杨卓

杨卓，女，教授，博士生导师。 1983年天津医科大学本科毕业；1989年浙江大学医学院，获医学硕士学位；1998年英国伯明翰大学医学院，获博士学位；2003起至今为南开大学教授，从事生理学教学和科研工作。目前每年招收1-2名硕士生及博士生。

一、教育经历

1983年天津医科大学本科毕业，1989年浙江大学医学院，医学硕士学位。1998年英国伯明翰大学医学院，博士学位。

二、工作经历

1983年天津医科大学本科毕业，1989年浙江大学医学院获医学硕士学位。1998年英国伯明翰大学医学院获博士学位。2003起至今为南开大学教授。

三、学术兼职

天津市生物医学检测技术与仪器重点实验室学术委员会委员

天津市神经损伤变异与再生重点实验室学术委员会委员

中华医学研究杂志专家编辑委员会常务编委

中华临床医学杂志英文版编委

天津医药编委及英文编辑

1． 生理学

2． 专业英语

3． 若干研究生及硕士生课程

研究方向：

1围绕神经系统重大疾病，开发和制备了相关的动物模型，并在动物模型基础上进行神经电生理、认知、神经细胞的免疫组化及突触机制等研究。

2纳米颗粒在中枢神经系统的作用和毒性的机制。

3 肾发育有关的离子通道机制研究。

4海马神经通路的交互作用与神经元突触传递效率。

天津市应用基础与前沿技术研究计划重点项目（10JCZDJC19100）

科技部973项目(2011CB944003)

国家自然科学基金项目(31070890)

英国皇家工程学院与中国研究交流项目Ref 5502）

1.Dehong Shan,Yongling Xie, Guogang Ren, Zhuo Yang. Inhibitory effect of tungsten carbide nanoparticles on voltage-gated potassium currents of hippocampal CA1 neurons. Toxicology Letters. 2012; (209): 129-135

2. Jing Xu, Pengjuan Xu, Zhigui Li, Jie Huang, Zhuo Yang*. Oxidative stress and apoptosis induced by hydroxyapatite nanoparticles in C6 cells. J Biomed Mater Res A. 2012;100(3): 738-745

3. Liu Ye, Guan Wei, Ren G, Yang Zhuo. The possible mechanism of silver nanoparticle impact on hippocampal synaptic plasticity and spatial cognition in rats. Toxicol Lett. 2012;(209): 227-231

4. Yongling Xie, Yiyi Wang, Tao Zhang, Guogang Ren, Zhuo Yang,Effects of nanoparticle zinc oxide on spatial cognition and synaptic plasticity in mice with depressive-like behaviors. The Journal of Biomedical Science. 2012;19(1):14

5. XU Jing, WANG Yiyi, LI Ning, XU Lanju, YANG Hanyu, YANG Zhuo. l-3-n-butylphthalide improves cognitive deficits in rats with chronic cerebral ischemia. Neuropharmacology. 2012;62(7):2423–2428

6. Liu Z, Zhang T, Ren G, Yang Z. Nano-Ag inhibiting action potential independent glutamatergic synaptic transmission but increasing excitability in rat CA1 pyramidal neurons. Nanotoxicology. 2012;6:414-423

7. Xu Pengjuan, Xu Jing, Li Zhigui, Yang Zhuo. Expression of TRPC6 in renal cortex and hippocampus of mouse during postnatal development. PLoS One.2012;7(6):e38503（P1-P8）

8. Jing Xu, Zhigui Li, Pengjuan Xu and Zhuo Yang. Protective effects of leukemia inhibitory factor against oxidative stress during high glucose-induced apoptosis in podocytes. Cell Stress Chaperones. 2012 Jul;17(4):485-93

9. Pengjuan Xu, Jing Xu, Shichang Liu, Guogang Ren, Yang Zhuo. In vitro to xicity of nanosized copper particles in PC12 cells induced by oxidative stress. Journal of Nanoparticle Research. 2012;14(906):1-9

10. Lu Xiao, Zhanyong Li, Pengjuan Xu, Zhigui Li, Jing Xu, Zhuo Yang.The Expression of EPOR in renal cortex during postnatal development. PLoS One. July 2012; 7(7): e41993

11. Han YG, Xu J, Li ZG, Ren GG, Yang Z. In vitro toxicity of multi-walled carbon nanotubes in C6 rat glioma cells. Neurotoxicology. 2012;33( 5): 128-134

12. Jing Xu, Zhigui Li, Pengjuan Xu, Lu Xiao, Zhuo Yang. Nanosized copper oxide induces apoptosis through oxidative stress in podocytes. Arch Toxicol DOI 10.1007/13. Jingxia Zhao, Yang Yao, Shichang Liu, Tao Zhang, Guogang Ren, Zhuo Yang. Involvement of reactive oxygen species and high-voltage-activated calcium currents in nanoparticles zinc oxide-induced cytotoxicity in vitro. J Nanopart Res (2012) 14:1238

14. Pengjuan Xu, Jing Xu, Shichang Liu, Zhuo Yang. Nano copper induced apoptosis in podocytes via increasing oxidative stress. Journal of Hazardous Materials. 2012;241–242:279–286

15．Yang-guang HAN, Shi-chang LIU, Tao ZHANG, Zhuo YANG， Induction of apoptosis by melamine in differentiated PC12 cells. Cell Mol Neurobiol, 2011; 31:65–71

16. Shichang Liu, Yangguang Han, Tao Zhang, Zhuo Yang, Protective effect of trifluoperazine on hydrogen peroxide-induced apoptosis in PC12 cells. Brain Research Bulletin, 2011;84:183–188

17. Xiaofan Yang, Yucheng Wang, Jia Luo, Shichang Liu and Zhuo Yang，Protective effects of YC-1 against glutamate induced PC12 cell apoptosis. Cell Mol Neurobiol. 2011;31(2):303-11

18. Quan MN, Zhang N, Wang YY, Zhang T, Yang Z. Possible antidepressant effects and mechanisms of memantine in behaviors and synaptic plasticity of a depression rat model. Neuroscience. 2011;182: 88–97

19. Quan M, Zheng C, Zhang N, Han D, Tian Y, Zhang T, Yang Z. Impairments of behavior, information flow between thalamus and cortex, and prefrontal cortical synaptic plasticity in an animal model of depression. Brain Research Bulletin，2011; 85 109–116

20. Dadong Han, Yutao Tian, Tao Zhang, Guogang Ren, Zhuo Yang. Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocampus of Wistar rats. International Journal of Nanomedicine.2011;6: 1453-1461

21. Yi-Yi Wang, Ning Li，Jie Huang，Zhuo Yang, Tao Zhang. Effects of ionic products from silicon-substituted hydroxyapatite on the rat brain activity: Morris water maze studies and long term potentiation in hippocampal CA1. Materials Science & Engineering: C (Materials for Biological Applications).2011;31:1558–1566

22. Liu Zhaowei, Ren Guogang, Zhang Tao, Yang Zhuo. The inhibitory effects of nano-Ag on voltage-gated potassium currents of hippocampal CA1 neurons, Environmental Toxicology, 2011;26(5):552-8

23. Liu Zhaowei, Liu Shichang, Ren Guogang , Zhang Tao, Yang Zhuo，Nano-CuO inhibited voltage-gated sodium current of hippocampal CA1 neurons via reactive oxygen species but independent from G-proteins pathway. J. Appl. Toxicol. 2011; 31: 439–445

24. Y. Yao, D.D. Han, T. Zhang, Z. Yang, Quercetin improves cognitive deficits in rats with chronic cerebral ischemia and inhibits voltage-dependent sodium channels in hippocampal CA1 pyramidal neurons, Phytotherapy Research,2010;24: 136–140

25. Shichang Liu, Lanju Xu, Tao Zhang, Guogang Ren, Zhuo Yang, Oxidative stress and apoptosis induced by nanosized titanium dioxide in PC12 cells，Toxicology,2010;267:172–177

26. Yinguo ZHANG, Ning LI, Zhuo YANG，Perinatal food restriction impaired spatial learning and memory behaviour and decreased the density of nitric oxide synthase neurons in the hippocampus of adult male rat offspring，Toxicology Letters，2010；193：167-172

27. Mei-Na Quan, Yu-Tao Tian, Kun-Han Xu, Tao Zhang, Zhuo Yang. Post weaning social isolation influences spatial cognition, prefrontal cortical synaptic plasticity and hippocampal potassium ion channels in Wistar rats, Neuroscience；2010;169:214–222

28. Z Yang, ZW Liu, R Allaker, P Reip, J Oxford, Z Ahmad, and G Ren, A review of nanoparticle functionality and toxicity on the central nervous system, J R Soc Interface. 2010; 7: S411–S422

29. ZHANG Yinguo, LI Ning,YANG Jiajia，ZHANG Tao，YANG Zhuo, Effects of maternal food restriction on physical growth and neurobehavior in newborn Wistar rats, Brain Research Bulletin; 2010：83: 1-8

30. Yinguo ZHANG, Jingxia ZHAO, Tao ZHANG , Zhuo YANG，In vitro assessment of the effect of methylene blue on voltage-gated sodium channels and action potentials in rat hippocampal CA1 pyramidal neurons, Neurotoxicology. 2010;31(6):724-9

31. ZHAO Jingxia, XU Lanju, ZHANG Tao, REN Guogang，YANG Zhuo，Influences of nanoparticle zinc oxide on acutely isolated rat hippocampal CA3 pyramidal neurons，Neurotoxicology,2009;30:220-230

32. Yang Z, Han D, Coote JH. Cardiac sympatho-excitatory action of PVN-spinal oxytocin neurones. Autonomic Neuroscience: Basic and Clinical, 2009; 147:80-85

33. Lan-ju XU, Jing-Xia ZHAO, Tao ZHANG, Guo-gang REN, Zhuo YANG, In vitro study on influence of nano particles of CuO on CA1 pyramidal neurons of rat hippocampus potassium currents, Environmental Toxicology, 2009; 24(3):211-217

34. Liu Zhaowei, Ren Guogang, Zhang Tao, Yang Zhuo.Action potential changes associated with the inhibitory effects on voltage-gated sodium current of hippocampal CA1 neurons by silver nanoparticles. Toxicology,2009;264:179-184

35. Zhangjie Su，Dadong Han, Bo Sun, Jiaheng Qiu, Ying Li, Mu Li, Tao Zhang, Zhuo Yang. Heat Stress Preconditioning Improves Cognitive Outcome following Diffuse Axonal Injury in Rats.Journal of Neurotrauma，2009, 26(10): 1695-1706