邹卫国

邹卫国，1994-1998年，南开大学生物化学系，理学学士。1998-2003年，中国科学院生物化学与细胞生物学研究所，理学博士。2003年-2007年，美国Scripps研究所，博士后。2007-2012年，美国哈佛大学公共卫生学院，博士后，Yerby Fellow。2012年8月起，在中国科学院生物化学与细胞生物学研究所任研究员，研究组长。^[1]

研究方向：骨发育及相关衰老与疾病的分子基础骨质疏松症引起的骨折，是老龄化社会里非常普遍的公共健康问题。50岁以上人群，大约55%罹患骨质疏松症。骨质疏松症的起因是骨的代谢平衡异常。骨的代谢主要涉及两类细胞，一是成骨细胞（Osteobalst），来源于间充质干细胞，负责形成新的骨组织，二是破骨细胞（Osteoclast），来源于骨髓造血干细胞，负责吸收（降解）旧的骨组织。正常成年人体内，骨的形成和吸收是一个不断循环、动态平衡的过程。骨的代谢平衡异常，导致多种疾病，包括骨质疏松症、先天性骨发育畸形、骨性关节炎等。本研究组主要研究成骨细胞、破骨细胞的分化和功能，研究成骨细胞和破骨细胞之间的动态平衡及相互影响，希望能综合运用多种体内体外研究手段，为治疗骨质疏松症等骨发育相关疾病提供新的思路和靶位点。 

代表论著：Zou, W., Chen, X., Shim, J.H., Huang, Z., Brady N., Hu, D.Z, Drapp, R., Sigrist, K., Glimcher, L.H. and Jones, D.C. (2011) The E3 ubiquitin ligase Wwp2 regulates craniofacial development through monoubiquitination of Goosecoid. Nature Cell Biology. 13, 59–65.Zou, W.*, Greenblatt, M.B.* (*co-first author), Shim, J.H., Kant, S., Zhai, B., Brady, B., Hu, D.Z., Gygi, S.P., Davis, R., Jones, D.C. and Glimcher, L.H. (2011) MLK3 regulates bone development downstream of the Faciogenital Dysplasia protein FGD1. J Clin Invest. 121, 4383-92.Wan, L.*, Zou, W.* (*co-first author), Gao, D., Inuzuka, H., Drapp, R., Shaik, S., Eguren, M., Hu, D.Z., Malumbres, M., Glimcher L.H. and Wei W. (2011) Cdh1 Regulates Osteoblast functions through an APC/C-independent modulation of Smurf1. Molecular Cell. 44, 721-33.Greenblatt, M.B., Shim, J.H., Zou, W., Sitara, D., Schweitzer, M., Hu, D., Lotinun, S., Sano, Y., Baron, R., Park, J.M., Arthur, S., Xie, M., Schneider, M.D., Zhai, B., Gygi, S., Davis, R., Glimcher, L.H. (2010) The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest. 120, 2457-73.Shim J,H., Greenblatt, M.B., Xie, M., Schneider, M.D., Zou, W., Zhai, B., Gygi, S., Glimcher, L.H. (2009) TAK1 is an essential regulator of BMP signalling in cartilage. EMBO J. 28, 2028-41.Zou, W., Kim, J.H., Handidu, A., Li, X., Kim, K.I., Yan, M., Li, J., Zhang D.E. (2007). Microarray analysis reveals that Type I interferon strongly increases the expression of immune-response related genes in Ubp43 (Usp18) deficient macrophages. Biochem Biophys Res Commun. 356, 193-9.Zou,W., Wang, J., and Zhang,D.E. (2007). Negative regulation of ISG15 E3 ligase EFP through its autoISGylation. Biochem Biophys Res Commun., 354, 321-327.Okumura, F., Zou, W., and Zhang, D.E. (2007).ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP. Genes Dev., 21, 255 – 260.Malakhova, O.A., Kim, K.I., Luo, J.K., Zou, W., Kumar, K.G., Fuchs, S.Y., Shuai, K., Zhang, D.E. (2006) UBP43 is a novel regulator of interferon signaling independent of its ISG15isopeptidase activity. EMBO J. 25, 2358-2367.Zou,W. and Zhang,D.E. (2006). The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase. J Biol. Chem. 281, 3989-3994.Kim, K.I., Yan, M., Malakhova, O., Luo, J.K., Shen, M.F., Zou, W., de la Torre, J.C., Zhang, DE. (2006). Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling. Mol Cell Biol. 26, 472-479.Zou,W., Papov,V., Malakhova,O., Kim,K.I., Dao,C., Li,J., and Zhang,D.E. (2005). ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin. Biochem. Biophys. Res. Commun. 336, 61-68.Liu, X., Qiu, S., Zou, W., Pei, Z., Gu, J., Luo, C., Ruan, H., Chen, Y., Qi, Y., Qian, C.. (2005) Effective gene-virotherapy for complete eradication of tumor mediated by the combination of hTRAIL (TNFSF10) and plasminogen k5. Mol Ther. 11, 531-541.Zhang, Z., Zou, W., Wang, J., Gu, J., Dang, Y., Li, B., Zhao, L., Qian, C., Qian, Q., Liu, X. (2005) Suppression of tumor growth by oncolytic adenovirus-mediated delivery of an antiangiogenic gene, soluble Flt-1. Mol Ther. 11, 553-562.Zou,W., Luo,C., Zhang,Z., Liu,J., Gu,J., Pei,Z., Qian,C., and Liu,X. (2004). A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent antitumoral efficiency. Oncogene23, 457-464.Xu, W., Yu, F., Yan, M., Lu, L., Zou, W., Sun, L., Zheng, Z., Liu, X. (2004). Geldanamycin, a heat shock protein 90-binding agent, disrupts Stat5 activation in IL-2-stimulated cells. J Cell Physiol. 198, 188-96.Pei, Z., Chu, L., Zou, W., Zhang, Z., Qiu, S., Qi, R., Gu, J., Qian, C., Liu, X. (2004) An oncolytic adenoviral vector of Smac increases antitumor activity of TRAIL against HCC in human cells and in mice. Hepatology. 39, 1371-1381.Zhang, Z*, Zou,W* (*co-first author), Luo,C., Li,B., Wang,J., Sun,L., Qian,Q., and Liu,X. (2003). An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy. Cell Res. 13, 481-489.Zou,W*., Zeng,J.* (*co-first author), Zhuo,M., Xu,W., Sun,L., Wang,J., and Liu,X. (2002). Involvement of caspase-3 and p38 mitogen-activated protein kinase in cobalt chloride-induced apoptosis in PC12 cells. J Neurosci. Res. 67, 837-843.Zou,W., Wang,D., Lang,M., Jin,D., Xu,D., Zheng,Z., Wu,Z., and Liu,X. (2002). Human interleukin 10 gene therapy decreases the severity and mortality of lethal pancreatitis in rats. J Surg. Res. 103, 121-126.Liu,J., Zou,W., Lang,M., Luo,J., Sun,L., Wang,X., Qian,Q., and Liu,X. (2002). Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter. Int. J Oncol. 21, 661-666.Zou,W., Yan,M., Xu,W., Huo,H., Sun,L., Zheng,Z., and Liu,X. (2001). Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP-1 activation. J Neurosci. Res. 64, 646-653.