巢晖

巢晖（Hui Chao），男，1970年3月出生，籍贯湖南汨mì罗，理学博士，中山大学教授，博士生导师。

学士（1988-1992）：湖南科技大学化学化工学院；

硕士（1994-1997）：南开大学化学学院；

博士（1997-2000）：中山大学化学与化学工程学院；

访问学者 (2000-2003)：香港科技大学化学系；

博士后（2004-2005）：美国Texas A&M大学化学系；

讲师（2000-2002）、副教授（2002-2007）：中山大学化学与化学工程学院；

教授（2008-至今）：中山大学化学与化学工程学院；

2002年6月被遴选为中山大学无机化学专业/化学生物学专业硕士生导师；

2005年-至今：中山大学光电材料与技术国家重点实验室固定研究人员。

2017年-至今：湖南科技大学理论有机化学与功能分子教育部重点实验室“湘江学者计划”特聘教授。

1.金属配合物与DNA/RNA相互作用研究（包括DNA/RNA结构识别、光断裂及转录抑制）。

2.配合物超分子体系光电转换和光致电子与能量转移调控研究。

3.多吡啶dìng配合物为基元的分子器件设计及其光电性能应用。

1．已发表学术论文40多篇, 其中SCI收录论文30篇。

2．现主持国家自然科学基金1项，参加国家、省自然科学基金及国家重点实验室开放课题基金5项。

(1) 国家自然科学基金项目（2002.1-2004.12）：钌多吡啶配合物为基元的某些分子器件设计及其应用，项目负责人。

(2) 国家自然科学基金项目（2001.1-2003.12）：金属配合物研究DNA的结构、功能及作用机制，主要成员。

(3) 国家自然科学基金重点项目（2003.1-2005.12）：金属配合物、生物大分子蛋白质和DNA的相互作用，主要成员。

(4) 广东省自然科学项目（2003.1-2005.12）：抗癌性多吡啶类配合物量子化学研究、计算机模拟及合成, 主要成员。

(5)配位化学国家重点实验室（南京大学）开放课题基金（2002.4-2004.3）：位点和顺序专一RNA和DNA切割剂合成及其作用机制，主要成员。

(6) 生命有机化学国家重点实验室（中科院上海有机化学研究所）开放课题基金(2000.7-2003.6)：核酸的结构与功能关系中的重大化学问题的研究，主要成员。

“金属酶模型化合物的结构、生物功能、作用机制之间规律性”，中国高校自然科学奖二等奖，2000年（排名第九）。

（均为SCI收录）：

1. Feng Gao,Hui Chao*, Feng Zhou, Xin Chen, Yuan-Fang Wei, Kang-Cheng Zheng, Liang-Nian Ji*, “Synthesis, DNA binding and topoisomerase II inhibition activities of ruthenium(II) polypyridyl complex containing 11-aminopteridino[6,7-f][1,10]phenanthrolin-13(12H)-one”,J. Inorg. Biochem. ,2008, in press.

2. Feng Gao,Hui Chao*, Liang-Nian Ji*,“DNA-Binding, Photocleavge and Topoisomerase Inhibiting of Functionalized Ruthenium(II) Polypyridyl Complexes”,Chemistry & Biodiversity, 2008, in press. (Review)

3. Hui-Juan Yu,Hui Chao*, Long Jiang, Lv-Ying Li, Shu-Mei Huang and Liang-Nian Ji*, “Single oxygen-mediated DNA photocleavage of a di-bithiazolyl ruthenium(II) complex [Ru(btz)2(dppz)]2+”,Inorg. Chem. Commun. ,2008, in press.

4. Feng Gao,Hui Chao*, Yuan-Fang Wei, Yi-Xian Yuan, Bin Peng, Xin Chen, Kang-Cheng Zheng and Liang-Nian Ji*, “Synthesis, DNA-Binding and Photocleavage Studies of Ruthenium(II) Complexes [Ru(phen)2(ppd)]2+ and [Ru(phen)(ppd)2]2+ (ppd = Pteridino[6,7-f][1,10]- phenanthroline-1,13(10H,12H)-dione, phen = 1,10-Phenanthroline)”,Helv. Chim. Acta, 2008, in press.

5. F. Albert Cotton,Hui Chao*, Zhong Li, Carlos A. Murillo, Qingsheng Wang, “Effect of axial anthracene ligands on the luminescence of trinickel molecular wires”,J. Organomet. Chem., 2008, in press.

6.巢晖*，高峰，计亮年*，“钌(II)多吡啶配合物与DNA相互作用研究”，化学进展，2007，19(12)，1844-1851。 (化学生物学专辑，Review)

7. Feng Gao,Hui Chao*, Jin-Quan Wang, Yi-Xian Yuan, Bin Sun, Yuan-Fang Wei, Bin Peng and Liang-Nian Ji*, “Targeting topoisomerase II with the chiral DNA-intercalating ruthenium(II) polypyridyl complexes”,J. Biol. Inorg. Chem., 2007, 12, 1015-1027.

8. Bin Peng,Hui Chao*, Bin Sun, Hong Li, Feng Gao and Liang-Nian Ji*, “Syntheses, DNA-binding and photocleavage studies of cobalt(III) mixed-polypyridyl complexes: [Co(phen)2(dpta)]3+ and [Co(phen)2(amtp)]3+”,J. Inorg. Biochem. ,2007, 101, 404-411.

9. Feng Gao,Hui Chao*, Feng Zhou, Bin Peng, Liang-Nian Ji*, “pH responsive “off-on-off” luminescent switch of a novel ruthenium(II) complex [Ru(bpy)2(pipipH2)]2+”,Inorg. Chem. Commun.,2007, 10, 170-173.

10. Feng Gao,Hui Chao*, Feng Zhou, Lian-Cai Xu, Kang-Cheng Zheng, Liang-Nian Ji*,“Synthesis, Characterization, and DNA-Binding Properties of the Chiral Ruthenium(II) Complexes Δ- and Λ-[Ru(bpy)2(dmppd)]2+ (dmppd = 10,12-Dimethylpteridino- [6,7-f][1,10]phenanthroline-11,13(10H,12H)-dione; bpy = 2,2’-Bipyridine)”,Helv. Chim. Acta, 2007, 90, 36-51.

11. F. Albert Cotton,Hui Chao*, Carlos A. Murillo* and Qingsheng Wang, “A trimetal chain cocooned by two heptadentate polypyridylamide ligands”,Dalton Trans. ,2006, 5416-5422.

12. Feng Gao,Hui Chao*, Feng Zhou, Yi-Xian Yuan, Bin Peng and Liang-Nian Ji*, “DNA interactions of a functionalized ruthenium(II) mixed-polypyridyl complex [Ru(bpy)2ppd]2+”,J. Inorg. Biochem.,2006, 100, 1487-1494.

13. Yun-Jun Liu,Hui Chao*, Yi-Xian Yuan, Hui-Juan Yu and Liang-Nian Ji*,“Ruthenium(II) mixed-ligand complexes containing 2-(6-methyl-3-chromonyl)imidazo- [4,5-f][1,10]phenanthroline: synthesis, DNA-binding and photocleavage studies”,Inorg. Chim. Acta, 2006, 359, 3807-3814.

14.Hui Chao, Liang-Nian Ji, “Chapter 11. Cobalt complexes as potential pharmaceutical agents”, in Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine, Eds. Marcel Gielen and Edward R. T. Tiekink, May, 2005, John Wiley & Sons Ltd (ISBN: 0-470-86403-6). (Book Chapter)

15.Hui Chao*, Lian-Nian Ji, “DNA interactions with Ru(II) polypyridine complexes containing asymmetric ligands”,Bioinorganic Chemistry and Application, 2005, 3, 15-28.（Review）

16. Yun-Jun Liu,Hui Chao*, Jun-Hua Yao, Li-Feng Tan, Yi-Xian Yuan, Liang-Nian Ji, “Ruthenium(II) complexes containing asymmetric 2-(pyrazin-2-yl)naphthoimidazole: syntheses, characterization, DNA-binding and photocleavage studies”,Inorg. Chim. Acta, 2005, 358, 1904-1910.

17. Li-Feng Tan,Hui Chao*, Yun-Jun Liu, Hong Li, Bin Sun, Liang-Nian Ji*, “DNA-binding and photocleavage studies of [Ru(phen)2(NMIP)]2+”,Inorg. Chim. Acta, 2005, 358, 2191-2198.

18. Yun-Jun Liu,Hui Chao*, Li-Feng Tan, Yi-Xian Yuan, Wei Wei, Liang-Nian Ji*. “Interaction of polypyridyl ruthenium(II) complex containing asymmetric ligand with DNA”.J. Inorg. Biochem. ,2005, 99, 530-537.

19. Li-Feng Tan,Hui Chao*, Hong Li, Yun-Jun Liu, Bin Sun, Wei Wei, Liang-Nian Ji*. “Synthesis, characterization, DNA-binding and photocleavage studies of [Ru(bpy)2(PPIP)]2+ and [Ru(phen)2(PPIP)]2+”.J. Inorg. Biochem. ,2005, 99, 513-520.

20. Yun-Jun Liu,Hui Chao*, Jun-Hua Yao, Hong Li, Yi-Xian Yuan, Liang-Nian Ji*. “Synthesis, characterization and DNA interaction studies of [Ru(bpy)2(CMIP)]2+ and [Ru(phen)2(CMIP)]2+ (CMIP = 2-(3-chromonyl)imidazo[4,5-f][1,10]-phenanthroline)”.Helv. Chim. Acta, 2004, 87, 3119-3130.

21. Xiang-Li Wang,Hui Chao*, Hong Li, Xian-Lan Hong, Yun-Jun Liu, Li-Feng Tan, Liang-Nian Ji*. “DNA interactions of cobalt(III) mixed-polypyridyl complexes containing asymmetric ligands.”J. Inorg. Biochem. ,2004, 6, 1143-1150.

22. Xiang-Li Wang,Hui Chao*, Hong Li, Xian-Lan Hong, Liang-Nian Ji*, Xiao-Yuan Li*. “Synthesis, crystal structure and DNA cleavage activities of copper(II) complexes with asymmetric tridentate ligands.”, ,2004, 98, 423-429.