卜鹏程

卜鹏程，博士，研究员，博士生导师，中科院“百人计划”获得者，中科院生物物理研究所，中国科学院核酸生物学重点实验室创新课题组长。

卜鹏程，博士，研究员，博士生导师

中科院“百人计划”获得者

中科院生物物理研究所，中国科学院核酸生物学重点实验室，创新课题组长

研究方向：非编码RNA与疾病，肿瘤代谢

1997-2001 大连工业大学，工学学士

2001-2004 大连理工大学，工学硕士

2004-2007 中科院生物物理研究所，理学博士

2008-2010 美国加州大学伯克利分校，博士后

2010-2015 美国康奈尔大学，研究助理

2015-2016 美国杜克大学，资深科学家

2016.09-至今 中科院生物物理研究所，研究员

2016 入选中科院率先行动“百人计划”B

1. 非编码RNA在人类重大疾病中的功能和作用机制

2. 细胞代谢对干细胞分裂、命运的影响

3.基于类器官培养的疾病靶基因鉴定和药物筛选

1. Bu P#, Wang L, Chen K-Y, …, Shen X#. miR-34a and Numb synergize for asymmetric cell fate determination to control stem cell proliferation. Cell Stem Cell

2. Wang L*, Bu P*, Ai Y, et al. A large non-coding RNA regulates colon cancer stem cell asymmetric division

3. Chen HJ,…,Bu P,…et al. A recellularized human colon model identifies cancer driver genes. Nat Biotechnol

4. Srinivasan T, Walters J, Bu P,… et al. Notch signaling regulates asymmetric cell fate of fast- and slow-cycling colon cancer initiating cells

5. Srinivasan T, Than EB, Bu P et al. Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells

6. Bu P#, Wang L, Chen K-Y, …, Shen X#. miR-1269 Promotes Metastasis through a Positive Feedback Loop with TGF-b

7. Sun S, …, Bu P…, et al. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

8. Li J, Ai Y, Wang L, Bu P,… et al. Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles

9. Chen, H, …, Bu, P, …, et al. Chemokine-Targeted Mouse Models of Human Primary and Metastatic Colorectal Cancer

10. Okada N, …, Bu P…, et al. A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression

11. Bu P, Chen K-Y, Chen JH et al. A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells

12. Bu P, Chen K-Y, Lipkin SM, Shen X. Asymmetric division: a marker for cancer stem cells in early stage tumors? Oncotarget

13. Chen JH, Edwards R, Tucci S, Bu P, et al. The chemokine 25 and chemokine receptor 9 axis suppresses colon cancer invasion and metastasis

14. Choi YJ, …, Bu P, …, et al. miR-34a miRNAs provide a barrier for somatic cell reprogramming

15. Bu P, Zhuang J, Feng J, et al. Visualization of CD146 dimerization and its regulation in living cells

16. Bu P, Gao L, Zhuang J, et al. Anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis via suppression of NF-kB activation