焦宁

焦宁，男，汉族，出生于山东，现任北京大学药学院教授、博士生导师、长江学者奖励计划特聘教授。他的研究领域包括绿色化学、地球丰产过渡金属催化以及基于内源性物质进行先导药物发现的绿色方法。焦宁教授致力于寻找生物活性分子合成新途径和新方法，利用简单原料和高效的合成方法为先导药物发现和构效关系研究服务。他曾在山东大学获得学士学位，后在上海有机化学研究所获得博士学位（导师为麻生明院士）。焦宁教授曾获得国家杰出青年科学基金，并于2021年9月荣获第三届“科学探索奖”。

时间院校专业学位1995-1999山东大学化学院化学学士1999-2004中科院上海有机化学研究所有机化学博士

2012-至今天然药物及仿生药物国家重点实验室副主任。

2010-至今教授，北京大学药学院，课题组长。

2007-2010副教授，北京大学药学院，课题组长。

2004-2006化学生物学博士后，洪堡奖学金，德国马普煤炭研究所。^[1]

研究领域

1）绿色化学：氧气氧化与活化，氧合反应（Oxygenation Reactions），氮合反应（Nitrogenation Reactions）。

2）地球丰产过渡金属催化。

3）基于内源性物质进行先导药物发现，通过可控自由基反应、惰性键活化、串联催化等过程寻求生物活性分子合成新途径、新方法，利用简单原料以简洁、高效的合成方法为先导药物发现及构效关系研究服务。

论文

1. Xiaoqiang Huang, Xinyao Li, Miancheng Zou, Song Song, Conghui Tang, Yizhi Yuan, andNing Jiao*, From Ketones to Esters by a Cu-Catalyzed Highly Selective C(CO)-C(alkyl) Bond Cleavage: Aerobic Oxidation and Oxygenation with Air,J. Am. Chem. Soc.2014,136, 14858-14865.

2. Feng Chen, Xiaoqiang Huang, Xinyao Li, Tao Shen, Miancheng Zou, andNing Jiao*, Dehydrogenative N-Incorporation: A Direct Approach to Quinoxaline N-Oxides under Mild Conditions,Angew. Chem. Int. Ed.2014, 53,10495-10499.

3. Conghui Tang andNing Jiao*, Copper-Catalyzed Aerobic Oxidative C−C bond Cleavage for C−N Bond Formation: From Ketones to Amides,Angew. Chem. Int. Ed.2014,53,6528-6532. (Hot Paper).

4. Yu-Feng Liang andNing Jiao*,Transition-Metal Free Highly Efficient C-H Hydroxylation of Carbonyls with Molecular Oxygen Under Mild Conditions,Angew. Chem. Int. Ed.2014,53, 548.

5. Chun Zhang, Peng Feng andNing Jiao*, Cu-Catalyzed Esterification Reaction via Aerobic Oxygenation and C-C Bond Cleavage: An Approach toα-Ketoesters,J. Am.Chem. Soc.2013,135, 15257–15262.

6. Teng Wang andNing Jiao*, TEMPO-catalyzed Aerobic Oxygenation and Nitrogenation of Olefins via C=C Double Bond Cleavage,J. Am. Chem. Soc.2013,135, 11692-11695.

7. Yijin Su, Xiang Sun, Guolin Wu, andNing Jiao*, Catalyst-controlled Highly Selective Coupling and Oxygenation of Olefins: A Direct Approach to Alcohols, Ketones and Diketones,Angew. Chem. Int. Ed.2013,52, 9808-9812 (10.1021/anie.201303917).

8. Chong Qin, Peng Feng, Yang Ou,Tao Shen, Teng Wang andNing Jiao*,Highly Selective Csp-Csp Bond Cleavage:The Nitrogenation of Alkynes to Amides,Angew. Chem. Int. Ed.2013,52, 7850-7854. (Hot Paper).

9. Tao Shen, Teng Wang, Chong Qin, andNing Jiao*, Ag-catalyzed Nitrogenation of Alkynes: A Direct Approach to Nitriles via C-C Triple Bond Cleavage,Angew. Chem. Int. Ed.2013,52, 6677-6680. (Hot Paper) (Highlighted bySynfact(2013, 9(9), 0949).

10. Yuepeng Yan, Peng Feng, Qing-Zhong Zheng,Yu-FengLiang,Jingfen Lu, andNing Jiao*, PdCl2and NHPI Cocatalyzed Csp-H HydroxylationviaDioxygen Activation,Angew. Chem. Int. Ed.2013,52, 5827-5831.

11. Conghui Tang andNing Jiao*, Copper-catalyzed C-H Azidation of Anilines under Mild Conditions,J. Am. Chem. Soc.2012,134, 18924-18927.(Highlighted bySynform(2013, 02, A21) andSynfact(2013,9(2), 0207), Highlighted byAngew. Chem. Int. Ed. 10.1002/anie.201302015)

12. Xejun Xu, Chun Zhang, (These two authors contributed equally to this work) andNing Jiao*, Cu-mediated Aerobic Oxidative Dehydrogenative Annulation and Oxygenation of Aldehydes and Amines for Oxazoles via C-H Functionalization and Dioxygen Activation,Angew. Chem. Int. Ed.2012,51, 11367–11370(Hot Paper).

13. Teng Wang, Wang Zhou, Hang Yin, Jun-An Ma, andNing Jiao*, Iron-Facilitated Oxidative Dehydrogenative C-O Bond Formation via Propargyl Csp3–H FunctionalizationAngew. Chem. Int. Ed.2012,51, 10823-10826.

14. Chong Qin, Tao Shen, Conghui Tang, andNing Jiao*, FeCl2-promoted Unactivated C-C Bond Cleavage of Alkylarenes and Polystyrene: Direct Synthesis of Versatile Arylamines,Angew. Chem. Int. Ed.2012,51, 6971-6975(Hot Paper).

15. Shengtao Ding, andNing Jiao*, N,N-Dimethylformamide: A Multipurpose Building Block,Angew. Chem. Int. Ed.2012,51, 9226-9237. (review, invited contribution).

16. Chong Qin, Wang Zhou, Feng Chen, Yang Ou, andNing Jiao*, Iron-catalyzed C-H and C-C Bond Cleavage: A Direct Approach to Amides from Simple Hydrocarbon Molecules,Angew. Chem. Int. Ed.2011,50, 12595-12599.

17. Feng Chen, Chong Qin, Yuxin Cui, andNing Jiao*, Implanting Nitrogen into Hydrocarbon Molecules via C-H/C-C Bonds Cleavage: The Direct Approach to Tetrazoles.Angew. Chem. Int. Ed.2011,50, 11487-11491. (Highlighted bySynfacts(Synfacts,2012,8, 0144.).

18. Chun Zhang, Zejun Xu, Liangren Zhang, andNing Jiao*, Copper-catalyzed Aerobic Oxidative Coupling of Aryl Acetaldehydes with Anilines Leading to α-Ketoamides.Angew. Chem. Int. Ed.2011,50, 11088-11092. (VIP articles, Frontispiece Paper, Highlighted byChemCatChem(ChemCatChem,2012,4, 175-176)

19. Shengtao Ding, andNing Jiao*, The Direct Transformation of DMF (N,N-Dimethylformamide) to -CN: Pd-catalyzed Cyanation of Heteroarenes via C-H Functionalization.J. Am. Chem. Soc.2011,133(32), 12374-12377. (Highlighted byOrg. Process Res. Dev.2011,15, 1216–1221).

20. Chong Qin, andNing Jiao*, Iron-Facilitated Direct Oxidative C−H Transformation of Allylarenes or Alkenes to Alkenyl Nitriles.J. Am. Chem. Soc.2010,132, 15893-15895. (Most accessed articles, Highlighted bySynfacts(Synfacts,2011,2, 203))

21. Chun Zhang, andNing Jiao*, Cu-catalyzed Aerobic Oxidative Dehydrogenative Coupling of Anilines Leading to Aromatic Azo Compounds using Dioxygen as Oxidant.Angew. Chem. Int. Ed.2010,49, 6174-6177. (Most accessed articles)

22. Zhuangzhi Shi,Bo Zhang, Yuxin Cui, andNing Jiao*, Palladium-Catalyzed Ring-expansion Reaction of Indoles with Alkynes: From Indoles to Tetrahydroquinoline Derivatives Under Mild Conditions.Angew. Chem. Int. Ed.2010,49, 4036-4041. (Frontispiece Paper, Most accessed articles)

23. Chun Zhang, andNing Jiao*, Dioxygen Activation at Ambient Conditions: Cu-catalyzed Oxidative Amidation-Diketonization of Terminal Alkynes Leading to α-Ketoamides.J. Am. Chem. Soc.2010,132, 28-29. (Highlighted byOrg. Chem.)

24. Zhuangzhi Shi,Shengtao Ding, Yuxin Cui, andNing Jiao*, Pd-catalyzed Oxidative Cycloaromatization of Biaryls with Alkynes Using Dioxygen as Oxidant.Angew. Chem. Int. Ed.2009,48, 7895-7898.

25. Wang Zhou, Liangren Zhang, andNing Jiao*, Direct Transformation of Methyl Aromatics to Aryl Nitriles at Room Temperature.Angew. Chem. Int. Ed.2009,48, 7094-7097. (Hot Paper) (Highlighted by “Synform,2009,A71”, “Org. Chem. Highlights” (2010, September 27), and “Nature China ”.

26. Zhuangzhi Shi, Chun Zhang, Si Li, Delin Pan, Sengtao Ding, Yuxin Cui, andNing Jiao*, Indoles from Simple Anilines and Alkynes: Palladium-Catalyzed C-H Activation Using Dioxygen as the Oxidant.Angew. Chem. Int. Ed.2009,48, 4572-4576. (Hot Paper, Highlighted bySynfacts(Synfacts,2009,8, 846)，and“Nature China ”, Most accessed articles).

27. Delin Pan, Anjun Chen, Yijin Su, Wang Zhou, Si Li, Wei Jia, Juan Xiao, Qingjian Liu, Liangren Zhang, andNing Jiao*,Ligand Free Pd-Catalyzed Highly Selective Arylation of Allylic Esters with Retention of the Traditional Leaving Group.Angew. Chem. Int. Ed.2008,47, 4729-4732.^[2]

时间职务名称2012年天然药物及仿生药物国家重点实验室副主任^[3]2017年7月Chinese Journal of Chemistry副主编^[3]2021年Chemical Science副主编^[4]2022年中国化学会有机化学学科委员会委员^[5]-北京大学药学院博雅特聘教授、药学院党委书记^[6]-中国化学会均相催化专业委员会委员^[7]-中国化学会物理有机化学专业委员会委员^[7]-中国化学会公共安全化学专业委员会委员^[7]-Chin.J.Chem.、Sci.Rep.、Heterocycl.Commun.、化学学报、中国药学等杂志编委^[7]

时间奖项全称2016年4月2015年度长江学者2017年12月第九届中国化学会-巴斯夫公司青年知识创新奖2021年9月荣获第三届“科学探索奖”^[8]

焦宁是国家级有突出贡献的中青年专家。（北京大学药学院评）^[9]

焦宁焦宁长期致力于绿色化学、药物合成的绿色化、基于代谢类疾病的新药发现研究；在碳碳键活化、氧化反应、氮化反应、卤化反应等研究中取得了一系列创新性的成果。（北京大学医学部评）^[10]

焦宁始终坚持把立德树人作为教育的根本任务。回国后，他一直奋斗在教学科研第一线，以为祖国培养有理想、有本领、有担当的药学、化学一流人才为己任。（北京大学新闻网评）^[6]

焦宁整洁干练，散发出的儒雅学者的气质和蓬勃朝气。（北京大学医学部新闻网评）^[11]