智旭

智旭，M.D.，Ph.D.，北京大学第三医院生殖医学中心医师、副研究员。研究方向：妇产科生殖医学与肿瘤学，蛋白泛素化修饰。曾为美国老龄化协会，美国肿瘤协会，日本妇产科协会，日本东洋医学会会员。

1999年毕业于中国医科大学临床医学系

2002年考入首都医科大学北京妇产医院硕士研究生

2004年考取日本大阪市立大学医学部妇产科博士，2008年取得博士学位

1999年毕业后就职于北京第二炮兵总医院，任妇产科医师

2004-2008年曾在日本深造生殖医学临床工作，科研重点为妇产科生殖与肿瘤相关生理病理的分子生物学机制研究

2008-2013年于美国Albany Medical Center和University of Central Florida从事博士后及助理研究员工作，致力于蛋白泛素化修饰，以及Prop1突变小鼠的泌乳素变化等生殖内分泌相关的分子生物学研究

2013年归国就职于北京大学第三医院生殖医学中心

2006年 日本ROTARY YONEYAMA优秀博士生奖项

2007年 中国国家优秀自费留学生奖项

1. Zhi X, Lamperska K, Golusinski P, Schork NJ, Luczewski L, Golusinski W, Masternak MM. Expression levels of insulin-like growth factors 1 and 2 in head and neck squamous cell carcinoma. Growth Horm IGF Res. 2014 Aug;24(4):137-41.

2. Menon V, Zhi X, Hossain T, Bartke A, Spong A, Gesing A, Masternak MM. The contribution of visceral fat to improved insulin signaling in Ames dwarf mice. Aging Cell. 2014 Jun;13(3):497-506.

3. List EO, Berryman DE, Funk K, Jara A, Kelder B, Wang F, Stout MB, Zhi X, Sun L, White TA, LeBrasseur NK, Pirtskhalava T, Tchkonia T, Jensen EA, Zhang W, Masternak MM, Kirkland JL, Miller RA, Bartke A, Kopchick JJ. Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology. 2014 May;155(5):1793-805.

4. Zhi X, Zhao D, Wang Z, Zhou Z, Wang C, Chen W, Liu R, Chen C. E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation. Cancer Research. 2013 Jan 1;73(1):385-94.

5. Wang X, Hu G, Gao X, Wang Y, Zhang W, Harmon EY, Zhi X, Xu Z, Lennartz MR, Barroso M, Trebak M, Chen C, Zhou J. The Induction of Yes-Associated Protein Expression After Arterial Injury Is Crucial for Smooth Muscle Phenotypic Modulation and Neointima Formation. Arteriosclerosis, thrombosis, and vascular biology. 2012 Nov;32(11):2662-9.

6. Zhi X, Zhao D, Zhou Z, Liu R, Chen C. YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor. The American Journal of Pathology. 2012 Jun;180(6):2452-61.

7. Zhi X, Chen C. WWP1: a versatile E3 ubiquitin ligase in signaling and diseases. Cellular and molecular life sciences: CMLS. 2012 May;69(9):1425-34.

8. Zhao D, Zhi X, Zhou Z, Chen C. TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis. Carcinogenesis. 2012 Jan;33(1):59-67.

9. Honda K, Kajitani K, Nobeyama K, Kira Y, Yabunaka Y, Egami M, Zhi X, Fukuda T, Yoshida Y, Matsumoto Y, Ichimura Y, Yaui T, Sumi T, Ishiko O. An Upstream Estrogen Response Element Linked to Exogenous p53 Tumor Suppressor Gene Expression Differentiates Effects of the Codon 72 Polymorphism. Asian Pacific Journal of Cancer Prevention : APJCP. 2011;12(4):865-8.

10. Yoshida H, Sumi T, Zhi X, Yasui T, Honda K, and Ishiko O. Claudin-4: a potential therapeutic target in chemotherapy-resistant ovarian cancer. Anticancer Research. 2011 Apr;31(4):1271-7.

11. Zhi X, Honda K, Sumi T, Yasui T, Nobeyama H, Yoshida H, Ishiko O. Estradiol-17β regulates vascular endothelial growth factor and Bcl-2 expression in HHUA cells. International Journal of Oncology. 2007 Dec;31(6):1333-8.

12. Zhi X, Honda K, Ozaki K, Misugi T, Sumi T, Ishiko O. Dandelion T-1 extract up-regulates reproductive hormone receptor expression in mice. International Journal of Molecular Medicine. 2007 Sep;20(3):287-92.

13. Noriyuki M, Sumi T, Zhi X, Misugi F, Nobeyama H, Yoshida H, Matsumoto Y, Yasui T, Honda K, and Ishiko O. Vascular endothelial growth factor, matrix metalloproteinases, and cyclooxygenase-2 influence prognosis of uterine cervical cancer in young women. International Journal of Oncology. 2007 Sep;31(3):531-6.