李华

李华，男，美国布朗大学分子生物学暨生物化学博士，华中科技大学同济药学院生物药学系主任；沈阳药科大学中药学院院长、博士生导师、教授。^[1]

本科毕业于沈阳药科大学日语药学专业，中国协和医科大学获得药理学硕士，美国东北大学(Northeastern University)获得有机化学硕士，美国布朗大学(Brown University)获得分子生物学暨生物化学博士学位，而后在霍华德休斯医学研究所(Howard Hughes Medical Institute)/德克萨斯大学西南医学中心(UT Southwestern Medical Center)进行膜蛋白结构生物学的博士后研究。

2013年起被华中科技大学同济药学院聘为教授、博士生导师。

2015年10月起担任沈阳药科大学中药学院院长，教授、博士生导师^[2]。

1.全国中医药高等教育研究会中药教育研究会副理事长

2. 中国中药学会中药新技术专业委员会专家组成员

3. 湖北省晶体学会秘书长兼副理事长

研究方向一：重大疾病相关蛋白质的结构生物学

研究方向二：基于蛋白质结构的天然产物作用靶点和机制研究

研究方向三：基于结构的药物设计与发现

代表论文^[3]

1. Meng-Zhu Zheng, Wei-Guang Sun, Su-Yu Gao, Shan-Shan Luan, Dan Li, Ren-Qi Chen, Qian Zhang, Li-Xia Chen*, Jian-Geng Huang*, Hua Li*. Structure Based Discovery of Clomifene as a Potent Inhibitor of Cancer-Associated Mutant IDH1. Oncotarget, 2017,doi:10.18632/oncotarget.17464. (SCI, IF 5.008)

2. Meng-Zhu Zheng, Shan-Shan Luan, Su-Yu Gao, Li Cheng, Bin Hao, Jia-Cheng Li, Yao Chen, Xue-Mei Hou*, Li-Xia Chen*, Hua Li*. Proton Pump Inhibitor Ilaprazole suppresses cancer growth by targeting T-cell-originated protein kinase, Oncotarget. 2017, doi: 10.18632/oncotarget.16609. (SCI, IF 5.008)

3. Wei Li, Meng-Zhu Zhang, Shuang-Ping Wu, Su-Yu Gao, Mei Yang, Zhi-Mei Li, Xiu-Xia Min, Wei-Guang Sun, Li-Xia Chen*, Guang-Ya Xiang*, Hua Li*. Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2. Journal of Experimental &Clinical Cancer Research, 2017, DOI: 10.1186/s13046-017-0530-4. (SCI, IF 4.357)

4. Yan He, Meng-Zhu Zheng, Qin Li, Zheng-Xi Hu, Hu-Cheng Zhu, Jun-Jun Liu, Jian-Ping Wang, Yong-Bo Xue*, Hua Li*, Yong-Hui Zhang*. Asperspiropene A, a novel fungal metabolite as an inhibitor of cancer-associated mutant isocitrate dehydrogenase 1, Organic Chemistry Frontier, 2017, doi.org/10.1039/C6QO00847J. (SCI, IF 4.693)

5. Qiu-Xia Min, Xin-Pei Cai, Wei-Guang Sun, Fei Gao, Zhi-Mei Li, Qian Zhang, Luo-Sheng Wan, Hua Li*, Jia-Chun Chen*. Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening. Scientific Reports. 2017, DOI: 10.1038/srep44681. (SCI, IF 5.228)

6. Li-Qing Wang, Ying Wang, Su-Yu Gao, Li-Han Zhu, Fei Wang, Hua Li*, Li-Xia Chen*. Phenolic amides with anti-Parkinson’sdisease (PD) effects from Nicandra physaloides. Journal of Functional Foods (2017), doi: 10.1016/j.jff.2017.01.045. (SCI, IF 3.973)

7. Wei-Guang Sun, Xin-Tao Chen, Qing-Yi Tong, Hu-Cheng Zhu, Yan He, Lei Liang, Yong-Bo Xue, Guang-Min Yao, Zeng-Wei Luo, Jian-Ping Wang, Hua Li*, Yong-Hui Zhang*. Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune. Scientific Reports. 2016, 6, 26418, doi: 10.1038/srep26418. (SCI, IF 5.228)

8. Yan He, Jun Tian, Xin-Tao Chen, Wei-Guang Sun, Hu-Cheng Zhu, Qin Li, Liang Lei, Guang-Min Yao, Yong-Bo Xue, Jian-Ping Wang, Hua Li*, Yong-Hui Zhang*. Fungal naphtho-γ-pyrones: Potent antibiotics for drug-resistant microbial pathogens. Scientific Reports. 2016, 6, 24291, doi: 10.1038/srep24291. (SCI, IF 5.228)

9. Xiao-Yu Zeng, Lin Liu, Meng-Zhu Zheng, Hui-Min Sun, Luan-Juan Xiao, Tao Lu, Guang-Qian Huang, Pian-Pian Chen, Jian-Min Zhang, Feng Zhu*, Hua Li*, Qiu-Hong Duan*. Pantoprazole, a FDA-approved proton-pump inhibitor, suppresses colorectal cancer growth by targeting T-cell-originated proteinkinase. Oncotarget. 2016, doi: 10.18632/oncotarget.7984. (SCI, IF 5.008)

10. Liao, J*; Li, H*; Zeng, W; Sauer, DB; Belmares, R; Jiang, Y. Structural Insight into the Ion Exchange Mechanism of Sodium/Calcium Exchanger. Science. 2012, 335: 686-690. (SCI, IF 34.661)