刘学波

刘学波，男，1975年9月出生，黑龙江克山县人，博士学位，毕业于名古屋大学。现任西北农林科技大学教授、博士生导师，食品科学与工程学院院长、测试中心主任。入选教育部“新世纪优秀人才”支持计划、科技部中青年科技创新领军人才计划，荣获2015年度中国食品科学技术学会科技创新奖-杰出青年奖，享受国务院政府特殊津贴。

1993.09 – 1997.07 东北农业大学食品科学系 本科

2002.04 – 2004.03 日本广岛大学生物圈科学研究科食品卫生学专业 硕士

2005.04 – 2008.03 日本名古屋大学生命农学研究科食品功能化学专业 博士

1997.08－2001.03 东北农业大学助教；

2004.05－2005.03 日本名古屋大学农学部研究员；

2008.03－2008.10 日本名古屋大学生命农学研究科博士后研究员；

2008.12－至今 西北农林科技大学食品科学与工程学院教授，博士生导师

2010.06－2016.12 西北农林科技大学食品科学与工程学院副院长

2014.12－2015.12 陕西科技大学校长助理（挂职）

2016.12－至今 西北农林科技大学食品科学与工程学院院长、测试中心主任

2022年4月，任西北农林科技大学校长助理（正处级）。

兼任中国食品科学技术学会理事、青年工作委员会副主任委员、食品营养与健康分会理事，陕西省食品科学技术学会副理事长，陕西省营养学会副理事长，《中国食品学报》《食品科学》《Food Science and Human Wellness》编委。

食品功能因子调节糖脂代谢及脑神经细胞保护作用的营养功能性评价；

膳食模式对“肠脑轴”营养健康状态的调控作用与机制；

新型营养健康食品研发。

（1）十三五国家重点研发计划项目子课题（No. 2017YFD0400200-04），2017-2020

（2）国家自然科学基金面上项目（No. 31571842），2016-2019

（3）十三五国家重点研发计划项目子课题（No. 2016YFD0400601-02），2016-2020

（4）陕西省科技统筹创新工程计划项目（No. 2014KTCL02-07），2014-2016

（5）国家自然科学基金面上项目（No.31271810），2013-2016

（6）国家”十二五”科技支撑计划课题（No.2012BAH30F03），2012-2014

（7）国家自然科学基金青年项目（No.31000757），2011-2013

（8）教育部“新世纪优秀人才支持计划”（No.2010-NCET-10-0656），2010-2012

（9）教育部高等学校博士点新教师基金（No.2009024120027），2010-2012

(1) Tan X., Ye J., Liu W., Zhao B., Shi X., Zhang C. and Liu X*. Acrylamide aggravates cognitive deficits at night period via the gut–brain axis by reprogramming the brain circadian clock. Archives of Toxicology, 2019, 93, 467-486.

(2) Qi G., Guo R., Tian H., Li L., LiuH., Mi Y. and Liu X*. Nobiletin protects against insulin resistance and disorders of lipid metabolism by reprogramming of circadian clock in hepatocytes. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2018, 1863, 549-562.

(3) Wang J., Wang Z., Li B., Qiang Y., Yuan T., Tan X. and Liu X*. Lycopene attenuates western-diet-induced cognitive deficits via improving glycolipid metabolism dysfunction and inflammatory responses in gut–liver–brain axis. International Journal of Obesity, 1. 2018 Dec 11. doi: 10.1038/s41366-018-0277-9. [Epub ahead of print].

(4) Wang J., Li L., Wang Z., Cui Y., Tan X., Yuan T. and Liu X*. Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress Journal of Nutritional Biochemistry, 2018, 56, 16-25.

(5) Ren B., Yuan T., Diao Z., Zhang C., Liu Z. and Liu X*. Protective effects of sesamol on systemic oxidative stress-induced cognitive impairments via regulation of Nrf2/Keap1 pathway. Food & Function, 2018, 9, 5912-5924.

(6) Tan X., Zhao T., Wang Z., Wang J., Wang Y., Liu Z. and Liu X*. Acrylamide Defects the Expression Pattern of the Circadian Clock and Mitochondrial Dynamics in C57BL/6J Mice Liver and HepG2 Cells. Journal of Agricultural and Food Chemistry, 2018, 66, 10252-10266.

(7) Guo R., Zhao B., Wang Y., Wu D., Wang Y., Yu Y. and Liu X*. Cichoric Acid Prevents Free-Fatty-Acid-Induced Lipid Metabolism Disorders via Regulating Bmal1 in HepG2 Cells. Journal of Agricultural and Food Chemistry, 2018, 66, 9667-9678.

(8) Qi G., Wu W., Mi Y., Shi R., Sun K., Li R. and Liu X*. Tea polyphenols direct Bmal1-driven ameliorating of the redox imbalance and mitochondrial dysfunction in hepatocytes. Food and Chemical Toxicology, 2018, 122, 181-193.

(9) Zhao T., Liu F., Duan X., Xiao C. and Liu X*. Physicochemical Properties of Lutein-Loaded Microcapsules and Their Uptake via Caco-2 Monolayers. Molecules, 2018, 23, 1805.

(10) Liu R., Zhang J., Zhao C., Duan X., McClements D. and Liu X*. Formation and Characterization of Lactoferrin-Hyaluronic Acid Conjugates and Their Effects on the Storage Stability of Sesamol Emulsions. Molecules, 2018, 23, 3291.

(11) Mi Y., Liu X., Tian H., Liu H., Li J., Qi G. and Liu X*. EGCG stimulates the recruitment of brite adipocytes, suppresses adipogenesis and counteracts TNF-α-triggered insulin resistance in adipocytes. Food & Function, 2018, 9, 3374-3386.

(12) Zhao B., Liu H., Wang J., Liu P., Tan X., Ren B. and Liu X*. Lycopene supplementation attenuates oxidative stress, neuroinflammation, and cognitive impairment in aged CD-1 mice. Journal of Agricultural and Food Chemistry, 2018, 66, 3127-3136.

(13) Mi Y., Zhang W., Tian H., Li R., Huang S., Li X. and Liu X*. EGCG evokes Nrf2 nuclear translocation and dampens PTP1B expression to ameliorate metabolic misalignment under insulin resistance condition.Food & Function, 2018, 9, 1510-1523.

(14) Liu Z., Liu X., Luo, S. Chu C., Wu D., Liu R. and Liu X*. Extract of sesame cake and sesamol alleviate chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits.Journal of Functional Foods, 2018, 42, 237-247.

(15) He P., Yan S., Zheng J., Gao Y., Zhang S., Liu Z. and Liu X*. Eriodictyol Attenuates LPS-Induced Neuroinflammation, Amyloidogenesis, and Cognitive Impairments via the Inhibition of NF-κB in Male C57BL/6J Mice and BV2 Microglial Cells. Journal of Agricultural and Food Chemistry, 2018, 66, 10205-10214.

(16) Li J., Zhao C., Wei L., Li X., Liu F., Zhang M. and Liu X*. Preservation of Cichoric Acid Antioxidant Properties Loaded in Heat Treated Lactoferrin Nanoparticles. Molecules, 2018, 23, 2678.

(17) Wang Y., Li L., Liu H., Zhao T., Meng C., Liu Z. and Liu X*. Bioactive compounds and in vitro antioxidant activities of peel, flesh and seed powder of kiwi fruit. International Journal of Food Science & Technology, 2018, 53, 2239-2245.

(18) Liu F., Zhang S., Li J., McClements D. J. and Liu X*. Recent development of lactoferrin-based vehicles for the delivery of bioactive compounds: Complexes, emulsions, and nanoparticles. Trends in Food Science & Technology. 2018, 79, 67-77.

(19) Xiao C., He P., Han J., Tang M., Wang Z., Mi Y. and Liu X*. 1, 3-Dichloro-2-propanol evokes inflammation and apoptosis in BV-2 microglia via MAPKs and NF-κB signaling pathways mediated by reactive oxygen species. Toxicology Letters, 2018, 284, 103-112.

(20) Mi Y., Qi G., Gao Y., Li R., Wang Y., Li X., Huang S. and Liu X*. EGCG Ameliorates Insulin Resistance and Mitochondrial Dysfunction in HepG2 Cells: Involvement of Bmal1. Molecular Nutrition & Food Research, 2017, 61, 1700440.

(21) Liu Z., Qiao Q., Sun Y., Chen Y., Ren B. and Liu X*. Sesamol ameliorates diet induced obesity in C57BL/6J mice and suppresses adipogenesis in 3T3-L1 cells via regulating mitochondria-lipid metabolism. Molecular Nutrition & Food Research, 2017, 61, 1600717.

(22) Mi, Y., Qi, G.., Rong, F., Ji, X., Liu, Z., and Liu X*. EGCG ameliorates diet-induced metabolic syndrome associating with the circadian clock. Biochim Biophys Acta, 2017, 1863, 1575-1589.

(23) Mi, Y., Qi, G., Fan, R., Qiao, Q., Sun, Y., Gao, Y., and Liu X*. EGCG ameliorates high-fat-and high-fructose-induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF. The FASEB Journal, 2017, 31, 4998-5011.

(24) Liu Q., Chen Y., Shen C., Xiao Y., Wang Y., Liu Z. and Liu X*. Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB. The FASEB Journal. 2017, 31, 1494-1507.

(25) Liu Q., Hu Y., Cao Y., Song G., Liu Z. and Liu X*. Chicoric Acid ameliorates lipopolysaccharide induced oxidative stress via promoting Keap1/Nrf2 transcriptional signaling pathway in BV-2 microglial cells and mice brain. Journal of Agricultural and Food Chemistry. 2017, 65, 338-347.

(26) Duan X, Li J, Zhang Q, Zhao T, Li M, Xu X, and Liu X*.Effect of a multiple freeze-thaw process on structural and foaming properties of individual egg white proteins. Food Chemistry, 2017, 228, 243-248.

(27) Duan X, Li M, Shao J, Chen H, Xu X, Jin Z, and Liu X*. Effect of oxidative modification on structural and foaming properties of egg white protein. Food Hydrocolloids, 2018. 75, 223-228.

(28) Liu Z., Chen Y., Qiao Q., Sun Y., Liu Q., Ren B. and Liu X*. Sesamol supplementation prevents systemic inflammation-induced memory amyloidogenesis via inhibition of nuclear factor kappaB. Molecular Nutrition & Food Research, 2017, 61(5), 1600734.

(29) Qi, G., Liu, Z., Fan, R., Yin, Z., Mi, Y., Ren, B., and Liu X*. Athyrium multidentatum (Doll.) Ching extract induce apoptosis via mitochondrial dysfunction and oxidative stress in HepG2 cells. Scientific Reports, 2017, 7(1), 2275.

(30) Qi, G., Mi, Y., Liu, Z., Fan, R., Qiao, Q., Sun, Y., Ren B., and Liu X*. Dietary tea polyphenols ameliorate metabolic syndrome and memory impairment via circadian clock related mechanisms. Journal of Functional Foods, 2017, 34, 168-180.

(31) Zhu D, Zhang X, Niu Y, Diao Z, Ren B, Li X, Liu Z, and Liu X*. Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice. Food and Chemical Toxicology, 2017, 107(Pt A):138-149.

(32) Qi, G., Mi, Y., Fan, R., Li, R., Wang, Y., Li, X., Huang S., and Liu X*. Tea polyphenols ameliorate hydrogen peroxide-and constant darkness-triggered oxidative stress via modulating the Keap1/Nrf2 transcriptional signaling pathway in HepG2 cells and mice liver. RSC Advances, 2017, 7, 32198-32208.

(33) Qi, G., Mi, Y., Wang, Y., Li, R., Huang, S., Li, X., and Liu X*. Neuroprotective action of tea polyphenols on oxidative stress-induced apoptosis through the activation of TrkB/CREB/BDNF pathway and Keap1/Nrf2 signaling pathway in SH-SY5Y cells and mice brain. Food & Function, 2017, 8(12), 4421-4432.

(34) Liu Z., Ren B., Wang Y., Zou C., Qiao Q., Diao Z., Mi Y., Zhu D. and Liu X*. Sesamol Induces Human Hepatocellular Carcinoma Cells Apoptosis by Impairing Mitochondrial Function and Suppressing Autophagy. Scientific Reports, 2017, 7, 45728.

(35) Qi, G., Mi, Y., Fan, R., Zhao B., Ren B., and Liu X*. Tea polyphenols ameliorates neural redox imbalance and mitochondrial dysfunction via mechanisms linking the key circadian regular Bmal1. Food and Chemical Toxicology, 2017. 110, 189-199.

(36) Zhu D, Zhang N, Zhou X, Zhang M, Liu Z, and Liu X*. Cichoric acid regulates the hepatic glucose homeostasis via AMPK pathway and activates the antioxidant response in high glucose-induced hepatocyte injury. RSC Advances, 2017, 7, 1363-1375.

(37) Song G., Liu Z., Liu Q., Liu X*. Lipoic acid prevents acrylamide-induced neurotoxicity in ICR mice and BV2 microglial cells via maintaining redox homeostasis. Journal of Functional Foods, 2017. 35: 363-375.

(38) Zhao B, Ren B, Guo R, Zhang W, Ma S, Yao Y, Yuan T, Liu Z, Liu X*. Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway. Food and Chemical Toxicology, 2017, 109(Pt 1):505-51613.

(39) Wang Y, Diao Z, Li J, Ren B, Zhu D, Liu Q, Liu Z, and Liu X*. Chicoric acid supplementation ameliorates cognitive impairment induced by oxidative stress via promotion of antioxidant defense system. RSC Advances, 2017, 7(57):36149-36162.

(40) Liu Q, Liu F, Zhang L, Niu Y, Liu Z, and Liu X*. Comparison of chicoric acid, and its metabolites caffeic acid and caftaric acid: in vitro protection of biological macromolecules and inflammatory responses in BV2 microglial cells. Food Science and Human Wellness, 2017, 6(4), 155-166.

(41) Liu Z, Sun Y, Qiao Q, Zhao T, Zhang W, Ren B, Liu Q, and Liu X*. Sesamol ameliorates high-fat and high-fructose induced cognitive defects via improving insulin signaling disruption in the central nervous system. Food & Function, 2017, 8, 710-719.

(42) Ma S., Ren B., Diao Z., Chen Y, Qiao Q. and Liu X*. Physicochemical properties and intestinal protective effect of ultra-micro ground insoluble dietary fibre from carrot pomace. Food & Function, 2016, 7, 3902-3909.

(43) Wang Y., Xie G., Liu Q., Duan X., Liu Z. and Liu X*. Pharmacokinetics, tissue distribution, and plasma protein binding study of chicoric acid by HPLC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2016, 1031:139-145.

(44) Cui Y., Lu P., Song G., Liu Q., Zhu D. and Liu X*. Involvement of PI3K/Akt, ERK and p38 signaling pathways in emodin-mediated extrinsic and intrinsic human hepatoblastoma cell apoptosis. Food and Chemical Toxicology, 2016, 92, 26-37.

(45) Duan X., Li M., Ma H., Xu X., Jin Z. and Liu X*. Physicochemical properties and antioxidant potential of phosvitin-resveratrol complexes in emulsion system. Food Chemistry, 2016, 206, 102-109.

(46) Mi Y., Xiao C., Du Q., Wu W., Qi G. and Liu X*. Momordin Ic couples apoptosis with autophage in human hepatoblastoma cancer cells by reactive oxygen species (ROS) –mediated PI3k/Akt and MAPK signaling pathways. Free Radical Biology & Medicine, 2016, 90,230-242.

(47) Yuan L., Wang J., Wu W., Liu Q. and Liu X*. Effect of isoorientin on intracellular antioxidant defence mechanisms in hepatoma and liver cell lines. Biomedicine & Pharmacotherapy, 2016, 81, 356-362

(48) Zhu D., Wang Y., Du Q., Liu Z. and Liu X*. Cichoric acid reverses insulin resistance and suppresses inflammatory responses in the glucosamine-induced HepG2 cells. Journal of Agricultural and Food Chemistry, 2015, 63, 10903-10913.

(49) Liu Z., Song G., Zou C., Liu G., Wu W., Yuan L. and Liu X*. Acrylamide induces mitochondrial dysfunction and apoptosis in BV-2 microglial cells. Free Radical Biology & Medicine, 2015, 84, 42-53.

(50) Wu W., Li Y., Wu Y., Zhang Y., Wang Z. and Liu X*. Lutein suppresses inflammatory responses through Nrf2 activation and NF-κB inactivation in lipopolysaccharide-stimulated BV-2microglia. Molecular Nutrition & Food Research, 2015, 59, 1663-1673.

(51) Qi G., Yang L., Xiao C., Shi J., Mi Y. and Liu X*. Nutrient values and bioactivities of the extracts from three fern species in China: a comparative assessment. Food & Function, 2015, 6, 2918-2929.

(52) Liu Q., Wang Y., Xiao C., Wu W. and Liu X*. Metabolism of chicoric acid by rat liver microsomes and bioactivity comparisons of chicoric acid and its metabolites. Food & Function, 2015, 6, 1928-1935.

(53) Yuan L., Wei S., Wang J. and Liu X*. Isoorientin Induces Apoptosis and Autophagy Simultaneously by Reactive Oxygen Species (ROS)-Related p53, PI3K/Akt, JNK, and p38 Signaling Pathways in HepG2 Cancer Cells. Journal of Agricultural and Food Chemistry, 2014, 62, 5390-5400.

(54) Wang J., Yuan L., Xiao H., Wang C., Xiao C., Wang Y. and Liu X*. A novel mechanism for momordin Ic-induced HepG2 apoptosis: involvement of PI3K- and MAPK-dependent PPARγ activation. Food & Function, 2014, 5, 859-868.

(55) Wang Y., Liu Y., Xiao C., Liu L., Hao M., Wang J. and Liu X*. Simultaneous determination of 15 phenolic constituents of Chinese black rice wine by HPLC-MS/MS with SPE. Journal of Food Science, 2014, 79, 1100-1105.

(56) Yuan L., Wang Y., Wang J., Xiao H. and Liu X*. Additive effect of zinc oxide nanoparticles and isoorientin on apoptosis in human hepatoma cell line. Toxicology letters, 2014, 225, 294-304

(57) Wu W., Wang X., Xiang Q., Meng X., Peng Y., Du N., Liu Z., Sun Q., Wang C. and Liu X*. Astaxanthin alleviates brain aging in rats by attenuating oxidative stress and increasing BDNF levels. Food & Function, 2014, 5, 158-166.

(58) Yuan L., Wu. Y., Ren X., Liu Q., Wang J. and Liu X*. Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-κB signaling pathway in BV-2 microglia. Molecular and Cellular Biochemistry, 2014, 386, 153-165

(59) Xiang Q., Liu Q., Xu L., Qiao Y., Wang Y. and Liu X*. Carnosic acid protects biomolecules from free radical-mediated oxidative damage in vitro. Food Science and Biotechnology, 2013, 22, 1381-1388

(60) Xiao H., Xie G., Wang J., Hou X., Wang X., Wu W. and Liu X*. Chicoric acid prevents obesity by attenuating hepatic steatosis, inflammation and oxidative stress in high-fat diet-fed mice. Food Research International, 2013, 54, 345-353

(61) Liu Z., Xiang Q., Du L., Song G., Wang Y. and Liu X*. The interaction of sesamol with DNA and cytotoxicity, apoptosis, and localization in HepG2 cells. Food Chemistry, 2013, 141, 289-296

(62) Wang J, Yuan L, Xiao H, Xiao C, Wang Y, and Liu X*. Momordin Ic induces HepG2 cell apoptosis through MAPK and PI3K/Akt-mediated mitochondrial pathways. Apoptosis, 2013, 18, 751-765

(63) Xiang Q., Wang Y., Wu W., Meng X., Qiao Y., Xu L. and Liu X*. Carnosic acid protects against ROS/RNS-induced protein damage and upregulates HO-1 expression in RAW264.7. Journal of Functional Foods, 2013, 5, 362-369

(64) Xiao H., Wang J., Yuan L., Xiao C., Wang Y. and Liu X*. Chicoric acid induces apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Journal of Agricultural and Food Chemistry. 2013, 61, 1509-1520.

(65) Yuan L., Wang J., Xiao H., Wu W., Wang Y. and Liu X*. MAPK signaling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells. Food and Chemical Toxicology, 2013, 53, 62-68.

(66) Xiang Q., Liu Z., Wang Y., Xiao H., Wu W., Xiao C. and Liu X*. Carnosic acid attenuates lipopolysaccharide-induced liver injury in rats via fortifying cellular antioxidant defense system. Food and Chemical Toxicology, 2013, 53, 1-9.

(67) Qiao Y., Xiang Q., Yuan L., Xu L., Liu Z. and Liu X*. Herbacetin induce apoptosis in HepG2 Cells : Involvements of ROS and PI3K/Akt. Food and Chemical Toxicology, 2013, 51, 426-433.

(68) Yuan L., Wang J., Xiao H., Xiao C., Wang Y. and Liu X*. Isoorientin induces apoptosis through disordering mitochondrial function and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells. Toxicology and Applied Pharmacology, 2012, 265, 83-92

(69) Xiao H., Wang Y., Xiang Q., Xiao C., Yuan L., Liu Z. and Liu X*. Novel physiological properties of ethanol extracts from Eremurus chinensis Fedtsch. roots: in vitro antioxidant and anticancer activities. Food & Function, 2012, 3, 1310-1318.

(70) Xiang Q., Xiao H., Gao S., Wen M., Jia G., Ren X. and Liu X*. In vitro antioxidant properties of Rosa roxburghii aqueous extracts. Australian Journal of Crop Science, 2012, 6, 854–860.

(71) Liu, X., Shibata, T., Hisaka, S. and Osawa, T. Astaxanthin inhibits reactive oxygen species-mediated cellular toxicity in dopaminergic SH-SY5Y cells via mitochondria-targeted protective mechanism. Brain Research, 2009, 1254, 18-27.

(72) Liu, X., Yamada, N., Shibata, T., Maruyama, W. and Osawa, T., Formation of dopamine adducts derived from brain polyunsaturated fatty acid: Mechanism for Parkinson’s disease. Journal of Biological Chemistry, 2008, 283, 34887-34895.

(73) Liu, X., Shibata, T., Hisaka, S., Kawai, Y. and Osawa, T. DHA hydroperoxides as a potential inducer of neuronal cell death: A mitochondrial dysfunction- mediated pathway. Journal of Clinical Biochemistry and Nutrition, 2008, 43, 26-33.

(74) Liu, X., and Osawa, T., Cis astaxanthin and especially 9-cis astaxanthin exhibits a higher antioxidant activity in vitro compared to the all-trans isomer. Biochemical and Biophysical Research Communications, 2007, 357, 187-93.

(75) Liu, X., and Osawa, T., Astaxanthin Protects Neuronal Cells against Oxidative Damage and Is a Potent Candidate for Brain Food. Forum of Nutrition,2009,61, 129-135.

刘学波主讲本科生《食品营养学》及研究生《食品科学学科进展》等课程。

参考资料：^[1]

获奖情况获奖项目获奖人员2023年度陕西省自然科学奖一等奖膳食营养调节脑健康作用评价与机制探索刘学波，刘志刚，肖春霞，赵贝塔，原田，刘小宁^[2]