白的结构与功能之间的关系，以及膜离子通道通道在生理、病理中的功能等方面研究。主要从以下几个方面开展：

(1) 温度敏感型TRP通道的结构与功能之间的关系研究；

(2) 对与重要疾病相关的离子通道的功能调节进行研究；

(3) 与从事医学遗传学的研究人员合作，就离子通道类遗传性疾病的致病机理进行研究；

(4) 围绕与钙离子相关的信号通路，对TRP通道在机体组织中的功能进行研究。

主持课题项目：

目前承担有国家自然科学基金面上项目和教育部博士点新教师基金，作为研究骨干参与国家重点基础研究发展计划（973计划）。

代表性论文

1)Xiang Yang Zhang, Jingmin Wen, Wei Yang, Cheng Wang, Luna Gao, Liang Hong Zheng, Tao Wang, Kaikai Ran, Yulei Li, Xiangyang Li, Ming Xu, Junyu Luo, Shenglei Feng, Xixiang Ma, Hongying Ma, Zuying Chai, Zhuan Zhou,Jing Yao, Xue Zhang, Jing Yu Liu . Gain-of-Function Mutations inSCN11A Cause Familial Episodic Pain.Am. J. Hum. Genet. 2013 Nov 7; 93(5):957-66. Doi: 10.1016/j.ajhg.2013.09.016 (corresponding author)

2)Jing Yao,Beiying Liu and Feng Qin. Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels.Proc. Natl. Aca. Sci. USA.2011 Jul 5; 108(27):11109-14.

3)Beiying Liu,Jing Yaoand Feng Qin. Hysteresis of Gating Underlines Sensitization of TRPV3 Channels.J Gen Physiol.2011 Nov; 138(5):509-20.(equal contribution, Recommended by Faculty of 1000)

4)Jing Yao,Beiying Liu and Feng Qin. Pore turret of thermal TRP channels is not essential for temperature sensing.Proc. Natl. Aca. Sci. USA.2010, Aug 10; 107(32):E125.

5)Jing Yao, Beiying Liu and Feng Qin. Kinetics and Energetic Analysis of Thermally Activated TRPV1 channels.Biophys. J. 2010 Sep 22; 99(6):1743-53.

6)Jing Yao, Beiying Liu and Feng Qin. Rapid temperature jump by infrared diode laser irradiation for patch-clamp studies.Biophys. J. 2009 May 6; 96(9): 3611-9.

7)Jing Yaoand Feng Qin. Interaction with phosphoinositides confers adaptation of pain receptors TRPV1.PLos. Biol.2009 Feb.24, 7 (2): e46.

8)Jing Yao, Xiang Chen, Hui Li, Yang Zhou, Lijun Yao, Gong Wu, Xiaoke Chen, Naixia Zhang, Zhuan Zhou, Tao Xu, Houming Wu, and Jiuping Ding. BmP09, a “Long Chain” scorpion peptide blocker of BK channels.J Biol Chem, 2005, 280: 14819-28.

9)Lisi Wei, Su Chen, Xianju Huang,Jing Yaoand Xiangming Liu. Material basis for inhibition of dragon’s blood on capsaicin-induced TRPV1 receptor currents in rat dorsal root ganglion neurons.Eur J Pharmacol.2013 Feb 28; 702(1-3):275-84. doi: 10.1016/j.ejphar.2013.01.052. Epub 2013 Feb 8.

10)Panpan Hou, Wenping Zeng, Geliang Gan, Caixia Lv, Xiying Guo, Zheng Zhang, Haowen Liu, Ying Wu,Jing Yao, Aguan D., Wei, Sheng Wang and Jiuping Ding. Inter-α/β subunits coupling mediating pre-inactivation and augmented activation of BKCa(β2).Sci Rep.2013 Apr 16; 3:1666. P1-8. doi: 10.1038/srep01666.

11)Ying Wu, Yongfeng Liu, Panpan Hou, Zonghe Yan, Wenjuan Kong, Beiying Liu , Xia Li,Jing Yao, Yuexuan Zhang, Feng Qin, Jiuping Ding. TRPV1 Channels Are Functionally Coupled with BK(mSlo1) Channels in Rat Dorsal Root Ganglion (DRG) Neurons.PLoS One. 2013 Oct 16; 8(10):e78203. doi: 10.1371/journal.pone.0078203.

12)Lu Zeng, Wenqiang Liu, Wenguo Feng, Xing Wang, Hui Dang, Luna Gao,Jing Yaoand Xianqin Zhang. A novel donor splice-site mutation of major intrinsic protein gene associated with congenital cataract in a Chinese family.Mol Vis.2013 Nov 14;19:2244-9.

13)Wei Wang, Feng Xiao, Xuhui Zeng,Jing Yao, Ming Yuchi and Jiuping Ding.Optimal Estimation of Ion-channel Kinetics from Macroscopic Currents.Plos One.2012 Mar; 7(4):e35208. Epub 2012 Apr 20.

14)Cheng Wang, Yulei Li, Lei Shi, Jie Ren, Monica Patti, Tao Wang, João R M de Oliveira, María-Jesús Sobrido, Beatriz Quintáns, Miguel Baquero, Xiaoniu Cui, Xiang-Yang Zhang, Lianqing Wang, Haibo Xu, Junhan Wang,Jing Yao, Xiaohua Dai, Juan Liu, Lu Zhang, Hongying Ma, Yong Gao, Xixiang Ma, Shenglei Feng, Mugen Liu, Qing K Wang, Ian C Forster, Xue Zhang & Jing-Yu Liu. Mutations inSLC20A2link familial idiopathic basal ganglia calcification with phosphate homeostasis.Nat Genet.2012 Feb 12. 44(3):254-6. doi: 10.1038/ng.1077.

15)Beiying Liu,Jing YaoYingwei Wang, Hui Li and Feng Qin. Proton inhibition of Unitary Currents of Vanilloid Receptors.J Gen Physiol.2009 Aug 31; 134(3):243-58.(equal contribution)

16)Sujung Ryu, Beiying Liu,Jing Yao, Qiang Fu ang Feng Qin. Uncoupling proton activation of vanilloid receptor TRPV1.J Neurosci. 2007 Nov 21，27(47): 12797-807.(equal contribution)

17)Hui Li,Jing Yao, Xiaotian Tong, Zhaohua Guo, Ying Wu, Liang Sun, Na Pan, Houming Wu, Tao Xu, and Jiuping Ding. Interaction sites between the Slo1 pore and the NHterminus of the β2 subunit, probed with a three-residue sensor.J Biol Chem, 2007, 282: 17720-8.(equal contribution)

18)Xiaotian Tong,Jing Yao, Feng He, Xiang Chen, X. Zheng, Chang Xie, Gong Wu, Naixia Zhang, Jiuping Ding and Houming Wu. NMR solution structure of BmK-betaIT, an excitatory scorpion beta-toxin without a 'hot spot' at the relevant position.Biochem Biophys Res Commun. 2006 Oct 27; 349(3): 890-9.(equal contribution)

19)Jing Yao, Hui Li, Geliang Gan, Ying Wu, and Jiuping Ding. Residue Phe266 in S5-S6 loop is not critical for Charybdotoxin binding to Ca-activated K (mSlo1) channels.Acta Pharmacologica Sinica, 2006, 27: 945-9.

These authors contributed equally to the work.