丁兆军

丁兆军，男，毕业于中国科学院植物研究所，现任是山东大学生命学院2011年新引进的“齐鲁学者”特聘教授。

主要从事植物激素尤其是生长素的极性运输和信号传导介导的植物生长发育的研究。

时间院校学位1994年-1998年聊城大学学士1998年-2003年中国科学院植物研究所博士

2004-2006，德国马普植物育种所，博士后。

2006-2011，比利时根特大学（PSB）VIB，博士后。

2004-2011年8月，先后在德国马普植物育种所和比利时根特大学博士后研究。

2011年9月至今，山东大学教授。^[1]

研究领域

生长素极性转运载体PIN基因家族的时空表达调控机理研究。

生长素的极性运输在单子叶植物的代表水稻和双子叶植物的代表拟南芥的比较性研究。

拟南芥和水稻根的干细胞和侧根发育调控的比较性研究。

植物激素和环境适应的生物学研究。^[1]

科研成果

1999-2003，在中国科学院植物研究所攻读博士，主要从事水稻花发育相关基因的分离和功能鉴定。通过筛选渐减法杂交的方法，分离到了水稻花药绒毡层特异基因R39和减数分裂相关基因OsDMC1,并对其功能进行了初步出分析。研究发现，RA39通过调控绒毡层的适时解体，参与水稻花粉的发育过程，部分结果于2002年已发表在Sex Plant Reprod杂志上。OsDMC1在水稻基因组中有两个拷贝而且是一个花优势表达基因，通过调控减数分裂，参与水稻花粉的发育过程，部分结果于2001年已发表在Sex Plant Reprod杂志上。^[1]

2004-2006，在德国马普植物育种所做博士后研究。主要以拟南芥为模式植物，从事生物钟的研究。通过图位克隆的方法，分离到了拟南芥中参与生物节律调节的关键基因TIME FOR COFFEE （TIC）并对其功能进行了深入地研究，部分结果于2007年已发表在Plant Cell杂志上。同时，我们通过遗传分析的方法，首次发现CIRCADIAN CLOCK ASSOCIATED 1 （CCA1）and LATE ELONGATED HYPOCOTYL （LHY）和TIMING OF CAB EXPRESSION 1 （TOC1）是拟南芥中最为关键的参与生物节律的中心调控基因，而且TOC1以不同的方式通过CCA1和LHY参与开花时间的调控，部分结果于2007年已发表在Genetics杂志上。

2007-2010，在比利时VIB（PSB, Gent）根特大学做博士后研究。主要从事生长素参与植物生长发育的研究。我们发现生长素除了参与植物细胞分裂的调控，还能促进植物干细胞的分化。对这一过程的分子机制也进行了较为深入地研究，部分结果于2010年已发表在PNAS杂志上，另外的结果目前在PNAS修改稿中。对于向光性的研究，我们首次证实，光信号通过对PINOID（PID）参与了对生长素极性转运蛋白PIN3磷酸化的调节，从而调控PIN3极性的光调控和向光性，部分结果已于2011年发表在Nat.Cell Bio。对于生长素极性调控的研究，我们首次证实，定位于endoplasmic reticulum （ER）的两个生长素极性转运蛋白PIN5和PIN8通过调控生长素向相反的方向转运，维持细胞内的生长素浓度，从而参与与植物生长发育的调节。通过定点突变的方法，对参与这一过程的分子机理也进行了较为深入地研究。部分结果已整理成论文，Nature Communication在修改中。

近日，生命科学学院植物细胞工程与种质创新教育部重点实验室丁兆军课题组与比利时根特大学Jiri Friml教授合作研究成果“ER-localized auxin transporter PIN8 regulates auxin homoeostasis and male gametophyte development in Arabidopsis”被《Nature Communications》（《自然通讯》）接收发表。该项研究成果山东大学为并列第一单位，得到了“齐鲁青年”学者启动基金的特别资助。

生长素的极性运输在调控植物生长发育过程中起着极其关键的作用。该研究首次发现生长素除了能够通过细胞与细胞之间的极性运输，还能够在细胞内部以极性运输的方式，横跨细胞内质网膜进行跨膜运输。该研究发现，细胞内部生长素极性运输载体PIN5和PIN8以拮抗的方式，调控生长素的极性运输和生长发育过程。^[1]

主要研究论文

1）Zhang C, Zhang M, Yan Z, Wang F, Yuan X, Zhao S, Zhang L, Tian H, Ding Z*.CO(2) is a key constituent of the plant growth-promoting volatiles generated by bacteria in a sealed system. Plant Cell Rep. 2020 Oct 3. doi: 10.1007/s00299-020-02610-3.

2）Kong X*, Zhang C, Zheng H, Sun M, Zhang F, Zhang M, Cui F, Lv D, Liu L, Guo S, Zhang Y, Yuan X, Zhao S, Tian H, Ding Z*. Antagonistic Interaction between Auxin and SA Signaling Pathways Regulates Bacterial Infection through Lateral Root in Arabidopsis. Cell Rep. 2020 Aug 25;32(8):108060.

3）Lv B, Hu K, Tian T, Wei K, Zhang F, Jia Y, Tian H, Ding Z*. The pre-mRNA splicing factor RDM16 regulates root stem cell maintenance in Arabidopsis. J Integr Plant Biol. 2020 Aug 13. doi: 10.1111/jipb.13006.

4）Yu Z, Duan X, Luo L, Dai S*, Ding Z*, Xia G*. How Plant Hormones Mediate Salt Stress Responses. Trends Plant Sci. 2020 Jul 13:S1360-1385(20)30204-1.

5）Sun XD, Yuan XZ, Jia Y, Feng LJ, Zhu FP, Dong SS, Liu J, Kong X, Tian H, Duan JL, Ding Z, Wang SG, Xing B. Differentially charged nanoplastics demonstrate distinct accumulation in Arabidopsis thaliana. Nat Nanotechnol. 2020 Sep;15(9):755-760.

6）Jia Y, Kong X, Hu K, Cao M, Liu J, Ma C, Guo S, Yuan X, Zhao S, Robert HS, Li C, Tian H, Ding Z*. PIFs coordinate shade avoidance by inhibiting auxin repressor ARF18 and metabolic regulator QQS. New Phytol. 2020 Jun 10. doi: 10.1111/nph.16732

7）Liu Y, Xu J, Guo S, Yuan X, Zhao S, Tian H, Dai S, Kong X*, Ding Z*. AtHB7/12 Regulate Root Growth in Response to Aluminum Stress. Int J Mol Sci. 2020 Jun 7;21(11):4080

8）Zhang ML, Huang PP, Ji Y, Wang S, Wang SS, Li Z, Guo Y, Ding Z, Wu WH, Wang Y. KUP9 maintains root meristem activity by regulating K+ and auxin homeostasis in response to low K. EMBO Rep. 2020 Jun 4;21(6):e50164.

9）Chen L, Huang XX, Zhao SM, Xiao DW, Xiao LT, Tong JH, Wang WS, Li YJ, Ding Z, Hou BK. IPyA glucosylation mediates light and temperature signaling to regulate auxin-dependent hypocotyl elongation in Arabidopsis. PNAS 2020 Mar 24;117(12):6910-6917.

10）Zhang F, Tao W, Sun R, Wang J, Li C, Kong X, Tian H, Ding Z*. PRH1 mediates ARF7-LBD dependent auxin signaling to regulate lateral root development in Arabidopsis thaliana. PLoS Genet. 2020 Feb 7;16(2):e1008044.

11）Feng LJ, Sun XD, Zhu FP, Feng Y, Duan JL, Xiao F, Li XY, Shi Y, Wang Q, Sun JW, Liu XY, Liu JQ, Zhou LL, Wang SG, Ding Z, Tian H, Galloway TS, Yuan XZ. Nanoplastics Promote Microcystin Synthesis and Release from Cyanobacterial Microcystis aeruginosa. Environ Sci Technol. 2020 Mar 17;54(6):3386-3394.

12）Lv B, Yu Q, Liu J, Wen X, Yan Z, Hu K, Li H, Kong X, Li C, Tian H, De Smet I, Zhang XS, Ding Z*. Non-canonical AUX/IAA protein IAA33 competes with canonical AUX/IAA repressor IAA5 to negatively regulate auxin signaling. EMBO J. 2020 Jan 2;39(1):e101515.

13）Chang J, Li X, Fu W, Wang J, Yong Y, Shi H, Ding Z, Kui H, Gou X, He K, Li J*. Asymmetric distribution of cytokinins determines root hydrotropism in Arabidopsis thaliana. Cell Res. 2019 Oct 10.

14）Wang H, Xu Y, Hong L, Zhang X, Wang X, Zhang J, Ding Z, Meng Z, Wang ZY, Long R, Yang Q, Kong F, Han L, Zhou C*. HEADLESS Regulates Auxin Response and Compound Leaf Morphogenesis in Medicago truncatula. Front Plant Sci. 2019 Aug 16;10:1024.

15)Jia Y, Tian H, Zhang S*, Ding Z*, Ma C*. GUN1-Interacting Proteins Open the Door for Retrograde Signaling. Trends Plant Sci. 2019 Oct;24(10):884-887

16)Lv B＃, Yan Z＃, Tian H*, Zhang X*, Ding Z*. Local Auxin Biosynthesis Mediates Plant Growth and Development. Trends Plant Sci. 2019, 24(1):6-9.

17)Zhang C, Zhang Y, Ding Z*, Bai Y*. Contribution of Microbial Inter-kingdom Balance to Plant Health. Mol Plant. 2019, 4;12(2):148-149.

18)Yang S, Yu Q, Zhang Y, Jia Y, Wan S*, Kong X*, Ding Z*. ROS: The Fine-Tuner of Plant Stem Cell Fate. Trends Plant Sci. 2018, 23(10):850-853.

19)Kong X#*, Li C#, Zhang F, Yu Q, Gao S, Zhang M, Tian H, Zhang J, Yuan X, Ding Z*. Ethylene promotes cadmium-induced root growth inhibition through EIN3 controlled XTH33 and LSU1 expression in Arabidopsis. Plant Cell and Environment. 2018, 41(10):2449-2462.

20)Zhang M, Lu X, Li CL, Zhang B, Zhang C, Zhang XS, Ding Z*. Auxin Efflux Carrier ZmPGP1 Mediates Root Growth Inhibition under Aluminum Stress. Plant Physiol. 2018 Jun;177(2):819-832.

21)Tian Y, Fan M, Qin Z, Lv H, Wang M, Zhang Z, Zhou W, Zhao N, Li X, Han C, Ding Z, Wang W, Wang ZY, Bai MY. Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor. Nat Commun. 2018 Mar 14;9(1):1063.

22)Kong X#, Liu G. #, Liu J. and Ding Z*. The Root Transition Zone: A Hot Spot for Signal Crosstalk. Trends Plant Sci. 2018, May;23(5):403-409.

23)Tian H#*, Lv B#, Ding T, Bai M*, Ding Z*. Auxin-BR Interaction Regulates Plant Growth and Development. Front Plant Sci., 2018, 18;8:2256-

24)Kong X, Tian H, Yu Q, Zhang F, Wang R, Gao S, Xu W, Liu J, Shani E, Fu C, Zhou G, Zhang L, Zhang X. and Ding Z*. PHB3 maintains root stem cell niche identity through ROS responsive AP2/ERF transcription factors in Arabidopsis. Cell Reports, 2018, 22(5):1350-1363.

25)Lv B, Tian H, Zhang F, Liu J, Lu S, Bai M, Li C. and Ding Z*. Brassinosteroids regulate root growth by controlling reactive oxygen species homeostasis and dual effect on ethylene synthesis in Arabidopsis PLOS Genetics, 2018, 14(1):e1007144..

26)Yang ZB#, Liu G#, Liu J, Zhang B, Meng W, Müller B, Hayashi KI, Zhang X, Zhao Z, De Smet I, Ding Z*. Synergistic action of auxin and cytokinin mediates aluminum-induced root growth inhibition inArabidopsis. EMBO Rep. 2017, 18(7):1213-1230.

27)Geng X, Horst WJ, Golz JF, Lee JE, Ding Z*, Yang ZB*. LEUNIG_HOMOLOG Transcriptional Co-repressor Mediates Aluminum Sensitivity through PECTIN METHYLESTERASE46-Modulated Root Cell Wall Pectin Methylesterification in Arabidopsis. Plant J. 2017 May;90(3):491-504.

28)Shin J, Sánchez-Villarrl A, Davis AM, Du SX, Berendzen KW, Koncz C, Ding Z, Li C, Davis SJ. The metabolic sensor AKIN10 modulates the Arabidopsis circadian clock in a light-dependent manner. Plant Cell Environ. 2017, 40(7):997-1008.

29)Yang Z#, He C#, Ma Y, Herde M, Ding Z*. Jasmonic acid enhances Al-induced root-growth inhibition. Plant Physiol. 2017 Feb;173(2):1420-1433.

30)Kong X. Tian H and Ding Z. Plant Hormone Signaling Mediates Plant Growth Plasticity in Response to Metal Stress. Mechanism of Plant Hormone Signaling under Stress, 2017, Volume 2: 223-235.

30)Sun Y, Mu C, Chen Y, Kong X, Xu Y, Zheng H, Zhang H, Wang Q, Xue Y, Li Z, Ding Z, Liu X*. Comparative transcript profiling of maize inbreds in response to long-term phosphorus deficiency stress. Plant Physiol Biochem. 2016, 109:467-481.

31)Liu G, Gao S, Tian H, WuW, Robert H and Ding Z*. Local transcriptional control of YUCCA regulates auxin promoted root-growth inhibition in response to aluminium stress in Arabidopsis. PLOS Genetics, 2016, 12(10):e1006360. doi: 10.1371/journal.pgen.1006360..

32)Yu Q, Tian H，Yue K and Ding Z*. A P-loop NTPase regulates quiescent center cell division and distal stem cell identity through the regulation of ROS homeostasis in Arabidopsis root. PLOS Genetics, 2016, 1;12(9):e1006175.

33)Kong X, Zhang L, Ding Z*. 26S Proteasome: Hunter and Prey in Auxin Signaling. Trends Plant Sci. 2016 Jul;21(7):546-8.

34)Yu Q, Liu J, Zheng H, Jia Y, Tian H*, Ding Z. Topoisomerase II-associated protein PAT1H1 is involved in the root stem cell niche maintenance in Arabidopsis thaliana. Plant Cell Rep. 2016, 35(6):1297-307.

35)Jiao Y#, Hamant O#, Ding Z#, Zhang XS*. Meristem Biology Flourishes Under Mt. Tai. Mol Plant. 2016, 9(8):1224-1227.

36)Kong X, Lu S, Tian H. and Ding Z*. WOX5 is shining in the root stem cell niche. Trends Plant Sci. 2015, Oct;20(10):601-3.

37)Jia Y, Tian H, Li H, Yu Q, Wang L, Friml J, Ding Z*. The Arabidopsis thaliana elongator complex subunit 2 epigenetically affects root development. J Exp Bot. 2015 Aug;66(15):4631-42.

38)Sun Y, Kong X, Li C, Liu Y, Ding Z*. Potassium Retention under Salt Stress Is Associated with Natural Variation in Salinity Tolerance among Arabidopsis Accessions. PLoS One. 2015 May 19;10(5):e0124032

39)Fan L, Li R, Pan J, Ding Z, Lin J. Endocytosis and its regulation in plants. Trends Plant Sci. 2015 (15)00081-3.

40)Zhang M, Kong X, Xu X, Li C, Tian H, Ding Z*. Comparative transcriptome profiling of the maize primary, crown and seminal root in response to salinity stress. PLoS One. 2015 Mar 24;10(3):e0121222.

41)Kong X, Zhang M, De Smet I and Ding Z*. Designer crops: optimal root system architecture for nutrient acquisition. Trends in Biotechnology. 2014, Dec;32(12):597-8.

42)Yang Z, Geng X, He C, Wang R, Zhang F, Horst W and Ding Z*. TAA1-regulated local auxin biosynthesis in the root-apex transition-zone mediates the aluminum-induced inhibition of root growth in Arabidopsis, Plant Cell. 2014, Jul;26(7):2889-904.

43)Kong X, Zhang M , Xu X, Li X, Li C and Ding Z*. System analysis of MicroRNAs in the development and aluminium-stress responses of the maize root system. , Plant Biotechnol J. 2014，Oct;12(8):1108-21.

44)Kong X, Zhang M, Ding Z*. D53: the missing link in strigolactone signaling. Mol Plant. 2014 May;7(5):761-3.

45)Tian H, De Smet I* and Ding Z*. Shaping a root system: regulating lateral versus primary root growth. Trends Plant Sci. 2014 Jul;19(7):426-31.

46)Tian H, Jia Y, Niu T, Yu Q and Ding Z*. The key players of the primary root growth and development also function in lateral roots in Arabidopsis. Plant Cell Rep. 2014, 33(5):745-753.

47)Le J, Liu XG, Yang KZ, Chen XL, Zou JJ, Wang HZ, Wang M, Vanneste S, Morita M, Tasaka M, Ding Z, Friml J, Beeckman T, Sack F. Auxin transport and activity regulate stomatal patterning and development. Nature Communications. 2014 Jan 27;5:3090.

48)Tian H, Wabnik K, Niu T, Li H, Yu Q, Pollmann S, Vanneste S, Govaerts W, Rolcík J, Geisler M, Friml J, Ding Z*.WOX5-IAA17 feedback circuit mediated cellular auxin response is crucial for the patterning of root stem cell niches in Arabidopsis. Mol Plant. 2014 Feb;7(2):277-289.

49)Tian H, Niu T, Yu Q, and Ding Z*. Auxin gradient is crucial for the maintenance of root distal stem cell identity in Arabidopsis. Plant Signaling & Behavior, 2013, Sep 20;8(12). pii: e26429.

50)Ding Z* and De Smet I*. Localised ABA signalling mediates root growth plasticity. Trends Plant Sci. 2013 Oct;18(10):533-535.

51)Alfredo SV, Jieun S, Nora B, Toshihiro O, Ulla N, Du SX, Ding Z, Davis A, Shindo T, Schmelzer E, Sulpice R, Nesi A, Stitt M, Fernie A, Davis S. TIME FOR COFFEE is an Essential Component in the Maintenance of Arabidopsis thaliana Metabolic Homeostasis. The Plant Journal.2013Oct;76(2):188-200.

52)Fan LS, Hao HQ, Xue YQ, Zhang L, Song K, Ding Z, Botella MA, Wang HY, Lin JX. Dynamic analysis of Arabidopsis AP2 σ reveals its key role in clathrin-mediated endocytosis and plant development, Development, 2013，140(18):3826-37.

53)Marhavý P, Vanstraelen M, De Rybel B, Ding Z, Bennett MJ, Beeckman T, Benková E. Auxin reflux between the endodermis and pericycle promotes lateral root initiation. EMBO J. 2013 Jan 9;32(1):149-58.

54)Ding Z, Wang B, Moreno I, Dupláková N, Simon S, Carraro N, Reemmer J, Pěnčík A, Chen X, Tejos R, Skůpa P, Pollmann S, Mravec J, Petrášek J, Zažímalová E, Honys D, Rolčík J, Murphy A, Orellana A, Geisler M, Friml J. ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis. Nature Communications.2012Jul3;3:941-947.

55)Ding Z, Carlos S. Galván Ampudia, Emilie Demarsy, Lukasz .angowski, Jürgen Kleine-Vehn,Yuanwei Fan, Miyo T. Morita, Masao Tasaka, Christian Fankhauser, Remko Offringa and Jirí Friml. Light-mediated polarization of auxin transport for phototropic response in Arabidopsis. Nat Cell Biology.2011Apr;13(4):447-52.

560 Kleine-Vehn J, Ding Z, Angharad R. Jones, Masao Tasaka, Miyo T. Gravity-induced PIN transcytosis for polarization of auxin fluxes in gravity-sensing root cells. PNAS,2010,107(51):22344-9.

57)Ding Z and Friml J. Auxin regulates distal stem cell differentiation in Arabidopsis roots. PNAS, 2010,107(26):12046-51.

58)Zádníková P, Petrásek J, Marhavy P, Raz V, Vandenbussche F, Ding Z, Schwarzerová K, Morita MT, Tasaka M, Hejátko J, Van Der Straeten D, Friml J, Benková E.　Role of PIN-mediated auxin efflux in apical hook development of Arabidopsis thaliana. Development,2010,137(4):607-17.

59)Ding Z, Millar AJ, Davis AM, Davis SJ. TIME FOR COFFEE encodes a nuclear regulator in the Arabidopsis thalianacircadian clock. Plant Cell,2007,19(5):1522-36.

60)Ding Z, Doyle MR, Amasino RM, Davis SJ.A complex genetic interaction between Arabidopsis thaliana TOC1 and CCA1/LHY in driving the circadian clock and in output regulation.Genetics,2007,176(3):1501-10.(Issue highlighted paper).

61)Ding Z, Deng Z, Tao J, Zhang L and Wang T.The molecular mechanism of chromosome segregation. Chinese Science Bulletin,2003,47(4)2014-2021.

62)Wang T, Ding Z. The Research Development of Genes about Meiosis. Chinese Science Bulletin,2002, 47(4)241-248.

63)Ding Z, Wu X and Wang T. The Rice Tapetum-specific Gene RA39 Encodes a TypeI Ribosome-inactivating Protein. Sex Plant Reprod, 2002, 15:205-212.

64)Ding Z,Wang T, Chong K and Bai S.Isolation and Characterization of OsDMC1,the Rice Homologue of the Yeast DMC1 Gene Essential for Meiosis. Sex Plant Reprod,2001,13:285-288.^[1]

时间奖项全称具体奖项颁发机构2020年自然科学奖一等奖山东省2020年农业科学院科学技术奖一等奖山东省