林建平

林建平 1997年和2000年先后在北京大学化学院获得学士和硕士学位。2005年7月毕业于美国杜克大学，获得理论生物物理和化学博士学位。2006年在美国希望之城医学中心从事博士后工作。2009年作为引进人才，回国到南开大学工作。主要工作有：通过分子动力学和虚拟化合物库计算机筛选以及实验组合作, 我们找到一个针对癌症增生蛋白(信号传送和转录激活因子,Signal transducers and Activators of Transcription 3 (Stat3))的抑制剂, 从而阻断癌症增生通道。这个抑制剂是第一个对Stat3有选择性的抗癌药。通过计算机辅助设计和分子动力学验证, 设计出憎水性的脱氧核糖核酸(DNA).设计出的憎水性DNA能穿过水和氯仿界面进入氯仿相。共发表SCI收载论文5篇。

姓名：林建平 性别：男 职称：教授

计算机辅助药物设计

计算生物学（计算机辅助药物设计，生物大分子模拟，蛋白质电子转移）

1) Jianping Lin; Ralf Buettner, Yate-Ching Yuan, Richard Yip, David Horne, Richard Jove, Nagerajan Vaidehi*. “Molecular dynamics simulations of the co nformational changes in Signal Transducers and Activators of Transcription, Stat1 and Stat3” J. Mole. Graphics Model. 2009, 28, 347-356.

2) Jianping Lin; Nadrian C. Seeman; Nagarajan Vaidehi*. “Molecular dynamics simulations of insertion of chemically modified DNA nanostructures into water-chloroform interface” Biophys. J. 2008, 95, 1099-1107.

3) Jianping Lin; Ilya A. Balabin; David N. Beratan*. “The Nature of Aqueous Tunneling Pathways between Electron-transfer Proteins” Science 2005, 310,1311-1313. related news: “Water can ease electron transfer between proteins” Chemical & Engineering News November 28, 2005. Page 11.

4) Jianping Lin; David N. Beratan*. “Simulation of Electron transfer between Cytochrome c2 and the Bacterial Photosynthetic Reaction Center: Brownian Dynamics Analysis of the Native Proteins and Double Mutants.” J. Phys. Chem. B 2005, 109, 7529-7534.

5) Jianping Lin; David N. Beratan*. "Tunneling while Pulling: The Dependence of Tunneling Current on End-to-End Distance in a Flexible Molecule." J. Phys. Chem. A 2004, 108, 5655-5661.

6) James C. Sung; Jianping Lin. Diamond Nanotechnology: Synthesis and applications, Pan Stanford Publishing, 2009.

7) Spiros S. Skourtis; Jianping Lin; David N. Beratan. “The Effects of Bridge Motion on Electron Transfer Reactions Mediated by Tunneling” Chapter 18 in Modern Methods for Theoretical Physical Chemistry of Biopolymers. Edited By E. B. Starikov; S. Tanaka; J. P. Lewis, Elsevier Press, June 2006.