付向东

付向东，1957年11月7日出生，毕业于凯西保留地（凯斯西储）大学，西湖大学RNA生物学与再生医学讲席教授^[1]。曾获Searle Scholar（1994）、Leukemia and Lymphoma Society Scholar（1997）、武汉大学杰出校友（2003）、Ray Wu Society终身成就奖（2016）和柏林墙2020年度创新科学突破奖（2020）。2010年入选美国科学促进会成员（AAAS Fellow）。2020年7月加州大学付向东教授实名举报中科院学者杨辉学术抄袭，杨辉所在单位已成立调查组。^[2]付向东实验室将继续关注RNA生物学及神经再生领域，致力于发育和疾病中RNA调节机制的探索，通过分子生物学、分子遗传学、生物化学，基因组学，动物行为学、电生理学等多种实验手段对疾病机理与干预展开研究。^[3]

1977年-1982年武大病毒系，本科。

1982年毕业于武汉大学病毒学学系。

1983年通过中美生物化学联合招生（CUSBEA）计划留学美国凯斯西储大学，并于1988年获得生物化学博士学位。

1988年-1992年 Harvard University，博后。

1992年获哈佛大学分子生物学博士后。

1992-1998 加州大学圣地亚哥分校（UCSD），细胞与分子医学助理教授

1998-2002 加州大学圣地亚哥分校，细胞与分子医学副教授

2002-2018 加州大学圣地亚哥分校，细胞与分子医学教授

2018-2022 加州大学圣地亚哥分校，细胞与分子医学杰出教授

2023年1月加入西湖大学，担任RNA生物学与再生医学讲席教授。^[1]

RNA processing and regulation

microRNA biogenesis and functions

Transcription and mRNA processing coupling

Functional genomics

Genetics and epigenetics regulation of gene expression

1. Xue, Y-C., Zhou, Y., Wu, T-B., Zhu, T., Ji, X., Zhang, C., Kwon, Y-S., Yeo, G., Sun, H., Fu, X-D, and Zhang, Yi (2009). Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping.Molecular Cell36:996-1006. (*co-corresponding authors).

2. Ji, X and Fu, X-D. (2012). The mediator couples transcription and splicing.Molecular Cell45:433-434.

3. Xiao, R., Tang, P., Yang, B., Huang, J., Zhou Y., Shao C-W., Li, H., Sun, H., Zhang, Y., and Fu, X-D. (2012). Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation.Molecular Cell45:656-668.

4. Xue, Y-C., Ouyang, K., Huang, J., Zhou, Y., Ouyang, H., Li, H., Wang, G., Wu, Q., Wei, C., Bi, Y., Jiang, L., Cai, Z., Sun, H., Zhang, K., Zhang, Y., Chen, J., and Fu, X-D. (2013) Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.Cell152:82-96.

5. Ji, X., Zhou, Y., Pandit, S., Huang, J., Li, H., Lin, C. L., Rui, X., Burge, C. B., and Fu, X-D. (2013). SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase.Cell153:855-868.

6. Qian, H., Kang, X.J., Hu, J., Zhang, D., Liang, Z., Meng, F., Zhang X., Xue, Y., Maion, R., Dowdy, S. F., Devaraj, N., Zhou, Z., Mobley, W. C., Cleveland, D. W., and Fu, X-D. (2020). Reversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature 582:550-556.

7. Gou, L-T., Lim, D-H., Ma, W., Aubol, B. E., Hao, Y., Wang, X., Zhao, J., Liang, Z., Shao, C., Zhang, X., Li, H., Zhang, X., Xu, R., Li, D., Rosenfeld, M. G., Mellon, P. L., Adams, J. A., Liu, M-F., and Fu, X-D. (2020). Initiation of parental genome reprogramming in fertilized oocyte by splicing kinase SRPK1-catalyzed protamine phosphorylation. Cell 180:1212-1227.

8. Chen, L., Chen, J-Y., Huang, Y-J., Gu, Y., Qiu, J., Shao, C., Zhang, X., Hu, J., Li, H., He., S., Zhou, Y., Zhang, D-E., and Fu, X-D. (2018). The augmented R-loop is a unifying mechanism for Myelodyplastic Syndromes induced by high risk splicing factor mutations. Mol Cell 69:412-425.

9. Zhang, X., Zuo, X., Yang, B., Li, Z., Xue, Y., Zhou, Y., Huang, J., Zhao, X., Zhou, J., Yan, Y., Zhang, H., Guo, P., Sun, H., Guo, L., Zhang, Y., and Fu, X-D. (2014).  microRNA directly enhances mitochondrial translation during muscle differentiation. Cell 158:607-619.

10. Wang, D., Garcia-Bassets, I., Benner, C., Li, W., Su. X., Zhou, Y., Qiu, J., Liu, W., Kaikkonen, M. U., Ohgi, K.A. Glass, C. K., Rosenfeld, M. G., and Fu, X-D. (2011). Reprogramming transcription via distinct classes of enhancers functionally defined by eRNA. Nature 474:390-394.

11. Xu, X., Yang, D., Ding, J-H., Wang, W., Chu, P-H., Dalton, N. D., Wang, H-Y., Bermingham, Jr., J. R., Ye, Z., Liu, F., Rosenfeld, M. G., Manley, J. L., Ross Jr. J., Chen, J., Xiao, R-P., Cheng, H., and Fu, X-D. (2005). ASF/SF2-regulated postnatal reprogramming of CaMKIId alternative splicing modulates excitation-contraction coupling in cardiac muscle. Cell 120:59-72.

12. Gui, J-F., Lane, W. S., and Fu, X-D. (1994). A serine kinase regulates the intracellular localization of splicing factors during the cell cycle. Nature 369:678-682.

13. Fu, X-D. (1993). Specific commitment of different pre-mRNAs to splicing by single SR proteins. Nature 365:82-85.

14. Fu, X-D. and Maniatis, T. (1990). Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus. Nature 343:437-441.

现任美国加州大学圣地亚哥分校细胞与分子医学系教授、美国先进科学协会会员，RNA协会会员、白血病与淋巴癌协会委员、美国生物医学科学RayWu协会会员、科技部蛋白质重大研究计划专家组成员。^[4]