张永清

张永清，曾任中国科学院前沿科学与教育局副局长。^[1]

1985年获武汉华中农业大学学士学位。

1991年获北京农业大学（现中国农业大学）博士学位。

1992－1993在中国科学院微生物研究所作博士后。

1994年在荷兰Wageningen大学作访问学者。

1995-1997年在英国剑桥大学作博士后。

1998-2003年先后在美国尤他大学和Vanderbilt大学作博士后和访问学者。

曾任中国科学院前沿科学与教育局副局长。^[1]

利用传统的模式动物果蝇进行神经生物学的基础应用研究。

1）以果蝇为材料，用分子、细胞、遗传、发育和神经生物学为主要实验检测手段研究神经系统的结构和功能。

2）以果蝇为模式动物研究人类重要神经疾病包括智力低下的分子遗传机制，从而为这类疾病的预防和治疗提供理论依据，同时为神经系统的正常发育和功能提供新的见解。

1. Yong Q. Zhang, David Friedman, Zhe Wang, Elvin Woodruff III, Luyuan Pan, Janis

O’Donnell and Kendal Broadie,Protein Expression Profiling of the Drosophila Fragile

X Mutant Brain Reveals Upregulation of Monoamine Synthesis. Molecular and Cellular

Proteomics, 4(3)278-290, 2005

2. Yong Q. Zhang and Kendal Broadie. Fathoming fragile X in fruit flies. Trends in

Genetics, 21(1):37-45, 2005

3. Luyuan Pan, Yong Q. Zhang, Elvin Woodruff and Kendal Broadie . The Drosophila

fragile X gene negatively regulates neuronal elaboration and synaptic differentiation.

Current Biology 14:1863-1870, 2004

4. Yong Q. Zhang, Heinrich J. G. Matthies, Joel Mancuso, Hillary K. Andrews, Elvin

Woodruff, III , David Friedman and Kendal Broadie. The Drosophila fragile X-related

gene regulates axoneme differentiation during spermatogenesis. Developmental

Biology 270(2): 290-307, 2004

5. Hillary Andrews, Yong Zhang, Nick Trotta and Kendal Broadie. Drosophila Sec10 is

required for hormone secretion but not general exocytosis or neurotransmission.

Traffic 3(12): 906-921, 2002

6. Yong Zhang, Christopher Rodesch and Kendal Broadie. A living synaptic vesicle

marker: synaptotagmin-GFP. Genesis: the journal of genetics and development

34: 142-145, 2002

7. Yong Zhang, Adina M. Bailey, Heinrich J. G. Matthies, Robert B. Renden, Mark A.

Smith, Sean D. Speese, Gerald M. Rubin and Kendal Broadie. Drosophila fragile X

related gene regulates the MAP1B homolog Futsch to control synaptic structure and

function. Cell 107: 591-603, 2001

8. Yong Zhang, David Featherstone, Warren Davis, Emma Rushton and Kendal Broadie.

Drosophila D-Titin is required for myoblast fusion and skeletal muscle striation.

Journal of Cell Science 113: 3101-3115, 2000

9. Yong Zhang, John Roote, Saverio Brogna, Andrew W. Davis, Daniel A. Barbash,

David Nash and Michael Ashburner. stress sensitive B encodes an adenine

nucleotide translocase in Drosophila melanogaster. Genetics 153 (2): 891-903, 1999

获得美国FRAXA Research Foundation（2001-2002）和 Vanderbilt大学Kennedy Center for Research on Human Development（2003）的研究奖。