卫立辛

卫立辛，男，1960年生，医学博士，现任第二军医大学东方肝胆外科医院肿瘤免疫与基因治疗研究中心主任、研究员、博士生导师。卫立辛曾就读于广州第一军医大学、西安第四军医大学和上海第二军医大学，分别获得学士、硕士和博士学位。他的职业生涯中，曾担任教师、医师和研究员。自1994年起，卫立辛一直专注于肿瘤免疫治疗和肿瘤发生机制的研究。他主持了15项相关的国家和地方基金，并发表了100多篇论文，其中65篇被SCI收录，国际上被引用超过3000次。

卫立辛早期从事单克隆抗体的制备与应用研究，自1994年起专注于肿瘤研究，先后针对端粒酶和肿瘤免疫开展肿瘤诊治的基础研究。近年来，他从干细胞和器官炎症损伤的角度深入研究肿瘤发生及复发的机制。

卫立辛曾获国家科技进步奖2项、军队科技进步奖3项、上海科技奖2项。他获得国家发明专利9项，并被评为上海市医学领军人才、上海市曙光学者、上海市优秀学科带头人及上海市浦江人。

卫立辛教授在国际学术期刊上发表了多篇重要论文，其中包括：

- Cai X, Zhai J, Kaplan DE, Zhang Y, Zhou L, Chen X, Qian G, Zhao Q, Li Y, Gao L, Cong W, Zhu M, Yan Z, Shi L, Wu D, Wei L, Shen F, Wu M. Background progenitor activation is associated with recurrence after hepatectomy of combined hepatocellular cholangiocarcinoma. Hepatology. 2012 Nov;56(5):1804-16.

- Liu Y, Han ZP, Zhang SS, Jing YY, Bu XX, Wang CY, Sun K, Jiang GC, Zhao X, Li R, Gao L, Zhao QD, Wu MC, Wei LX. Effects of inflammatory factors on mesenchymal stem cells and their role in the promotion of tumor angiogenesis in colon cancer. J Biol Chem. 2011 Jul 15;286(28):25007-15.

- Shi Y, Wei L, Wang Y, Ren G. Stem cells deployed for bone repair hijacked by T cells. Cell Stem Cell. 2012 Jan 6;10(1):6-8.

- Li F, Liu P, Liu C, Xiang D, Deng L, Li W, Wangensteen K, Song J, Ma Y, Hui L, Wei L, Li L, Ding X, Hu Y, He Z, Wang X. Hepatoblast-like progenitor cells derived from embryonic stem cells can repopulate livers of mice. Gastroenterology. 2010 Dec;139(6):2158-2169. (IF 12.899)

- Song J, Qu Z, Guo X, Zhao Q, Zhao X, Gao L, Sun K, Shen F, Wu M, Wei L. Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells. Autophagy. 2009 Nov;5(8):1131-44.

- Klionsky DJ. Wei L. Weihl CC, Zschocke J, Zuckerbraun B. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr;8(4):445-544.

- Jing YY, Han ZP, Sun K, Zhang SS, Hou J, Liu Y, Li R, Gao L, Zhao X, Zhao QD, Wu MC, Wei LX. Toll-like receptor 4 signaling promotes epithelial-mesenchymal transition in human hepatocellular carcinoma induced by lipopolysaccharide. BMC Med. 2012 Aug 31;10:98.

- Zhang SS, Han ZP, Jing YY, Tao SF, Li TJ, Wang H, Wang Y, Li R, Yang Y, Zhao X, Xu XD, Yu ED, Rui YC, Liu HJ, Zhang L, Wei LX. CD133(+)CXCR4(+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patients. BMC Med. 2012 Aug 7;10:85.

- Xiong HY, Guo XL, Bu XX, Zhang SS, Ma NN, Song JR, Hu F, Tao SF, Sun K, Li R, Wu MC, Wei LX. Autophagic cell death induced by 5-FU in Bax or PUMA deficient human colon cancer cell. Cancer Lett. 2010 Feb 1;288(1):68-74.

- Guo X, Ma N, Wang J, Song J, Bu X, Cheng Y, Sun K, Xiong H, Jiang G, Zhang B, Wu M, Wei L. Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells. BMC Cancer. 2008 Dec 18;8:375.

- Sun K, Guo XL, Zhao QD, Jing YY, Kou XR, Xie XQ, Zhou Y, Cai N, Gao L, Zhao X, Zhang SS, Song JR, Li D, Deng WJ, Li R, Wu MC, Wei LX. Paradoxical role of autophagy in the dysplastic and tumor-forming stages of hepatocarcinoma development in rats. Cell Death Dis. 2013 Feb 21;4:e501. doi: 10.1038/cddis.2013.35.