孙宝发

孙宝发，男，中国科学院大学硕导。

2009-09--2013-01，中国科学院大学，博士

2006-09--2009-09，汕头大学，硕士

2002-09--2006-09，湖南科技大学，学士^[1]

2016-01~现在，中国科学院北京基因组研究所，副研究员

2013-07~2015-12，中国科学院北京基因组研究所，助理研究员^[1]

中国科学院青年创新促进会会员,院级,2016^[1]

Epitranscriptomic 5-methylcytosine profile in PM2.5-induced mouse pulmonary fibrosis, Genomics Proteomics Bioinformatics, 2020,第8作者RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function, Genome Biology, 2020,第7作者OsNSUN2-mediated 5-methylcytosine mRNA modification enhances rice adaptation to high temperature, Developmental Cell, 2020,第8作者Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma, Cell Res, 2019,第1作者5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs, Nature Cell Biology, 2019,第1作者A novel m6A reader Prrc2a controls oligodendroglial specification and myelination, Cell Research, 2019,第1作者Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1, Science Translational Medicine, 2019,第1作者mRNA m6A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes, Int J Obes (Lond), 2018,第1作者METTL3-mediated m6A modification is required for cerebellar development, Plos Biology, 2018,第7作者 Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer, Cell Research, 2018,第1作者5-Hydroxymethylome in Circulating Cell-free DNA as A Potential Biomarker for Non-small-cell Lung Cancer, Genomics Proteomics Bioinformatics, 2018,通讯作者Cytoplasmic m6A reader YTHDF3 promotes mRNA translation, Cell Research, 2017,通讯作者Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation, Cell Research, 2017,第1作者5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m5C reader., Cell Research, 2017,第1作者m6A modulates haematopoietic stem and progenitor cell specification, Nature, 2017,第1作者A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size, Dev Cell, 2017,第5作者Nuclear m6A reader YTHDC1 regulates mRNA splicing, Molecular Cell, 2016,第1作者Deep RNA sequencing analysis of syncytialization-related genes during BeWo cell fusion, Reproduction, 2016,第5作者Bacteriophage WO can mediate horizontal gene transfer in endosymbiotic Wolbachia genomes, Front Microbiol, 2016,第2作者Contribution of Multiple Inter-Kingdom Horizontal Gene Transfers to Evolution and Adaptation of Amphibian-Killing Chytrid, Batrachochytrium dendrobatidis, Front Microbiol, 2016,第1作者Molecular analysis of DNA in blastocoele fluid using next-generation sequencing, J Assist Reprod Genet, 2016,通讯作者 Dynamic m6A modification and its emerging regulatory role in mRNA splicing, Science Bulletin, 2015,第1作者 Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia, Oncotarget, 2015,第2作者Discriminative host sanction together with relatedness promote the cooperation in fig/fig wasp mutualism, J Anim Ecol, 2015,第2作者Non-quantitative adjustment of offspring sex ratios in pollinating fig wasps, Sci Rep, 2015,第2作者 Regulation of transcription factors on sexual dimorphism of fig wasps, Sci Rep, 2015,第1作者 Horizontal functional gene transfer from bacteria to fishes, Sci Rep, 2015,第1作者Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay, EMBO J, 2015,第5作者FTO and obesity: mechanisms of association, Diabetes Reports, 2014,第2作者Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase, Cell Research, 2014,第1作者 FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis, Cell Research, 2014,第1作者Discriminative host sanctions in a fig-wasp mutualism, Ecology, 2014,第3作者Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism, Nucleic Acids Res, 2014,第10作者 piRBase: a web resource assisting piRNA functional study, Database, 2014,第4作者Multiple ancient horizontal gene transfers and duplications in lepidopteran species, Insect molecular biology, 2013,第1作者 Multiple interkingdom horizontal gene transfers in Pyrenophora and closely related species and their contributions to phytopathogenic lifestyles, PLoS One, 2013,第1作者Obligate mutualism within a host drives the extreme specialization of a fig wasp genome, Genome biology,2013,第2作者^[1]

m5C调控mRNA翻译的功能研究,主持,国家级, 2017-01--2020-12RNA m6A甲基化修饰调控mRNA选择性剪接机制研究,主持,国家级, 2015-01--2017-12 RNA m6A 修饰甲基转移酶复合物及其表观调控因子鉴定和作用机制研究,参与,国家级, 2015-01--2018-12mRNA甲基化调控儿童TEL/AML1阳性急性淋巴细胞白血病发生发展机制研究,参与,国家级, 2015-01--2018-12污染物诱发核酸损伤、修复与基因突变的分子机制,参与,部委级, 2014-06--2014-12可逆化学修饰调控lncRNA二级结构机制及其功能研究,参与,国家级, 2018-01--2020-122016年青年创新促进会,主持,部委级, 2016-01--2019-12RNA结构对斑马鱼胚胎发育的调控机制研究,主持,国家级,2019-01--2022-12^[1]