任立群

任立群 1963年2月出生，女，汉族，河北省涞水县人。教授，博士研究生导师。现任中华医学会地方病学分会第五届委员、《中华中西医杂志》专家编辑委员会常务编委等职。

1985年毕业于白求恩医科大学医疗系，1985年起在白求恩医科大学基础医学部攻读组织胚胎学硕士学位，1988年获医学硕士学位。1988年~1993年工作于大连医科大学附属二院病理科，于1991年晋升主治医师。1993年考入白求恩医科大学地方病研究所攻读博士学位，1996年获得博士学位。毕业后留校工作至今。期间于1997年至1998年间在日本爱知医科大学做外国人研究员，2002年赴加拿大Laval大学做博士后研究。1998年和1994年分别晋升为副教授和教授。

曾从事代谢性骨病、克山病的研究，研究过量氟fú对骨软化性氟骨症骨转换的影响及发病机理研究以及肠道病毒感染及其基因变异在克山病发病中的作用研究。1998起从事心血管病分子病理与药理学研究。先后利用培养动脉平滑肌细胞，从蛋白和基因水平探讨动脉粥样硬化时平滑肌细胞胶原代谢的规律及药物干预措施的作用机制；从细胞和分子水平探讨心肌纤维化发生的分子机制及其中药等的防治作用；利用大鼠心肌缺血-再灌注模型来模拟人类急性心肌梗死后的溶栓过程，从蛋白和基因水平探讨再灌注损伤与细胞凋亡的关系，并用葛根素进行干预，观察其在再灌注损伤中的作用，寻找安全有效、通过抑制细胞凋亡来挽救心肌的药物；已建立了心肌缺血-再灌注模型、抗动脉粥样硬化、抗心肌纤维化研究的实验方法及实验技术，能较系统进行本研究方向药物筛选及研究。

先后主持和参加了国家自然科学基金、吉林省科技发展计划重大项目、国家教委之留学归国人员启动基金等科研课题近10项，在国内外刊物发表学术论文40余篇。参编教材《疾病模型与实验病理学》、《疾病模型与实验病理学实验指导》。

(1) Huang P, Cheng H, Ji J, Zhang W, Ma J, Wei D, Ren L（*）. LncRNA Miat knockdown enhances pirarubicin-mediated anticancer sensitivity in breast cancer cells. Environ Toxicol. 2023 Online ahead of print.

(2) Huang P, Zhang W, Ji J, Ma J, Cheng H, Qin M, Wei D, Ren L（*）. LncRNA Miat knockdown protects against pirarubicin-induced cardiotoxicity by targeting miRNA-129-1-3p. Environ Toxicol. 2023 Online ahead of print.

(3) Huang P, Zhang Y, Wang F, Qin M, Ma J, Ji J, Wei D, Ren L（*）. MiR-494-3p aggravates pirarubicin-induced cardiomyocyte injury by regulating MDM4/p53 signaling pathway. Environ Toxicol. Online ahead of print.

(4) Ma J, Chen C, Fan Z, Zhang Y, Ji J, Wei D, Zhang F, Sun B, Huang P, Ren L（*）. CircEGFR reduces the sensitivity of pirarubicin and regulates the malignant progression of triple-negative breast cancer via the miR-1299/EGFR axis. Int J Biol Macromol. 2023 31;244:125295.

(5) Huang P, Wang F, Zhang Y, Zhang Y, Qin M, Ji J, Wei D, Ren L（*）. Icariin alleviates atherosclerosis by regulating the miR-205-5p/ERBB4/AKT signaling pathway. Int Immunopharmacol. 2023 ;114:109611.

(6) Ma J, Wang F, Chen C, Ji J, Huang P, Wei D, Zhang Y, Ren L（*）. Identification of prognostic genes signature and construction of ceRNA network in pirarubicin treatment of triple-negative breast cancer. Breast Cancer. 2023 ;30(3):379-392.

(7) Zhang Y, Ma J, Liu S, Chen C, Li Q, Qin M, Ren L（*）. Ginsenoside F1 attenuates pirarubicin-induced cardiotoxicity by modulating Nrf2 and AKT/Bcl-2 signaling pathways. J Ginseng Res. 2023;47(1):106-116.

(8) Ma J, Chen C, Liu S, Ji J, Wu D, Huang P, Wei D, Fan Z, Ren L（*）. Identification of a five genes prognosis signature for triple-negative breast cancer using multi-omics methods and bioinformatics analysis. Cancer Gene Ther. 2022 ;29(11):1578-1589.

(9) Huang P, Zhang Y, Wang F, Qin M, Ren L（*）. MiRNA-205-5p regulates the ERBB4/AKT signaling pathway to inhibit the proliferation and migration of HAVSMCs induced by ox-LDL. Pathol Res Pract. 2022 ;233:153858.

(10) Zhang Y, Liu S, Ma JL, Chen C, Huang P, Ji JH, Wu D, Ren LQ（*）. Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity through the AKT/Bcl-2 signaling pathway. Phytomedicine. 2022. 94:153815.

(11) Zhang Y, Li Q, Xu D, Li T, Gu Z, Huang P, Ren L（*）. Idarubicin-induced oxidative stress and apoptosis in cardiomyocytes: An in vitro molecular approach. Hum Exp Toxicol. 2021;40(12_suppl):S553-S562.

(12) Li Q, Xu D, Gu Z, Li T, Huang P, Ren L（*）. Rutin restrains the growth and metastasis of mouse breast cancer cells by regulating the microRNA-129-1-3p-mediated calcium signaling pathway. J Biochem Mol Toxicol. 2021;35(7):e22794.

(13) Zhang Y, Xu D, Huang P, Zhang Y, Li Q, Fan Z, Ren L（*）. Essential role of protein kinase C βI in icariin-mediated protection against atherosclerosis. J Pharm Pharmacol. 2021 12;73(9):1169-1179.

(14) Qin M, Li Q, Wang Y, Li T, Gu Z, Huang P, Ren L（*）. Rutin treats myocardial damage caused by pirarubicin via regulating miR-22-5p-regulated RAP1/ERK signaling pathway. J Biochem Mol Toxicol. 2021;35(1):e22615.

(15) Liu S, Xu DS, Ma JL, Huang P, Wu D, Ren LQ（*）. LncRNA H19 Mitigates Oxidized Low-Density Lipoprotein Induced Pyroptosis via Caspase-1 in Raw 264.7 Cells. Inflammation. 2021;44(6):2407-2418.

(16)Li Q, Qin M, Li T, Gu Z, Tan Q, Huang P, Ren L（*）. Rutin protects against pirarubicin-induced cardiotoxicity by adjusting microRNA-125b-1-3p-mediated JunD signaling pathway. Mol Cell Biochem. 2020;466(1-2):139-148.

(17) Zhang Y, Ma XY, Zhang T, Qin M, Sun B, Li Q, Hu DW, Ren LQ（*）. Protective Effects of Apocynum venetum Against Pirarubicin-Induced Cardiotoxicity. Am J Chin Med. 2019. 47(5):1.

(18) Lou X, Ma X, Wang D, Li X, Sun B, Zhang T, Qin M, Ren L（*）. Systematic analysis of long non-coding RNA and mRNA expression changes in ApoE-deficient mice during atherosclerosis. Mol Cell Biochem. 2019;462(1-2):61-73.

(19) Zhang Y, Li M, Li X, Zhang T, Qin M, Ren L（*）. Isoquinoline Alkaloids and Indole Alkaloids Attenuate Aortic Atherosclerosis in Apolipoprotein E Deficient Mice: A Systematic Review and Meta-Analysis. Front Pharmacol. 2018 5;9:602. 075-1097.

(20) Mu XP, Ren LQ, Yan HW, Zhang XM, Xu TM, Wei AH（*）, Jiang JL（*）. Enhanced differentiation of human amniotic fluid-derived stem cells into insulin-producing cells in vitro. J Diabetes Investig. 2017;8(1):34-43.

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