陈清西(1959.2— )龙海人,厦门大学教授,博士生导师。1985年1月毕业于厦门大学生物系生化专业,获硕士学位,毕业后留校任教。1997年考取清华大学生物物理学在职博士,1999年7月毕业获得清华大学理学博士学位。2000年1月至2002年2月在美国加州Berkeley大学工作2年。现任厦门大学生物学系生物化学教研室主任,厦门大学生命科学院生化与分子生物学研究所所长。厦门大学生命科学学院学术委员会、学位委员会成员;中国生物化学与分子生物学学会蛋白质专业学术委员会委员;酶学专业学生委员会委员;中国农业生物化学与分子生物学理事;福建省生物化学与分子生物学学会副理事长;厦门市农业学会常务理事;《厦门大学学报(自然科学版)》、《中国生物化学与分子生物学学报》编委;福建省重点学科“生化与分子生物学”学术带头人。2003年入选教育部跨世纪人才。主要从事分子酶学机理及其应用的研究。
人物履历
1985.1毕业厦门大学生物化学专业,硕士学位;
1999.7毕业清华大学生物化学与分子生物学专业,理学博士学位;
2000.1~2002.2在美国加州Berkeley大学工作2年。
1998年至今,厦门大学生命科学学院,教授;
研究方向
主要贡献
主持或参加国家自然科学基金7项,省市基金5项,发表研究论文228篇,其中在国际SCI源学术刊物发表92篇。近5年发表研究论文83篇,其中SCI论文39篇(JCR一区16篇、二区7篇),申请9个专利,其中8个已获得证书。
1. Huang GF, Wu XB*, Bai LP, Liu K, Jiang LJ, Long MN, Chen QX*. Improved O2-tolerance in variants of a H2-evolving [NiFe]-hydrogenase from Klebsiella oxytoca HP1.FEBS Lett.2015, 589(8): 910-8.
2. Gui-Li Huang1, Wei Zhang2, Hong-Yue Ren3, Xue-Ying Shen1, Qing-Xi Chen*and Dong-Yan Shen*. Retinoid X receptor α enhances human cholangiocarcinoma growth through simultaneous activation of Wnt/β-catenin and nuclear factor-kB pathways.Cancer Science. 2015, 106(11): 1515–1523.
3. Cui Y, Liang G, Hu YH, Shi Y, Cai YX, Gao HJ, Chen QX, Wang Q*. Alpha-substituted derivatives of cinnamaldehyde as tyrosinase inhibitors: inhibitory mechanism and molecular analysis.J. Agric. Food Chem. 2015, 63(2): 716–722.
4. Feng Yu, Yu-Long Jia, Hui-Fang Wang, Jing Zheng, Yi Cui, Xin-Yu Fang, Lin-Min Zhang, and Qing-Xi Chen*. Synthesis of Triazole Schiff's Base Derivatives and Their Inhibitory Kinetics on Tyrosinase Activity.PLoS One. 2015, 10(9): e0138578.
5. Wei Song, Ling Tian, Shan-Shan Li, Dong-Yan Shen, Qing-Xi Chen. The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz-ChA-1 cells.FEBS Letters. 2014, 588(3): 422–428.
6. Zhizhen Pan, Lian Xu, Yujing Zhu, Huai Shi, Zheng Chen, Meichun Chen, Qingxi Chen*,Bo Liu*. Characterization of a new cry2Ab gene of Bacillus thuringiensis with high insecticidal activity against Plutella xylostella L.World Journal of Microbiology and Biotechnology. 2014, 30(10): 2655-2662.
7.Apoptosis Induced by Aqueous Extracts of Crocodile Bile in Human Heptacarcinoma SMMC-7721.Wei Song, Shan-Shan Li, Ping-ping Qiu, Dong-Yan Shen, Ling Tian, Qiu-Yan Zhang, Long-Xing Liao, Qing-Xi Chen*.Applied Biochemistry and Biotechnology. 2013, 170(1): 15-24.
8. Huang GL1, Luo Q, Rui G, Zhang W, Zhang QY, Chen QX, Shen DY*. Oncogenic Activity of Retinoic Acid Receptor γ Is Exhibited through Activation of the Akt/NF-κB and Wnt/β-Catenin Pathways in Cholangiocarcinoma.Mol Cell Biol. 2013, 33(17): 3416-25.
9. Huang QS, Xie XL, Liang G, Gong F, Wang Y, Wei XQ, Wang Q, Ji ZL, Chen QX*. The GH18 Family of Chitinases: their domain architectures, functions, and evolutions.Glycobiology. 22: 23-34, 2012. (*Corresponding author).
10. Chai WM, Shi Y, Feng HL, Qiu L, Zhou HC, Deng ZW, Yan CL, Chen QX*. NMR, HPLC-ESI-MS, and MALDI-TOF MS analysis of condensed tannins from (Bojer ex Hook.) Raf. and their bioactivities.J Agric Food Chem.2012, 60: 5013-5022.
11. Pan ZZ , Li HL , Yu XJ , Zuo QX , Zheng GX , Shi Y, Liu X, Lin YM , Liang G, Wang Q, Chen QX*. Synthesis and Antityrosinase Activities of Alkyl 3,4-Dihydroxybenzoates.J Agric Food Chem. 2011, 59: 6645-6649.
12. Zhang JP, Hu YH, Wang Q, Wang W, Wang Y, Yan JH, Chen QX*. Inhibitory kinetics of β-N-Acetyl-D-glucosaminidase from green crab (Scylla Serrata) by Zinc ion.J Agric Food Chem. 2010, 58: 8763-8767.
13. Huang QS, Yan JH, Tang JY, Tao YM,Xie XL, Wang Y, Wei XQ, Yan QH, Chen QX*. Cloning and tissue expressions of seven chitinase family genes in L. vannamei.Fish Shellfish Immunol. 2010, 29: 76-82.
14. Han P, Kang JH, Li HL, Hu SX, Lian HH, Qiu PP, Zhang J, Li WG, Chen QX*. Antiproliferation and apoptosis induced by tamoxifen in human bile duct carcinoma QBC939 cells via upregulated p53 expression.Biochem Biophys Res Commun. 2009, 385: 251-256.