薛雷

薛雷，北京大学生物系学士，中国科学院上海细胞生物学研究所硕士，瑞士苏黎世大学分子生物学研究所博士，美国耶鲁大学医学院博士后。历任耶鲁大学医学院副研究员 (Associate Research Scientist)，霍华德修斯医学研究院 (Howard Hughes Medical Institute) 研究专家 (Research Specialist)，自2008年9月起任同济大学生命科学与技术学院教授，博导，首席科学家。^[1]

1.肿瘤发生的分子遗传学机制

The molecular and genetic mechanism of tumorigenesis.

2. 细胞凋亡的分子生物学机制

The molecular mechanism of apoptosis.

3.阿尔茨海默病的分子生物学机制

The molecular mechanism of Alzheimer's disease.

4.Pax基因对胚胎发育和器官形成的调控作用及机制

Genetic regulation of embryonic development and organogenesis by Pax genes.

5.治疗肿瘤迁移和神经退行性疾病的中药筛选

A screen for Chinese herbal medicines against tumor metastasis and neurodegenerative diseases.

JNK信号通道在细胞增殖、迁移、凋亡、应激反应和个体衰老中起着至关重要的作用，其失调可导致发育缺陷和过早衰老，并和肿瘤发生和迁移、免疫失调、阿尔兹海默症及多种重要疾病的发生与发展密切相关。

以果蝇为模式动物进行遗传筛选，找到了JNK信号通道上30多个新的基因，已分析鉴定其中部分基因，成果发表在DevelopmentalCell和Science等国际顶级学术杂志。我们将继续研究其余的基因，探索它们在JNK信号通道中的分子功能，阐明其在细胞凋亡、个体衰老、癌症及阿尔兹海默症中的作用机制。

选择是一种行为，也代表着智慧，其调控分子和作用机制仍有待破解。利用果蝇的择偶方式和取向，研究选择的分子机制以及调控选择的遗传因素。

还建立了癌症和阿尔兹海默症的果蝇模型，并利用这些疾病模型筛选和检验各类中药成分对延缓衰老、治疗癌症和老年痴呆症等疾病的效果。

1.S Zhang, X Guo, H Wu, Y Sun, X Ma, J Li, Q Xu, C Wu, Q Li, C Jiang, W Li, MS Ho, Z Lv, and L Xue* (2019) Wingless modulates activator protein-1-mediated tumor invasion. Oncogene. doi: 10.1038/s41388-018-0629-x

2.Y Sun, D Zhang, X Guo, W Li, C Li, J Luo, M Zhou and L Xue* (2019) MKK3 modulates JNK-dependent cell migration and invasion. Cell Death Dis. 10:149.

3.Y Sun, D Zhang, C Li, J Huang, W Li, Y Qiu, A Mao, M Zhou and L Xue* (2019) Lic regulates JNK‐mediated cell death in Drosophila. Cell Proliferation. e12593

4.X Ma, X Guo, HE Richardson, T Xu and L Xue* (2018) POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation. PNAS115:2150-2155.

5.X Wang, X Huang, C Wu and L Xue* (2018) Pontin/Tip49 acts as a novel regulator of JNK pathway. Cell Death Disease9: 978.

6.X Wang, X Huang, C Wu and L Xue* (2018) Pontin/Tip49 negatively regulates JNK-mediated cell death in Drosophila.Cell Death Discov.4:74.

7.X Wang, X Guo, Y Ma, C Wu, W Li and L Xue* (2018) APLP2 Modulates JNK-Dependent Cell Migration in Drosophila. BioMed Research International: Article ID **.

8.X Ma, H Wang, J Ji, W Xu, Y Sun, W Li, X Zhang, J Chen and L Xue* (2017) Hippo Signaling Promotes JNK-dependent Cell Migration. PNAS114:1934-1939.

9.X Ma, J Huang, Y Tian,Y Chen, Y Yang, X Zhang*, F Zhang*and L Xue*(2017) Myc Suppresses Tumor Invasion and Cell Migration by inhibiting JNK Signaling. Oncogene36：3159-3167

10.X Wang, Y Sun, S Han, C Wu, Y Ma, Y Zhao, Y Shao, Y Chen, L Kong, W Li, F Zhang, L Xue*(2017) Amyloid precursor like protein-1 promotes JNK-mediated cell migration in Drosophila. Oncotarget8:49725-49734.

11.J Huang, Y Feng, X Chen, W Li and L Xue* (2017) Myc inhibits JNK-mediated cell death in vivo. Apoptosis22:479-490

12.P Ren, W Li and L Xue* (2017) GLYAT regulates JNK-mediated cell death in Drosophila.Scientific Reports7:5183.

13.L Zhuang, Y Sun, M Hu, C Wu, X La, X Chen, Y Feng, X Wang, Y Hu*and L Xue*(2016) Or47b plays a role in Drosophila males’ preference for younger mates. Open Biology6: 160086.

14.S Zhang, X Guo, C Chen, Y Chen, J Li, Y Sun, C Wu, Y Yang, C Jiang, W Li* and L Xue*(2016) dFoxO promotes Wingless signaling in Drosophila. Scientific Reports6:22348.

15.X Ma, Y Chen, S Zhang, W Xu, Y Shao, Y Yang, W Li, M Li*and L Xue* (2016) Rho1–Wnd signaling regulates loss-of-cell polarity-induced cell invasion in Drosophila.Oncogene35, 846–855.

16.X Ma, Y Chen, W Xu, N Wu, M Li, Y Cao, S Wu, Q Li and L Xue* (2015) Impaired Hippo signaling promotes Rho1-JNK-dependent growth. PNAS112:1065-70.

17.C Wu, Y Chen, F Wang, C Chen, S Zhang, C Li, W Li, S Wu and L Xue* (2015) Pelle Modulates dFoxO-Mediated Cell Death in Drosophila. PLOS Genetics11:e**.

18.F Peng, Y Zhao, X Huang, C Chen, L Sun, L Zhuang and L Xue* (2015) Loss of Polo ameliorates APP-induced Alzheimer’s disease-like symptoms in Drosophila. Scientific Reports5:16816/DOI: 10.1038/srep16816.

19.Y Hu, Y Han, Y Shao, X Wang, Y Ma, E Ling and L Xue* (2015) Gr33a Modulates Drosophila Male Courtship Preference. Scientific Reports5:7777

20.X Ma, W Xu, D Zhang, Y Yang, W Li and L Xue*(2015) Wallenda regulates JNK-mediated cell death in Drosophila. Cell Death Disease6, e1737.

21.S Zhang, C Chen, C Wu, Y Yang, W Li and L Xue*(2015) The canonical Wg signaling modulates Bsk-mediated cell death in Drosophila. Cell Death Disease6, e1713.

22.C Wu, C Chen, J Dai, F Zhang, Y Chen, W Li, J Pastor-Pareja and L Xue*(2015) Toll pathway modulates TNF-induced JNK-dependent cell death in Drosophila. Open Biology5: 140171

23.L Li, P Li and L Xue* (2015) The RED domain of Paired is specifically required for Drosophila accessory gland maturation. Open Biology5: 140179

24.J Huang and L Xue*(2015) Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila. BioMed Research International: Article ID 623573.

25.X Wang, Y Ma, Y Zhao, Y Chen, Y Hu, C Chen, Y Shao and L Xue* (2015) APLP1 promotes dFoxO-dependent cell death in Drosophila. Apoptosis 20, 778-786.

26.X Wang, Z Wang, Y Chen, X Huang, Y Hu, R Zhang, M S Ho and L Xue* (2014）FoxO Mediates APP-Induced AICD-Dependent Cell Death. Cell Death Disease5, e1233.

27.Y Hu, Y Han, X Wang and L Xue* (2014) Aging-related Neurodegeneration Eliminates Male Courtship Choice in Drosophila. Neurobiology of Aging35, 2174-2178.

28.X Ma, W Li, H Yu, Y Yang, M Li, L Xue*and T Xu* (2014) Bendless modulates JNK-mediated cell death and migration in Drosophila. Cell Death Diff.21, 407-415.

29.H Yang, W Li, H Yu, R Yuan, Y Yang, K Pung, P Li and L Xue*(2013) Physiological Effects of L-Theanine on Drosophila melanogaster. Molecules18,13175-13187.

30.X Ma, Y Shao, H Zheng, M Li, W Li* and L Xue* (2013) Src42A modulates tumor invasion and cell death via Ben/dUev1a-mediated JNK activation in Drosophila. Cell Death Disease 4, e864.

31.X Ma, L Yang, Y Yang, M Li, W Li* and L Xue* (2013) dUev1aModulates TNF-JNK Mediated Tumor Progression and Cell Death in Drosophila. Dev. Biol.380, 211-221.

32.W Li, S Li, S Zhang and L Xue* (2012) A Broad Expression Profile of the GMR-GAL4 driver in Drosophila melanogaster. Genet. Mol. Res.11, 1997-2002.

33.X Ma, J Huang, YYang, W Li and L Xue* (2012) NOPO Modulates Egr- induced JNK- independent cell death in Drosophila. Cell Research22, 425-431.^[2]

胡雨佳,薛雷.雄性果蝇求偶选择的神经机制[J].科学,2014,66(05):35-37+4.陈怡,薛雷.果蝇——小昆虫的大成就[J].自然杂志,2013,35(06):431-435.黄玖红,马仙珏jué,薛雷.Myc suppresses tumor metastasis by inhibiting JNK pathway[A].中国细胞生物学学会（Chinese Society for Cell Biology）.细胞—生命的基础——中国细胞生物学学会2013年全国学术大会·武汉论文摘要集[C].中国细胞生物学学会（Chinese Society for Cell Biology）:中国细胞生物学学会,2013:128-129.黄玖红,薛雷.Inhibition of JNK Signaling pathway by MYC Oncoprotein[A].中国生物化学与分子生物学会(The Chinese Society of Biochemistry and Molecular Biology).生命的分子机器及其调控网络——2012年全国生物化学与分子生物学学术大会摘要集[C].中国生物化学与分子生物学会(The Chinese Society of Biochemistry and Molecular Biology):中国生物化学与分子生物学会,2012:142.张柿平,薛雷.黑腹果蝇细胞谱系分析方法进展[J].遗传,2012,34(07):28-37.马仙珏,薛雷.双亮氨酸拉链激酶DLK对JNK信号通路的调控作用及机制[J].遗传,2010,32(08):785-790.李莉,杨杨,薛雷.Pax基因家族在果蝇发育过程中的调控作用[J].遗传,2010,32(02):115-121.^[3]