刘志杰

刘志杰，男，1984年获天津师范大学学士学位，1994年获中国科学院生物物理研究所博士学位。

1995-1995年在美国匹兹堡大学做博士后。

1995-1997年在美国佐治亚大学做博士后。

1997-2002年任美国佐治亚大学助理研究员。

2002-2006年任美国佐治亚大学副研究员。

2006-2013年任中国科学院生物物理研究所“百人计划”研究员。

2013年5月加入上海科技大学iHuman研究所。

主要从事与人源细胞信号传导相关蛋白，如G蛋白偶联受体（GPCR）的结构生物学和基于结构的药物设计研究。

主要集中在以下两方面： 1. 人源细胞信号传导相关蛋白的结构生物学研究； 2. 基于GPCR三维结构的药物筛选与优化。

近五年代表性论文：^[1]

Batyuk, L Galli, A Ishchenko, G W Han, C Gati, P Popov, M Lee, T. White, A Barty, A Aquila, M Hunter, M Liang, S Boutet, M Pu, Z-J Liu, G Nelson, D James, C Li, Y Zhao, J Spence, W Liu, P Fromme, V Katritch, U Weierstall, R Stevens, V Cherezov (2016) Native Phasing of X-ray Free Electron Laser data for a G protein-coupled receptor. Science Advances, accepted。

Liu B, Ouyang S, Makarova K, Xia Q, Zhu Y, Li Z, Guo L, Koonin E, Liu ZJ*, Huang L*. (2015) A primase subunit essential for efficient primer synthesis by an archaeal eukaryal-type primase. Nat Commun. DOI: 10.1038/ncomms8300。

Gu, Y. Feng, X. Feng, C. Sun, L. Lei, W. Ding, F. Niu, L. Jiao, M. Yang, Y. Li, X. Liu, J. Song, Z. Cui, D. Han, C. Du, Y. Yang, S. Ouyang, Z. J. Liu, W. Han, (2014) Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented “EF-Hand-Like” Calcium-Binding Phage Lysin, PLOS Pathogens, 10(5) e1004109。

Ntashin PV, Ding W, Eremeeva EV, Markova SV, Lee J, Vysotski ES, Liu ZJ., (2014) Structures of the Ca(2+)-regulated photoprotein obelin Y138F mutant before and after bioluminescence support the catalytic function of a water molecule in the reaction. Acta Cryst. D, 70(Pt3):720-32。

Zang L, Mo J, Swanson KV, Wen H, Petrucelli A, Gregory SM, Zhang Z, Schneider M, Jiang Y, Fitzgerald KA, Ouyang S, Liu ZJ, Damania B, Shu HB, Duncan JA, Ting J (2014) NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING , Immunity, 40(3): 329-341。

Zhao, L., Hua, t., Crowley, C., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Hung, L., Huang, W., Liu, L., Ye, K., OuYang, S*, Cheng, G*, and Liu, Z. J*, (2014) Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage, Cell Res, 24(3):344-58。

Niu, F., Shaw, N., Wang, Y., Jiao, L., Ding, W., Li, X., Zhu, P., Upur, H., OuYang, S*, Cheng, G*, and Liu, J*, (2013) Structure of the Leanyer Orthobunyavirus Nucleoprotein-RNA complex reveals novel architecture for RNA encapsidation, PNAS, 110(22):9054-9。

Ru, H., Ni, X., Zhao, L., Crowley, C., Ding, W., Hung, L., Shaw, N., Cheng, G*. and Liu, Z. J*, (2013) Structural basis for termination of AIM2-mediated signaling by p202. Cell Research, 23(6):855-8。

Jiao, L., OuYang, S., N., Liang, M., Niu, F., Shaw, N., Wu, W., Ding, W., Jin, C., Peng, Y., Zhu, Y., Zhang, F., Wang, T., Li, C., Zuo, X., Luan, C.*, Li., D.*, and Liu, Z. J*, (2013) Structure of Severe Fever with Thrombocytopenia Syndrome Virus Nucleocapsid protein in Complex with Suramin Reveals Therapeutic Potentials. J. VI, 87(12):6829-39。

Won, E, Xie, Y, Takemoto, C, Chen, L, Liu, J, Wang, B. C, Lee, D, Woo, E, Park, S, Shirouzu, M, Yokoyama, S, Kim, S and Chi, S, (2013) High-resolution crystal structure of the catalytic domain of human dual-specificity phosphatase 26, Acta Cryst D, 69(6):1160-70。

OuYang, S, Song, X, Wang, Y, Ru, H., Shaw, N., Jiang, Y., Niu, F., Zhu, Y., Qiu, W., Parvatiyar, K., Li, Y., Zhang, R., Cheng, G*., and Liu, J*, (2012) Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding, Immunity, 36(6): 1073-1086。

Parvatiyar, K., Zhang, Z., Teles, R. M., Ouyang, S., Jiang, Y., Iyer, S. S., Zaver, S. A., Schenk, M., Zeng, S., Zhong, W., Liu, Z. J., Modlin, R. L., Liu, Y. J*., and Cheng, G*. (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response, Nat Immunol 13, 1155-1161。

Ru, H., Zhao, L., Ding, W., Jiao, L., Shaw, N., Liang, W., Zhang, L., Hung, L., Matsugaki, N., Wakatsuki, S. and Liu, J*, (2012) The S-SAD phasing study of DR6 and its solution conformation revealed by SAXS. Acta Cryst, D68, 521–530。

Zhan, Z., OuYang, S., Liang, W., Zhang, Z., Liu, J* and Huang, L.*, (2012) Structural and functional characterization of the C-terminal catalytic domain of the SSV1 integrase. Acta Cryst D68, 659–670。

Liu, Z. J*, Chen, L., Wu, D., Ding, W., Zhang H., Zhou, W., Fu, Z. & Wang, BC*, (2011) A multi-dataset data-collection strategy produces better diffraction data. Acta Cryst A67, 544-549。^[1]

何梁何利基金科学与技术进步奖发布，刘志杰获得生命科学奖。^[2]

2023年8月31日，入选2023年中国科学院院士增选有效候选人名单。^[3]