欧阳松应

欧阳松应 博士 研究员，男，中国科学院青年创新促进会会员，北京市科技新星计划入选者。

欧阳松应 博士 研究员

中国科学院青年创新促进会会员

北京市科技新星计划入选者

研究方向：病原体感染与DNA识别天然免疫反应分子机制研究

1997.07-2001.09 南昌大学 生物科学工程系 学士

2001.08-2004.07 吉林大学（农学部）生物化学与分子生物学教研室 硕士

2004.08-2007.06 中国协和医科大学 基础所生物化学与分子生物学系 博士

2007.07-2010.08 中国科学院生物物理研究所 助理研究员

2010.09-2013.11 中国科学院生物物理研究所 副研究员

2013.12-至今 中国科学院生物物理研究所 研究员

（2013年12月获中国科学院生物物理研究所“青年研究员计划”支持）

2014年度北京市科技新星计划入选者

2013年荣获中科院“卢嘉锡青年人才奖”

病毒感染与DNA识别天然免疫反应分子机制研究

1. Jiao L*, Ouyang S*, Shaw N, Song G, Feng Y, Niu F, Qiu W, Zhu H, Hung LW, Zuo X, Shtykova E, Zhu P, Dong YH, Xu R#, Liu ZJ#. Mechanism of the Rpn13-induced activation of Uch37

2. Gu J, Feng Y, Feng X, Sun C, Lei L, Ding W, Niu F, Jiao L, Yang M, Li Y, Liu X, Song J, Cui Z, Han D, Du C, Yang Y, Ouyang S#, Liu ZJ#, Han W#. Structural and biochemical characterization reveals LysGH15 as an unprecedented “EF-hand-like” calcium-binding phage lysin

3. Zhang L, Mo J, Swanson K, Wen H, Petrucelli A, Gregory S, Zhang Z, Schneider M, Jiang Y, Fitzgerald K, Ouyang S, Liu ZJ, Damania B, Shu HB, Duncan J, Ting J. NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING

4. Zhao L*, Hua T*, Crowley C, Ru H, Ni X, Shaw N, Jiao L, Ding W, Jiang Y, Hung LW, Liu L, Ye K, Ouyang S#, Cheng G#, Liu ZJ#. Structural analysis of AEP reveals activation mechanism and reversible maturation intermediate. Cell Res

5. Niu F, Ru H, Ding W, Ouyang S#, Liu ZJ#. Structural biology study of human TNF receptor associated factor 4 TRAF domain

6. Niu F*, Shaw N*, Wang Y*, Jiao L*, Ding W, Upurd H, Ouyang S#, Cheng G#, Liu ZJ#. From the Cover: Structure of the LeanyerOrthobunyavirus Nucleoprotein-RNA complex reveals novel architecture for RNA encapsidation

7. Jiao L*, Ouyang S*, Liang M*, Niu F*, Shaw N, Wu W, Ding W, Jin C, Peng Y, Zhu Y, Zhang F, Wang T, Li C, Zuo X, Luan CH, Li D, Liu ZJ. Structure of severe fever with thrombocytopenia syndrome virus nucleoprotein in complex with Suramin reveals therapeutic potentials

8. Shaw N, Ouyang S, Liu ZJ. Binding of bacterial secondary messenger molecule c di-GMP is a STING operation

9. Parvatiyar K*, Zhang Z*, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA, Schenk M, Zeng S, Zhong W, Liu ZJ, Modlin RL, Liu YJ, Cheng G. The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

10. Ouyang S*, Song X*, Wang Y*, Ru H*, Shaw N, Jiang Y, Niu F, Zhu Y, Qiu W, Parvatiyar K, Li Y, Zhang R, Cheng G, Liu ZJ. Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

11. Zhan Z*, Ouyang S*, Liang W, Zhang Z, Liu ZJ, Huang L. Structural and functional characterization of the C-terminal catalytic domain of the SSV1 integrase

12. Ouyang S*, Gong B*, Li JZ*, Zhao L*, Wu W, Zhang FS, Sun L, Wang SJ, Pan M, Li C, Liang W, Shaw N, Zheng J, Zhao GP, Wang Y, Liu ZJ, Liang M. Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus

13. Liang W*, Ouyang S*, Shaw N, Joachimiak A, Zhang R, Liu ZJ. Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE

14. Wu W, Song W, Li S, Ouyang S, Fok KL, Diao R, Miao S, Chan HC, Wang L. Regulation of apoptosis by Bat3-enhanced YWK-II protein/APLP2 stability

15. Yin XQ*, Ouyang S*, Xu WM*, Zhang XP, Fok K.L., Zhang JP, Miao SY, Chan HC, and Wang LF. YWK-II as a novel Go protein-coupled receptor for Müllerian Inhibiting Substance in cell survival. J Cell Sci

16. Qiu XB*, Ouyang S*, Li CJ, Miao S, Wang L, Goldberg AL. hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37

2022年9月23日消息，福建师范大学生命科学学院欧阳松应教授团队联合福建佰孟医学科技有限公司，成功研发猴痘病毒荧光PCR检测试剂盒（荧光探针法），并取得欧盟CE认证，获得CE注册证书。这意味着该试剂盒可在欧盟国家以及认可欧盟CE认证的国家销售。^[1]